The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Kenneth M. Lloyd - One of the best experts on this subject based on the ideXlab platform.
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The Significance of Targetoid Nevus
Archives of Dermatology, 2006Co-Authors: Kenneth M. LloydAbstract:A DOLESCENT CHILDREN AND YOUNG ADULTS often have many acquired nevocellular nevi. By age 40 years, many of the nevi have disappeared. The evolutional changes can be so subtle that the nevi disappear without notice. The Targetoid nevus is distinctive in appearance, with its striking targetlike shape, reduced color contrast, and softer melanin pigmentation. This nevus is much more common than the literature would suggest. The evolutionary pattern is, like the halo nevus, patient and type specific. Once initiated, the process is usually completed within 6 to 12 months. The photographs are representative of the Targetoid nevus. Figure 1 shows 3 typical Targetoid nevi on the back. Figure 2 represents a classic Targetoid nevus in an early regressive stage. Figure 3 shows the typical appearance of a Targetoid nevus with a more significant pigmented pattern. Figure 4 shows a nevus in a late stage of evolution. These lesions should be recognized clinically. Surgical removal is not medically indicated. The Targetoid nevus has been reported as a cockade (spelled “cockarde”) nevus. Since few dermatologists today are familiar with the cockade (ie, the rosette or knot of ribbons worn on hats during the French Revolution as a badge of recognition), the term Targetoid nevus now seems more appropriate.
Ya-hui Chuang - One of the best experts on this subject based on the ideXlab platform.
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chromoblastomycosis in taiwan a report of 30 cases and a review of the literature
Medical Mycology, 2018Co-Authors: C H Yang, Ya-hui Chuang, Chunbing Chen, Yungyi Lee, Chihhsun Yang, Yaching Chang, Wenhung Chung, Huaen Lee, Rosaline Chungyee Hui, Hong-shang HongAbstract:Chromoblastomycosis (CBM) is an implantation mycosis characterized by the presence of pigmented muriform cells in tissue. CBM is endemic in Taiwan, but only three formal cases have been reported to date because of underreporting. To describe and update its epidemiologic features, we report a series of 30 cases between 2003 and 2016 at a single medical center. Patients were predominately male (2.75:1). The mean age of onset was 65.9 years, and disease duration ranged from 2 months to 20 years. Diabetes was the most common comorbidity, and extremities were the most frequent sites of involvement. The lesions presented as papuloplaque, verrucous, cicatricial, Targetoid, or mixed types. The dermoscopic features were variable, including red dots, white vague areas, black globules, and sand-like patterns. Among 10 Fonsecaea isolates further identified by sequencing the ITS regions of ribosomal DNA, nine were F. monophora and one was F. nubica. All but one patient received either systemic antifungal agents, surgical excision, or both. Surgical excision achieved a higher complete remission rate than the other forms of treatment did.
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Early congenital syphilis and erythema multiforme-like bullous Targetoid lesions in a 1-day-old newborn: detection of Treponema pallidum genomic DNA from the Targetoid plaque using nested polymerase chain reaction.
Journal of the American Academy of Dermatology, 2006Co-Authors: Chi-neu Tsai, Wen-rou Wong, Hong-shang Hong, Ya-hui ChuangAbstract:A 1-day-old male newborn was born with respiratory distress, low birth weight, hepatosplenomegaly, and bullous Targetoid skin lesions over the face, back, buttocks, and extremities. A diagnosis of early congenital syphilis was made based on a treponemal serologic test. Pathologic examination of the skin lesion showed scattered dyskeratotic cells in the epidermis and interface dermatitis consistent with erythema multiforme. No spirochete could be found in the skin sections staining with Warthin-Starry stain. Using nested polymerase chain reaction, treponemal genomic DNA fragments encoding DNA polymerase I were detected.
Hong-shang Hong - One of the best experts on this subject based on the ideXlab platform.
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chromoblastomycosis in taiwan a report of 30 cases and a review of the literature
Medical Mycology, 2018Co-Authors: C H Yang, Ya-hui Chuang, Chunbing Chen, Yungyi Lee, Chihhsun Yang, Yaching Chang, Wenhung Chung, Huaen Lee, Rosaline Chungyee Hui, Hong-shang HongAbstract:Chromoblastomycosis (CBM) is an implantation mycosis characterized by the presence of pigmented muriform cells in tissue. CBM is endemic in Taiwan, but only three formal cases have been reported to date because of underreporting. To describe and update its epidemiologic features, we report a series of 30 cases between 2003 and 2016 at a single medical center. Patients were predominately male (2.75:1). The mean age of onset was 65.9 years, and disease duration ranged from 2 months to 20 years. Diabetes was the most common comorbidity, and extremities were the most frequent sites of involvement. The lesions presented as papuloplaque, verrucous, cicatricial, Targetoid, or mixed types. The dermoscopic features were variable, including red dots, white vague areas, black globules, and sand-like patterns. Among 10 Fonsecaea isolates further identified by sequencing the ITS regions of ribosomal DNA, nine were F. monophora and one was F. nubica. All but one patient received either systemic antifungal agents, surgical excision, or both. Surgical excision achieved a higher complete remission rate than the other forms of treatment did.
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Early congenital syphilis and erythema multiforme-like bullous Targetoid lesions in a 1-day-old newborn: detection of Treponema pallidum genomic DNA from the Targetoid plaque using nested polymerase chain reaction.
Journal of the American Academy of Dermatology, 2006Co-Authors: Chi-neu Tsai, Wen-rou Wong, Hong-shang Hong, Ya-hui ChuangAbstract:A 1-day-old male newborn was born with respiratory distress, low birth weight, hepatosplenomegaly, and bullous Targetoid skin lesions over the face, back, buttocks, and extremities. A diagnosis of early congenital syphilis was made based on a treponemal serologic test. Pathologic examination of the skin lesion showed scattered dyskeratotic cells in the epidermis and interface dermatitis consistent with erythema multiforme. No spirochete could be found in the skin sections staining with Warthin-Starry stain. Using nested polymerase chain reaction, treponemal genomic DNA fragments encoding DNA polymerase I were detected.
Kyoung Doo Song - One of the best experts on this subject based on the ideXlab platform.
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rim arterial enhancing primary hepatic tumors with other Targetoid appearance show early recurrence after radiofrequency ablation
European Radiology, 2021Co-Authors: Dong Ik Cha, Min Woo Lee, Woo Kyoung Jeong, Soohyun Ahn, Tae Wook Kang, Kyoung Doo SongAbstract:To evaluate early (≤ 2 years) local tumor progression (LTP), intrahepatic distant metastasis (IDR), and extrahepatic metastasis (EM) of primary hepatic malignant tumors with arterial rim enhancement (RE) after RFA in comparison with non-RE tumors. Three hundred forty-nine patients who underwent RFA for primary hepatic malignant tumors between January 2009 and December 2016 were included. The patients’ tumors were classified into non-RE, RE only (RO), and RE plus other Targetoid appearances (REoT). Cumulative LTP, IDR, and EM rates at 1 and 2 years after RFA were calculated using the Kaplan-Meier method and compared using the log-rank test. Prognostic factors for the outcomes were assessed using a Cox proportional hazards model. There were 303 non-RE, 19 RO, and 27 REoT tumors. The REoT tumors had a significantly higher rate of IDR and EM than non-RE (p = 0.04 for IDR; and p < 0.01 for EM, respectively) at 1 year after RFA. At 2 years, LTP and EM rates were significantly higher for REoT than for non-RE (p = 0.001 for LTP; and p = 0.444 for EM, respectively). The RO tumors did not have different outcomes than non-RE at 1 and 2 years after RFA. Multivariable analysis verified that REoT was a significant factor for IDR (p = 0.04) and EM (p = 0.01) at 1 year and LTP (p = 0.02) at 2 years. Tumors with REoT had poor LTP, IDR, and EM within 2 years after RFA than non-RE tumors. However, tumors with RO showed similar results as non-RE tumors. • Tumors with Rim enhancement plus other Targetoid appearances (REoT) had a significantly higher rate of recurrence than non-rim enhancing (RE) tumors at 1 and 2 years after RFA. • Tumors with rim enhancement only did not have different outcomes than non-RE at 1 and 2 years after RFA.
Jasna Lipozenčić - One of the best experts on this subject based on the ideXlab platform.
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Shape and configuration of skin lesions: Targetoid lesions
Clinics in Dermatology, 2011Co-Authors: Ronni Wolf, Jasna LipozenčićAbstract:What is probably the first description of Targetoid or iris lesions, as they appear in erythema multiforme (EM), can be found in Thomas Bateman's 1836 textbook "Practical Synopsis of Cutaneous Diseases According to the Arrangement of Dr. Willan." EM was initially described by Bateman and later by von Hebra as an acute self-limiting skin disease, symmetrically distributed on the extremities with typical concentric "Targetoid" or "iris" lesions, and often recurrent. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) were added to this syndrome later. A newer classification has created two disease spectra: EM consisting of EM minor and EM major (or bullous EM), and SJS and TEN. EM minor and EM major are often recurrent, postinfectious (especially after herpes and mycoplasma) disorders with low morbidity and almost no mortality. SJS and TEN are usually severe drug-induced reactions with high morbidity and poor prognosis. The target lesions found in each form of the disease are described and defined. Although the term "target lesion" originated from the description of EM and despite its being the dominant lesion in this disease, it is not pathognomonic for EM, and these lesions can sometimes appear in other diseases. Short descriptions of these other diseases are presented.
