The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform
Jae Youl Cho - One of the best experts on this subject based on the ideXlab platform.
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Regulation of macrophage and monocyte immune responses by water extract from the inner bark of Tabebuia avellanedae.
Journal of Medicinal Plants Research, 2010Co-Authors: Byung Hun Kim, Jaehwi Lee, Kook Hyun Kim, Jae Youl ChoAbstract:Tabebuia sp. (Bignoniaceae) is representative traditional herbal plants, found in tropical rain forest areas throughout Central and South America. These plants have been mostly used as a folk medicine to treat bacterial infection, blood coagulation, cancer and inflammatory diseases. In this study, we aimed to demonstrate the modulatory role of Tabebuia avellanedae in various macrophage- or monocyte-mediated immune responses using its water extract (Ta-WE). Ta-WE was able to up-regulate cell-cell interaction by decreasing the migration of cells and by enhancing CD29-mediated cell-cell adhesion, and the surface levels of adhesion molecules (CD18, CD29, and CD82) and costimulatory molecules (CD80 and CD86) linked to macrophage stimulation as seen in up-regulation of ROS release. In addition, this fraction also suppressed an alteration in the membrane levels of macrophages such as phagocytic uptake and morphological changes. Therefore, these results suggest that the water extract of T. avellanedae can strongly modulate an ability of macrophages and monocytes to manage immune cell-cell interaction in host defence system. Key words: Tabebuia avellanedae (Bignoniaceae), water extract, macrophages, monocytes, cell-to-cell interaction.
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In vitro and in vivo anti-inflammatory effects of taheebo, a water extract from the inner bark of Tabebuia avellanedae
Journal of ethnopharmacology, 2008Co-Authors: Eun Byeon, Byung Hun Kim, Kook Hyun Kim, Joo Young Chung, Yong Gyu Lee, Jae Youl ChoAbstract:Abstract Aim of study Tabebuia spp. (Bignoniaceae) are native to tropical rain forests throughout Central and South America and have long been used as a folk medicine to treat bacterial infection, blood coagulation, cancer and inflammatory diseases. In this study, we aimed to demonstrate the ethnopharmacological activity of Tabebuia avellanedae in various in vitro and in vivo inflammatory conditions. Materials and methods To do this, LPS-stimulated macrophages and arachidonic acid or croton oil-induced mouse ear edema models were employed. Results The water extract (taheebo) of Tabebuia avellanedae significantly suppressed the production of prostaglandin (PG) E 2 and nitric oxide (NO), and blocked the mRNA expression of their catalyzing enzymes (cyclooxygenase [COX)-II] and inducible NO synthase [iNOS], respectively), in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The blockade of inflammatory mediators by taheebo seemed to be the result of the interruption of extracellular signal-related kinase (ERK) activation, according to immunoblotting analysis and the NO assay, where LPS strongly induced the phosphorylation (a hallmark of activation) of ERK, and U0126, a selective ERK inhibitor, was found to strongly inhibit PGE 2 production. Similarly, oral administration of taheebo (100 mg/kg) for 1 week completely diminished mouse ear edema induced by arachidonic acid, an activator of COX-II, but not croton oil, an activator of lipoxygenase. Conclusions These data suggest that the ethnopharmacological action of taheebo may be due to its negative modulation of macrophage-mediated inflammatory responses by suppressing PGE 2 production. Thus, this water extract may be developed as a new therapeutic remedy for various inflammatory diseases such as arthritis and atherosclerosis.
Maria Consuelo Andrade Marques - One of the best experts on this subject based on the ideXlab platform.
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Antiulcer effect of bark extract of Tabebuia avellanedae: activation of cell proliferation in gastric mucosa during the healing process.
Phytotherapy research : PTR, 2012Co-Authors: Isabela Tiemy Pereira, Lígia Moura Burci, Luisa Mota Da Silva, Cristiane Hatsuko Baggio, Melina Heller, Gustavo Amadeu Micke, Moacir Geraldo Pizzolatti, Maria Consuelo Andrade Marques, Maria Fernanda De Paula WernerAbstract:Tabebuia avellanedae (syn. Handroanthus impetiginosus) is popularly known as ‘ipe-roxo’ and has been used in folk medicine as anti-inflammatory and in the treatment of ulcers, bacterial and fungal infections. This study evaluated the gastric ulcer healing property of the ethanolic extract (EET) of barks from Tabebuia avellanedae and investigated the mechanisms that may underlie this effect. Rats were treated with EET (twice a day for 7 days) after induction of chronic gastric ulcers by 80% acetic acid. Following treatment, histological and immunohistochemical analysis were performed in gastric ulcer tissues. Oral administration of EET (100 and 300 mg/kg) significantly reduced the gastric lesion induced by acetic acid in 44 and 36%, respectively. Histopathological evaluation demonstrated a contraction of gastric ulcer size, increase of mucus layer (periodic acid-Schiff stained mucin-like glycoproteins) and cell proliferation (proliferating cell nuclear antigen immunohistochemistry) in animals treated with EET (100 and 300 mg/kg). The results demonstrate that EET significantly accelerates healing of acetic acid induced gastric ulcer in rats through increase of mucus content and cell proliferation, indicating a potential usefulness for treatment of peptic ulcer diseases. Copyright © 2012 John Wiley & Sons, Ltd.
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Antiulcerogenic activity of bark extract of Tabebuia avellanedae, Lorentz ex Griseb
Journal of ethnopharmacology, 2008Co-Authors: André Twardowschy, Cristiane Hatsuko Baggio, Moacir Geraldo Pizzolatti, Cristina Setim Freitas, Bárbara Mayer, Ana Cristina Dos Santos, Aline Alvarez Zacarias, Élide Pereira Dos Santos, Michel Fleith Otuki, Maria Consuelo Andrade MarquesAbstract:Abstract Tabebuia avellanedae is commonly used for the treatment of peptic ulcers. We carried out this study with the ethanolic extract of bark from Tabebuia avellanedae (EET) (30–1000 mg/kg) to determine its gastroprotective activity and to clarify the pathways involved in this effect. Acute gastric ulceration in rats was produced by oral administration of ethanol and ibuprofen. After ethanol administration, the gastric wall mucus was examined. Chronic gastric ulceration was produced by injection of acetic acid in rat gastric subserosa. Anti-secretory studies were undertaken using Shay rat pylorus ligature technique and measurement of enzymatic activity of H+, K+-ATPase in vitro. Administration of EET p.o. or i.p. significantly inhibited gastric mucosa damage induced by ethanol and ibuprofen. The anti-ulcer effect was further confirmed by enhanced gastric mucus production. In pylorus ligature rats, EET significantly reduced the basal gastric acid secretion and total acidity; moreover, it inhibited the increase in total acidity induced by histamine. In addition, EET reduced the activity of H+, K+, ATPase. The results obtained in the present pharmacological assay indicate that this plant has a protective action against gastric lesions, involving the maintenance of protective factors, such as mucus and prostaglandin, besides the reduction of gastric total acidity.
Ana Lilia Alzate-marin - One of the best experts on this subject based on the ideXlab platform.
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Transferability and characterization of nine microsatellite markers for the tropical tree species Tabebuia roseo-alba.
Molecular ecology resources, 2009Co-Authors: Juliana Massimino Feres, Marcelo Martinez, Carlos Alberto Martinez, Moacyr Antonio Mestriner, Ana Lilia Alzate-marinAbstract:Microsatellite loci that were previously developed in the tropical tree Tabebuia aurea were used for the genetic analysis of Tabebuia roseo-alba populations. Nine of 10 simple sequence repeat markers were amplified, and the polymorphism was assessed in 58 individuals sampled from two stands in southeastern Brazil. All loci were polymorphic with Mendelian inheritance. The allele numbers were high, ranging from 5 to 13 in population I and 3 to 7 in population II, with means of 8.9 and 5.5, respectively. We conclude that these markers can be efficiently used for parentage and gene-flow studies.
Tadataka Noro - One of the best experts on this subject based on the ideXlab platform.
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Constituents from the bark of Tabebuia impetiginosa.
Chemical & pharmaceutical bulletin, 2006Co-Authors: Tsutomu Warashina, Yoshimi Nagatani, Tadataka NoroAbstract:Thirteen new phenolic glycosides were obtained by further study of constituents from the bark of Tabebuia impetiginosa (MART. ex DC) Standley (Bignoniaceae). The structures of these compounds were determined based on NMR, mass spectral and chemical evidence. Most of them have a glycosyl unit esterified by a benzoic acid derivative.
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Further constituents from the bark of Tabebuia impetiginosa.
Phytochemistry, 2005Co-Authors: Tsutomu Warashina, Yoshimi Nagatani, Tadataka NoroAbstract:Further study on the constituents from the bark of Tabebuia impetiginosa (Mart. ex DC) Standley afforded twelve compounds, consisting of four iridoid glycosides, one phenylethanoid glycoside, five phenolic glycosides, and one lignan glycoside, along with seven known compounds. The structures of these compounds were determined based on the interpretation of their NMR and MS measurements and by chemical evidence.
Moacir Geraldo Pizzolatti - One of the best experts on this subject based on the ideXlab platform.
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Antiulcer effect of bark extract of Tabebuia avellanedae: activation of cell proliferation in gastric mucosa during the healing process.
Phytotherapy research : PTR, 2012Co-Authors: Isabela Tiemy Pereira, Lígia Moura Burci, Luisa Mota Da Silva, Cristiane Hatsuko Baggio, Melina Heller, Gustavo Amadeu Micke, Moacir Geraldo Pizzolatti, Maria Consuelo Andrade Marques, Maria Fernanda De Paula WernerAbstract:Tabebuia avellanedae (syn. Handroanthus impetiginosus) is popularly known as ‘ipe-roxo’ and has been used in folk medicine as anti-inflammatory and in the treatment of ulcers, bacterial and fungal infections. This study evaluated the gastric ulcer healing property of the ethanolic extract (EET) of barks from Tabebuia avellanedae and investigated the mechanisms that may underlie this effect. Rats were treated with EET (twice a day for 7 days) after induction of chronic gastric ulcers by 80% acetic acid. Following treatment, histological and immunohistochemical analysis were performed in gastric ulcer tissues. Oral administration of EET (100 and 300 mg/kg) significantly reduced the gastric lesion induced by acetic acid in 44 and 36%, respectively. Histopathological evaluation demonstrated a contraction of gastric ulcer size, increase of mucus layer (periodic acid-Schiff stained mucin-like glycoproteins) and cell proliferation (proliferating cell nuclear antigen immunohistochemistry) in animals treated with EET (100 and 300 mg/kg). The results demonstrate that EET significantly accelerates healing of acetic acid induced gastric ulcer in rats through increase of mucus content and cell proliferation, indicating a potential usefulness for treatment of peptic ulcer diseases. Copyright © 2012 John Wiley & Sons, Ltd.
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Antiulcerogenic activity of bark extract of Tabebuia avellanedae, Lorentz ex Griseb
Journal of ethnopharmacology, 2008Co-Authors: André Twardowschy, Cristiane Hatsuko Baggio, Moacir Geraldo Pizzolatti, Cristina Setim Freitas, Bárbara Mayer, Ana Cristina Dos Santos, Aline Alvarez Zacarias, Élide Pereira Dos Santos, Michel Fleith Otuki, Maria Consuelo Andrade MarquesAbstract:Abstract Tabebuia avellanedae is commonly used for the treatment of peptic ulcers. We carried out this study with the ethanolic extract of bark from Tabebuia avellanedae (EET) (30–1000 mg/kg) to determine its gastroprotective activity and to clarify the pathways involved in this effect. Acute gastric ulceration in rats was produced by oral administration of ethanol and ibuprofen. After ethanol administration, the gastric wall mucus was examined. Chronic gastric ulceration was produced by injection of acetic acid in rat gastric subserosa. Anti-secretory studies were undertaken using Shay rat pylorus ligature technique and measurement of enzymatic activity of H+, K+-ATPase in vitro. Administration of EET p.o. or i.p. significantly inhibited gastric mucosa damage induced by ethanol and ibuprofen. The anti-ulcer effect was further confirmed by enhanced gastric mucus production. In pylorus ligature rats, EET significantly reduced the basal gastric acid secretion and total acidity; moreover, it inhibited the increase in total acidity induced by histamine. In addition, EET reduced the activity of H+, K+, ATPase. The results obtained in the present pharmacological assay indicate that this plant has a protective action against gastric lesions, involving the maintenance of protective factors, such as mucus and prostaglandin, besides the reduction of gastric total acidity.