The Experts below are selected from a list of 36 Experts worldwide ranked by ideXlab platform
Tack Lee - One of the best experts on this subject based on the ideXlab platform.
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nonselective Blocking of the Sympathetic nervous system decreases detrusor overactivity in spontaneously hypertensive rats
International Journal of Molecular Sciences, 2012Co-Authors: Khae Hawn Kim, Long Hu Jin, Gwoan Youb Choo, Hun Jae Lee, Bo Hwa Choi, Jiyeon Kwak, Sangmin Yoon, Changshin Park, Tack LeeAbstract:The involuntary dual control systems of the autonomic nervous system (ANS) in the bladder of awake spontaneously hypertensive rats (SHRs) were investigated through simultaneous registrations of intravesical and intraabdominal pressures to observe detrusor overactivity (DO) objectively as a core symptom of an overactive bladder. SHRs (n = 6) showed the features of overactive bladder syndrome during urodynamic study, especially DO during the filling phase. After injection of the nonselective Sympathetic Blocking agent labetalol, DO disappeared in 3 of 6 SHRs (50%). DO frequency decreased from 0.98 ± 0.22 min(-1) to 0.28 ± 0.19 min(-1) (p < 0.01), and DO pressure decreased from 3.82 ± 0.57 cm H(2)O to 1.90 ± 0.86 cm H(2)O (p < 0.05). This suggests that the DO originating from the overactive paraSympathetic nervous system is attenuated by the nonselective Blocking of the Sympathetic nervous system. The detailed mechanism behind this result is still not known, but paraSympathetic overactivity seems to require overactive Sympathetic nervous system activity in a kind of balance between these two systems. These findings are consistent with recent clinical findings suggesting that patients with idiopathic overactive bladder may have ANS dysfunction, particularly a Sympathetic dysfunction. The search for newer and better drugs than the current anticholinergic drugs as the mainstay for overactive bladder will be fueled by our research on these Sympathetic mechanisms. Further studies of this principle are required.
D Barry M D L Eppley - One of the best experts on this subject based on the ideXlab platform.
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Sympathetic blockade of isolated rat hindlimbs by intra arterial guanethidine the effect on blood flow and arterial venous shunting
Microsurgery, 1995Co-Authors: E Michael M D Mccarty, A Eugene M D Grossi, M Court D Cutting, D Christopher M D Prevel, M Raguram D Elluru, D Barry M D L EppleyAbstract:In order to improve the understanding of the role of Sympathetic nerve degeneration in reimplantation failure, the hindlimbs of eight rats (Group I) underwent near-complete amputation. The soft tissues of the hindlimb were transected at the proximal thigh with the femoral artery, vein and femur left intact. The femoral vessels were clamped and guanethidine was infused into a branch of the femoral artery of the right leg of each animal, while saline was injected into the left leg. The clamps were removed after 15 minutes. A baseline preoperative injection of radiolabeled microspheres was made, and subsequent injections at 6, 12, 18, and 24 hours postoperation. Twelve rats (Group II) were then used to assess the amount of arterial-venous shunting preoperatively (n = 6) and at 18 hours postoperation (n = 6), by venous sampling. Blood flow to both limbs increased postoperation, but there was significantly more flow in the guanethidine treated limb at 18 and 24 hours postoperation. The amount of shunting was approximately 50% in both limbs at 18 hours, as compared to 10% preoperation. These results highlight the potential benefit of guanethidine and other Sympathetic Blocking agents in reimplantation to increase blood flow, decrease tissue ischemia and increase anastomotic patency rates. They also suggest that Sympathetic nerve degeneration did not affect the volume of arterial-venous shunting in this model, but the difference in blood flow was likely due to arteriolar vasospasm. Further study is needed to elucidate the clinical significance of Sympathetic nerve degeneration in reimplantation failure.
Gerald F. Dibona - One of the best experts on this subject based on the ideXlab platform.
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Effect of Sympathetic Blocking agents on the antinatriuresis of reflex renal nerve stimulation
2016Co-Authors: Edward J. Zambraski, Gerald F. Dibona, George J. Kaloyanides, Edward JAbstract:A number of studies have provided evidence that increased renal Sympathetic nerve activity participates in the regulation of renal tubular sodium reabsorption in normal and pathologic states. Studies from this laboratory employing renal clearance and micropuncture techniques showed that acute surgical or pharmacological renal denervation with phenoxybenzamine or guanethidine resulted in a restoration of the Received for publication December 8, 1975
Khae Hawn Kim - One of the best experts on this subject based on the ideXlab platform.
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nonselective Blocking of the Sympathetic nervous system decreases detrusor overactivity in spontaneously hypertensive rats
International Journal of Molecular Sciences, 2012Co-Authors: Khae Hawn Kim, Long Hu Jin, Gwoan Youb Choo, Hun Jae Lee, Bo Hwa Choi, Jiyeon Kwak, Sangmin Yoon, Changshin Park, Tack LeeAbstract:The involuntary dual control systems of the autonomic nervous system (ANS) in the bladder of awake spontaneously hypertensive rats (SHRs) were investigated through simultaneous registrations of intravesical and intraabdominal pressures to observe detrusor overactivity (DO) objectively as a core symptom of an overactive bladder. SHRs (n = 6) showed the features of overactive bladder syndrome during urodynamic study, especially DO during the filling phase. After injection of the nonselective Sympathetic Blocking agent labetalol, DO disappeared in 3 of 6 SHRs (50%). DO frequency decreased from 0.98 ± 0.22 min(-1) to 0.28 ± 0.19 min(-1) (p < 0.01), and DO pressure decreased from 3.82 ± 0.57 cm H(2)O to 1.90 ± 0.86 cm H(2)O (p < 0.05). This suggests that the DO originating from the overactive paraSympathetic nervous system is attenuated by the nonselective Blocking of the Sympathetic nervous system. The detailed mechanism behind this result is still not known, but paraSympathetic overactivity seems to require overactive Sympathetic nervous system activity in a kind of balance between these two systems. These findings are consistent with recent clinical findings suggesting that patients with idiopathic overactive bladder may have ANS dysfunction, particularly a Sympathetic dysfunction. The search for newer and better drugs than the current anticholinergic drugs as the mainstay for overactive bladder will be fueled by our research on these Sympathetic mechanisms. Further studies of this principle are required.
E Michael M D Mccarty - One of the best experts on this subject based on the ideXlab platform.
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Sympathetic blockade of isolated rat hindlimbs by intra arterial guanethidine the effect on blood flow and arterial venous shunting
Microsurgery, 1995Co-Authors: E Michael M D Mccarty, A Eugene M D Grossi, M Court D Cutting, D Christopher M D Prevel, M Raguram D Elluru, D Barry M D L EppleyAbstract:In order to improve the understanding of the role of Sympathetic nerve degeneration in reimplantation failure, the hindlimbs of eight rats (Group I) underwent near-complete amputation. The soft tissues of the hindlimb were transected at the proximal thigh with the femoral artery, vein and femur left intact. The femoral vessels were clamped and guanethidine was infused into a branch of the femoral artery of the right leg of each animal, while saline was injected into the left leg. The clamps were removed after 15 minutes. A baseline preoperative injection of radiolabeled microspheres was made, and subsequent injections at 6, 12, 18, and 24 hours postoperation. Twelve rats (Group II) were then used to assess the amount of arterial-venous shunting preoperatively (n = 6) and at 18 hours postoperation (n = 6), by venous sampling. Blood flow to both limbs increased postoperation, but there was significantly more flow in the guanethidine treated limb at 18 and 24 hours postoperation. The amount of shunting was approximately 50% in both limbs at 18 hours, as compared to 10% preoperation. These results highlight the potential benefit of guanethidine and other Sympathetic Blocking agents in reimplantation to increase blood flow, decrease tissue ischemia and increase anastomotic patency rates. They also suggest that Sympathetic nerve degeneration did not affect the volume of arterial-venous shunting in this model, but the difference in blood flow was likely due to arteriolar vasospasm. Further study is needed to elucidate the clinical significance of Sympathetic nerve degeneration in reimplantation failure.
