The Experts below are selected from a list of 2166 Experts worldwide ranked by ideXlab platform
Ting Ye - One of the best experts on this subject based on the ideXlab platform.
-
Tachypleus tridentatus lectin enhances oncolytic vaccinia virus replication to suppress in vivo hepatocellular carcinoma growth
Marine Drugs, 2018Co-Authors: Gongchu Li, Jianhong Cheng, Tao Wu, Ting YeAbstract:Lectins play diverse roles in physiological processes as biological recognition molecules. In this report, a gene encoding Tachypleus tridentatus Lectin (TTL) was inserted into an oncolytic vaccinia virus (oncoVV) vector to form oncoVV-TTL, which showed significant antitumor activity in a hepatocellular carcinoma mouse model. Furthermore, TTL enhanced oncoVV replication through suppressing antiviral factors expression such as interferon-inducible protein 16 (IFI16), mitochondrial antiviral signaling protein (MAVS) and interferon-beta (IFN-β). Further investigations revealed that oncoVV-TTL replication was highly dependent on ERK activity. This study might provide insights into a novel way of the utilization of TTL in oncolytic viral therapies.
Kit Yue Kwan - One of the best experts on this subject based on the ideXlab platform.
-
ontogenetic resource use and trophic dynamics of endangered juvenile Tachypleus tridentatus among diversified nursery habitats in the northern beibu gulf china
Integrative Zoology, 2020Co-Authors: Kit Yue Kwan, Justin J Bopp, Shuyan Huang, Qiao Chen, Chunchieh Wang, Xueping Wang, Wenquan Zhen, Junhua Zhu, Xing HuangAbstract:Horseshoe crabs, the most well-known example of "living fossils", are iconic and ecologically important macroinvertebrates in coastal and estuarine ecosystems. Their blood is a crucial resource for manufacturing Limulus or Tachypleus amebocyte lysate to detect bacterial endotoxins or fungal contamination in drug and medical devices. An enhanced understanding of their ecological roles and trophic interactions in the food webs is fundamental to facilitate resource management for the declining populations in Asia. Foraging information of the Asian species, however, is mainly derived from preliminary, scattered reports from a limited number of study locations. In this study, resource utilization, trophic niche dynamics, and trophic interaction of the juvenile tri-spine horseshoe crab, Tachypleus tridentatus (instars 1-12, approximately 0.5-8 years old) across ontogeny was assessed in diversified nursery habitats along the northern Beibu Gulf, China, using carbon and nitrogen stable isotopes. Our results suggest that: (i) T. tridentatus are ecological generalists given the vast range of carbon isotopic values and trophic niche width estimates exhibited between multiple instar groups; (ii) juvenile T. tridentatus across most habitat types predominantly assimilated energy from a variety of basal production sources in the food web, but primarily depended on sedimentary organic matter and seagrass resource pools; (iii) ontogenetic shifts in juvenile dietary proportions were evident, with decreased reliance on sedimentary organic matter, coupled with increased reliance on benthic macroinvertebrate grazers, detritivores, and omnivores with age; and (iv) nearly all juvenile instars occupied similar trophic positions in the food web with slight shifts in trophic position present with increasing size. Our findings indicate that resource availability and ontogenetic diet shifts strongly influence horseshoe crab trophic dynamics, and age should be accounted when formulating habitat conservation measures based on resource use for Asian horseshoe crabs.
-
how survival and food intake of tri spine horseshoe crabs Tachypleus tridentatus respond to thermal variation implications for understanding its distribution limit
Journal of Natural History, 2019Co-Authors: Yongyan Liao, Youhou Xu, Shuqing Xu, Haiping Wu, Hu Huang, Kit Yue KwanAbstract:ABSTRACTTemperature appears to have pervasive effects on larval development, feeding and movement patterns of tri-spine horseshoe crabs, Tachypleus tridentatus. To investigate how temperature deter...
-
How survival and food intake of tri-spine horseshoe crabs, Tachypleus tridentatus respond to thermal variation: implications for understanding its distribution limit
Journal of Natural History, 2019Co-Authors: Yongyan Liao, Hu Huang, Ke Liu, Kit Yue KwanAbstract:Temperature appears to have pervasive effects on larval development, feeding and movement patterns of tri-spine horseshoe crabs, Tachypleus tridentatus. To investigate how temperature determines th...
-
draft genomic and transcriptome resources for marine chelicerate Tachypleus tridentatus
Scientific Data, 2019Co-Authors: Yongyan Liao, Kit Yue Kwan, Peng Wei Xu, Huai Yi Fang, Jun Yang Xu, Peng Liang Wang, Shao-yu Yang, Shuqing Xu, Dan Qian, Wei-feng LiAbstract:Chinese horseshoe crabs (Tachypleus tridentatus), ancient marine arthropods dating back to the mid-Palaeozoic Era, have provided valuable resources for the detection of bacterial or fungal contamination. However, excessive exploitation for the amoebocyte lysate of Tachypleus has dramatically decreased the population of the Chinese horseshoe crabs. Thus, we present sequencing, assembly and annotation of T. tridentatus, with the hope of understanding the genomic feature of the living fossil and assisting scientists with the protection of this endangered species. The final genome contained a total size of 1.943 Gb, covering 90.23% of the estimated genome size. The transcriptome of three larval stages was constructed to investigate the candidate gene involved in the larval development and validate annotation. The completeness of the genome and gene models was estimated by BUSCO, reaching 96.2% and 95.4%, respectively. The synonymous substitution distribution of paralogues revealed that T. tridentatus had undergone two rounds of whole-genome duplication. All genomic and transcriptome data have been deposited in public databases, ready to be used by researchers working on horseshoe crabs. Machine-accessible metadata file describing the reported data (ISA-Tab format)
Gongchu Li - One of the best experts on this subject based on the ideXlab platform.
-
Tachypleus tridentatus lectin enhances oncolytic vaccinia virus replication to suppress in vivo hepatocellular carcinoma growth
Marine Drugs, 2018Co-Authors: Gongchu Li, Jianhong Cheng, Tao Wu, Ting YeAbstract:Lectins play diverse roles in physiological processes as biological recognition molecules. In this report, a gene encoding Tachypleus tridentatus Lectin (TTL) was inserted into an oncolytic vaccinia virus (oncoVV) vector to form oncoVV-TTL, which showed significant antitumor activity in a hepatocellular carcinoma mouse model. Furthermore, TTL enhanced oncoVV replication through suppressing antiviral factors expression such as interferon-inducible protein 16 (IFI16), mitochondrial antiviral signaling protein (MAVS) and interferon-beta (IFN-β). Further investigations revealed that oncoVV-TTL replication was highly dependent on ERK activity. This study might provide insights into a novel way of the utilization of TTL in oncolytic viral therapies.
Jianhong Cheng - One of the best experts on this subject based on the ideXlab platform.
-
Tachypleus tridentatus lectin enhances oncolytic vaccinia virus replication to suppress in vivo hepatocellular carcinoma growth
Marine Drugs, 2018Co-Authors: Gongchu Li, Jianhong Cheng, Tao Wu, Ting YeAbstract:Lectins play diverse roles in physiological processes as biological recognition molecules. In this report, a gene encoding Tachypleus tridentatus Lectin (TTL) was inserted into an oncolytic vaccinia virus (oncoVV) vector to form oncoVV-TTL, which showed significant antitumor activity in a hepatocellular carcinoma mouse model. Furthermore, TTL enhanced oncoVV replication through suppressing antiviral factors expression such as interferon-inducible protein 16 (IFI16), mitochondrial antiviral signaling protein (MAVS) and interferon-beta (IFN-β). Further investigations revealed that oncoVV-TTL replication was highly dependent on ERK activity. This study might provide insights into a novel way of the utilization of TTL in oncolytic viral therapies.
-
Tachypleus tridentatus Lectin Enhances Oncolytic Vaccinia Virus Replication to Suppress In Vivo Hepatocellular Carcinoma Growth
MDPI AG, 2018Co-Authors: Jianhong Cheng, Shengsheng MeiAbstract:Lectins play diverse roles in physiological processes as biological recognition molecules. In this report, a gene encoding Tachypleus tridentatus Lectin (TTL) was inserted into an oncolytic vaccinia virus (oncoVV) vector to form oncoVV-TTL, which showed significant antitumor activity in a hepatocellular carcinoma mouse model. Furthermore, TTL enhanced oncoVV replication through suppressing antiviral factors expression such as interferon-inducible protein 16 (IFI16), mitochondrial antiviral signaling protein (MAVS) and interferon-beta (IFN-β). Further investigations revealed that oncoVV-TTL replication was highly dependent on ERK activity. This study might provide insights into a novel way of the utilization of TTL in oncolytic viral therapies
A. H. Parulekar - One of the best experts on this subject based on the ideXlab platform.
-
Morphometric characteristics in the horseshoe crab Tachypleus gigas (Arthropoda: Merostomata)
Indian Journal of Marine Sciences, 2000Co-Authors: R. Vijayakumar, Subrata K. Das, A. Chatterji, A. H. ParulekarAbstract:The relationships observed between total carapace length with carapace width, carapace weight, telson length, body weight were found statistically significant (p< 0.05) in the male and female horseshoe crab, Tachypleus gigas (Muller). In females, increase in weight was found to follow the cube law strictly. The carapace width grew faster at higher carapace length in females whereas, carapace weight in males was more at lower carapace. In general, a proportional increment in morphometry was seen with increase in age.
-
Feeding behaviour and food selection in the horseshoe crab, Tachypleus gigas (Müller)
Hydrobiologia, 1992Co-Authors: Anil Chatterji, J. K. Mishra, A. H. ParulekarAbstract:The Indian horseshoe crab, Tachypleus gigas (Müller), is a benthic feeder which subsists mainly on molluscs, decayed organic matter and polychaetes, in order of prevalence. A strong and positive preference was recorded for molluscs over other food organisms. The intensity of feeding was maximum during the north-east monsoon (November to January) in females and during the intermonsoon season (February to May) in males. It was minimum during the south-west monsoon (June to September).
