The Experts below are selected from a list of 8529 Experts worldwide ranked by ideXlab platform
Juan Pedro Laclette - One of the best experts on this subject based on the ideXlab platform.
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genetic vaccination against murine cysticercosis by using a plasmid vector carrying Taenia Solium paramyosin
Infection and Immunity, 2005Co-Authors: Carlos F Solis, Pedro Ostoasaloma, Veronica H Lugomartinez, Stephen Albert Johnston, Juan Pedro LacletteAbstract:A plasmid vector carrying the immunoprotective amino-terminal fragment of Taenia Solium paramyosin (VW2-1) was designed for genetic vaccination studies. Mice that were genetically immunized with VW2-1 and challenged by intraperitoneal inoculation of Taenia crassiceps cysticerci showed 43 to 48% reductions in the parasite burden, values which were similar to values obtained previously when the recombinant protein was used.
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gene structure of Taenia Solium paramyosin
Parasitology Research, 2003Co-Authors: Laura Vargasparada, Juan Pedro LacletteAbstract:Paramyosin is a muscle protein that probably plays a role in the survival of the larval stage of Taenia Solium during its prolonged host-parasite relationship. Here we describe the structure of the gene coding for the paramyosin of T. Solium. The characterization of two clones obtained from a genomic library showed that the complete gene of paramyosin contains 13 introns delimited by conventional eukaryotic splice signals. Comparison with the paramyosin genes of Drosophila melanogaster and Caenorhabditis elegans showed a lack of conservation of the exon/intron organization in contrast to other muscle genes. No evidence of alternative splicing sites were found, excluding the possibility that T. Solium expresses a mini-paramyosin like D. melanogaster.
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epitope mapping on n terminal region of Taenia Solium paramyosin
Immunology Letters, 2000Co-Authors: Karlen G. Gazarian, Tatiana G. Gazarian, Ricardo Hernández, Carlos F Solis, Charles B. Shoemaker, Juan Pedro LacletteAbstract:Abstract Epitope mapping of the amino-terminal 20aa sequence from Taenia Solium paramyosin (TPmy), an immunodominant protein involved in the complex host–parasite relationship in human and porcine cysticercosis is reported. A 12-mer random peptide phage display library was screened with antibodies raised against a synthetic peptide corresponding to the amino-terminal 20aa sequence of TPmy, its highly immunodominant region. In total, 57 clones isolated in two panning conditions were analyzed, of which a single group of 14 sequences found in 25 clones shared a consensus motif showing structural similarity with the antigen Arg10-Thr16 region.
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Purification of antigen B from Taenia Solium cysticerci by affinity to mammalian collagen.
The Journal of Parasitology, 1990Co-Authors: Juan Pedro Laclette, Alejandro Alagón, Kaethe Willms, Alfonso Torre-blancoAbstract:A 1-step procedure for the easy and rapid purification of milligram amounts of antigen B from a crude extract of Taenia Solium cysticerci is described here. This procedure takes advantage of the property of the antigen B to bind to collagen and is based on antigen adsorption to polymeric collagen.
Laura Vargasparada - One of the best experts on this subject based on the ideXlab platform.
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gene structure of Taenia Solium paramyosin
Parasitology Research, 2003Co-Authors: Laura Vargasparada, Juan Pedro LacletteAbstract:Paramyosin is a muscle protein that probably plays a role in the survival of the larval stage of Taenia Solium during its prolonged host-parasite relationship. Here we describe the structure of the gene coding for the paramyosin of T. Solium. The characterization of two clones obtained from a genomic library showed that the complete gene of paramyosin contains 13 introns delimited by conventional eukaryotic splice signals. Comparison with the paramyosin genes of Drosophila melanogaster and Caenorhabditis elegans showed a lack of conservation of the exon/intron organization in contrast to other muscle genes. No evidence of alternative splicing sites were found, excluding the possibility that T. Solium expresses a mini-paramyosin like D. melanogaster.
Carlos F Solis - One of the best experts on this subject based on the ideXlab platform.
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genetic vaccination against murine cysticercosis by using a plasmid vector carrying Taenia Solium paramyosin
Infection and Immunity, 2005Co-Authors: Carlos F Solis, Pedro Ostoasaloma, Veronica H Lugomartinez, Stephen Albert Johnston, Juan Pedro LacletteAbstract:A plasmid vector carrying the immunoprotective amino-terminal fragment of Taenia Solium paramyosin (VW2-1) was designed for genetic vaccination studies. Mice that were genetically immunized with VW2-1 and challenged by intraperitoneal inoculation of Taenia crassiceps cysticerci showed 43 to 48% reductions in the parasite burden, values which were similar to values obtained previously when the recombinant protein was used.
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epitope mapping on n terminal region of Taenia Solium paramyosin
Immunology Letters, 2000Co-Authors: Karlen G. Gazarian, Tatiana G. Gazarian, Ricardo Hernández, Carlos F Solis, Charles B. Shoemaker, Juan Pedro LacletteAbstract:Abstract Epitope mapping of the amino-terminal 20aa sequence from Taenia Solium paramyosin (TPmy), an immunodominant protein involved in the complex host–parasite relationship in human and porcine cysticercosis is reported. A 12-mer random peptide phage display library was screened with antibodies raised against a synthetic peptide corresponding to the amino-terminal 20aa sequence of TPmy, its highly immunodominant region. In total, 57 clones isolated in two panning conditions were analyzed, of which a single group of 14 sequences found in 25 clones shared a consensus motif showing structural similarity with the antigen Arg10-Thr16 region.
Hector H. Garcia - One of the best experts on this subject based on the ideXlab platform.
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Disease Centered Around Calcified Taenia Solium Granuloma.
Trends in Parasitology, 2017Co-Authors: Theodore E. Nash, Javier A. Bustos, Hector H. GarciaAbstract:Taenia Solium (the pork tapeworm) is present in most developing countries, where it is a frequent cause of seizures and other neurological disease. Parasitic larvae invade the human brain, establish, and eventually resolve, leaving a calcified scar. While these lesions are common in endemic regions, and most of these are clinically silent, a proportion of individuals with calcified cysticerci develop seizures from these lesions, and 30–65% of these cases are associated with perilesional edema (PE), likely due to host inflammation. This manuscript summarizes the importance, characteristics, natural history, and potential prevention and treatments of symptomatic calcified neurocysticercosis (NCC).
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Pathogenesis of Taenia Solium Taeniasis and cysticercosis.
Parasite Immunology, 2016Co-Authors: I. Gonzales, J. T. Rivera, Hector H. GarciaAbstract:Taenia Solium infections (Taeniasis/cysticercosis) are a major scourge to most developing countries. Neurocysticercosis, the infection of the human nervous system by the cystic larvae of this parasite, has a protean array of clinical manifestations varying from entirely asymptomatic infections to aggressive, lethal courses. The diversity of clinical manifestations reflects a series of contributing factors which include the number, size and location of the invading parasites, and particularly the inflammatory response of the host. This manuscript reviews the different presentations of T. Solium infections in the human host with a focus on the mechanisms or processes responsible for their clinical expression.
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immunology of Taenia Solium Taeniasis and human cysticercosis
Parasite Immunology, 2014Co-Authors: Hector H. Garcia, Silvia Rodriguez, Jon S FriedlandAbstract:The life cycle of Taenia Solium, the pork tapeworm, is continuously closed in many rural settings in developing countries when free roaming pigs ingest human stools containing T. Solium eggs and develop cysticercosis, and humans ingest pork infected with cystic larvae and develop intestinal Taeniasis, or may also accidentally acquire cysticercosis by faecal-oral contamination. Cysticercosis of the human nervous system, neurocysticercosis, is a major cause of seizures and other neurological morbidity in most of the world. The dynamics of exposure, infection and disease as well as the location of parasites result in a complex interaction which involves immune evasion mechanisms and involutive or progressive disease along time. Moreover, existing data are limited by the relative lack of animal models. This manuscript revises the available information on the immunology of human Taeniasis and cysticercosis.
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Taenia Solium: Biological Characteristics and Life Cycle
Cysticercosis of the Human Nervous System, 2013Co-Authors: Oscar H. Del Brutto, Hector H. GarciaAbstract:Taenia Solium is one of the many species of cestodes (tapeworms) that can infect humans (Flisser 1994; Pawlowski 2002). It belongs to the phylum Platyhelminthes, class Cestoidea, order Cyclophyllidea, family Taeniidae. In general terms, tapeworms are complex organisms having complex life cycles that require at least two hosts for their completion. In the case of Taenia Solium, humans are the most important definitive hosts, whereas both pigs and humans are the main intermediate hosts. The list of other animals that may act as definitive or intermediate hosts of Taenia Solium is large but clinically irrelevant.
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prevention and control of Taenia Solium Taeniasis cysticercosis in peru
Pathogens and Global Health, 2012Co-Authors: Robert H. Gilman, Armando E. Gonzalez, Victor C. W. Tsang, Fernando Llanoszavalaga, Hector H. GarciaAbstract:Taenia Solium is endemic in most of the world, causing seizures and other neurological symptoms. Transmission is mainly maintained in rural areas by a human to pig cycle. Despite claims on its eradicability, sustainable interruption of transmission has not yet been reported. This manuscript reviews the conceptual basis for control, available diagnostic and control tools, and recent experiences on control in the field performed in Peru along the past decade
Brecht Devleesschauwer - One of the best experts on this subject based on the ideXlab platform.
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Potential Elimination of Active Taenia Solium Transmission in Africa
New England Journal of Medicine, 2020Co-Authors: Sarah Gabriël, Kabemba E. Mwape, Emma C. Hobbs, Brecht Devleesschauwer, Inge Van Damme, Gideon Zulu, Chembensofu Mwelwa, Chishimba Mubanga, Maxwell Masuku, Moses MambweAbstract:Eliminating Taenia Solium Transmission in Africa Taenia Solium causes cysticercosis. Control of the zoonotic reservoir is an important component of eliminating this disease. In this study conducted...
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Input variables, interventions and principal outcomes for Taenia Solium transmission dynamics models: Intervention included and main model outcomes.
2019Co-Authors: Matthew A. Dixon, Sarah Gabriël, Brecht Devleesschauwer, Uffe C. Braae, Peter Winskill, Martin Walker, Maria-gloria BasáñezAbstract:Input variables, interventions and principal outcomes for Taenia Solium transmission dynamics models: Intervention included and main model outcomes.
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Summary of the structure and key features of Taenia Solium transmission dynamics models identified from the systematic literature search.
2019Co-Authors: Matthew A. Dixon, Sarah Gabriël, Brecht Devleesschauwer, Uffe C. Braae, Peter Winskill, Martin Walker, Maria-gloria BasáñezAbstract:Summary of the structure and key features of Taenia Solium transmission dynamics models identified from the systematic literature search.
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Represented parameters, derived and nominal values for Taenia Solium transmission dynamics models, outlining how parameters are represented, derived and their nominal values.
2019Co-Authors: Matthew A. Dixon, Sarah Gabriël, Brecht Devleesschauwer, Uffe C. Braae, Peter Winskill, Martin Walker, Maria-gloria BasáñezAbstract:Represented parameters, derived and nominal values for Taenia Solium transmission dynamics models, outlining how parameters are represented, derived and their nominal values.
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Taenia Solium in europe still endemic
Acta Tropica, 2017Co-Authors: Brecht Devleesschauwer, Maria Vang Johansen, Chiara Trevisan, Alberto Allepuz, Veronique Dermauw, Minerva Laranjogonzalez, Suzanne G A Smit, Smaragda Sotiraki, Nicola A WardropAbstract:The pork tapeworm, Taenia Solium, causes an important economic and health burden, mainly in rural or marginalized communities of sub-Saharan Africa, Asia, and Latin-America. Although improved pig rearing conditions seem to have eliminated the parasite in most Western European countries, little is known about the true endemicity status of T. Solium throughout Europe. Three recent reviews indicate that autochthonous human T. Solium Taeniasis/cysticercosis may be possible in Europe, but that current peer-reviewed literature is biased towards Western Europe. Officially reported data on porcine cysticercosis are highly insufficient. Favourable conditions for local T. Solium transmission still exist in eastern parts of Europe, although the ongoing integration of the European Union is speeding up modernisation and intensification of the pig sector. Further evidence is urgently needed to fill the gaps on the European T. Solium endemicity map. We urge to make human cysticercosis notifiable and to improve the reporting of porcine cysticercosis.
