The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Rakesh Kumar - One of the best experts on this subject based on the ideXlab platform.
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apocrine Sweat Gland Carcinoma initial evaluation staging and response monitoring using 18f fdg pet ct
Clinical Nuclear Medicine, 2013Co-Authors: Harmandeep Singh, Punit Sharma, Sudhir Suman Kc, Pramod Kumar Julka, Arun Malhotra, Rakesh KumarAbstract:Primary apocrine Sweat Gland Carcinomas (PASGCs) are rare tumors, commonly located in the axilla. Metastases are common and confer poor prognosis. Given the rarity of these tumors, there is limited knowledge re- garding its diagnosis and management. Here we show 18 F-FDG PET/CT images of a 61-year-old man with PASGCs of the left axilla. PET/CT confirmed the diagnosis as primary axillary malignancy with nodal, pulmonary, and skeletal metastases. Another interesting finding in this case was the presence of FDG- avid calcified metastatic lymph nodes during the initial evaluation. Follow-up PET/CT showed progression of the disease. FDG PET/CT seems to be a promising tool in the management of PASGCs.
Artur Zembowicz - One of the best experts on this subject based on the ideXlab platform.
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endocrine mucin producing Sweat Gland Carcinoma of the eyelid
Ophthalmic Plastic and Reconstructive Surgery, 2008Co-Authors: Sonia Mehta, Artur Zembowicz, Sureka Thiagalingam, Mark P HattonAbstract:A 70-year-old woman was examined for a 4-mm bluish nodule in the left upper eyelid. The lesion was excised and pathology showed it to be endocrine mucin-producing Sweat Gland Carcinoma with positive margins. She underwent Mohs surgery and reconstruction of the resulting defect. Clinicians should be aware of this entity given its association with invasive mucinous adenoCarcinoma, a locally aggressive tumor with metastatic potential.
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endocrine mucin producing Sweat Gland Carcinoma twelve new cases suggest that it is a precursor of some invasive mucinous Carcinomas
The American Journal of Surgical Pathology, 2005Co-Authors: Artur Zembowicz, Zeina Tannous, Martin C Mihm, Christine F Garcia, Frederick C Koerner, Ben Z PilchAbstract:Endocrine mucin-producing Sweat Gland Carcinoma (EMPSGC) is an underrecognized low-grade Carcinoma with predilection to the eyelid. Only 4 cases of this entity have been described in the literature. Here, we describe 12 cases of EMPSGC. The lesions were twice as frequent in females than males with an average age of 70 years (range, 48-84 years). Clinically, they presented as a slowly growing cyst or swelling. The most common site of occurrence was the lower eyelid (8 cases). Two lesions occurred on the upper eyelid and 2 on the cheek. Histologically, they were well-circumscribed, typically multinodular tumors with solid or partially cystic nodules, frequently showing areas of papillary architecture. Focal cribriform arrangements were also present. The nodules were formed by uniform small- to medium-sized oval to polygonal epithelial cells with lightly eosinophilic to bluish cytoplasm. The nuclei were bland with diffusely stippled chromatin and inconspicuous nucleoli. Intracytoplasmic and extracellular mucin was usually present. Mitotic activity was present but never brisk. All tumors examined immunohistochemically expressed at least one neuroendocrine marker, synaptophysin or chromogranin. CD57 and neuron specific enolase, secondary markers of neuroendocrine differentiation, were expressed in most cases. All tumors tested expressed estrogen and progesterone receptors, cytokeratin 7, low molecular cytokeratin Cam5.2, and epithelial membrane antigen and were negative for cytokeratin 20 and S-100 protein. Calponin, smooth muscle actin, and p63 immunohistochemical stains did not disclose myoepithelial cells around larger tumor nests in most cases, supporting the notion that EMPSGC is an invasive Carcinoma. In 10 cases, cystic areas lined by benign epithelium indistinguishable from eccrine ducts were present. In some foci, the benign ductal epithelium was undermined or replaced by Carcinoma in situ with similar cytologic features to the solid or papillary areas of EMPSGC. Myoepithelial cells were preserved in the areas of in situ Carcinoma. In 6 cases, EMPSGC was associated with invasive mucinous Carcinoma. In situ Carcinoma and mucinous Carcinoma also expressed neuroendocrine markers. Clinical follow-up showed no recurrences or metastases, consistent with low-grade Carcinoma. The series provides histologic evidence for a multistage progression of noninvasive Sweat Gland neuroendocrine Carcinoma to EMPSGC and then to mucinous Carcinoma of the eyelid. Although the data from this series support the notion that the prognosis of EMPSGC and mucinous Carcinoma is good, longer follow-up is needed for better understanding of their pathogenesis and clinical behavior.
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treatment of synchronous mucinous Carcinoma and endocrine mucin producing Sweat Gland Carcinoma with mohs micrographic surgery
Dermatologic Surgery, 2005Co-Authors: Zeina Tannous, J Mathew D M Avram, Artur Zembowicz, Martin C Mihm, Merrill Liteplo, Theodore H Kwan, Suzanne M OlbrichtAbstract:Background Endocrine mucin–producing Sweat Gland Carcinoma is a very rare cutaneous tumor that has been reported only in three patients previously. We report a case of an endocrine mucin–producing Sweat Gland Carcinoma associated with mucinous Carcinoma treated by Mohs' micrographic surgery. Objective The purpose of this report is to test the utility of Mohs' micrographic surgery in the treatment of mucinous Carcinomata. Methods A 79-year-old female with a 2-year history of four lesions of biopsy-proven endocrine mucin–producing Sweat Gland Carcinomas and mucinous Carcinoma was treated with Mohs' micrographic surgery. Results Three of the lesions were completely cleared by Mohs' micrographic surgery. The fourth lesion, in the right lateral canthus, was not cleared by the Mohs' technique because of its location within the orbit and the difficulty of retraction of the globe for appropriate visualization and excision. The patient underwent wide excision of the remaining orbital tumor and reconstruction, which was successfully accomplished. The patient did not experience a recurrence in any of her four lesions over a 2-year follow-up period. Conclusion Mohs' micrographic surgery is an appropriate treatment for mucinous Carcinomata, including endocrine mucin–producing Sweat Gland Carcinoma and mucinous Carcinoma. ZEINA S. TANNOUS, MD, MATHEW M. AVRAM, MD, JD, ARTUR ZEMBOWICZ, MD, PHD, MARTIN C. MIHM, MD, MERRILL LITEPLO, MD, THEODORE KWAN, MD, AND SUZANNE M. OLBRICHT, MD, HAVE INDICATED NO SIGNIFICANT INTEREST WITH COMMERCIAL SUPPORTERS.
Zeina Tannous - One of the best experts on this subject based on the ideXlab platform.
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endocrine mucin producing Sweat Gland Carcinoma twelve new cases suggest that it is a precursor of some invasive mucinous Carcinomas
The American Journal of Surgical Pathology, 2005Co-Authors: Artur Zembowicz, Zeina Tannous, Martin C Mihm, Christine F Garcia, Frederick C Koerner, Ben Z PilchAbstract:Endocrine mucin-producing Sweat Gland Carcinoma (EMPSGC) is an underrecognized low-grade Carcinoma with predilection to the eyelid. Only 4 cases of this entity have been described in the literature. Here, we describe 12 cases of EMPSGC. The lesions were twice as frequent in females than males with an average age of 70 years (range, 48-84 years). Clinically, they presented as a slowly growing cyst or swelling. The most common site of occurrence was the lower eyelid (8 cases). Two lesions occurred on the upper eyelid and 2 on the cheek. Histologically, they were well-circumscribed, typically multinodular tumors with solid or partially cystic nodules, frequently showing areas of papillary architecture. Focal cribriform arrangements were also present. The nodules were formed by uniform small- to medium-sized oval to polygonal epithelial cells with lightly eosinophilic to bluish cytoplasm. The nuclei were bland with diffusely stippled chromatin and inconspicuous nucleoli. Intracytoplasmic and extracellular mucin was usually present. Mitotic activity was present but never brisk. All tumors examined immunohistochemically expressed at least one neuroendocrine marker, synaptophysin or chromogranin. CD57 and neuron specific enolase, secondary markers of neuroendocrine differentiation, were expressed in most cases. All tumors tested expressed estrogen and progesterone receptors, cytokeratin 7, low molecular cytokeratin Cam5.2, and epithelial membrane antigen and were negative for cytokeratin 20 and S-100 protein. Calponin, smooth muscle actin, and p63 immunohistochemical stains did not disclose myoepithelial cells around larger tumor nests in most cases, supporting the notion that EMPSGC is an invasive Carcinoma. In 10 cases, cystic areas lined by benign epithelium indistinguishable from eccrine ducts were present. In some foci, the benign ductal epithelium was undermined or replaced by Carcinoma in situ with similar cytologic features to the solid or papillary areas of EMPSGC. Myoepithelial cells were preserved in the areas of in situ Carcinoma. In 6 cases, EMPSGC was associated with invasive mucinous Carcinoma. In situ Carcinoma and mucinous Carcinoma also expressed neuroendocrine markers. Clinical follow-up showed no recurrences or metastases, consistent with low-grade Carcinoma. The series provides histologic evidence for a multistage progression of noninvasive Sweat Gland neuroendocrine Carcinoma to EMPSGC and then to mucinous Carcinoma of the eyelid. Although the data from this series support the notion that the prognosis of EMPSGC and mucinous Carcinoma is good, longer follow-up is needed for better understanding of their pathogenesis and clinical behavior.
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treatment of synchronous mucinous Carcinoma and endocrine mucin producing Sweat Gland Carcinoma with mohs micrographic surgery
Dermatologic Surgery, 2005Co-Authors: Zeina Tannous, J Mathew D M Avram, Artur Zembowicz, Martin C Mihm, Merrill Liteplo, Theodore H Kwan, Suzanne M OlbrichtAbstract:Background Endocrine mucin–producing Sweat Gland Carcinoma is a very rare cutaneous tumor that has been reported only in three patients previously. We report a case of an endocrine mucin–producing Sweat Gland Carcinoma associated with mucinous Carcinoma treated by Mohs' micrographic surgery. Objective The purpose of this report is to test the utility of Mohs' micrographic surgery in the treatment of mucinous Carcinomata. Methods A 79-year-old female with a 2-year history of four lesions of biopsy-proven endocrine mucin–producing Sweat Gland Carcinomas and mucinous Carcinoma was treated with Mohs' micrographic surgery. Results Three of the lesions were completely cleared by Mohs' micrographic surgery. The fourth lesion, in the right lateral canthus, was not cleared by the Mohs' technique because of its location within the orbit and the difficulty of retraction of the globe for appropriate visualization and excision. The patient underwent wide excision of the remaining orbital tumor and reconstruction, which was successfully accomplished. The patient did not experience a recurrence in any of her four lesions over a 2-year follow-up period. Conclusion Mohs' micrographic surgery is an appropriate treatment for mucinous Carcinomata, including endocrine mucin–producing Sweat Gland Carcinoma and mucinous Carcinoma. ZEINA S. TANNOUS, MD, MATHEW M. AVRAM, MD, JD, ARTUR ZEMBOWICZ, MD, PHD, MARTIN C. MIHM, MD, MERRILL LITEPLO, MD, THEODORE KWAN, MD, AND SUZANNE M. OLBRICHT, MD, HAVE INDICATED NO SIGNIFICANT INTEREST WITH COMMERCIAL SUPPORTERS.
Suzanne M Olbricht - One of the best experts on this subject based on the ideXlab platform.
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treatment of synchronous mucinous Carcinoma and endocrine mucin producing Sweat Gland Carcinoma with mohs micrographic surgery
Dermatologic Surgery, 2005Co-Authors: Zeina Tannous, J Mathew D M Avram, Artur Zembowicz, Martin C Mihm, Merrill Liteplo, Theodore H Kwan, Suzanne M OlbrichtAbstract:Background Endocrine mucin–producing Sweat Gland Carcinoma is a very rare cutaneous tumor that has been reported only in three patients previously. We report a case of an endocrine mucin–producing Sweat Gland Carcinoma associated with mucinous Carcinoma treated by Mohs' micrographic surgery. Objective The purpose of this report is to test the utility of Mohs' micrographic surgery in the treatment of mucinous Carcinomata. Methods A 79-year-old female with a 2-year history of four lesions of biopsy-proven endocrine mucin–producing Sweat Gland Carcinomas and mucinous Carcinoma was treated with Mohs' micrographic surgery. Results Three of the lesions were completely cleared by Mohs' micrographic surgery. The fourth lesion, in the right lateral canthus, was not cleared by the Mohs' technique because of its location within the orbit and the difficulty of retraction of the globe for appropriate visualization and excision. The patient underwent wide excision of the remaining orbital tumor and reconstruction, which was successfully accomplished. The patient did not experience a recurrence in any of her four lesions over a 2-year follow-up period. Conclusion Mohs' micrographic surgery is an appropriate treatment for mucinous Carcinomata, including endocrine mucin–producing Sweat Gland Carcinoma and mucinous Carcinoma. ZEINA S. TANNOUS, MD, MATHEW M. AVRAM, MD, JD, ARTUR ZEMBOWICZ, MD, PHD, MARTIN C. MIHM, MD, MERRILL LITEPLO, MD, THEODORE KWAN, MD, AND SUZANNE M. OLBRICHT, MD, HAVE INDICATED NO SIGNIFICANT INTEREST WITH COMMERCIAL SUPPORTERS.
Yoshiro Ebihara - One of the best experts on this subject based on the ideXlab platform.
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two cases of apocrine Sweat Gland Carcinoma of axilla
The Journal of the Japanese Society of Clinical Cytology, 2002Co-Authors: Masako Otani, Koh Nakazawa, Yoshiro Ebihara, Hiromi Serizawa, Tohru Shimizu, Kayoko HiguchiAbstract:背景:皮膚原発のアポクリン癌はまれで, さまざまな抗体を用いることにより組織学的診断が可能であるが, 細胞所見の報告は少ない.われわれは腋窩部原発アポクリン癌の2例を経験し, その細胞学的特徴を検討した.症例:症例1は49歳男性で5年前に左腋窩部腫瘍摘出術を受けたが, 局所再発をきたした.吸引細胞診ではほとんどが孤立散在性で, 一部に上皮性細胞集塊が含まれていた.腫瘍細胞は細胞質が厚くて広く, 断頭分泌を認めた.組織学的には充実性, 索状および腺管状構造を示し, 腫瘍細胞の細胞質は広く好酸性で, 断頭分泌, ジアスターゼ抵抗性PAS陽性顆粒が認められた.GCDFP-15が陽性であった.症例2は53歳の男性で, 15年前に左腋窩部腫瘤の診断を受け, 摘出術が施行された.リンパ節の擦過細胞診では比較的重積性の少ない上皮性細胞集塊が主体で, 腫瘍細胞は大型で広い細胞質, 円形から卵円形の偏在核と明瞭な核小体を持ち, 断頭分泌が認められた.組織学的には潰瘍を形成し, 腺管形成を伴い皮下脂肪織まで浸潤していた.細胞質は広く好酸性で断頭分泌が認められ, ジアスターゼ抵抗性PAS陽性顆粒を含んでいた.GCDFP-15が陽性であった.結論:腋窩部に発生するアポクリン癌は汗腺あるいは副乳由来のアポクリン癌や転移性腺癌が鑑別となる.皮膚原発アポクリン癌は細胞診でも特徴的な像を保持しており, 詳細な検討によって推定診断が可能であると考えられた.
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cytologic features of pleural effusion in apocrine Sweat Gland Carcinoma a case report
Acta Cytologica, 2001Co-Authors: Masako Otani, Yoko Maeda, Motoshige Kudo, Yoko Miyake, Myota Miura, Yoshiro EbiharaAbstract:BACKGROUND: Carcinoma arising in the apocrine Sweat Glands is very rare, and there are few reports of the cytologic features. We encountered a case of metastatic apocrine Carcinoma in a pleural effusion. CASE: A 46-year-old male had a dark reddish nodule in the right axillary region that was diagnosed as apocrine Carcinoma of skin appendage origin. Three years after wide resection and chemotherapy, widespread metastases developed with a massive pleural effusion. Needle aspiration fluid cytology contained clusters of adenoCarcinoma. Some tumor cells had abundant cytoplasm or periodic acid‐Schiff-positive, coarse granules. Decapitation secretion was occasionally found on the cell surface. Immunohistochemically, the tumor cells were often positive for BRST-2 and BRST-3. CONCLUSION: Cytologic features of metastatic apocrine Sweat Gland carinoma show some characteristics of adenoCarcinoma. Moreover, its definitive diagnosis in a pleural effusion can be made because of retaining the characteristics of apocrine Sweat Gland. (Acta Cytol 2001;45:74‐78)
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a case of apocrine Sweat Gland Carcinoma cytologic features of the metastatic lesion
The Journal of the Japanese Society of Clinical Cytology, 1999Co-Authors: Masako Otani, Yoshie Wakatsuki, Hiromi Serizawa, Toru Shimizu, Yoshiro EbiharaAbstract:An 83-year-old male was diagnosed with apocrine Sweat Gland Carcinoma in the right axillary region. After the first operation, a metastatic lesion near the primary site was noticed and a second operation was performed. Cytological examination showed tumor clusters arranged in papillary or sheet-like pattern. Some of the tumor cells had abundant eosinophilic cytoplasm with Orange G-stained coarse granules and were positive for GCDFP-15 and B 72.3 immunohistochemically.In conclusion, cytological features of the metastatic lesion retain the characteristic cytological appearance of apocrine Sweat Glands, which enabled a diagnosis of Carcinoma of apocrine Sweat Gland origin.
