The Experts below are selected from a list of 10056 Experts worldwide ranked by ideXlab platform
Badiaa Lyoussi - One of the best experts on this subject based on the ideXlab platform.
-
the antioxidant content and protective effect of argan oil and Syzygium aromaticum essential oil in hydrogen peroxide induced biochemical and histological changes
International Journal of Molecular Sciences, 2018Co-Authors: Meryem Bakour, Najoua Soulo, Nawal Hammas, Hinde El Fatemi, Abderrazak Aboulghazi, Amal Taroq, Abdelfattah Abdellaoui, Noori S Alwaili, Badiaa LyoussiAbstract:Oxidative stress is an important etiology of chronic diseases and many studies have shown that natural products might alleviate oxidative stress-induced pathogenesis. The study aims to evaluate the effect of Argan oil and Syzygium aromaticum essential oil on hydrogen peroxide (H2O2)-induced liver, brain and kidney tissue toxicity as well as biochemical changes in wistar rats. The antioxidant content of Argan oil and Syzygium aromaticum essential oil was studied with the use of gas chromatography. The animals received daily by gavage, for 21 days, either distilled water, Syzygium aromaticum essential oil, Argan oil, H2O2 alone, H2O2 and Syzygium aromaticum essential oil, or H2O2 and Argan oil. Blood samples were withdrawn on day 21 for the biochemical blood tests, and the kidney, liver and brain tissue samples were prepared for histopathology examination. The results showed that the content of antioxidant compounds in Syzygium aromaticum essential oil is higher than that found in Argan oil. H2O2 increased level of blood urea, liver enzymes, total cholesterol, Low Density Lipoprotein (LDL-C), Triglycerides (TG) and Very Low Density Lipoprotein (VLDL), and decreased the total protein, albumin and High Density Lipoprotein-cholesterol (HDL-C). There was no significant effect on blood electrolyte or serum creatinine. The histopathology examination demonstrated that H2O2 induces dilatation in the central vein, inflammation and binucleation in the liver, congestion and hemorrhage in the brain, and congestion in the kidney. The H2O2-induced histopathological and biochemical changes have been significantly alleviated by Syzygium aromaticum essential oil or Argan oil. It is concluded that the Argan oil and especially the mixture of Argan oil with Syzygium aromaticum essential oil can reduce the oxidative damage caused by H2O2, and this will pave the way to investigate the protective effects of these natural substances in the diseases attributed to the high oxidative stress.
P.s Reddy - One of the best experts on this subject based on the ideXlab platform.
-
Antibacterial activity of Syzygium cumini and Syzygium travancoricum leaf essential oils.
Fitoterapia, 2002Co-Authors: P.m Shafi, M.k Rosamma, Kaiser Jamil, P.s ReddyAbstract:The leaf essential oils of Syzygium cumini and Syzygium travancoricum were tested for their antibacterial property. The activity of S. cumini essential oil was found to be good, while that of S. travancoricum was moderate.
Ian Edwin Cock - One of the best experts on this subject based on the ideXlab platform.
-
Inhibition of Shewanella spp. growth by Syzygium australe and Syzygium luehmannii extracts: natural methods for the prevention of fish spoilage.
Journal of food science and technology, 2017Co-Authors: Shweta Murhekar, Mitchell Henry Wright, Anthony Carlson Greene, Jeremy C. Brownlie, Ian Edwin CockAbstract:Syzygium australe and Syzygium luehmannii fruit and leaf were investigated for their ability to inhibit Shewanella spp. growth. Extracts of both Syzygium spp. displayed potent growth inhibitory properties against all Shewanella spp. tested in disc diffusion and liquid diffusion assays. In general, S. australe extracts were more potent inhibitors of Shewanella spp. growth, and the fruit extracts were generally better than the corresponding leaf extracts. The methanolic S. australe fruit extract was a particularly potent inhibitor of all Shewanella spp. growth, with MIC values as low as 87 µg/mL. The aqueous and ethyl acetate S. australe fruit extracts were similarly potent inhibitors of Shewanella spp. growth, albeit with slightly higher MIC values. Several other Syzygium spp. extracts also were potent bacterial growth inhibitors, albeit with MIC values generally >1000 µg/mL. The most potent S. australe fruit extracts were nontoxic in the Artemia franciscana bioassay, with LC50 values substantially >1000 µg/mL. The potent bacterial growth inhibitory activity and lack of toxicity of the S. australe fruit extracts indicate their potential as natural fish and seafood preservatives.
-
Antibacterial Activity of Selected Australian Syzygium species
Pharmacognosy Communications, 2013Co-Authors: Getmore Chikowe, Lindiwe Nomathemba Mpala, Ian Edwin CockAbstract:Introduction: Many species of Syzygium are known to have antiseptic activity. Australian Syzygium species had roles as traditional bush medicines for Australian Aborigines although their antiseptic potential has not been rigorously studied. Methods: Methanol extracts of leaves from Syzygium forte, Syzygium francissi, Syzygium moorei, Syzygium puberulum and Syzygium wilsonii were tested for antimicrobial activity by disc diffusion assay. Antibacterial strength was measured by MIC determination. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: S. forte, S. francissi, S. moorei, S. puberulum and S. wilsonii leaf methanolic extracts inhibited the growth of 5 (36%), 3 (21%), 3 (21%), 5 (36%) and 2 (14%) of the 14 bacteria tested respectively. Both Gram-positive and Gram- negative bacterial growth was inhibited by the Syzygium extracts, although Gram-positive bacteria appeared slightly more susceptible. With the exception of S. forte, all Syzygium leaf extracts tested also displayed low toxicity (LC 50 > 1000 µg/ml) in the Artemia fransiscana bioassay. S. forte had a 48 h LC 50 of 392.4 ± 33.0 µg/ml, making it slightly more toxic than Mevinphos (495.0 ± 35.1 µg/ml) and approximately 28 fold less toxic than potassium dichromate (14.0 ± 2.4 µg/ml) at 48 h. Conclusions: The antibacterial activity and low toxicity of the Syzygium spp. validate their medicinal usage by Australian Aborigines and indicate their potential as antibacterial medicinal agents.
-
Antimicrobial Activity of Syzygium australe and Syzygium leuhmannii Leaf Methanolic Extracts
Pharmacognosy Communications, 2012Co-Authors: Ian Edwin CockAbstract:ABSTRACT Introduction: Many species of Syzygium are known to have antiseptic activity. Australian Syzygium species had roles as traditional bush medicines for Australian Aborigines although their antiseptic potential has not been rigorously studied. Methods: The antimicrobial activity of methanolic extracts of Syzygium australe and Syzygium leuhmannii leaves was investigated by disc diffusion assay and growth time course assay against a panel of bacteria and fungi. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: S. australe leaf extract inhibited the growth of 10 of the 14 bacteria tested (71%). Gram-positive and Gram-negative bacteria were equally susceptible. 8 of the 11 Gram-negative bacteria (73%) and 2 of the 3 Gram-positive bacteria (67%) tested had their growth inhibited by S. australe leaf extract. The extract also displayed antifungal activity against a nystatin resistant strain of A. niger but did not affect C. albicans or S. cerevisiae growth. In comparison, S. leuhmannii leaf extract did not inhibit the growth of any of the microbial agents tested in the disc diffusion assay. The antibacterial activity of S. australe leaf extract was further investigated by growth time course assays which showed significant growth inhibition in cultures of A. hydrophilia, B. cereus, and P. fluorescens within 1 h but not of B. subtilis. S. leuhmannii also inhibited the growth of P. fluorescens and to a lesser extent, A. hydrophilia in the time course assay. Both Syzygium extracts displayed low toxicity in the Artemia franciscana bioassay. Conclusions: The low toxicity of these Syzygium extracts and the inhibitory bioactivity of S. australe against the bacterial panel validate Australian Aboriginal usage of S. australe leaves as antiseptic agents and confirms their medicinal potential.Griffith Sciences, School of Natural SciencesFull Tex
Shio Kumar Singh - One of the best experts on this subject based on the ideXlab platform.
-
biphasic effect of Syzygium aromaticum flower bud on reproductive physiology of male mice
Andrologia, 2016Co-Authors: Raghav Kumar Mishra, Shio Kumar SinghAbstract:Summary The flower buds of Syzygium aromaticum (clove) have been used for the treatment of male sexual disorders in indigenous medicines of Indian subcontinent. Therefore to evaluate the efficacy of Syzygium aromaticum on the male reproductive health, chronic oral exposure of aqueous extract of flower buds of Syzygium in three doses (15 mg, 30 mg and 60 mg kg−1 BW) were studied for a single spermatogenic cycle (35 days) in Parkes (P) strain mice. Lower dose (15 mg) of Syzygium aromaticum flower buds increased serum testosterone level and testicular hydroxysteroid dehydrogenase (HSD) activities and improved sperm motility, sperm morphology, secretory activity of epididymis and seminal vesicle, and number of litters per female. On the other hand, higher doses (30 and 60 mg) of the treatment adversely affected above parameters. Further, higher doses of the extract also had adverse effects on daily sperm production, 1C cell population and on histology of testis. In conclusion, Syzygium aromaticum flower buds extract exhibits biphasic effect on reproductive physiology of male mice. Lower dose of Syzygium aromaticum flower bud extract is androgenic in nature and may have a viable future as an indigenous sexual rejuvenator, while higher doses adversely affected functional physiology of reproductive organs.
-
Reproductive effects of lipid soluble components of Syzygium aromaticum flower bud in male mice
Journal of Ayurveda and Integrative Medicine, 2013Co-Authors: Raghav Kumar Mishra, Shio Kumar SinghAbstract:Background: The flower buds of Syzygium aromaticum (clove) have been used in indigenous medicines for the treatment of male sexual disorders in Indian subcontinent. Objective: To evaluate the effect of Syzygium aromaticum flower bud on male reproduction, using Parkes (P) strain mice as animal model. Materials and Methods: Mice were orally administered lipid soluble components of Syzygium aromaticum flower bud in doses of 15, 30, and 60 mg/kg body weight for 35 days, and several male reproductive endpoints were evaluated. Results: Treatment with lower dose (15 mg) of Syzygium increased the motility of sperm and stimulated the secretory activities of epididymis and seminal vesicle, while higher doses (30 and 60 mg) had adverse effects on sperm dynamics of cauda epididymidis and on the secretory activities of epididymis and seminal vesicle. Libido was not affected in treated males; however, a significant decrease in litter in females sired by males treated with higher doses of Syzygium was recorded. Conclusion: Treatment with Syzygium aromaticum flower bud causes dose-dependent biphasic effect on male reproductive indices in P mice; lower dose of Syzygium appears stimulatory, while the higher doses have adverse effect on male reproduction. The results suggest that the lower dose of Syzygium may have androgenic effect, but further studies are needed to support this contention.
-
Reproductive effects of lipid soluble components of Syzygium aromaticum flower bud in male mice
Journal of Ayurveda and integrative medicine, 2013Co-Authors: Raghav Kumar Mishra, Shio Kumar SinghAbstract:The flower buds of Syzygium aromaticum (clove) have been used in indigenous medicines for the treatment of male sexual disorders in Indian subcontinent. To evaluate the effect of Syzygium aromaticum flower bud on male reproduction, using Parkes (P) strain mice as animal model. Mice were orally administered lipid soluble components of Syzygium aromaticum flower bud in doses of 15, 30, and 60 mg/kg body weight for 35 days, and several male reproductive endpoints were evaluated. Treatment with lower dose (15 mg) of Syzygium increased the motility of sperm and stimulated the secretory activities of epididymis and seminal vesicle, while higher doses (30 and 60 mg) had adverse effects on sperm dynamics of cauda epididymidis and on the secretory activities of epididymis and seminal vesicle. Libido was not affected in treated males; however, a significant decrease in litter in females sired by males treated with higher doses of Syzygium was recorded. Treatment with Syzygium aromaticum flower bud causes dose-dependent biphasic effect on male reproductive indices in P mice; lower dose of Syzygium appears stimulatory, while the higher doses have adverse effect on male reproduction. The results suggest that the lower dose of Syzygium may have androgenic effect, but further studies are needed to support this contention.
Meryem Bakour - One of the best experts on this subject based on the ideXlab platform.
-
the antioxidant content and protective effect of argan oil and Syzygium aromaticum essential oil in hydrogen peroxide induced biochemical and histological changes
International Journal of Molecular Sciences, 2018Co-Authors: Meryem Bakour, Najoua Soulo, Nawal Hammas, Hinde El Fatemi, Abderrazak Aboulghazi, Amal Taroq, Abdelfattah Abdellaoui, Noori S Alwaili, Badiaa LyoussiAbstract:Oxidative stress is an important etiology of chronic diseases and many studies have shown that natural products might alleviate oxidative stress-induced pathogenesis. The study aims to evaluate the effect of Argan oil and Syzygium aromaticum essential oil on hydrogen peroxide (H2O2)-induced liver, brain and kidney tissue toxicity as well as biochemical changes in wistar rats. The antioxidant content of Argan oil and Syzygium aromaticum essential oil was studied with the use of gas chromatography. The animals received daily by gavage, for 21 days, either distilled water, Syzygium aromaticum essential oil, Argan oil, H2O2 alone, H2O2 and Syzygium aromaticum essential oil, or H2O2 and Argan oil. Blood samples were withdrawn on day 21 for the biochemical blood tests, and the kidney, liver and brain tissue samples were prepared for histopathology examination. The results showed that the content of antioxidant compounds in Syzygium aromaticum essential oil is higher than that found in Argan oil. H2O2 increased level of blood urea, liver enzymes, total cholesterol, Low Density Lipoprotein (LDL-C), Triglycerides (TG) and Very Low Density Lipoprotein (VLDL), and decreased the total protein, albumin and High Density Lipoprotein-cholesterol (HDL-C). There was no significant effect on blood electrolyte or serum creatinine. The histopathology examination demonstrated that H2O2 induces dilatation in the central vein, inflammation and binucleation in the liver, congestion and hemorrhage in the brain, and congestion in the kidney. The H2O2-induced histopathological and biochemical changes have been significantly alleviated by Syzygium aromaticum essential oil or Argan oil. It is concluded that the Argan oil and especially the mixture of Argan oil with Syzygium aromaticum essential oil can reduce the oxidative damage caused by H2O2, and this will pave the way to investigate the protective effects of these natural substances in the diseases attributed to the high oxidative stress.
