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Gert Jan Fleuren - One of the best experts on this subject based on the ideXlab platform.
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different profiles of allelic losses in cervical carcinoma cases in Surinam and the netherlands
Cancer, 1999Co-Authors: Eveline J T Krul, Lex A W Peters, F Annemarie M S Kersemaekers, Yvon A Zomerdijknooyen, Cees J Cornelisse, Gert Jan FleurenAbstract:BACKGROUND Cervical carcinoma is the second most common malignancy among women worldwide. The highest incidence rates are observed in developing countries. The increased susceptibility to cervical carcinoma in high incidence populations may result from several factors including human papillomavirus exposure and both inherited and acquired genetic traits. Using comparative molecular analysis of cervical carcinomas from Surinam, a high incidence area, and the Netherlands, a low incidence area, distinct molecular genetic profiles were studied in two populations with contrasting risk for the disease. METHODS In the two populations, the authors compared allelic loss as a marker for the involvement of putative tumor suppressor genes in 40 and 67 carcinoma specimens from Surinam and the Netherlands, respectively. Loss of heterozygosity (LOH) analysis was performed using polymorphic microsatellite markers at sites of known tumor suppressor genes (17p [p53], 13q [Rb, BRCA2], 16q [E-cadherin], and 17q [BRCA1]) and at chromosomes 3p, 6p, 6q, and 11q, which frequently are lost in cervical carcinoma. RESULTS Remarkable differences in LOH were found between both populations. The most prominent observation was the extremely high frequency of LOH, up to 72%, in the region of the major histocompatibility complex on chromosome 6p in specimens from Surinam. In the group of specimens from the Netherlands, only 45% of LOH was observed at this locus. In addition, LOH was detected significantly more frequently at 6q and 13q in the cases from Surinam whereas LOH was found more frequently at 17p in cases from the Netherlands. CONCLUSIONS The results of the current study show that heterogeneity exists in tumor-associated somatic genetic alterations between these two populations that may be indicative of the existence of multiple genetic pathways in cervical tumorigenesis. Cancer 1999;86:997–1004. © 1999 American Cancer Society.
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human papillomavirus in malignant cervical lesions in Surinam a high risk country compared to the netherlands a low risk country
International Journal of Gynecological Cancer, 1999Co-Authors: E J T Krul, R W Van Kanten, M J Van De Vijver, Ed Schuuring, A A W Peters, Gert Jan FleurenAbstract:Krul EJT, van de Vijver MJ, Schuuring E, Van Kanten RW, Peters AAW, Fleuren GJ. Human papillomavirus in malignant cervical lesions in Surinam, a high-risk country, compared to the Netherlands, a low-risk country. Int J Gynecol Cancer 1999; 9: 206-211. In various countries epidemiologic studies show an association between human papillomavirus (HPV) and cancer of the uterine cervix. We de- termined the presence of HPV and the distribution of the different HPV genotypes in cervical carcinomas from Surinam, a high-incidence coun- try. The results were compared to the Netherlands where the incidence is five times lower. One hundred thirty cervical carcinomas from pa- tients in Surinam were randomly selected and compared to an unse- lected group of 128 cervical carcinomas from caucasoid Dutch patients. Presence of HPV and distribution of HPV genotypes was determined in DNA extracted from paraffin-embedded specimens by polymerase chain reaction and sequence analysis. HPV DNA was detected in 82% of the Surinamese cervical cancer patients and in 87% of the Dutch patients. Thirteen different HPV genotypes were detected in the Surinamese group, and nine different HPV genotypes were detected in the Dutch group. Among the HPV-positive samples, HPV 16 was present in 68% in the Netherlands compared to only 49% in Surinam, where less common genotypes such as HPV 35, 45, and 58 were more prevalent. The results show a strong association between HPV and cervical cancer in both groups. However, the observed significant variation in distribution of the genotypes in the two populations with a large difference in cervical carcinoma incidence is important to the general understanding of the etiology of cervical cancer and to the development of HPV vaccination strategies.
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cervical carcinoma in Surinam
Cancer, 1996Co-Authors: J Eveline T M D Krul, Lex A W Peters, J P Vandenbroucke, Albert M Vrede, W Rob M D Van Kanten, Gert Jan FleurenAbstract:BACKGROUND Epidemiologic data show a high incidence of cervical cancer throughout the world and a high mortality, particularly in developing countries. The aim of this study was to describe the incidence and stages of cervical carcinoma in Surinam. Results were compared with data from The Netherlands (used as representative of western European countries) because of a medical and patient exchange program. METHODS Data for Surinamese patients analyzed in this study were based on the files from the Department of Pathology at the University of Surinam from 1989 through 1994. Cumulative and incidence rates standardized to the World Standard Population were calculated and compared with rates in other South American countries and in The Netherlands. Age distribution and stage of disease (according to the International Federation of Gynecology and Obstetrics) among Surinamese and Dutch women were compared. Furthermore, differences in incidence rates among the multiple ethnicities of the Surinamese population were evaluated. RESULTS Age standardized incidence rates for Surinam and The Netherlands were 26.7 and 6.2 per 100,000 women, respectively. The cumulative rate up to age 74 years was 2.9 in Surinam versus 0.6 in The Netherlands. Incidence in Surinam rose sharply with age. More than 40% of the Surinamese women presented with Stage IIB disease or higher compared with 12% in The Netherlands. In Surinam, low stage of disease was highest in the youngest group (48%), whereas only 18% of women 65 years or older presented with Stage I disease. Incidence rates in Surinam varied by ethnic group. Amerindians and Javanese were more likely to develop cervical cancer than were other ethnicities. CONCLUSIONS Cervical carcinoma in Surinam was characterized by high incidence rates and relatively advanced stage of disease at presentation. Moreover, incidence was not equally distributed among the different ethnic groups. This may reflect a greater exposure to risk factors and differential access to diagnostic and treatment services. Cancer 1996;77:1329-33.
René S. Kahn - One of the best experts on this subject based on the ideXlab platform.
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first contact incidence of schizophrenia in Surinam first contact incidence of schizophrenia in Surinam
2005Co-Authors: African Surinamese, Jean-paul Selten, René S. Kahn, Caroline Zeyl, Rudi Dwarkasing, Vincent Lumsden, East Indians, Peter N Van HartenAbstract:explained by a similarly high incidence in Surinam.We conducted a1-year firstSurinam.We conducted a1-year firstcontact incidence study in Surinam and contact incidence study in Surinam and compared the findings with data from a compared the findings with data from a similar study conducted in The similar study conducted in The Netherlands using the same inclusion Netherlands using the same inclusion criteria and instruments .The risk of criteria and instruments .The risk of developing a schizophrenic disorder was developing a schizophrenic disorder was 2.4 times higher (95% CI1.3^4.2) in 2.4 times higher (95% CI1.3^4.2) in Surinamese immigrants than in residents Surinamese immigrants than in residents of Surinam.The increased risk is probably of Surinam.The increased risk is probably due to environmental factors inThe due to environmental factors inThe
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first contact incidence of schizophrenia in Surinam
British Journal of Psychiatry, 2005Co-Authors: Jean-paul Selten, René S. Kahn, Caroline Zeyl, Rudi Dwarkasing, Vincent Lumsden, Peter N Van HartenAbstract:We tested the hypothesis that the increased incidence of schizophrenia among Surinamese immigrants to The Netherlands could be explained by a similarly high incidence in Surinam. We conducted a 1-year first-contact incidence study in Surinam and compared the findings with data from a similar study conducted in The Netherlands using the same inclusion criteria and instruments. The risk of developing a schizophrenic disorder was 2.4 times higher (95% CI 1.3-4.2) in Surinamese immigrants than in residents of Surinam. The increased risk is probably due to environmental factors in The Netherlands.
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Incidence of schizophrenia in Surinam
Schizophrenia research, 2002Co-Authors: Mahinder Hanoeman, Jean-paul Selten, René S. KahnAbstract:More than one-third of the population of Surinam has migrated to The Netherlands in the 1970s and 1980s. If selective migration explains the increased incidence in these migrants, one expects to find a very low incidence of the disorder in Surinam. We examined the medical records of the sole psychiatric hospital in Surinam and found that the mean annual rate of first admissions for schizophrenia or schizophreniform disorder (DSM-III-R criteria) in 1992 and 1993 was 1.61 per 10,000 (95% Confidence interval: 1.24-1.98 per 10,000), a normal figure. These findings constitute a challenge to the hypothesis that selection explains the increased incidence in the migrants. The possibility of an increased incidence of the disorder in Surinam (which might also explain the increased incidence among migrants) has not been ruled out by the results of this study.
Peter N Van Harten - One of the best experts on this subject based on the ideXlab platform.
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first contact incidence of schizophrenia in Surinam
British Journal of Psychiatry, 2005Co-Authors: Jean-paul Selten, René S. Kahn, Caroline Zeyl, Rudi Dwarkasing, Vincent Lumsden, Peter N Van HartenAbstract:We tested the hypothesis that the increased incidence of schizophrenia among Surinamese immigrants to The Netherlands could be explained by a similarly high incidence in Surinam. We conducted a 1-year first-contact incidence study in Surinam and compared the findings with data from a similar study conducted in The Netherlands using the same inclusion criteria and instruments. The risk of developing a schizophrenic disorder was 2.4 times higher (95% CI 1.3-4.2) in Surinamese immigrants than in residents of Surinam. The increased risk is probably due to environmental factors in The Netherlands.
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first contact incidence of schizophrenia in Surinam first contact incidence of schizophrenia in Surinam
2005Co-Authors: African Surinamese, Jean-paul Selten, René S. Kahn, Caroline Zeyl, Rudi Dwarkasing, Vincent Lumsden, East Indians, Peter N Van HartenAbstract:explained by a similarly high incidence in Surinam.We conducted a1-year firstSurinam.We conducted a1-year firstcontact incidence study in Surinam and contact incidence study in Surinam and compared the findings with data from a compared the findings with data from a similar study conducted in The similar study conducted in The Netherlands using the same inclusion Netherlands using the same inclusion criteria and instruments .The risk of criteria and instruments .The risk of developing a schizophrenic disorder was developing a schizophrenic disorder was 2.4 times higher (95% CI1.3^4.2) in 2.4 times higher (95% CI1.3^4.2) in Surinamese immigrants than in residents Surinamese immigrants than in residents of Surinam.The increased risk is probably of Surinam.The increased risk is probably due to environmental factors inThe due to environmental factors inThe
Jean-paul Selten - One of the best experts on this subject based on the ideXlab platform.
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first contact incidence of schizophrenia in Surinam first contact incidence of schizophrenia in Surinam
2005Co-Authors: African Surinamese, Jean-paul Selten, René S. Kahn, Caroline Zeyl, Rudi Dwarkasing, Vincent Lumsden, East Indians, Peter N Van HartenAbstract:explained by a similarly high incidence in Surinam.We conducted a1-year firstSurinam.We conducted a1-year firstcontact incidence study in Surinam and contact incidence study in Surinam and compared the findings with data from a compared the findings with data from a similar study conducted in The similar study conducted in The Netherlands using the same inclusion Netherlands using the same inclusion criteria and instruments .The risk of criteria and instruments .The risk of developing a schizophrenic disorder was developing a schizophrenic disorder was 2.4 times higher (95% CI1.3^4.2) in 2.4 times higher (95% CI1.3^4.2) in Surinamese immigrants than in residents Surinamese immigrants than in residents of Surinam.The increased risk is probably of Surinam.The increased risk is probably due to environmental factors inThe due to environmental factors inThe
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first contact incidence of schizophrenia in Surinam
British Journal of Psychiatry, 2005Co-Authors: Jean-paul Selten, René S. Kahn, Caroline Zeyl, Rudi Dwarkasing, Vincent Lumsden, Peter N Van HartenAbstract:We tested the hypothesis that the increased incidence of schizophrenia among Surinamese immigrants to The Netherlands could be explained by a similarly high incidence in Surinam. We conducted a 1-year first-contact incidence study in Surinam and compared the findings with data from a similar study conducted in The Netherlands using the same inclusion criteria and instruments. The risk of developing a schizophrenic disorder was 2.4 times higher (95% CI 1.3-4.2) in Surinamese immigrants than in residents of Surinam. The increased risk is probably due to environmental factors in The Netherlands.
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Incidence of schizophrenia in Surinam
Schizophrenia research, 2002Co-Authors: Mahinder Hanoeman, Jean-paul Selten, René S. KahnAbstract:More than one-third of the population of Surinam has migrated to The Netherlands in the 1970s and 1980s. If selective migration explains the increased incidence in these migrants, one expects to find a very low incidence of the disorder in Surinam. We examined the medical records of the sole psychiatric hospital in Surinam and found that the mean annual rate of first admissions for schizophrenia or schizophreniform disorder (DSM-III-R criteria) in 1992 and 1993 was 1.61 per 10,000 (95% Confidence interval: 1.24-1.98 per 10,000), a normal figure. These findings constitute a challenge to the hypothesis that selection explains the increased incidence in the migrants. The possibility of an increased incidence of the disorder in Surinam (which might also explain the increased incidence among migrants) has not been ruled out by the results of this study.
Aldert Bart - One of the best experts on this subject based on the ideXlab platform.
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first cases of cutaneous leishmaniasis caused by leishmania viannia naiffi infection in Surinam
American Journal of Tropical Medicine and Hygiene, 2010Co-Authors: Pieterpaul A M Van Thiel, Tom Van Gool, Piet A Kager, Aldert BartAbstract:Cutaneous leishmaniasis in Surinam is generally caused by infection by Leishmania guyanensis. We report three cases of infection with Leishmania (Viannia) naiffi, a Leishmania species not described from Surinam before. Treatment with pentamidine proved to be effective.
