Synthetic Progestogens

14,000,000 Leading Edge Experts on the ideXlab platform

Scan Science and Technology

Contact Leading Edge Experts & Companies

Scan Science and Technology

Contact Leading Edge Experts & Companies

The Experts below are selected from a list of 963 Experts worldwide ranked by ideXlab platform

Guang-guo Ying - One of the best experts on this subject based on the ideXlab platform.

  • Microbial transformation of progesterone and dydrogesterone by bacteria from swine wastewater: Degradation kinetics and products identification.
    The Science of the total environment, 2019
    Co-Authors: Shuang-shuang Liu, Jun Chen, Jin-na Zhang, You-sheng Liu, Xiaowen Chen, Shan Liu, Guang-guo Ying
    Abstract:

    Natural and Synthetic Progestogens in livestock environments have become a concern due to the frequent presence and potential adverse effects on aquatic organisms. Here we investigated the biotransformation of Progestogens by wastewater-borne bacteria in the field and laboratory under oxic and anoxic conditions. The results showed that all Progestogens dissipated faster under oxic conditions than under anoxic conditions, and natural progesterone transformed faster than Synthetic Progestogens. Meanwhile, dozens of bacterial strains capable of degrading Progestogens were successfully isolated from the swine wastewater, and Bacillus sp. P19 and Bacillus sp. DGT2 were found the best for progesterone and dydrogesterone transformation, respectively. In the degradation experiments using a single bacterial strain, progesterone and dydrogesterone dissipated under oxic conditions with half-lives of 11.6 h and 18.2 h, respectively. The transformation pathways were proposed based on the identified transformation products. The findings from this study showed that Progestogens can be biotransformed, but not fully mineralized in the environment.

Zhanlan Fan - One of the best experts on this subject based on the ideXlab platform.

  • occurrence of androgens and Progestogens in wastewater treatment plants and receiving river waters comparison to estrogens
    Water Research, 2011
    Co-Authors: Hong Chang, Yi Wan, Zhanlan Fan
    Abstract:

    Research has shown that exposure to androgens and Progestogens can cause undesirable biological responses in the environment. To date, however, no detailed or direct study of their presence in wastewater treatment plants has been conducted. In this study, nine androgens, nine Progestogens, and five estrogens were analyzed in influent and final effluent wastewaters in seven wastewater treatment plants (WWTPs) of Beijing, China. Over a period of three weeks, the average total hormone concentrations in influent wastewaters were 3562 (Wujiacun WWTP)-5400 ng/L (Fangzhuang WWTP). Androgens contributed 96% of the total hormone concentrations in all WWTP influents, with natural androgen (androsterone: 2977±739 ng/L; epiandrosterone: 640±263 ng/L; and androstenedione: 270±132 ng/L) being the predominant compounds. The concentrations of Synthetic Progestogens (megestrol acetate: 41±25 ng/L; norethindrone: 6.5±3.3 ng/L; and medroxyprogesterone acetate: 6.0±3.2 ng/L) were comparable to natural ones (progesterone: 66±36 ng/L; 17α,20β-dihydroxy-4-progegnen-3-one: 4.9±1.2 ng/L; 21α-hydroxyprogesterone: 8.5±3.0 ng/L; and 17α-hydroxyprogesterone: 1.5±0.95 ng/L), probably due to the wide and relatively large usage of Synthetic Progestogens in medical therapy. In WWTP effluents, androgens were still the dominant class accounting for 60% of total hormone concentrations, followed by Progestogens (24%), and estrogens (16%). Androstenedione and testosterone were the main androgens detected in all effluents. High removal efficiency (91-100%) was found for androgens and Progestogens compared with estrogens (67-80%), with biodegradation the major removal route in WWTPs. Different profiles of Progestogens in the receiving rivers and WWTP effluents were observed, which could be explained by the discharge of a mixture of treated and untreated wastewater into the receiving rivers.

Shuang-shuang Liu - One of the best experts on this subject based on the ideXlab platform.

  • Microbial transformation of progesterone and dydrogesterone by bacteria from swine wastewater: Degradation kinetics and products identification.
    The Science of the total environment, 2019
    Co-Authors: Shuang-shuang Liu, Jun Chen, Jin-na Zhang, You-sheng Liu, Xiaowen Chen, Shan Liu, Guang-guo Ying
    Abstract:

    Natural and Synthetic Progestogens in livestock environments have become a concern due to the frequent presence and potential adverse effects on aquatic organisms. Here we investigated the biotransformation of Progestogens by wastewater-borne bacteria in the field and laboratory under oxic and anoxic conditions. The results showed that all Progestogens dissipated faster under oxic conditions than under anoxic conditions, and natural progesterone transformed faster than Synthetic Progestogens. Meanwhile, dozens of bacterial strains capable of degrading Progestogens were successfully isolated from the swine wastewater, and Bacillus sp. P19 and Bacillus sp. DGT2 were found the best for progesterone and dydrogesterone transformation, respectively. In the degradation experiments using a single bacterial strain, progesterone and dydrogesterone dissipated under oxic conditions with half-lives of 11.6 h and 18.2 h, respectively. The transformation pathways were proposed based on the identified transformation products. The findings from this study showed that Progestogens can be biotransformed, but not fully mineralized in the environment.

Hong Chang - One of the best experts on this subject based on the ideXlab platform.

  • occurrence of androgens and Progestogens in wastewater treatment plants and receiving river waters comparison to estrogens
    Water Research, 2011
    Co-Authors: Hong Chang, Yi Wan, Zhanlan Fan
    Abstract:

    Research has shown that exposure to androgens and Progestogens can cause undesirable biological responses in the environment. To date, however, no detailed or direct study of their presence in wastewater treatment plants has been conducted. In this study, nine androgens, nine Progestogens, and five estrogens were analyzed in influent and final effluent wastewaters in seven wastewater treatment plants (WWTPs) of Beijing, China. Over a period of three weeks, the average total hormone concentrations in influent wastewaters were 3562 (Wujiacun WWTP)-5400 ng/L (Fangzhuang WWTP). Androgens contributed 96% of the total hormone concentrations in all WWTP influents, with natural androgen (androsterone: 2977±739 ng/L; epiandrosterone: 640±263 ng/L; and androstenedione: 270±132 ng/L) being the predominant compounds. The concentrations of Synthetic Progestogens (megestrol acetate: 41±25 ng/L; norethindrone: 6.5±3.3 ng/L; and medroxyprogesterone acetate: 6.0±3.2 ng/L) were comparable to natural ones (progesterone: 66±36 ng/L; 17α,20β-dihydroxy-4-progegnen-3-one: 4.9±1.2 ng/L; 21α-hydroxyprogesterone: 8.5±3.0 ng/L; and 17α-hydroxyprogesterone: 1.5±0.95 ng/L), probably due to the wide and relatively large usage of Synthetic Progestogens in medical therapy. In WWTP effluents, androgens were still the dominant class accounting for 60% of total hormone concentrations, followed by Progestogens (24%), and estrogens (16%). Androstenedione and testosterone were the main androgens detected in all effluents. High removal efficiency (91-100%) was found for androgens and Progestogens compared with estrogens (67-80%), with biodegradation the major removal route in WWTPs. Different profiles of Progestogens in the receiving rivers and WWTP effluents were observed, which could be explained by the discharge of a mixture of treated and untreated wastewater into the receiving rivers.

Shan Liu - One of the best experts on this subject based on the ideXlab platform.

  • Microbial transformation of progesterone and dydrogesterone by bacteria from swine wastewater: Degradation kinetics and products identification.
    The Science of the total environment, 2019
    Co-Authors: Shuang-shuang Liu, Jun Chen, Jin-na Zhang, You-sheng Liu, Xiaowen Chen, Shan Liu, Guang-guo Ying
    Abstract:

    Natural and Synthetic Progestogens in livestock environments have become a concern due to the frequent presence and potential adverse effects on aquatic organisms. Here we investigated the biotransformation of Progestogens by wastewater-borne bacteria in the field and laboratory under oxic and anoxic conditions. The results showed that all Progestogens dissipated faster under oxic conditions than under anoxic conditions, and natural progesterone transformed faster than Synthetic Progestogens. Meanwhile, dozens of bacterial strains capable of degrading Progestogens were successfully isolated from the swine wastewater, and Bacillus sp. P19 and Bacillus sp. DGT2 were found the best for progesterone and dydrogesterone transformation, respectively. In the degradation experiments using a single bacterial strain, progesterone and dydrogesterone dissipated under oxic conditions with half-lives of 11.6 h and 18.2 h, respectively. The transformation pathways were proposed based on the identified transformation products. The findings from this study showed that Progestogens can be biotransformed, but not fully mineralized in the environment.