The Experts below are selected from a list of 49575 Experts worldwide ranked by ideXlab platform
Antonios G. Mikos - One of the best experts on this subject based on the ideXlab platform.
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review mineralization of Synthetic Polymer scaffolds for bone tissue engineering
Tissue Engineering, 2007Co-Authors: James D Kretlow, Antonios G. MikosAbstract:It has repeatedly been shown that demineralization improves the ability of bone auto- and allografts to regenerate natural bone tissue. Conversely, much work in the field of bone tissue engineering...
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review mineralization of Synthetic Polymer scaffolds for bone tissue engineering
Tissue Engineering, 2007Co-Authors: James D Kretlow, Antonios G. MikosAbstract:It has repeatedly been shown that demineralization improves the ability of bone auto- and allografts to regenerate natural bone tissue. Conversely, much work in the field of bone tissue engineering has used composite materials consisting of a mineralized phase or materials designed to mineralize rapidly in situ. In this review, we seek to examine these disparate roles of mineralization and the underlying factors that cause this discordance and to examine methods and principles of the mineralization of Synthetic Polymer scaffolds. Biomimetic approaches to mineralization and phosphorus-containing materials are highlighted, and a brief section focusing on drug-delivery strategies using mineralized scaffolds is included.
Kenichi Kuroda - One of the best experts on this subject based on the ideXlab platform.
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catechol functionalized Synthetic Polymer as a dental adhesive to contaminated dentin surface for a composite restoration
Biomacromolecules, 2015Co-Authors: Carlos Gonzalezcabezas, Kenichi KurodaAbstract:This study reports a Synthetic Polymer functionalized with catechol groups as dental adhesives. We hypothesize that a catechol-functionalized Polymer functions as a dental adhesive for wet dentin surfaces, potentially eliminating the complications associated with saliva contamination. We prepared a random coPolymer containing catechol and methoxyethyl groups in the side chains. The mechanical and adhesive properties of the Polymer to dentin surface in the presence of water and salivary components were determined. It was found that the new Polymer combined with an Fe3+ additive improved bond strength of a commercial dental adhesive to artificial saliva contaminated dentin surface as compared to a control sample without the Polymer. Histological analysis of the bonding structures showed no leakage pattern, probably due to the formation of Fe–catechol complexes, which reinforce the bonding structures. Cytotoxicity test showed that the Polymers did not inhibit human gingival fibroblast cells proliferation. Re...
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catechol functionalized Synthetic Polymer as a dental adhesive to contaminated dentin surface for a composite restoration
Biomacromolecules, 2015Co-Authors: Sangbae Lee, Carlos Gonzalezcabezas, Kwangmahn Kim, Kyoungnam Kim, Kenichi KurodaAbstract:This study reports a Synthetic Polymer functionalized with catechol groups as dental adhesives. We hypothesize that a catechol-functionalized Polymer functions as a dental adhesive for wet dentin surfaces, potentially eliminating the complications associated with saliva contamination. We prepared a random coPolymer containing catechol and methoxyethyl groups in the side chains. The mechanical and adhesive properties of the Polymer to dentin surface in the presence of water and salivary components were determined. It was found that the new Polymer combined with an Fe(3+) additive improved bond strength of a commercial dental adhesive to artificial saliva contaminated dentin surface as compared to a control sample without the Polymer. Histological analysis of the bonding structures showed no leakage pattern, probably due to the formation of Fe-catechol complexes, which reinforce the bonding structures. Cytotoxicity test showed that the Polymers did not inhibit human gingival fibroblast cells proliferation. Results from this study suggest a potential to reduce failure of dental restorations due to saliva contamination using catechol-functionalized Polymers as dental adhesives.
Tetsuya Tateishi - One of the best experts on this subject based on the ideXlab platform.
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tissue engineering of cartilage using a hybrid scaffold of Synthetic Polymer and collagen
Tissue Engineering, 2004Co-Authors: Guoping Chen, Takashi Ushida, Takashi Sato, Naoyuki Ochiai, Tetsuya TateishiAbstract:A biodegradable hybrid scaffold of Synthetic Polymer, poly (DL-lactic-co-glycolic acid) (PLGA), and naturally derived Polymer, collagen, was prepared by forming collagen microsponges in the pores of PLGA sponge. This was then used as the three-dimensional scaffold for tissue engineering of bovine articular cartilage, both in vitro and in vivo. In vitro studies show that hybridization with collagen facilitated cell seeding in the sponge and raised seeding efficiency. Chondrocytes adhered to the collagen microsponges, where they proliferated and secreted extracellular matrices with time, filling the space within the sponge. Hematoxylin and eosin staining revealed that most of the chondrocytes after 4 weeks of culture, and almost all cell types after 6 weeks of culture, maintained their phenotypically rounded morphology. While new tissue formed, the scaffold degraded and lost almost 36.9% of its original weight after 10 weeks. Subcutaneous implantation studies in nude mice demonstrated more homogeneous tissu...
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tissue engineering of cartilage using a hybrid scaffold of Synthetic Polymer and collagen
Tissue Engineering, 2004Co-Authors: Guoping Chen, Takashi Ushida, Takashi Sato, Naoyuki Ochiai, Tetsuya TateishiAbstract:A biodegradable hybrid scaffold of Synthetic Polymer, poly (DL-lactic-co-glycolic acid) (PLGA), and naturally derived Polymer, collagen, was prepared by forming collagen microsponges in the pores o...
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a hybrid network of Synthetic Polymer mesh and collagen sponge
Chemical Communications, 2000Co-Authors: Guoping Chen, Takashi Ushida, Tetsuya TateishiAbstract:A novel hybrid network of Synthetic Polymer mesh and collagen sponge was prepared by forming collagen sponges with interconnected microporous structures in the interstices of the Synthetic Polymer mesh.
James D Kretlow - One of the best experts on this subject based on the ideXlab platform.
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review mineralization of Synthetic Polymer scaffolds for bone tissue engineering
Tissue Engineering, 2007Co-Authors: James D Kretlow, Antonios G. MikosAbstract:It has repeatedly been shown that demineralization improves the ability of bone auto- and allografts to regenerate natural bone tissue. Conversely, much work in the field of bone tissue engineering...
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review mineralization of Synthetic Polymer scaffolds for bone tissue engineering
Tissue Engineering, 2007Co-Authors: James D Kretlow, Antonios G. MikosAbstract:It has repeatedly been shown that demineralization improves the ability of bone auto- and allografts to regenerate natural bone tissue. Conversely, much work in the field of bone tissue engineering has used composite materials consisting of a mineralized phase or materials designed to mineralize rapidly in situ. In this review, we seek to examine these disparate roles of mineralization and the underlying factors that cause this discordance and to examine methods and principles of the mineralization of Synthetic Polymer scaffolds. Biomimetic approaches to mineralization and phosphorus-containing materials are highlighted, and a brief section focusing on drug-delivery strategies using mineralized scaffolds is included.
Guoping Chen - One of the best experts on this subject based on the ideXlab platform.
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tissue engineering of cartilage using a hybrid scaffold of Synthetic Polymer and collagen
Tissue Engineering, 2004Co-Authors: Guoping Chen, Takashi Ushida, Takashi Sato, Naoyuki Ochiai, Tetsuya TateishiAbstract:A biodegradable hybrid scaffold of Synthetic Polymer, poly (DL-lactic-co-glycolic acid) (PLGA), and naturally derived Polymer, collagen, was prepared by forming collagen microsponges in the pores of PLGA sponge. This was then used as the three-dimensional scaffold for tissue engineering of bovine articular cartilage, both in vitro and in vivo. In vitro studies show that hybridization with collagen facilitated cell seeding in the sponge and raised seeding efficiency. Chondrocytes adhered to the collagen microsponges, where they proliferated and secreted extracellular matrices with time, filling the space within the sponge. Hematoxylin and eosin staining revealed that most of the chondrocytes after 4 weeks of culture, and almost all cell types after 6 weeks of culture, maintained their phenotypically rounded morphology. While new tissue formed, the scaffold degraded and lost almost 36.9% of its original weight after 10 weeks. Subcutaneous implantation studies in nude mice demonstrated more homogeneous tissu...
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tissue engineering of cartilage using a hybrid scaffold of Synthetic Polymer and collagen
Tissue Engineering, 2004Co-Authors: Guoping Chen, Takashi Ushida, Takashi Sato, Naoyuki Ochiai, Tetsuya TateishiAbstract:A biodegradable hybrid scaffold of Synthetic Polymer, poly (DL-lactic-co-glycolic acid) (PLGA), and naturally derived Polymer, collagen, was prepared by forming collagen microsponges in the pores o...
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a hybrid network of Synthetic Polymer mesh and collagen sponge
Chemical Communications, 2000Co-Authors: Guoping Chen, Takashi Ushida, Tetsuya TateishiAbstract:A novel hybrid network of Synthetic Polymer mesh and collagen sponge was prepared by forming collagen sponges with interconnected microporous structures in the interstices of the Synthetic Polymer mesh.
