The Experts below are selected from a list of 167295 Experts worldwide ranked by ideXlab platform
Maries Van Den Broek - One of the best experts on this subject based on the ideXlab platform.
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Expression of Costimulatory Ligand CD70 on Steady-State Dendritic Cells Breaks CD8+ T Cell Tolerance and Permits Effective Immunity
Immunity, 2008Co-Authors: Anna M. Keller, Maries Van Den Broek, Yanling Xiao, Anita Schildknecht, Jannie BorstAbstract:Steady-state dendritic cells (DCs) maintain peripheral T cell Tolerance, whereas mature DCs generate immunity. CD70 is a costimulatory ligand acquired upon DC maturation. To determine its impact on T cell fate, we have generated mice that constitutively express CD70 in conventional DCs (cDCs). In these mice, naive CD4+ and CD8+ T cells spontaneously convert into effector cells. Administration of peptide without adjuvant, which is ordinarily tolerogenic, elicited tumor-eradicating CD8+ T cell responses and robust CD4+ T cell-independent memory. CD70 was also constitutively expressed in cDCs that inducibly present viral epitopes. In this case, Tolerance induction was prevented as well. The antigen-presenting DCs generated protective immunity to virus infection and broke a pre-existing state of CD8+ T cell Tolerance. Thus, the sole expression of CD70 by otherwise immature cDCs sufficed to convert CD8+ T cell Tolerance into immunity, defining the importance of CD27-CD70 interactions at the interface between T cell and DC.
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Resting dendritic cells induce peripheral CD8 + T cell Tolerance through PD-1 and CTLA-4
Nature Immunology, 2005Co-Authors: Hans Christian Probst, Kathy D. Mccoy, Taku Okazaki, Tasuku Honjo, Maries Van Den BroekAbstract:T cells recognizing self proteins exist without causing autoimmunity in healthy individuals. These autoreactive T cells are kept in check by peripheral Tolerance. Using a model for peripheral CD8(+) T cell Tolerance resulting from antigen presentation by resting dendritic cells in vivo, we show here that CD8(+) T cell Tolerance operates through T cell-intrinsic mechanisms such as deletion or functional inactivation. Peripheral CD8(+) T cell Tolerance depended on signaling via the costimulatory molecule PD-1, as an absence of PD-1 converted Tolerance induction into priming. Blocking of the costimulatory molecule CTLA-4 resulted in impaired Tolerance and enhanced the effect of the absence of PD-1, suggesting that PD-1 and CTLA-4 act synergistically. Thus PD-1 and CTLA-4 are crucial molecules for peripheral CD8(+) T cell Tolerance induced by resting dendritic cells.
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resting dendritic cells induce peripheral cd8 t cell Tolerance through pd 1 and ctla 4
Nature Immunology, 2005Co-Authors: Hans Christian Probst, Kathy D. Mccoy, Taku Okazaki, Tasuku Honjo, Maries Van Den BroekAbstract:T cells recognizing self proteins exist without causing autoimmunity in healthy individuals. These autoreactive T cells are kept in check by peripheral Tolerance. Using a model for peripheral CD8(+) T cell Tolerance resulting from antigen presentation by resting dendritic cells in vivo, we show here that CD8(+) T cell Tolerance operates through T cell-intrinsic mechanisms such as deletion or functional inactivation. Peripheral CD8(+) T cell Tolerance depended on signaling via the costimulatory molecule PD-1, as an absence of PD-1 converted Tolerance induction into priming. Blocking of the costimulatory molecule CTLA-4 resulted in impaired Tolerance and enhanced the effect of the absence of PD-1, suggesting that PD-1 and CTLA-4 act synergistically. Thus PD-1 and CTLA-4 are crucial molecules for peripheral CD8(+) T cell Tolerance induced by resting dendritic cells.
Hans Christian Probst - One of the best experts on this subject based on the ideXlab platform.
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Resting dendritic cells induce peripheral CD8 + T cell Tolerance through PD-1 and CTLA-4
Nature Immunology, 2005Co-Authors: Hans Christian Probst, Kathy D. Mccoy, Taku Okazaki, Tasuku Honjo, Maries Van Den BroekAbstract:T cells recognizing self proteins exist without causing autoimmunity in healthy individuals. These autoreactive T cells are kept in check by peripheral Tolerance. Using a model for peripheral CD8(+) T cell Tolerance resulting from antigen presentation by resting dendritic cells in vivo, we show here that CD8(+) T cell Tolerance operates through T cell-intrinsic mechanisms such as deletion or functional inactivation. Peripheral CD8(+) T cell Tolerance depended on signaling via the costimulatory molecule PD-1, as an absence of PD-1 converted Tolerance induction into priming. Blocking of the costimulatory molecule CTLA-4 resulted in impaired Tolerance and enhanced the effect of the absence of PD-1, suggesting that PD-1 and CTLA-4 act synergistically. Thus PD-1 and CTLA-4 are crucial molecules for peripheral CD8(+) T cell Tolerance induced by resting dendritic cells.
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resting dendritic cells induce peripheral cd8 t cell Tolerance through pd 1 and ctla 4
Nature Immunology, 2005Co-Authors: Hans Christian Probst, Kathy D. Mccoy, Taku Okazaki, Tasuku Honjo, Maries Van Den BroekAbstract:T cells recognizing self proteins exist without causing autoimmunity in healthy individuals. These autoreactive T cells are kept in check by peripheral Tolerance. Using a model for peripheral CD8(+) T cell Tolerance resulting from antigen presentation by resting dendritic cells in vivo, we show here that CD8(+) T cell Tolerance operates through T cell-intrinsic mechanisms such as deletion or functional inactivation. Peripheral CD8(+) T cell Tolerance depended on signaling via the costimulatory molecule PD-1, as an absence of PD-1 converted Tolerance induction into priming. Blocking of the costimulatory molecule CTLA-4 resulted in impaired Tolerance and enhanced the effect of the absence of PD-1, suggesting that PD-1 and CTLA-4 act synergistically. Thus PD-1 and CTLA-4 are crucial molecules for peripheral CD8(+) T cell Tolerance induced by resting dendritic cells.
Seung Pyo Park - One of the best experts on this subject based on the ideXlab platform.
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Correction: In situ induction of dendritic cell-based T cell Tolerance in humanized mice and nonhuman primates.
Journal of Experimental Medicine, 2016Co-Authors: Kyeong Cheon Jung, Chung Gyu Park, Yoon Kyung Jeon, Hyojin Park, Young Larn Ban, Hye Sook Min, Eunji Kim, Ju Hyun Kim, Byung Hyun Kang, Seung Pyo ParkAbstract:Vol. 208, No. 12, November 21, 2011. Pages [2477–2488][1]. The authors regret that a measurement was incorrect and that the source of the 5C8 clone was left out of the original publication. The corrected sentence in the Results section MD-3 efficiently induces antigen-specific T cell Tolerance in
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In situ induction of dendritic cell–based T cell Tolerance in humanized mice and nonhuman primates
Journal of Experimental Medicine, 2011Co-Authors: Kyeong Cheon Jung, Chung Gyu Park, Yoon Kyung Jeon, Hyojin Park, Young Larn Ban, Hye Sook Min, Eunji Kim, Ju Hyun Kim, Byung Hyun Kang, Seung Pyo ParkAbstract:Induction of antigen-specific T cell Tolerance would aid treatment of diverse immunological disorders and help prevent allograft rejection and graft versus host disease. In this study, we establish a method of inducing antigen-specific T cell Tolerance in situ in diabetic humanized mice and Rhesus monkeys receiving porcine islet xenografts. Antigen-specific T cell Tolerance is induced by administration of an antibody ligating a particular epitope on ICAM-1 (intercellular adhesion molecule 1). Antibody-mediated ligation of ICAM-1 on dendritic cells (DCs) led to the arrest of DCs in a semimature stage in vitro and in vivo. Ablation of DCs from mice completely abrogated anti–ICAM-1–induced antigen-specific T cell Tolerance. T cell responses to unrelated antigens remained unaffected. In situ induction of DC-mediated T cell Tolerance using this method may represent a potent therapeutic tool for preventing graft rejection.
Tasuku Honjo - One of the best experts on this subject based on the ideXlab platform.
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Resting dendritic cells induce peripheral CD8 + T cell Tolerance through PD-1 and CTLA-4
Nature Immunology, 2005Co-Authors: Hans Christian Probst, Kathy D. Mccoy, Taku Okazaki, Tasuku Honjo, Maries Van Den BroekAbstract:T cells recognizing self proteins exist without causing autoimmunity in healthy individuals. These autoreactive T cells are kept in check by peripheral Tolerance. Using a model for peripheral CD8(+) T cell Tolerance resulting from antigen presentation by resting dendritic cells in vivo, we show here that CD8(+) T cell Tolerance operates through T cell-intrinsic mechanisms such as deletion or functional inactivation. Peripheral CD8(+) T cell Tolerance depended on signaling via the costimulatory molecule PD-1, as an absence of PD-1 converted Tolerance induction into priming. Blocking of the costimulatory molecule CTLA-4 resulted in impaired Tolerance and enhanced the effect of the absence of PD-1, suggesting that PD-1 and CTLA-4 act synergistically. Thus PD-1 and CTLA-4 are crucial molecules for peripheral CD8(+) T cell Tolerance induced by resting dendritic cells.
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resting dendritic cells induce peripheral cd8 t cell Tolerance through pd 1 and ctla 4
Nature Immunology, 2005Co-Authors: Hans Christian Probst, Kathy D. Mccoy, Taku Okazaki, Tasuku Honjo, Maries Van Den BroekAbstract:T cells recognizing self proteins exist without causing autoimmunity in healthy individuals. These autoreactive T cells are kept in check by peripheral Tolerance. Using a model for peripheral CD8(+) T cell Tolerance resulting from antigen presentation by resting dendritic cells in vivo, we show here that CD8(+) T cell Tolerance operates through T cell-intrinsic mechanisms such as deletion or functional inactivation. Peripheral CD8(+) T cell Tolerance depended on signaling via the costimulatory molecule PD-1, as an absence of PD-1 converted Tolerance induction into priming. Blocking of the costimulatory molecule CTLA-4 resulted in impaired Tolerance and enhanced the effect of the absence of PD-1, suggesting that PD-1 and CTLA-4 act synergistically. Thus PD-1 and CTLA-4 are crucial molecules for peripheral CD8(+) T cell Tolerance induced by resting dendritic cells.
Kathy D. Mccoy - One of the best experts on this subject based on the ideXlab platform.
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Resting dendritic cells induce peripheral CD8 + T cell Tolerance through PD-1 and CTLA-4
Nature Immunology, 2005Co-Authors: Hans Christian Probst, Kathy D. Mccoy, Taku Okazaki, Tasuku Honjo, Maries Van Den BroekAbstract:T cells recognizing self proteins exist without causing autoimmunity in healthy individuals. These autoreactive T cells are kept in check by peripheral Tolerance. Using a model for peripheral CD8(+) T cell Tolerance resulting from antigen presentation by resting dendritic cells in vivo, we show here that CD8(+) T cell Tolerance operates through T cell-intrinsic mechanisms such as deletion or functional inactivation. Peripheral CD8(+) T cell Tolerance depended on signaling via the costimulatory molecule PD-1, as an absence of PD-1 converted Tolerance induction into priming. Blocking of the costimulatory molecule CTLA-4 resulted in impaired Tolerance and enhanced the effect of the absence of PD-1, suggesting that PD-1 and CTLA-4 act synergistically. Thus PD-1 and CTLA-4 are crucial molecules for peripheral CD8(+) T cell Tolerance induced by resting dendritic cells.
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resting dendritic cells induce peripheral cd8 t cell Tolerance through pd 1 and ctla 4
Nature Immunology, 2005Co-Authors: Hans Christian Probst, Kathy D. Mccoy, Taku Okazaki, Tasuku Honjo, Maries Van Den BroekAbstract:T cells recognizing self proteins exist without causing autoimmunity in healthy individuals. These autoreactive T cells are kept in check by peripheral Tolerance. Using a model for peripheral CD8(+) T cell Tolerance resulting from antigen presentation by resting dendritic cells in vivo, we show here that CD8(+) T cell Tolerance operates through T cell-intrinsic mechanisms such as deletion or functional inactivation. Peripheral CD8(+) T cell Tolerance depended on signaling via the costimulatory molecule PD-1, as an absence of PD-1 converted Tolerance induction into priming. Blocking of the costimulatory molecule CTLA-4 resulted in impaired Tolerance and enhanced the effect of the absence of PD-1, suggesting that PD-1 and CTLA-4 act synergistically. Thus PD-1 and CTLA-4 are crucial molecules for peripheral CD8(+) T cell Tolerance induced by resting dendritic cells.
