The Experts below are selected from a list of 24 Experts worldwide ranked by ideXlab platform
Aase Bengaard Andersen - One of the best experts on this subject based on the ideXlab platform.
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Mycobacterium arosiense, an unexpected cause of osteomyelitis in a patient with sarcoidosis: a case report.
BMC infectious diseases, 2019Co-Authors: Didi Bang, Erik Michael Rasmussen, Aase Bengaard AndersenAbstract:Nontuberculous mycobacteria belonging to the Mycobacterium avium complex are recognized as opportunistic pathogens to humans. Mycobacterium arosiense is one of the novel members of the Mycobacterium avium complex. The organism has only rarely been reported in human clinical cases and may be routinely misidentified. An adult male with a history of a discus prolapse and sarcoidosis presented with high fever and a strong back pain with projection to the extremities. A Magnetic Resonance Imaging scan of columna revealed a tumor Suspect Process at thoracic vertebrae 11/12 with changes at the second lumbar vertebra, which was partly removed by laminectomy. Biopsy smears revealed acid-fast bacilli and turned out to be Mycobacterium tuberculosis complex PCR negative. The routine line probe assay INNO-LiPa v2 (INNOGENETICS NV, Gent), which differentiates 16 mycobacterial species indicated the presence of a not readily identifiable NTM species. Whereas, the GenoType Mycobacterium CM v2.0 (HAIN Lifescience GmbH) that routinely differentiates 14 clinically relevant mycobacteria revealed a Mycobacterium intracellulare species. However, additional diagnostic sequencing of the 16S rRNA gene confirmed the presence of a Mycobacterium arosiense species. This is the second unusual case of osteomyelitis with clinical significance ever to be reported, caused by Mycobacterium arosiense and complicated by an underlying sarcoidosis. Mycobacterium arosiense has rarely been reported clinically and the first description of the species was identified as the cause of osteomyelitis in a child with a hereditary partial interferon gamma deficiency. Symptoms attributed to sarcoidosis waned on Mycobacterium arosiense treatment and it is inconclusive whether the patient ever suffered from sarcoidosis. Mycobacterium arosiense was misidentified by the GenoType as Mycobacterium intracellulare and implicates that the diagnosis requires supplemental sequencing of the 16S rRNA gene.
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Mycobacterium arosiense, an unexpected cause of osteomyelitis in a patient with sarcoidosis: a case report
BMC Infectious Diseases, 2019Co-Authors: Didi Bang, Erik Michael Rasmussen, Aase Bengaard AndersenAbstract:Background Nontuberculous mycobacteria belonging to the Mycobacterium avium complex are recognized as opportunistic pathogens to humans. Mycobacterium arosiense is one of the novel members of the Mycobacterium avium complex. The organism has only rarely been reported in human clinical cases and may be routinely misidentified. Case presentation An adult male with a history of a discus prolapse and sarcoidosis presented with high fever and a strong back pain with projection to the extremities. A Magnetic Resonance Imaging scan of columna revealed a tumor Suspect Process at thoracic vertebrae 11/12 with changes at the second lumbar vertebra, which was partly removed by laminectomy. Biopsy smears revealed acid-fast bacilli and turned out to be Mycobacterium tuberculosis complex PCR negative. The routine line probe assay INNO-LiPa v2 (INNOGENETICS NV, Gent), which differentiates 16 mycobacterial species indicated the presence of a not readily identifiable NTM species. Whereas, the GenoType Mycobacterium CM v2.0 (HAIN Lifescience GmbH) that routinely differentiates 14 clinically relevant mycobacteria revealed a Mycobacterium intracellulare species. However, additional diagnostic sequencing of the 16S rRNA gene confirmed the presence of a Mycobacterium arosiense species. Conclusions This is the second unusual case of osteomyelitis with clinical significance ever to be reported, caused by Mycobacterium arosiense and complicated by an underlying sarcoidosis. Mycobacterium arosiense has rarely been reported clinically and the first description of the species was identified as the cause of osteomyelitis in a child with a hereditary partial interferon gamma deficiency. Symptoms attributed to sarcoidosis waned on Mycobacterium arosiense treatment and it is inconclusive whether the patient ever suffered from sarcoidosis. Mycobacterium arosiense was misidentified by the GenoType as Mycobacterium intracellulare and implicates that the diagnosis requires supplemental sequencing of the 16S rRNA gene.
Didi Bang - One of the best experts on this subject based on the ideXlab platform.
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Mycobacterium arosiense, an unexpected cause of osteomyelitis in a patient with sarcoidosis: a case report.
BMC infectious diseases, 2019Co-Authors: Didi Bang, Erik Michael Rasmussen, Aase Bengaard AndersenAbstract:Nontuberculous mycobacteria belonging to the Mycobacterium avium complex are recognized as opportunistic pathogens to humans. Mycobacterium arosiense is one of the novel members of the Mycobacterium avium complex. The organism has only rarely been reported in human clinical cases and may be routinely misidentified. An adult male with a history of a discus prolapse and sarcoidosis presented with high fever and a strong back pain with projection to the extremities. A Magnetic Resonance Imaging scan of columna revealed a tumor Suspect Process at thoracic vertebrae 11/12 with changes at the second lumbar vertebra, which was partly removed by laminectomy. Biopsy smears revealed acid-fast bacilli and turned out to be Mycobacterium tuberculosis complex PCR negative. The routine line probe assay INNO-LiPa v2 (INNOGENETICS NV, Gent), which differentiates 16 mycobacterial species indicated the presence of a not readily identifiable NTM species. Whereas, the GenoType Mycobacterium CM v2.0 (HAIN Lifescience GmbH) that routinely differentiates 14 clinically relevant mycobacteria revealed a Mycobacterium intracellulare species. However, additional diagnostic sequencing of the 16S rRNA gene confirmed the presence of a Mycobacterium arosiense species. This is the second unusual case of osteomyelitis with clinical significance ever to be reported, caused by Mycobacterium arosiense and complicated by an underlying sarcoidosis. Mycobacterium arosiense has rarely been reported clinically and the first description of the species was identified as the cause of osteomyelitis in a child with a hereditary partial interferon gamma deficiency. Symptoms attributed to sarcoidosis waned on Mycobacterium arosiense treatment and it is inconclusive whether the patient ever suffered from sarcoidosis. Mycobacterium arosiense was misidentified by the GenoType as Mycobacterium intracellulare and implicates that the diagnosis requires supplemental sequencing of the 16S rRNA gene.
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Mycobacterium arosiense, an unexpected cause of osteomyelitis in a patient with sarcoidosis: a case report
BMC Infectious Diseases, 2019Co-Authors: Didi Bang, Erik Michael Rasmussen, Aase Bengaard AndersenAbstract:Background Nontuberculous mycobacteria belonging to the Mycobacterium avium complex are recognized as opportunistic pathogens to humans. Mycobacterium arosiense is one of the novel members of the Mycobacterium avium complex. The organism has only rarely been reported in human clinical cases and may be routinely misidentified. Case presentation An adult male with a history of a discus prolapse and sarcoidosis presented with high fever and a strong back pain with projection to the extremities. A Magnetic Resonance Imaging scan of columna revealed a tumor Suspect Process at thoracic vertebrae 11/12 with changes at the second lumbar vertebra, which was partly removed by laminectomy. Biopsy smears revealed acid-fast bacilli and turned out to be Mycobacterium tuberculosis complex PCR negative. The routine line probe assay INNO-LiPa v2 (INNOGENETICS NV, Gent), which differentiates 16 mycobacterial species indicated the presence of a not readily identifiable NTM species. Whereas, the GenoType Mycobacterium CM v2.0 (HAIN Lifescience GmbH) that routinely differentiates 14 clinically relevant mycobacteria revealed a Mycobacterium intracellulare species. However, additional diagnostic sequencing of the 16S rRNA gene confirmed the presence of a Mycobacterium arosiense species. Conclusions This is the second unusual case of osteomyelitis with clinical significance ever to be reported, caused by Mycobacterium arosiense and complicated by an underlying sarcoidosis. Mycobacterium arosiense has rarely been reported clinically and the first description of the species was identified as the cause of osteomyelitis in a child with a hereditary partial interferon gamma deficiency. Symptoms attributed to sarcoidosis waned on Mycobacterium arosiense treatment and it is inconclusive whether the patient ever suffered from sarcoidosis. Mycobacterium arosiense was misidentified by the GenoType as Mycobacterium intracellulare and implicates that the diagnosis requires supplemental sequencing of the 16S rRNA gene.
Erik Michael Rasmussen - One of the best experts on this subject based on the ideXlab platform.
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Mycobacterium arosiense, an unexpected cause of osteomyelitis in a patient with sarcoidosis: a case report.
BMC infectious diseases, 2019Co-Authors: Didi Bang, Erik Michael Rasmussen, Aase Bengaard AndersenAbstract:Nontuberculous mycobacteria belonging to the Mycobacterium avium complex are recognized as opportunistic pathogens to humans. Mycobacterium arosiense is one of the novel members of the Mycobacterium avium complex. The organism has only rarely been reported in human clinical cases and may be routinely misidentified. An adult male with a history of a discus prolapse and sarcoidosis presented with high fever and a strong back pain with projection to the extremities. A Magnetic Resonance Imaging scan of columna revealed a tumor Suspect Process at thoracic vertebrae 11/12 with changes at the second lumbar vertebra, which was partly removed by laminectomy. Biopsy smears revealed acid-fast bacilli and turned out to be Mycobacterium tuberculosis complex PCR negative. The routine line probe assay INNO-LiPa v2 (INNOGENETICS NV, Gent), which differentiates 16 mycobacterial species indicated the presence of a not readily identifiable NTM species. Whereas, the GenoType Mycobacterium CM v2.0 (HAIN Lifescience GmbH) that routinely differentiates 14 clinically relevant mycobacteria revealed a Mycobacterium intracellulare species. However, additional diagnostic sequencing of the 16S rRNA gene confirmed the presence of a Mycobacterium arosiense species. This is the second unusual case of osteomyelitis with clinical significance ever to be reported, caused by Mycobacterium arosiense and complicated by an underlying sarcoidosis. Mycobacterium arosiense has rarely been reported clinically and the first description of the species was identified as the cause of osteomyelitis in a child with a hereditary partial interferon gamma deficiency. Symptoms attributed to sarcoidosis waned on Mycobacterium arosiense treatment and it is inconclusive whether the patient ever suffered from sarcoidosis. Mycobacterium arosiense was misidentified by the GenoType as Mycobacterium intracellulare and implicates that the diagnosis requires supplemental sequencing of the 16S rRNA gene.
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Mycobacterium arosiense, an unexpected cause of osteomyelitis in a patient with sarcoidosis: a case report
BMC Infectious Diseases, 2019Co-Authors: Didi Bang, Erik Michael Rasmussen, Aase Bengaard AndersenAbstract:Background Nontuberculous mycobacteria belonging to the Mycobacterium avium complex are recognized as opportunistic pathogens to humans. Mycobacterium arosiense is one of the novel members of the Mycobacterium avium complex. The organism has only rarely been reported in human clinical cases and may be routinely misidentified. Case presentation An adult male with a history of a discus prolapse and sarcoidosis presented with high fever and a strong back pain with projection to the extremities. A Magnetic Resonance Imaging scan of columna revealed a tumor Suspect Process at thoracic vertebrae 11/12 with changes at the second lumbar vertebra, which was partly removed by laminectomy. Biopsy smears revealed acid-fast bacilli and turned out to be Mycobacterium tuberculosis complex PCR negative. The routine line probe assay INNO-LiPa v2 (INNOGENETICS NV, Gent), which differentiates 16 mycobacterial species indicated the presence of a not readily identifiable NTM species. Whereas, the GenoType Mycobacterium CM v2.0 (HAIN Lifescience GmbH) that routinely differentiates 14 clinically relevant mycobacteria revealed a Mycobacterium intracellulare species. However, additional diagnostic sequencing of the 16S rRNA gene confirmed the presence of a Mycobacterium arosiense species. Conclusions This is the second unusual case of osteomyelitis with clinical significance ever to be reported, caused by Mycobacterium arosiense and complicated by an underlying sarcoidosis. Mycobacterium arosiense has rarely been reported clinically and the first description of the species was identified as the cause of osteomyelitis in a child with a hereditary partial interferon gamma deficiency. Symptoms attributed to sarcoidosis waned on Mycobacterium arosiense treatment and it is inconclusive whether the patient ever suffered from sarcoidosis. Mycobacterium arosiense was misidentified by the GenoType as Mycobacterium intracellulare and implicates that the diagnosis requires supplemental sequencing of the 16S rRNA gene.
Xuxian Jiang - One of the best experts on this subject based on the ideXlab platform.
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Process out grafting an efficient out of vm approach for fine grained Process execution monitoring
Computer and Communications Security, 2011Co-Authors: Deepa Srinivasan, Zhi Wang, Xuxian Jiang, Dongyan XuAbstract:Recent rapid malware growth has exposed the limitations of traditional in-host malware-defense systems and motivated the development of secure virtualization-based out-of-VM solutions. By running vulnerable systems as virtual machines (VMs) and moving security software from inside the VMs to outside, the out-of-VM solutions securely isolate the anti-malware software from the vulnerable system. However, the presence of semantic gap also leads to the compatibility problem in not supporting existing defense software. In this paper, we present Process out-grafting, an architectural approach to address both isolation and compatibility challenges in out-of-VM approaches for fine-grained Process-level execution monitoring. Specifically, by relocating a Suspect Process from inside a VM to run side-by-side with the out-of-VM security tool, our technique effectively removes the semantic gap and supports existing user-mode Process monitoring tools without any modification. Moreover, by forwarding the system calls back to the VM, we can smoothly continue the execution of the out-grafted Process without weakening the isolation of the monitoring tool. We have developed a KVM-based prototype and used it to natively support a number of existing tools without any modification. The evaluation results including measurement with benchmark programs show it is effective and practical with a small performance overhead.
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ACM Conference on Computer and Communications Security - Process out-grafting: an efficient "out-of-VM" approach for fine-grained Process execution monitoring
Proceedings of the 18th ACM conference on Computer and communications security - CCS '11, 2011Co-Authors: Deepa Srinivasan, Zhi Wang, Xuxian JiangAbstract:Recent rapid malware growth has exposed the limitations of traditional in-host malware-defense systems and motivated the development of secure virtualization-based out-of-VM solutions. By running vulnerable systems as virtual machines (VMs) and moving security software from inside the VMs to outside, the out-of-VM solutions securely isolate the anti-malware software from the vulnerable system. However, the presence of semantic gap also leads to the compatibility problem in not supporting existing defense software. In this paper, we present Process out-grafting, an architectural approach to address both isolation and compatibility challenges in out-of-VM approaches for fine-grained Process-level execution monitoring. Specifically, by relocating a Suspect Process from inside a VM to run side-by-side with the out-of-VM security tool, our technique effectively removes the semantic gap and supports existing user-mode Process monitoring tools without any modification. Moreover, by forwarding the system calls back to the VM, we can smoothly continue the execution of the out-grafted Process without weakening the isolation of the monitoring tool. We have developed a KVM-based prototype and used it to natively support a number of existing tools without any modification. The evaluation results including measurement with benchmark programs show it is effective and practical with a small performance overhead.
Deepa Srinivasan - One of the best experts on this subject based on the ideXlab platform.
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Process out grafting an efficient out of vm approach for fine grained Process execution monitoring
Computer and Communications Security, 2011Co-Authors: Deepa Srinivasan, Zhi Wang, Xuxian Jiang, Dongyan XuAbstract:Recent rapid malware growth has exposed the limitations of traditional in-host malware-defense systems and motivated the development of secure virtualization-based out-of-VM solutions. By running vulnerable systems as virtual machines (VMs) and moving security software from inside the VMs to outside, the out-of-VM solutions securely isolate the anti-malware software from the vulnerable system. However, the presence of semantic gap also leads to the compatibility problem in not supporting existing defense software. In this paper, we present Process out-grafting, an architectural approach to address both isolation and compatibility challenges in out-of-VM approaches for fine-grained Process-level execution monitoring. Specifically, by relocating a Suspect Process from inside a VM to run side-by-side with the out-of-VM security tool, our technique effectively removes the semantic gap and supports existing user-mode Process monitoring tools without any modification. Moreover, by forwarding the system calls back to the VM, we can smoothly continue the execution of the out-grafted Process without weakening the isolation of the monitoring tool. We have developed a KVM-based prototype and used it to natively support a number of existing tools without any modification. The evaluation results including measurement with benchmark programs show it is effective and practical with a small performance overhead.
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ACM Conference on Computer and Communications Security - Process out-grafting: an efficient "out-of-VM" approach for fine-grained Process execution monitoring
Proceedings of the 18th ACM conference on Computer and communications security - CCS '11, 2011Co-Authors: Deepa Srinivasan, Zhi Wang, Xuxian JiangAbstract:Recent rapid malware growth has exposed the limitations of traditional in-host malware-defense systems and motivated the development of secure virtualization-based out-of-VM solutions. By running vulnerable systems as virtual machines (VMs) and moving security software from inside the VMs to outside, the out-of-VM solutions securely isolate the anti-malware software from the vulnerable system. However, the presence of semantic gap also leads to the compatibility problem in not supporting existing defense software. In this paper, we present Process out-grafting, an architectural approach to address both isolation and compatibility challenges in out-of-VM approaches for fine-grained Process-level execution monitoring. Specifically, by relocating a Suspect Process from inside a VM to run side-by-side with the out-of-VM security tool, our technique effectively removes the semantic gap and supports existing user-mode Process monitoring tools without any modification. Moreover, by forwarding the system calls back to the VM, we can smoothly continue the execution of the out-grafted Process without weakening the isolation of the monitoring tool. We have developed a KVM-based prototype and used it to natively support a number of existing tools without any modification. The evaluation results including measurement with benchmark programs show it is effective and practical with a small performance overhead.
