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Nino Russo - One of the best experts on this subject based on the ideXlab platform.
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oenin Syringic Acid copigmentation insights from a theoretical study
Frontiers in chemistry, 2019Co-Authors: Yunkui Li, Mario Prejanò, Marirosa Toscano, Nino RussoAbstract:On the basis of the dispersion-corrected density functional theory, a computational model is proposed to describe the oenin/Syringic Acid copigmentation and to explore the non-covalent interaction between the anthocyanin and the copigment in the framework of implicit solvent approach. The predicted binding free energy and visible spectrum shift of this copigmentation complex are in accordance with the experimental observations. The used model provides a good structural description of oenin/Syringic Acid complex and suggests that the intermolecular hydrogen bonding, in which the hydroxyl-rich sugar moiety in oenin plays a key role, may be the determinant for the formation and nature of the copigmentation complex.
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Oenin/Syringic Acid Copigmentation: Insights From a Theoretical Study.
Frontiers in chemistry, 2019Co-Authors: Yunkui Li, Mario Prejanò, Marirosa Toscano, Nino RussoAbstract:On the basis of the dispersion-corrected density functional theory, a computational model is proposed to describe the oenin/Syringic Acid copigmentation and to explore the non-covalent interaction between the anthocyanin and the copigment in the framework of implicit solvent approach. The predicted binding free energy and visible spectrum shift of this copigmentation complex are in accordance with the experimental observations. The used model provides a good structural description of oenin/Syringic Acid complex and suggests that the intermolecular hydrogen bonding, in which the hydroxyl-rich sugar moiety in oenin plays a key role, may be the determinant for the formation and nature of the copigmentation complex.
Markus Atong - One of the best experts on this subject based on the ideXlab platform.
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HPC fingerprints and in vitro antimicrobial activity of Syringic Acid, caffeic Acid and 4-hydroxybenzoic Acid against Ganoderma boninense.
Journal of Applied Sciences, 2011Co-Authors: Khim Phin Chong, Stephen Rossall, Markus AtongAbstract:This study discusses the in vitro antimicrobial activity and fungitoxicity of Syringic Acid, caffeic Acid and 4-hydroxybenzoic Acid which is found in oil palm root. The presence of these phenolics were first confirmed with the injection of standards using HPLC in a gradient system developed with methanol and 0.1% phosphoric Acid. Experiments were observed for fourteen days, repeated at least three times and data were recorded daily. The antimicrobial activities and fungitoxicity of the phenolics against Ganoderma boninense were expressed in inhibition of radial growth of G. boninense on PDA ameliorated with the three different phenolics with a range concentration of 0.5-2.5 mg mL¯¹. Syringic Acid was found to be very fungitoxic to G. boninense even at concentration of 0.5 mg mL-1, the lowest concentration tested in this experiment. When the concentration is increase to 1.0 mg mL¯¹ of Syringic Acid, the pathogen is inhibited. Caffeic Acid and 4-hydroxybenzoic Acid were having inhibitory effect with the highest concentration tested; 2.5 mg mL¯¹ strongly inhibited the growth of G. boninense in comparison to the control.
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in vitro antimicrobial activity and fungitoxicity of Syringic Acid caffeic Acid and 4 hydroxybenzoic Acid against ganoderma boninense
The Journal of Agricultural Science, 2009Co-Authors: Khim Phin Chong, Stephen Rossall, Markus AtongAbstract:This paper discusses the in vitro antimicrobial activity and fungitoxicity of Syringic Acid, caffeic Acid and 4-hydroxybenzoic Acid which is found in oil palm root. Experiments were observed for fourteen days, repeated at least three times and data were recorded daily. The antimicrobial activities and fungitoxicity of the phenolics against Ganoderma boninense were expressed in inhibition of radial growth of G. boninense on PDA ameliorated with the three different phenolics with a range concentration of 0.5-2.5 mg/ml. Syringic Acid was found to be very fungitoxic to G. boninense even at concentration of 0.5 mg/ml, the lowest concentration tested in this experiment. When the concentration is increase to 1.0mg/ml of Syringic Acid, the pathogen is inhibited. Caffeic Acid and 4-hydroxybenzoic Acid were having inhibitory effect with the highest concentration tested; 2.5mg/ml strongly inhibited the growth of G. boninense in comparison to the control.
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In Vitro Synergy Effect of Syringic Acid, Caffeic Acid and 4-hydroxybenzoic Acid against Ganoderma boninense
International Journal of Engineering and Technology, 2009Co-Authors: Chong Khim Phin, Stephen Rossall, Markus AtongAbstract:This paper discusses the in vitro synergy effect of Syringic Acid, caffeic Acid and 4-hydroxybenzoic Acid which found in oil palm root. Experiments were observed for fourteen days, repeated at least three times and data were recorded daily. The synergy effect of the phenolics against Ganoderma boninense were expressed in inhibition of radial growth of G. boninense on PDA ameliorated with the combination of either two or three different phenolics with concentration of 0.5 to 2.5 mg/ml. Several combinations showed strong fungitoxicity effect to G. boninense. Combinations of 4-hydroxybenz oic Acid, Syringic Acid and caffeic Acid up to 2.5 mg/ml strongly inhibited the growth of G. boninense in comparison to the control. currently no effective cure for G. boninense infection in an existing stand. Preventive and ameliorative treatments which are commonly carried out show various degrees of effectiveness (13). Determination of total phenolic content in G. boninense infected and healthy oil palm roots showed susceptible palm roots at week four had low phenolic content, whereas week one had high phenolic content. Gallic Acids concentrations decreased in the four weeks old roots of infected susceptible palms compared to healthy roots. Determination of total phenolic content in infected palm seedlings root (D X P) also showed low phenolic content compared to the non infected palm seedlings root. This indicate phenolic compounds are involved in oil palm resistance against Ganoderma (11).To identify the possibility of oil palm resistance against G. boninense in certain circumstances need further investigation. However, if resistance in oil palm against G. boninense is possible, it may contribute to tackling the problem. In a collaborative experiment to this research, we found Syringic Acid, caffeic Acid and 4-hydroxybenzoic Acid present in oil palm roots in natural condition or after elicitation. In this paper, we present the works on in vitro synergy effect of Syringic Acid, caffeic Acid and 4-hydroxybenzoic Acid to G. boninense.
Antriksh Gupta - One of the best experts on this subject based on the ideXlab platform.
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Improvement of selective lignin degradation in fungal pretreatment of sweet sorghum bagasse using synergistic CuSO4-Syringic Acid supplements
Journal of environmental management, 2017Co-Authors: Vartika Mishra, Asim K. Jana, Mithu Maiti Jana, Antriksh GuptaAbstract:Abstract Sweet sorghum bagasse (SSB) generated in large quantities could be hydrolyzed to sugar and then fermented to green fuels. The hydrolysis of SSB polysaccharides interlocked in recalcitrant lignin network is the major problem. Pretreatment of SSB in SSF by using Coriolus versicolor with CuSO4-Syringic Acid supplements for effects on production of ligninocellulolytic enzymes, lignin degradation and selectivity values (SV) were studied. C. versicolor was selected based on high ligninolytic and low cellulolytic abilily. Individually, CuSO4 increased the activities of laccase (4.9 folds) and PPO (1.9 folds); Syringic Acid increased LiP (13 folds), AAO (2.8 folds) and laccase (5.6 folds) resulting in increased lignin degradation and SVs. Combined Syringic Acid (4.4 μmol g−1 SSB) and CuSO4 (4.4 μmol g−1 SSB) increased the activities of laccase, LiP, MnP, PPO and AAO by 11.2, 17.6, 2.8, 2.4 and 2.3 folds respectively due to synergistic effect, resulting in maximum lignin degradation 35.9 ± 1.3% (w w−1) (1.86 fold) and highest SV 3.07 (4.7 fold). Enzymatic hydrolysis of pretreated SSB yielded higher (∼2.2 times) fermentable sugar. Pretreated SSB was characterized by XRD, SEM, FTIR and TGA/DTG analysis to confirm results. It is possible to improve fungal pretreatment of agricultural waste by combination of supplements.
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Synergistic effect of Syringic Acid and gallic Acid supplements in fungal pretreatment of sweet sorghum bagasse for improved lignin degradation and enzymatic saccharification
Process Biochemistry, 2017Co-Authors: Vartika Mishra, Asim K. Jana, Mithu Maiti Jana, Antriksh GuptaAbstract:Abstract Sweet Sorghum Bagasse (SSB) has potential for uses in production of ligninocellulosic biofuel and other fermentation products due to higher biomass yield. Pretreatment of SSB by Coriolus versicolor with synergistic Syringic Acid-gallic Acid supplements for enhanced ligninolytic enzyme production, lignin degradation, selectivity value (SV) and enzymatic saccharification have been studied. C. versicolor was selected due to its high ligninolytic and low cellulolytic enzyme activities in SSF with 19.3 ± 0.8% w w −1 of lignin degradation in 20 days and SV 0.65. Supplement gallic Acid increased the production of MnP; while Syringic Acid increased the production of LiP, AAO and laccase with enhanced lignin degradation and SV. Combined supplements increased the production of multiple ligninolytic enzymes further than the effect of individual supplements due to synergistic interactions. Activities of laccase, LiP, MnP, PPO and AAO increased by 9.1, 14.6, 2.6, 1.9 and 2.2 folds respectively, which resulted in highest lignin degradation (1.56 times) and SV (3.87 times). Enzymatic hydrolysis of SSB pretreated with combined supplements yielded higher fermentable sugar (∼2.18 times). Combined supplements could be used for improvement in pretreatment by SSF. XRD, SEM, FTIR and TGA/DTG analysis of SSB confirmed the results.
Yunkui Li - One of the best experts on this subject based on the ideXlab platform.
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oenin Syringic Acid copigmentation insights from a theoretical study
Frontiers in chemistry, 2019Co-Authors: Yunkui Li, Mario Prejanò, Marirosa Toscano, Nino RussoAbstract:On the basis of the dispersion-corrected density functional theory, a computational model is proposed to describe the oenin/Syringic Acid copigmentation and to explore the non-covalent interaction between the anthocyanin and the copigment in the framework of implicit solvent approach. The predicted binding free energy and visible spectrum shift of this copigmentation complex are in accordance with the experimental observations. The used model provides a good structural description of oenin/Syringic Acid complex and suggests that the intermolecular hydrogen bonding, in which the hydroxyl-rich sugar moiety in oenin plays a key role, may be the determinant for the formation and nature of the copigmentation complex.
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Oenin/Syringic Acid Copigmentation: Insights From a Theoretical Study.
Frontiers in chemistry, 2019Co-Authors: Yunkui Li, Mario Prejanò, Marirosa Toscano, Nino RussoAbstract:On the basis of the dispersion-corrected density functional theory, a computational model is proposed to describe the oenin/Syringic Acid copigmentation and to explore the non-covalent interaction between the anthocyanin and the copigment in the framework of implicit solvent approach. The predicted binding free energy and visible spectrum shift of this copigmentation complex are in accordance with the experimental observations. The used model provides a good structural description of oenin/Syringic Acid complex and suggests that the intermolecular hydrogen bonding, in which the hydroxyl-rich sugar moiety in oenin plays a key role, may be the determinant for the formation and nature of the copigmentation complex.
Jing Chen - One of the best experts on this subject based on the ideXlab platform.
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Syringic Acid mitigates myocardial ischemia reperfusion injury by activating the pi3k akt gsk 3β signaling pathway
Biochemical and Biophysical Research Communications, 2020Co-Authors: Gen Liu, Bofang Zhang, Xiao-pei Liu, Jing ChenAbstract:Syringic Acid is an abundant phenolic Acid compound that possesses anti-oxidant, anti-microbial, anti-inflammatory, and anti-endotoxic properties. However, the research of pretreatment with Syringic Acid against myocardial ischemia reperfusion is still limited. Thus, our research revealed the protective effect of Syringic Acid in the rat model with myocardial ischemia reperfusion injury. Histological analysis was performed by hematoxylin and eosin (H&E). The myocardial systolic function was detected by echocardiographic. Myocardial infarct size was measured by Evans blue and 2,3,5-triphenyltetrazolium chloride (TTC) double staining. The apoptosis index was recorded by Terminal deoxynucleotidyl transferase dUTP nick end labeling staining (TUNEL). The contents of creatine kinase MB (CK-MB) and lactate dehydrogenase (LDH) in the serum were determined by a commercial kit. The expression of the PI3K/Akt/GSK-3β signaling pathway-related molecules and apoptosis-associated indicators was detected by western blotting or real-time PCR. We found that pretreatment with Syringic Acid obviously increased the myocardial systolic function (LVEF and LVFS) and decreased the infarct size, the apoptosis index as well as the serum level of CK-MB and LDH. Meanwhile, Syringic Acid also remarkably augmented the contents of p-PI3K, p-Akt, p-GSK-3β, Bcl-2 and mitochondria cytochrome c. However, the expression of caspase-3, -9 and Bax significantly reduced. Interestingly, co-treatment with PI3K inhibitor of LY294002 counteracted those effects induced by Syringic Acid. In conclusion, pretreatment with Syringic Acid can mitigate myocardial ischemia reperfusion injury by inhibiting mitochondria-induced apoptosis which is regulated by the PI3K/Akt/GSK-3β signaling pathway.
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Syringic Acid mitigates myocardial ischemia reperfusion injury by activating the PI3K/Akt/GSK-3β signaling pathway
Biochemical and biophysical research communications, 2020Co-Authors: Liu, Bofang Zhang, Xiao-pei Liu, Jing ChenAbstract:Syringic Acid is an abundant phenolic Acid compound that possesses anti-oxidant, anti-microbial, anti-inflammatory, and anti-endotoxic properties. However, the research of pretreatment with Syringic Acid against myocardial ischemia reperfusion is still limited. Thus, our research revealed the protective effect of Syringic Acid in the rat model with myocardial ischemia reperfusion injury. Histological analysis was performed by hematoxylin and eosin (H&E). The myocardial systolic function was detected by echocardiographic. Myocardial infarct size was measured by Evans blue and 2,3,5-triphenyltetrazolium chloride (TTC) double staining. The apoptosis index was recorded by Terminal deoxynucleotidyl transferase dUTP nick end labeling staining (TUNEL). The contents of creatine kinase MB (CK-MB) and lactate dehydrogenase (LDH) in the serum were determined by a commercial kit. The expression of the PI3K/Akt/GSK-3β signaling pathway-related molecules and apoptosis-associated indicators was detected by western blotting or real-time PCR. We found that pretreatment with Syringic Acid obviously increased the myocardial systolic function (LVEF and LVFS) and decreased the infarct size, the apoptosis index as well as the serum level of CK-MB and LDH. Meanwhile, Syringic Acid also remarkably augmented the contents of p-PI3K, p-Akt, p-GSK-3β, Bcl-2 and mitochondria cytochrome c. However, the expression of caspase-3, -9 and Bax significantly reduced. Interestingly, co-treatment with PI3K inhibitor of LY294002 counteracted those effects induced by Syringic Acid. In conclusion, pretreatment with Syringic Acid can mitigate myocardial ischemia reperfusion injury by inhibiting mitochondria-induced apoptosis which is regulated by the PI3K/Akt/GSK-3β signaling pathway.
