The Experts below are selected from a list of 3159678 Experts worldwide ranked by ideXlab platform
Aaron M. Zorn - One of the best experts on this subject based on the ideXlab platform.
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A Molecular atlas of Xenopus respiratory System Development
Developmental Dynamics, 2014Co-Authors: Scott A. Rankin, Hong Thi Tran, Marcin Wlizla, Pamela Mancini, Emily T. Shifley, Sean D. Bloor, Kris Vleminckx, Susan E. Wert, Aaron M. ZornAbstract:Background: Respiratory System Development is regulated by a complex series of endoderm–mesoderm interactions that are not fully understood. Recently Xenopus has emerged as an alternative model to investigate early respiratory System Development, but the extent to which the morphogenesis and molecular pathways involved are conserved between Xenopus and mammals has not been Systematically documented. Results: In this study, we provide a histological and molecular atlas of Xenopus respiratory System Development, focusing on Nkx2.1+ respiratory cell fate specification in the developing foregut. We document the expression patterns of Wnt/β-catenin, fibroblast growth factor (FGF), and bone morphogenetic protein (BMP) signaling components in the foregut and show that the molecular mechanisms of respiratory lineage induction are remarkably conserved between Xenopus and mice. Finally, using several functional experiments we refine the epistatic relationships among FGF, Wnt, and BMP signaling in early Xenopus respiratory System Development. Conclusions: We demonstrate that Xenopus trachea and lung Development, before metamorphosis, is comparable at the cellular and molecular levels to embryonic stages of mouse respiratory System Development between embryonic days 8.5 and 10.5. This molecular atlas provides a fundamental starting point for further studies using Xenopus as a model to define the conserved genetic programs controlling early respiratory System Development. Developmental Dynamics 244:69–85, 2015. © 2014 Wiley Periodicals, Inc.
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A molecular atlas of Xenopus respiratory System Development
Developmental dynamics : an official publication of the American Association of Anatomists, 2014Co-Authors: Scott A. Rankin, Hong Thi Tran, Marcin Wlizla, Pamela Mancini, Emily T. Shifley, Sean D. Bloor, Kris Vleminckx, Susan E. Wert, Lu Han, Aaron M. ZornAbstract:Background Respiratory System Development is regulated by a complex series of endoderm-mesoderm interactions that are not fully understood. Recently Xenopus has emerged as an alternative model to investigate early respiratory System Development, but the extent to which the morphogenesis and molecular pathways involved are conserved between Xenopus and mammals has not been Systematically documented. Results In this study, we provide a histological and molecular atlas of Xenopus respiratory System Development, focusing on Nkx2.1+ respiratory cell fate specification in the developing foregut. We document the expression patterns of Wnt/β-catenin, fibroblast growth factor (FGF), and bone morphogenetic protein (BMP) signaling components in the foregut and show that the molecular mechanisms of respiratory lineage induction are remarkably conserved between Xenopus and mice. Finally, using several functional experiments we refine the epistatic relationships among FGF, Wnt, and BMP signaling in early Xenopus respiratory System Development. Conclusions We demonstrate that Xenopus trachea and lung Development, before metamorphosis, is comparable at the cellular and molecular levels to embryonic stages of mouse respiratory System Development between embryonic days 8.5 and 10.5. This molecular atlas provides a fundamental starting point for further studies using Xenopus as a model to define the conserved genetic programs controlling early respiratory System Development.
T. Mizuyama - One of the best experts on this subject based on the ideXlab platform.
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Root-System Development and water-extraction model considering hydrotropism
Soil Science Society of America Journal, 2003Co-Authors: Daizo Tsutsumi, Ken'ichiro Kosugi, T. MizuyamaAbstract:A two-dimensional model that combines root-System Development and water extraction by roots is proposed to simulate the dynamic interaction between root growth and soil-water flow. Both of hydrotropism and gravitropism were considered as the controlling factors of root growth in the proposed root-System Development model. The finite-element method was employed to compute the soil-water flow caused by water extraction, evaporation, and irrigation. We succeeded in simulating the plagiogravitropic elongations of lateral roots under a plane condition, and the asymmetric architecture of root System under a slope condition by the proposed model in which the root hydrotropism is considered. On the other hand, we cannot simulate such morphological characteristics of-a root System by the use of the conventional model in which a random elongation factor is employed, and root hydrotropism is not considered. The results support the importance of hydrotropism in root-System Development and the availability of the proposed model in which the hydrotropism is considered.
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Effect of Hydrotropism on Root System Development in Soybean (Glycine max): Growth Experiments and a Model Simulation
Journal of Plant Growth Regulation, 2002Co-Authors: Daizo Tsutsumi, Ken'ichiro Kosugi, T. MizuyamaAbstract:To observe root System Development, soybean plants ( Glycine max ) were grown in root boxes that were set horizontally to reduce the effect of gravity. Along with the root System Development, the two-dimensional distribution of soil water content in the root boxes was measured continuously by the time domain reflectometry (TDR) method. Root System Development and its morphological architecture were strongly affected by the positions of the water supply. It is suggested that root hydrotropism plays the dominant role in root System Development. In addition to root hydrotropism, the importance of root compensatory growth is suggested. A combined model of root System Development and soil water flow considering root hydrotropism and compensatory growth was used to simulate root System Development and soil water flow. The morphological architecture of root Systems and the distribution of soil water content obtained in the experiment were successfully explained by the model simulation. These results confirmed that root hydrotropism and compensatory growth are dominant factors in root System Development under a reduced effect of gravity. The validity of the model was confirmed, and its applications for various purposes were suggested.
Scott A. Rankin - One of the best experts on this subject based on the ideXlab platform.
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A Molecular atlas of Xenopus respiratory System Development
Developmental Dynamics, 2014Co-Authors: Scott A. Rankin, Hong Thi Tran, Marcin Wlizla, Pamela Mancini, Emily T. Shifley, Sean D. Bloor, Kris Vleminckx, Susan E. Wert, Aaron M. ZornAbstract:Background: Respiratory System Development is regulated by a complex series of endoderm–mesoderm interactions that are not fully understood. Recently Xenopus has emerged as an alternative model to investigate early respiratory System Development, but the extent to which the morphogenesis and molecular pathways involved are conserved between Xenopus and mammals has not been Systematically documented. Results: In this study, we provide a histological and molecular atlas of Xenopus respiratory System Development, focusing on Nkx2.1+ respiratory cell fate specification in the developing foregut. We document the expression patterns of Wnt/β-catenin, fibroblast growth factor (FGF), and bone morphogenetic protein (BMP) signaling components in the foregut and show that the molecular mechanisms of respiratory lineage induction are remarkably conserved between Xenopus and mice. Finally, using several functional experiments we refine the epistatic relationships among FGF, Wnt, and BMP signaling in early Xenopus respiratory System Development. Conclusions: We demonstrate that Xenopus trachea and lung Development, before metamorphosis, is comparable at the cellular and molecular levels to embryonic stages of mouse respiratory System Development between embryonic days 8.5 and 10.5. This molecular atlas provides a fundamental starting point for further studies using Xenopus as a model to define the conserved genetic programs controlling early respiratory System Development. Developmental Dynamics 244:69–85, 2015. © 2014 Wiley Periodicals, Inc.
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A molecular atlas of Xenopus respiratory System Development
Developmental dynamics : an official publication of the American Association of Anatomists, 2014Co-Authors: Scott A. Rankin, Hong Thi Tran, Marcin Wlizla, Pamela Mancini, Emily T. Shifley, Sean D. Bloor, Kris Vleminckx, Susan E. Wert, Lu Han, Aaron M. ZornAbstract:Background Respiratory System Development is regulated by a complex series of endoderm-mesoderm interactions that are not fully understood. Recently Xenopus has emerged as an alternative model to investigate early respiratory System Development, but the extent to which the morphogenesis and molecular pathways involved are conserved between Xenopus and mammals has not been Systematically documented. Results In this study, we provide a histological and molecular atlas of Xenopus respiratory System Development, focusing on Nkx2.1+ respiratory cell fate specification in the developing foregut. We document the expression patterns of Wnt/β-catenin, fibroblast growth factor (FGF), and bone morphogenetic protein (BMP) signaling components in the foregut and show that the molecular mechanisms of respiratory lineage induction are remarkably conserved between Xenopus and mice. Finally, using several functional experiments we refine the epistatic relationships among FGF, Wnt, and BMP signaling in early Xenopus respiratory System Development. Conclusions We demonstrate that Xenopus trachea and lung Development, before metamorphosis, is comparable at the cellular and molecular levels to embryonic stages of mouse respiratory System Development between embryonic days 8.5 and 10.5. This molecular atlas provides a fundamental starting point for further studies using Xenopus as a model to define the conserved genetic programs controlling early respiratory System Development.
Sherlock A. Licorish - One of the best experts on this subject based on the ideXlab platform.
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PROFES - 3rd Workshop on Hybrid Development Approaches in Software System Development
Product-Focused Software Process Improvement, 2018Co-Authors: Paolo Tell, Stephen G. Macdonell, Sherlock A. LicorishAbstract:Software and System Development is complex and diverse, and a multitude of Development approaches is used and combined with each other to address the manifold challenges companies face today. To study the current state of the practice and to build a sound understanding about the utility of different Development approaches and their application to modern software System Development, in 2016, we launched the HELENA initiative. This paper introduces the 2nd HELENA workshop and provides an overview of the current project state. In the workshop, six teams present initial findings from their regions, impulse talk are given, and further steps of the HELENA roadmap are discussed.
Daizo Tsutsumi - One of the best experts on this subject based on the ideXlab platform.
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Root-System Development and water-extraction model considering hydrotropism
Soil Science Society of America Journal, 2003Co-Authors: Daizo Tsutsumi, Ken'ichiro Kosugi, T. MizuyamaAbstract:A two-dimensional model that combines root-System Development and water extraction by roots is proposed to simulate the dynamic interaction between root growth and soil-water flow. Both of hydrotropism and gravitropism were considered as the controlling factors of root growth in the proposed root-System Development model. The finite-element method was employed to compute the soil-water flow caused by water extraction, evaporation, and irrigation. We succeeded in simulating the plagiogravitropic elongations of lateral roots under a plane condition, and the asymmetric architecture of root System under a slope condition by the proposed model in which the root hydrotropism is considered. On the other hand, we cannot simulate such morphological characteristics of-a root System by the use of the conventional model in which a random elongation factor is employed, and root hydrotropism is not considered. The results support the importance of hydrotropism in root-System Development and the availability of the proposed model in which the hydrotropism is considered.
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Effect of Hydrotropism on Root System Development in Soybean (Glycine max): Growth Experiments and a Model Simulation
Journal of Plant Growth Regulation, 2002Co-Authors: Daizo Tsutsumi, Ken'ichiro Kosugi, T. MizuyamaAbstract:To observe root System Development, soybean plants ( Glycine max ) were grown in root boxes that were set horizontally to reduce the effect of gravity. Along with the root System Development, the two-dimensional distribution of soil water content in the root boxes was measured continuously by the time domain reflectometry (TDR) method. Root System Development and its morphological architecture were strongly affected by the positions of the water supply. It is suggested that root hydrotropism plays the dominant role in root System Development. In addition to root hydrotropism, the importance of root compensatory growth is suggested. A combined model of root System Development and soil water flow considering root hydrotropism and compensatory growth was used to simulate root System Development and soil water flow. The morphological architecture of root Systems and the distribution of soil water content obtained in the experiment were successfully explained by the model simulation. These results confirmed that root hydrotropism and compensatory growth are dominant factors in root System Development under a reduced effect of gravity. The validity of the model was confirmed, and its applications for various purposes were suggested.
