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Shoichiro Tsugane - One of the best experts on this subject based on the ideXlab platform.
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associations of coffee and Tea Consumption with lung cancer risk
International Journal of Cancer, 2020Co-Authors: Jingjing Zhu, Yongbing Xiang, Stephanie A Smithwarner, Xuehong Zhang, William J Blot, Rashmi Sinha, Yikyung Park, Shoichiro Tsugane, Emily White, Woonpuay KohAbstract:Associations of coffee and Tea Consumption with lung cancer risk have been inconsistent, and most lung cancer cases investigated were smokers. Included in this study were over 1.1 million participants from 17 prospective cohorts. Cox regression analyses were conducted to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Potential effect modifications by sex, smoking, race, cancer subtype and coffee type were assessed. After a median 8.6 years of follow-up, 20 280 incident lung cancer cases were identified. Compared with noncoffee and nonTea Consumption, HRs (95% CIs) associated with exclusive coffee drinkers (≥2 cups/d) among current, former and never smokers were 1.30 (1.15-1.47), 1.49 (1.27-1.74) and 1.35 (1.15-1.58), respectively. Corresponding HRs for exclusive Tea drinkers (≥2 cups/d) were 1.16 (1.02-1.32), 1.10 (0.92-1.32) and 1.37 (1.17-1.61). In general, the coffee and Tea associations did not differ significantly by sex, race or histologic subtype. Our findings suggest that higher Consumption of coffee or Tea is associated with increased lung cancer risk. However, these findings should not be assumed to be causal because of the likelihood of residual confounding by smoking, including passive smoking, and change of coffee and Tea Consumption after study enrolment.
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abstract 632 associations of coffee and Tea Consumption with lung cancer risk a pooled analysis of 17 cohort studies involving over 1 2 million participants
Cancer Research, 2019Co-Authors: Jingjing Zhu, Yongbing Xiang, Wei Zheng, Stephanie A Smithwarner, Yikyung Park, Shoichiro Tsugane, Emily White, Woonpuay Koh, Rashimi Sinha, Sue K ParkAbstract:Background Epidemiological studies investigating the associations of coffee and Tea intake with lung cancer risk have yielded inconsistent results. These previous studies included mostly lung cancer patients diagnosed among smokers. Because coffee and Tea Consumption are closely related to smoking behavior, these previous studies could suffer from biases due to residual confounding of smoking. To better characterize the relationship, a large study with a large number of lung cancer cases diagnosed among never smokers and detailed information on Tea and coffee Consumption, is needed. Using data from a large-scale pooled analysis that consists of over 1.2 million participants in the U.S. and Asia, we carried out a comprehensive evaluation on the association of coffee and Tea intake with lung cancer risk. Methods Individual-level data from seven prospective cohort studies conducted in the U.S., and ten studies conducted in Asia, were included. Demographic, lifestyle, coffee and Tea intake data were collected at the baseline survey for each study. Multivariable-adjusted Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). The first 2 years of follow-up time was excluded to minimize potential influence of reverse causality on study results. Subgroup analyses by smoking status, sex, race, histologic subtype and coffee type (caffeinated or decaffeinated) were also conducted to assess potential effect modification, as well as heterogeneity of the association. Results After a median follow-up of 8.6 years, 20,519 incident lung cancer cases were identified. Both coffee and Tea Consumption were associated with an increased risk of lung cancer. Comparing non-coffee and non-Tea Consumption, HRs for lung cancer associated with exclusive coffee drinkers (≥2 cups/day) among current, former and never smokers were 1.30 (95% CI, 1.15-1.47), 1.49 (1.27-1.74) and 1.41 (95% CI, 1.21-1.63), respectively. Similar positive associations were observed for caffeinated and decaffeinated coffee. The HRs associated with exclusive Tea drinkers (>2 cups/day) were 1.16 (95% CI, 1.02-1.32), 1.10 (0.92, 1.32) and 1.37 (95% CI, 1.17-1.60) for current, former and never smokers, respectively. These associations did not differ significantly by sex, race or histologic subtypes. Conclusion A high Consumption of coffee or Tea was both associated with an increased risk of lung cancer regardless of race or smoking status. Our study included a large number of never-smoker lung cancer patients, which minimized potential confounding effects due to smoking. The positive association observed for both caffeinated and decaffeinated coffee suggests that compounds other than caffeine may play a role in the etiology of lung cancer. Citation Format: Jingjing Zhu, Wei Zheng, Rashimi Sinha, Stephanie A. Smith-Warner, Yong-Bing Xiang, Yikyung Park, Shoichiro Tsugane, Emily White, Woon-Puay Koh, Sue K. Park, Norie Sawada, Seiki Kanemura, Yumi Sugawara, Ichiro Tsuji, Kim Robien, Yasutake Tomata, Keun-Young Yoo, Jeongseon Kim, Jian-Min Yuan, Yu-Tang Gao, Yumie Takata, Eiko Saito, William Blot, Xiao-Ou Shu. Associations of coffee and Tea Consumption with lung cancer risk: A pooled analysis of 17 cohort studies involving over 1.2 million participants [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 632.
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association of green Tea Consumption with mortality due to all causes and major causes of death in a japanese population the japan public health center based prospective study jphc study
Annals of Epidemiology, 2015Co-Authors: Eiko Saito, Taichi Shimazu, Hiroyasu Iso, Manami Inoue, Norie Sawada, Taiki Yamaji, Motoki Iwasaki, Shizuka Sasazuki, Mitsuhiko Noda, Shoichiro TsuganeAbstract:Abstract Purpose We examined the association between green Tea Consumption and mortality due to all causes, cancer, heart disease, cerebrovascular disease, respiratory disease, injuries, and other causes of death in a large-scale population-based cohort study in Japan. Methods We studied 90,914 Japanese (aged between 40 and 69 years) recruited between 1990 and 1994. After 18.7 years of follow-up, 12,874 deaths were reported. The association between green Tea Consumption and risk of all causes and major causes of mortality was assessed using the Cox proportional hazards regression model with adjustment for potential confounders. Results Hazard ratios for all-cause mortality among men who consumed green Tea compared with those who drank less than 1 cup/day were 0.96 (0.89–1.03) for 1–2 cups/day, 0.88 (0.82–0.95) for 3–4 cups/day, and 0.87 (0.81–0.94) for more than 5 cups/day ( P for trend P for trend Conclusions This prospective study suggests that the Consumption of green Tea may reduce the risk of all-cause mortality and the three leading causes of death in Japan.
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endometrial cancer in relation to coffee Tea and caffeine Consumption a prospective cohort study among middle aged women in sweden
Nutrition and Cancer, 2014Co-Authors: Elisabete Weiderpass, Shoichiro Tsugane, Taichi Shimazu, Manami Inoue, Sven Sandin, Marie Lof, Hansolov AdamiAbstract:This study aimed to add to prospective data on the possible inverse association between coffee Consumption and endometrial cancer risk, already supported by several case-control studies. Coffee and Tea Consumption and possible confounding factors were assessed among 42,270 women aged 30-49 years at enrollment in 1991-1992 in the Swedish Women's Lifestyle and Health cohort study, with complete follow-up through 2009. We calculated caffeine intake per day; Cox proportional hazard models were used to estimate multivariable relative risks (mRR) for endometrial cancer with 95% confidence intervals (CIs). One hundred forty-four endometrial cancers were diagnosed during follow-up. Women with and without endometrial cancer had a similar mean daily coffee Consumption (549 vs. 547 g), Tea Consumption (104 vs. 115 g), and caffeine intake (405 vs. 406 mg). Compared to those consuming 3 cups had a mRR of 1.56 (95% CI: 0.94-2.59; P for trend = 0.17). Compared with the lowest tertile of caffeine intake, the highest tertile had a mRR of 1.32 (95% CI: 0.87-1.99; P for trend = 0.27). Our study provides no convincing evidence of an association between coffee Consumption, Tea Consumption, or caffeine intake and endometrial cancer risk among middle-aged women.
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the impact of green Tea and coffee Consumption on the reduced risk of stroke incidence in japanese population the japan public health center based study cohort
Stroke, 2013Co-Authors: Yoshihiro Kokubo, Hiroyasu Iso, Kazumasa Yamagishi, Manami Inoue, Isao Saito, Hiroshi Yatsuya, Junko Ishihara, Shoichiro TsuganeAbstract:Background and Purpose—Few prospective studies have examined the impact of both green Tea and coffee Consumption on strokes. We investigated the association of the combination of those Consumption with stroke incidence in a general population. Methods—We studied 82 369 Japanese (aged 45–74 years; without cardiovascular disease [CVD] or cancer in 1995 and 1998 for Cohort I and II, respectively) who received 13 years of mean follow-up through the end of 2007. Green Tea and coffee Consumption was assessed by self-administered food frequency questionnaire at baseline. Results—In the 1 066 718 person-years of follow-up, we documented the incidence of strokes (n=3425) and coronary heart disease (n=910). Compared with seldom drinking green Tea, the multivariable-adjusted hazard ratios (95% confidence intervals) of all strokes were 0.86 (0.78–0.95) and 0.80 (0.73–0.89) in green Tea 2 to 3 and ≥4 cups/d, respectively. Higher green Tea Consumption was associated with inverse risks of CVD and strokes subtypes. Compa...
Hiroyasu Iso - One of the best experts on this subject based on the ideXlab platform.
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association of Tea Consumption and the risk of gastric cancer in japanese adults the japan collaborative cohort study
BMJ Open, 2020Co-Authors: Haytham Sheerah, Liu Keyang, Ehab S Eshak, Renzhe Cui, Kokoro Shirai, Isao Muraki, Hiroyasu Iso, Akiko TamakoshiAbstract:Objective To examine the possible relationship between Tea Consumption and risk of gastric cancer (GC) among Japanese men and women included in a large Japanese population-based study titled the Japan Collaborative Cohort (JACC) Study. Design Prospective cohort study. Setting A population-based cohort included subjects who were recruited from 24 areas of JACC Study, in which data regarding the incidence of cancer were available. Participants 63 848 participants (26 025 men and 37 823 women), aged 40–79, were included in the analyses and underwent follow-up (median 13.3 years) prospectively in research on cancer incidence. Primary and secondary outcome measures The primary outcome variable was the risk of GC according to the frequency intakes of total Tea, green Tea, black Tea and oolong Tea. The adjusted HRs for the risk of GC associated with Tea Consumption were calculated using the Cox proportional hazards model. Results 1494 cases of GC were detected (960 men and 534 women) during the follow-up period. The multivariable-adjusted HRs for the risk of GC in the highest versus lowest quintiles of total Tea intake were 1.05 (0.83–1.33); p trend=0.50 in men, and 0.82 (0.60–1.12); p trend=0.45 in women. There was no association found between the Consumption of green Tea, black Tea or oolong Tea with the risk for GC in either gender. Conclusions In this large community-based prospective cohort study, Tea Consumption was not associated with the risk of GC in either gender.
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green Tea Consumption and risk of hematologic neoplasms the japan collaborative cohort study for evaluation of cancer risk jacc study
Cancer Causes & Control, 2019Co-Authors: Hiroyasu Iso, Midori Takada, Kazumasa Yamagishi, Akiko TamakoshiAbstract:Experimental studies suggested that green Tea may have an anticancer effect on hematologic neoplasms. However, few prospective studies have been conducted. A total of 65,042 individuals aged 40–79 years participated in this study and completed a self-administered questionnaire about their lifestyle and medical history at baseline (1988–1990). Of these, 52,462 individuals living in 24 communities with information on incident hematologic neoplasms available in the cancer registry, who did not have a history of cancer and provided valid information on frequency of green Tea Consumption, were followed through 2009. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of hematologic neoplasms according to green Tea Consumption were analyzed. The incidence of hematologic neoplasms during a median follow-up of 13.3 years was 323. Compared with the never-drinkers of green Tea, the multivariate HRs and 95% CIs for total hematologic neoplasms in green Tea drinkers of ≤ 2 cups/day, 3–4 cups/day, and ≥ 5 cups/day were 0.65 (0.42–1.00), 0.73 (0.47–1.13), and 0.63 (0.42–0.96), respectively. The association was more prominent for acute myeloid leukemias and follicular lymphomas. The present cohort study suggests a protective effect of green Tea against hematologic neoplasms, especially acute myeloid leukemias.
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association of green Tea Consumption with mortality due to all causes and major causes of death in a japanese population the japan public health center based prospective study jphc study
Annals of Epidemiology, 2015Co-Authors: Eiko Saito, Taichi Shimazu, Hiroyasu Iso, Manami Inoue, Norie Sawada, Taiki Yamaji, Motoki Iwasaki, Shizuka Sasazuki, Mitsuhiko Noda, Shoichiro TsuganeAbstract:Abstract Purpose We examined the association between green Tea Consumption and mortality due to all causes, cancer, heart disease, cerebrovascular disease, respiratory disease, injuries, and other causes of death in a large-scale population-based cohort study in Japan. Methods We studied 90,914 Japanese (aged between 40 and 69 years) recruited between 1990 and 1994. After 18.7 years of follow-up, 12,874 deaths were reported. The association between green Tea Consumption and risk of all causes and major causes of mortality was assessed using the Cox proportional hazards regression model with adjustment for potential confounders. Results Hazard ratios for all-cause mortality among men who consumed green Tea compared with those who drank less than 1 cup/day were 0.96 (0.89–1.03) for 1–2 cups/day, 0.88 (0.82–0.95) for 3–4 cups/day, and 0.87 (0.81–0.94) for more than 5 cups/day ( P for trend P for trend Conclusions This prospective study suggests that the Consumption of green Tea may reduce the risk of all-cause mortality and the three leading causes of death in Japan.
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the impact of green Tea and coffee Consumption on the reduced risk of stroke incidence in japanese population the japan public health center based study cohort
Stroke, 2013Co-Authors: Yoshihiro Kokubo, Hiroyasu Iso, Kazumasa Yamagishi, Manami Inoue, Isao Saito, Hiroshi Yatsuya, Junko Ishihara, Shoichiro TsuganeAbstract:Background and Purpose—Few prospective studies have examined the impact of both green Tea and coffee Consumption on strokes. We investigated the association of the combination of those Consumption with stroke incidence in a general population. Methods—We studied 82 369 Japanese (aged 45–74 years; without cardiovascular disease [CVD] or cancer in 1995 and 1998 for Cohort I and II, respectively) who received 13 years of mean follow-up through the end of 2007. Green Tea and coffee Consumption was assessed by self-administered food frequency questionnaire at baseline. Results—In the 1 066 718 person-years of follow-up, we documented the incidence of strokes (n=3425) and coronary heart disease (n=910). Compared with seldom drinking green Tea, the multivariable-adjusted hazard ratios (95% confidence intervals) of all strokes were 0.86 (0.78–0.95) and 0.80 (0.73–0.89) in green Tea 2 to 3 and ≥4 cups/d, respectively. Higher green Tea Consumption was associated with inverse risks of CVD and strokes subtypes. Compa...
Akiko Tamakoshi - One of the best experts on this subject based on the ideXlab platform.
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association of Tea Consumption and the risk of gastric cancer in japanese adults the japan collaborative cohort study
BMJ Open, 2020Co-Authors: Haytham Sheerah, Liu Keyang, Ehab S Eshak, Renzhe Cui, Kokoro Shirai, Isao Muraki, Hiroyasu Iso, Akiko TamakoshiAbstract:Objective To examine the possible relationship between Tea Consumption and risk of gastric cancer (GC) among Japanese men and women included in a large Japanese population-based study titled the Japan Collaborative Cohort (JACC) Study. Design Prospective cohort study. Setting A population-based cohort included subjects who were recruited from 24 areas of JACC Study, in which data regarding the incidence of cancer were available. Participants 63 848 participants (26 025 men and 37 823 women), aged 40–79, were included in the analyses and underwent follow-up (median 13.3 years) prospectively in research on cancer incidence. Primary and secondary outcome measures The primary outcome variable was the risk of GC according to the frequency intakes of total Tea, green Tea, black Tea and oolong Tea. The adjusted HRs for the risk of GC associated with Tea Consumption were calculated using the Cox proportional hazards model. Results 1494 cases of GC were detected (960 men and 534 women) during the follow-up period. The multivariable-adjusted HRs for the risk of GC in the highest versus lowest quintiles of total Tea intake were 1.05 (0.83–1.33); p trend=0.50 in men, and 0.82 (0.60–1.12); p trend=0.45 in women. There was no association found between the Consumption of green Tea, black Tea or oolong Tea with the risk for GC in either gender. Conclusions In this large community-based prospective cohort study, Tea Consumption was not associated with the risk of GC in either gender.
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green Tea Consumption and risk of hematologic neoplasms the japan collaborative cohort study for evaluation of cancer risk jacc study
Cancer Causes & Control, 2019Co-Authors: Hiroyasu Iso, Midori Takada, Kazumasa Yamagishi, Akiko TamakoshiAbstract:Experimental studies suggested that green Tea may have an anticancer effect on hematologic neoplasms. However, few prospective studies have been conducted. A total of 65,042 individuals aged 40–79 years participated in this study and completed a self-administered questionnaire about their lifestyle and medical history at baseline (1988–1990). Of these, 52,462 individuals living in 24 communities with information on incident hematologic neoplasms available in the cancer registry, who did not have a history of cancer and provided valid information on frequency of green Tea Consumption, were followed through 2009. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of hematologic neoplasms according to green Tea Consumption were analyzed. The incidence of hematologic neoplasms during a median follow-up of 13.3 years was 323. Compared with the never-drinkers of green Tea, the multivariate HRs and 95% CIs for total hematologic neoplasms in green Tea drinkers of ≤ 2 cups/day, 3–4 cups/day, and ≥ 5 cups/day were 0.65 (0.42–1.00), 0.73 (0.47–1.13), and 0.63 (0.42–0.96), respectively. The association was more prominent for acute myeloid leukemias and follicular lymphomas. The present cohort study suggests a protective effect of green Tea against hematologic neoplasms, especially acute myeloid leukemias.
Yongbing Xiang - One of the best experts on this subject based on the ideXlab platform.
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associations of coffee and Tea Consumption with lung cancer risk
International Journal of Cancer, 2020Co-Authors: Jingjing Zhu, Yongbing Xiang, Stephanie A Smithwarner, Xuehong Zhang, William J Blot, Rashmi Sinha, Yikyung Park, Shoichiro Tsugane, Emily White, Woonpuay KohAbstract:Associations of coffee and Tea Consumption with lung cancer risk have been inconsistent, and most lung cancer cases investigated were smokers. Included in this study were over 1.1 million participants from 17 prospective cohorts. Cox regression analyses were conducted to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Potential effect modifications by sex, smoking, race, cancer subtype and coffee type were assessed. After a median 8.6 years of follow-up, 20 280 incident lung cancer cases were identified. Compared with noncoffee and nonTea Consumption, HRs (95% CIs) associated with exclusive coffee drinkers (≥2 cups/d) among current, former and never smokers were 1.30 (1.15-1.47), 1.49 (1.27-1.74) and 1.35 (1.15-1.58), respectively. Corresponding HRs for exclusive Tea drinkers (≥2 cups/d) were 1.16 (1.02-1.32), 1.10 (0.92-1.32) and 1.37 (1.17-1.61). In general, the coffee and Tea associations did not differ significantly by sex, race or histologic subtype. Our findings suggest that higher Consumption of coffee or Tea is associated with increased lung cancer risk. However, these findings should not be assumed to be causal because of the likelihood of residual confounding by smoking, including passive smoking, and change of coffee and Tea Consumption after study enrolment.
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abstract 632 associations of coffee and Tea Consumption with lung cancer risk a pooled analysis of 17 cohort studies involving over 1 2 million participants
Cancer Research, 2019Co-Authors: Jingjing Zhu, Yongbing Xiang, Wei Zheng, Stephanie A Smithwarner, Yikyung Park, Shoichiro Tsugane, Emily White, Woonpuay Koh, Rashimi Sinha, Sue K ParkAbstract:Background Epidemiological studies investigating the associations of coffee and Tea intake with lung cancer risk have yielded inconsistent results. These previous studies included mostly lung cancer patients diagnosed among smokers. Because coffee and Tea Consumption are closely related to smoking behavior, these previous studies could suffer from biases due to residual confounding of smoking. To better characterize the relationship, a large study with a large number of lung cancer cases diagnosed among never smokers and detailed information on Tea and coffee Consumption, is needed. Using data from a large-scale pooled analysis that consists of over 1.2 million participants in the U.S. and Asia, we carried out a comprehensive evaluation on the association of coffee and Tea intake with lung cancer risk. Methods Individual-level data from seven prospective cohort studies conducted in the U.S., and ten studies conducted in Asia, were included. Demographic, lifestyle, coffee and Tea intake data were collected at the baseline survey for each study. Multivariable-adjusted Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). The first 2 years of follow-up time was excluded to minimize potential influence of reverse causality on study results. Subgroup analyses by smoking status, sex, race, histologic subtype and coffee type (caffeinated or decaffeinated) were also conducted to assess potential effect modification, as well as heterogeneity of the association. Results After a median follow-up of 8.6 years, 20,519 incident lung cancer cases were identified. Both coffee and Tea Consumption were associated with an increased risk of lung cancer. Comparing non-coffee and non-Tea Consumption, HRs for lung cancer associated with exclusive coffee drinkers (≥2 cups/day) among current, former and never smokers were 1.30 (95% CI, 1.15-1.47), 1.49 (1.27-1.74) and 1.41 (95% CI, 1.21-1.63), respectively. Similar positive associations were observed for caffeinated and decaffeinated coffee. The HRs associated with exclusive Tea drinkers (>2 cups/day) were 1.16 (95% CI, 1.02-1.32), 1.10 (0.92, 1.32) and 1.37 (95% CI, 1.17-1.60) for current, former and never smokers, respectively. These associations did not differ significantly by sex, race or histologic subtypes. Conclusion A high Consumption of coffee or Tea was both associated with an increased risk of lung cancer regardless of race or smoking status. Our study included a large number of never-smoker lung cancer patients, which minimized potential confounding effects due to smoking. The positive association observed for both caffeinated and decaffeinated coffee suggests that compounds other than caffeine may play a role in the etiology of lung cancer. Citation Format: Jingjing Zhu, Wei Zheng, Rashimi Sinha, Stephanie A. Smith-Warner, Yong-Bing Xiang, Yikyung Park, Shoichiro Tsugane, Emily White, Woon-Puay Koh, Sue K. Park, Norie Sawada, Seiki Kanemura, Yumi Sugawara, Ichiro Tsuji, Kim Robien, Yasutake Tomata, Keun-Young Yoo, Jeongseon Kim, Jian-Min Yuan, Yu-Tang Gao, Yumie Takata, Eiko Saito, William Blot, Xiao-Ou Shu. Associations of coffee and Tea Consumption with lung cancer risk: A pooled analysis of 17 cohort studies involving over 1.2 million participants [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 632.
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prospective cohort study of Tea Consumption and risk of digestive system cancers results from the shanghai women s health study
The American Journal of Clinical Nutrition, 2012Co-Authors: Sarah Nechuta, Xiaoou Shu, Gong Yang, Yongbing Xiang, Hui Cai, Wong Ho Chow, Yutang Gao, Wei ZhengAbstract:Background: Data from in vitro and animal studies support a protective role for Tea in the etiology of digestive system cancers; however, results from prospective cohort studies have been inconsistent. In addition, to our knowledge, no study has investigated the association of Tea Consumption with the incidence of all digestive system cancers in Chinese women. Objective: We investigated the association of regular Tea intake (≥3 times/wk for >6 mo) with risk of digestive system cancers. Design: We used the Shanghai Women's Health Study, a population-based prospective cohort study of middle-aged and older Chinese women who were recruited in 1996–2000. Adjusted HRs and associated 95% CIs were derived from Cox regression models. Results: After a mean follow-up of 11 y, 1255 digestive system cancers occurred (stomach, esophagus, colorectal, liver, pancreas, and gallbladder/bile duct cancers) in 69,310 nonsmoking and non–alcohol-drinking women. In comparison with women who never drank Tea, regular Tea intake (mostly green Tea) was associated with reduced risk of all digestive system cancers combined (HR: 0.86; 95% CI: 0.74, 0.98), and the reduction in risk increased as the amount and years of Tea Consumption increased (P-trend = 0.01 and P-trend < 0.01, respectively). For example, women who consumed ≥150 g Tea/mo (∼2–3 cups/d) had a 21% reduced risk of digestive system cancers combined (HR: 0.79; 95% CI: 0.63, 0.99). The inverse association was found primarily for colorectal and stomach/esophageal cancers. Conclusion: In this large prospective cohort study, Tea Consumption was associated with reduced risk of colorectal and stomach/esophageal cancers in Chinese women.
Stephanie A Smithwarner - One of the best experts on this subject based on the ideXlab platform.
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associations of coffee and Tea Consumption with lung cancer risk
International Journal of Cancer, 2020Co-Authors: Jingjing Zhu, Yongbing Xiang, Stephanie A Smithwarner, Xuehong Zhang, William J Blot, Rashmi Sinha, Yikyung Park, Shoichiro Tsugane, Emily White, Woonpuay KohAbstract:Associations of coffee and Tea Consumption with lung cancer risk have been inconsistent, and most lung cancer cases investigated were smokers. Included in this study were over 1.1 million participants from 17 prospective cohorts. Cox regression analyses were conducted to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Potential effect modifications by sex, smoking, race, cancer subtype and coffee type were assessed. After a median 8.6 years of follow-up, 20 280 incident lung cancer cases were identified. Compared with noncoffee and nonTea Consumption, HRs (95% CIs) associated with exclusive coffee drinkers (≥2 cups/d) among current, former and never smokers were 1.30 (1.15-1.47), 1.49 (1.27-1.74) and 1.35 (1.15-1.58), respectively. Corresponding HRs for exclusive Tea drinkers (≥2 cups/d) were 1.16 (1.02-1.32), 1.10 (0.92-1.32) and 1.37 (1.17-1.61). In general, the coffee and Tea associations did not differ significantly by sex, race or histologic subtype. Our findings suggest that higher Consumption of coffee or Tea is associated with increased lung cancer risk. However, these findings should not be assumed to be causal because of the likelihood of residual confounding by smoking, including passive smoking, and change of coffee and Tea Consumption after study enrolment.
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a prospective study of coffee and Tea Consumption and the risk of glioma in the uk biobank
European Journal of Cancer, 2020Co-Authors: Jordan H Creed, Stephanie A Smithwarner, Travis Gerke, Kathleen M EganAbstract:Abstract Background Coffee and Tea have been hypothesised to reduce the risk of some cancers; however, their impact on glioma is less well studied. Methods We examined associations between self-reported intake of Tea and coffee in relation to glioma risk in the UK Biobank. We identified 487 incident glioma cases among 379,259 participants. Hazard ratios (HR) and 95% confidence intervals (CI) for glioma according to caffeinated beverage Consumption were calculated using Cox proportional hazards regression with adjustment for age, gender, race and education; daily cups of Tea or coffee were included in models considering the other beverage. Results Consuming 4 or more cups of Tea was associated with reduced risk of glioma when compared to no Tea Consumption (HR = 0.69; 95% CI, 0.51–0.94). A significant inverse association was observed for glioblastoma (HR = 0.93 per 1 cup/d increment; 95% CI, 0.89–0.98) and among males for all gliomas combined (HR = 0.95 per 1 cup/d increment; 95% CI, 0.90–1.00). A suggestive inverse association was also observed with greater Consumption of coffee (HR = 0.71; 95% CI, 0.49–1.05 for >4 versus 0 cups/d). Results were not materially changed with further adjustment for smoking, alcohol and body mass index. Associations were similar in 2-year and 3-year lagged analyses. Conclusions In this prospective study, we found a significant inverse association between Tea Consumption and the risk of developing glioma, and a suggestive inverse association for the Consumption of coffee. Further investigation on the possible preventive role of caffeine in glioma is warranted.
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abstract 632 associations of coffee and Tea Consumption with lung cancer risk a pooled analysis of 17 cohort studies involving over 1 2 million participants
Cancer Research, 2019Co-Authors: Jingjing Zhu, Yongbing Xiang, Wei Zheng, Stephanie A Smithwarner, Yikyung Park, Shoichiro Tsugane, Emily White, Woonpuay Koh, Rashimi Sinha, Sue K ParkAbstract:Background Epidemiological studies investigating the associations of coffee and Tea intake with lung cancer risk have yielded inconsistent results. These previous studies included mostly lung cancer patients diagnosed among smokers. Because coffee and Tea Consumption are closely related to smoking behavior, these previous studies could suffer from biases due to residual confounding of smoking. To better characterize the relationship, a large study with a large number of lung cancer cases diagnosed among never smokers and detailed information on Tea and coffee Consumption, is needed. Using data from a large-scale pooled analysis that consists of over 1.2 million participants in the U.S. and Asia, we carried out a comprehensive evaluation on the association of coffee and Tea intake with lung cancer risk. Methods Individual-level data from seven prospective cohort studies conducted in the U.S., and ten studies conducted in Asia, were included. Demographic, lifestyle, coffee and Tea intake data were collected at the baseline survey for each study. Multivariable-adjusted Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). The first 2 years of follow-up time was excluded to minimize potential influence of reverse causality on study results. Subgroup analyses by smoking status, sex, race, histologic subtype and coffee type (caffeinated or decaffeinated) were also conducted to assess potential effect modification, as well as heterogeneity of the association. Results After a median follow-up of 8.6 years, 20,519 incident lung cancer cases were identified. Both coffee and Tea Consumption were associated with an increased risk of lung cancer. Comparing non-coffee and non-Tea Consumption, HRs for lung cancer associated with exclusive coffee drinkers (≥2 cups/day) among current, former and never smokers were 1.30 (95% CI, 1.15-1.47), 1.49 (1.27-1.74) and 1.41 (95% CI, 1.21-1.63), respectively. Similar positive associations were observed for caffeinated and decaffeinated coffee. The HRs associated with exclusive Tea drinkers (>2 cups/day) were 1.16 (95% CI, 1.02-1.32), 1.10 (0.92, 1.32) and 1.37 (95% CI, 1.17-1.60) for current, former and never smokers, respectively. These associations did not differ significantly by sex, race or histologic subtypes. Conclusion A high Consumption of coffee or Tea was both associated with an increased risk of lung cancer regardless of race or smoking status. Our study included a large number of never-smoker lung cancer patients, which minimized potential confounding effects due to smoking. The positive association observed for both caffeinated and decaffeinated coffee suggests that compounds other than caffeine may play a role in the etiology of lung cancer. Citation Format: Jingjing Zhu, Wei Zheng, Rashimi Sinha, Stephanie A. Smith-Warner, Yong-Bing Xiang, Yikyung Park, Shoichiro Tsugane, Emily White, Woon-Puay Koh, Sue K. Park, Norie Sawada, Seiki Kanemura, Yumi Sugawara, Ichiro Tsuji, Kim Robien, Yasutake Tomata, Keun-Young Yoo, Jeongseon Kim, Jian-Min Yuan, Yu-Tang Gao, Yumie Takata, Eiko Saito, William Blot, Xiao-Ou Shu. Associations of coffee and Tea Consumption with lung cancer risk: A pooled analysis of 17 cohort studies involving over 1.2 million participants [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 632.
