The Experts below are selected from a list of 174 Experts worldwide ranked by ideXlab platform
Abdul-kader Souid - One of the best experts on this subject based on the ideXlab platform.
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Persistent wandering atrial pacemaker after epinephrine overdosing – a case report
BMC Pediatrics, 2013Co-Authors: Elhadi H Aburawi, Hassib Narchi, Abdul-kader SouidAbstract:Background Long-term complications of Sympathomimetic Drug overdosing have not been adequately investigated in infants and young children. Despite reports discouraging their use in children, these formulations are frequently administered for “cold-like symptoms”. Their frequent adverse events are different forms of arrhythmias, including multifocal atrial tachycardia. Case presentation A 3-year-old toddler developed multifocal atrial tachycardia following an iatrogenic overdose of epinephrine accidentally administered intravenously. His ECG showed wandering atrial pacemaker (p-waves with different origins and configurations) that persisted for at least one year. This event demonstrated the sensitivity of young children to the Sympathomimetic Drugs, especially overdosing. Conclusions Health care providers and parents should be warned of toxicities associated with Sympathomimetic Drug overdosing. Future studies are needed to determine whether wandering atrial pacemaker is a potential long-term complication of high-dose Sympathomimetics.
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persistent wandering atrial pacemaker after epinephrine overdosing a case report
BMC Pediatrics, 2013Co-Authors: Elhadi H Aburawi, Hassib Narchi, Abdul-kader SouidAbstract:Background Long-term complications of Sympathomimetic Drug overdosing have not been adequately investigated in infants and young children. Despite reports discouraging their use in children, these formulations are frequently administered for “cold-like symptoms”. Their frequent adverse events are different forms of arrhythmias, including multifocal atrial tachycardia.
Askiel Bruno - One of the best experts on this subject based on the ideXlab platform.
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cerebrovascular and cardiovascular complications of alcohol and Sympathomimetic Drug abuse
Medical Clinics of North America, 2005Co-Authors: Ayrn D Oconnor, Daniel E. Rusyniak, Askiel BrunoAbstract:Alcohol and stimulant abuse represents a major cause of cerebrovascular and cardiovascular disease in young adults. Although mild-to-moderate alcohol consumption has been linked to a decreased risk for stroke and CVD, excessive use is associated with an increased risk for intracranial hemorrhage and cardiomyopathy. Cocaine represents the single largest,cause of medical complications related to illegal Drug use. Cocaine has been associated with cerebral infarction, intracranial hemorrhage, myocardial infarction, cardiomyopathy, and cardiac arrhythmias. Abuse of amphetamines is associated with complications similar to those of cocaine. The complications associated with stimulant abuse are thought to be primarily mediated through excess catecholamines, resulting in acute arterial hypertension, vasospasm, thrombosis, and accelerated atherosclerosis. Because many complications of alcohol and stimulant abuse are preventable and reversible, it is important to screen for these in patients with cerebrovascular and cardiovascular disease.
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Cerebrovascular and Cardiovascular Complications of Alcohol and Sympathomimetic Drug Abuse
Medical Clinics of North America, 2005Co-Authors: Ayrn D. O’connor, Daniel E. Rusyniak, Askiel BrunoAbstract:Alcohol abuse is found worldwide and leads to multiple medicalcomplications, including stroke, cardiomyopathy, cardiac arrhythmias,and hypertension. Despite the well-publicized negative effects of alcohol,light-to-moderate consumption may actually reduce the risk of cerebrovas-cular and cardiovascular disease. One drink is typically defined as 12 g ofalcohol, which is the equivalent of 12 oz of beer, 6 oz of wine, and 1.5 oz of90-proof spirits. The National Institute on Alcohol Abuse and Alcoholismdefines at-risk drinking in men as more than 14 drinks per week or morethan four drinks per occasion and in women as more than seven drinks perweek or more than three drinks per occasion [1]. Some of the challenges toresearch on alcohol use and vascular disease include an underreporting ofconsumption and difficulty in separating alcohol use from other vascularrisk factors.Drug abuse is a heterogeneous problem, often involving multiple Drugsand various routes of abuse. Cocaine is the most commonly reported Drugassociated with emergency department visits, with amphetamines, metham-phetamine, and Ecstasy being fourth, fifth, and sixth, respectively [2].Together these Drugs are classified as stimulants and share a commonmechanism of activating the adrenergic nervous system. This effect mayresult in ischemic and hemorrhagic stroke, as well as severe cardiovascular
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Cerebrovascular complications of alcohol and Sympathomimetic Drug abuse.
Current Neurology and Neuroscience Reports, 2003Co-Authors: Askiel BrunoAbstract:Alcohol abuse has been linked to intracranial hemorrhage, both intracerebral and subarachnoid. Some studies have found a dose-response relationship, so that increasing levels of abuse are associated with greater risk of hemorrhage. However, alcohol abuse has not been clearly linked to cerebral infarction, and some studies find that mild-to-moderate drinking appears to be associated with a decreased risk of cerebral infarction. Intravenous administration of Drugs of abuse predisposes to endocarditis, which may lead to embolic stroke. Associations have been reported between various Sympathomimetic Drugs and cerebral infarction. A possible mechanism for cerebral infarction is focal arterial vasoconstriction and occasionally cerebral vasculitis. Associations have also been reported between various Sympathomimetic Drugs and intracranial hemorrhage. A likely mechanism for intracranial hemorrhage is acute arterial hypertension. With the exception of endocarditis, management of stroke related to Drug abuse is largely supportive, with emphasis on supportive care to prevent stroke complications, physical and occupational therapy, and aggressive addiction rehabilitation.
Elhadi H Aburawi - One of the best experts on this subject based on the ideXlab platform.
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Persistent wandering atrial pacemaker after epinephrine overdosing – a case report
BMC Pediatrics, 2013Co-Authors: Elhadi H Aburawi, Hassib Narchi, Abdul-kader SouidAbstract:Background Long-term complications of Sympathomimetic Drug overdosing have not been adequately investigated in infants and young children. Despite reports discouraging their use in children, these formulations are frequently administered for “cold-like symptoms”. Their frequent adverse events are different forms of arrhythmias, including multifocal atrial tachycardia. Case presentation A 3-year-old toddler developed multifocal atrial tachycardia following an iatrogenic overdose of epinephrine accidentally administered intravenously. His ECG showed wandering atrial pacemaker (p-waves with different origins and configurations) that persisted for at least one year. This event demonstrated the sensitivity of young children to the Sympathomimetic Drugs, especially overdosing. Conclusions Health care providers and parents should be warned of toxicities associated with Sympathomimetic Drug overdosing. Future studies are needed to determine whether wandering atrial pacemaker is a potential long-term complication of high-dose Sympathomimetics.
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persistent wandering atrial pacemaker after epinephrine overdosing a case report
BMC Pediatrics, 2013Co-Authors: Elhadi H Aburawi, Hassib Narchi, Abdul-kader SouidAbstract:Background Long-term complications of Sympathomimetic Drug overdosing have not been adequately investigated in infants and young children. Despite reports discouraging their use in children, these formulations are frequently administered for “cold-like symptoms”. Their frequent adverse events are different forms of arrhythmias, including multifocal atrial tachycardia.
Teresa Herrero - One of the best experts on this subject based on the ideXlab platform.
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Sympathomimetic Drug allergy: cross-reactivity study by patch test.
American Journal of Clinical Dermatology, 2012Co-Authors: Ruth Barranco, Angel Rodríguez, Manuel Barrio, Mā J. Trujillo, Consolación Frutos, Vāctor Matheu, Pilar Tornero, Teresa HerreroAbstract:Introduction: Sympathomimetic (α-adrenergic) Drugs are mainly used because of their vasoconstrictor properties, for nasal congestion, or as mydriatics. Although Sympathomimetic Drugs are used often, allergic reactions are rare, especially when the Drugs are administered systemically. Cross-reactivity may exist among catecholamine derivatives, although reported data on this are contradictory. In this study, we investigate if there is cross-reactivity in patch tests among these Drugs.
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Sympathomimetic Drug Allergy
American Journal of Clinical Dermatology, 2004Co-Authors: Ruth Barranco, Angel Rodríguez, Manuel Barrio, Mā J. Trujillo, Consolación Frutos, Vāctor Matheu, Pilar Tornero, Teresa HerreroAbstract:Introduction: Sympathomimetic (α-adrenergic) Drugs are mainly used because of their vasoconstrictor properties, for nasal congestion, or as mydriatics. Although Sympathomimetic Drugs are used often, allergic reactions are rare, especially when the Drugs are administered systemically. Cross-reactivity may exist among catecholamine derivatives, although reported data on this are contradictory. In this study, we investigate if there is cross-reactivity in patch tests among these Drugs. Material and methods: Patch tests with 10% phenylephrine and 10% pseudoephedrine in petrolatum, and 10% and 20% ephedrine, 10% phenylpropanolamine, 5% fepradinol, 1% methoxamine, and 10% oxymetazoline, all administered in dimethyl sulfoxide (DMSO), were carried out in 14 patients with a history of allergy to any of these Drugs. DMSO was used as the negative control. Results: All patients except one (patient number five) showed positive patch-test reactions to at least two different Drugs. Nine patients (64.3%) were cross-sensitized to three or more different Drugs, and 57.1% of patients were sensitized to four or more Sympathomimetic Drugs. Patients who experienced generalized rashes caused by orally administered pseudoephedrine had a stronger response and more cross-reactivity with other Sympathomimetic Drugs in patch tests than those who experienced local contact dermatitis. Conclusions: We conclude that there is cross-reactivity among the different Sympathomimetic Drugs tested, especially if the Drug is administered systemically.
Dipak K. Das - One of the best experts on this subject based on the ideXlab platform.
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Induction of Differential Heat Shock Gene Expression in Heart, Lung, Liver, Brain and Kidney by a Sympathomimetic Drug, Amphetamine
Biochemical and Biophysical Research Communications, 1993Co-Authors: Dipak K. DasAbstract:Abstract Amphetamine, a Sympathomimetic Drug, can elevate the body temperature by causing enhancement of endogenous lipolysis. This study was designed to examine whether this Drug could induce the expression of the genes of heat shock proteins (HSP) in different tissues. Subcutaneous administration of amphetamine (10 mg/kg wt) to the rats increased the rectal temperature of the rats to 42°C within 60 min. After 3 hr rats were sacrificed; and heart, lung, liver, kidney and brain tissue were removed to examine the induction of mRNAs for HSPs by Northern blot analysis using cDNA probes of 27 kDa, 70 kDa and 89 kDa HSPs. The results of this study indicate striking regional and cell type differences in the pattern of induction of the HSP mRNAs by amphetamine suggesting that different organs and cell types respond differently to amphetamine.
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induction of differential heat shock gene expression in heart lung liver brain and kidney by a Sympathomimetic Drug amphetamine
Biochemical and Biophysical Research Communications, 1993Co-Authors: Dipak K. DasAbstract:Amphetamine, a Sympathomimetic Drug, can elevate the body temperature by causing enhancement of endogenous lipolysis. This study was designed to examine whether this Drug could induce the expression of the genes of heat shock proteins (HSP) in different tissues. Subcutaneous administration of amphetamine (10 mg/kg wt) to the rats increased the rectal temperature of the rats to 42 degrees C within 60 min. After 3 hr rats were sacrificed; and heart, lung, liver, kidney and brain tissue were removed to examine the induction of mRNAs for HSPs by Northern blot analysis using cDNA probes of 27 kDa, 70 kDa and 89 kDa HSPs. The results of this study indicate striking regional and cell type differences in the pattern of induction of the HSP mRNAs by amphetamine suggesting that different organs and cell types respond differently to amphetamine.
