The Experts below are selected from a list of 18435 Experts worldwide ranked by ideXlab platform
Daniel S Berman - One of the best experts on this subject based on the ideXlab platform.
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diagnostic accuracy of gated tc 99m sestamibi stress myocardial perfusion spect with combined supine and prone acquisitions to detect coronary artery disease in obese and nonobese patients
Journal of Nuclear Cardiology, 2006Co-Authors: Daniel S Berman, Xingping Kang, Hidetaka Nishina, Piotr J Slomka, Leslee J Shaw, Sean W Hayes, Ishac CohenAbstract:Background The diagnostic value of gated myocardial perfusion single-photon emission computed tomography (MPS) with combined supine and prone acquisitions to detect coronary artery disease (CAD) in obese and nonobese patients has not been defined. Methods and Results We studied 1511 patients without prior myocardial infarction or coronary revascularization who either had coronary angiography within 3 months of MPS (n = 785) or had a low pretest likelihood of CAD (n = 726). All patients underwent rest thallium 201/gated exercise or adenosine stress technetium 99m sestamibi MPS in both the supine and prone positions. According to body mass index (BMI), patients were categorized as normal weight (BMI of 18.5-24.9 kg/m2), overweight (BMI of 25.0-29.9 kg/m2), or obese (BMI ≥30.0 kg/m2). There were no significant differences in stress, fixed, or ischemic defects among patients in different weight categories. The sensitivity of MPS was 85%, 86%, and 89% for detecting patients with 50% or greater coronary stenosis and 89%, 91%, and 92% for detecting those with 70% or greater coronary stenosis in the normal-weight, overweight, and obese groups, respectively. Normalcy rates were nearly identical among the 3 weight groups (99%, 98%, and 99%, respectively). Multivariate logistic regression analysis further confirmed that BMI was a nonsignificant predictor for the detection of CAD. In a subset of 290 patients, automated quantitative MPS analysis confirmed that combined supine and prone MPS increased specificity (86%) in identifying CAD, without a significant reduction in sensitivity (83% for ≥50% stenosis and 88% for ≥70% stenosis). Conclusion The findings of this study suggest that MPS performed with gating and combined supine and prone acquisitions without attenuation correction had a similar diagnostic accuracy for the detection of CAD in normal-weight, overweight, and obese patients.
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separate acquisition rest thallium 201 stress technetium 99m sestamibi dual isotope myocardial perfusion single photon emission computed tomography a clinical validation study
Journal of the American College of Cardiology, 1993Co-Authors: Daniel S Berman, Hosen Kiat, John D Friedman, Fan Ping Wang, Kenneth Van Train, Lisa Matzer, Jamshid Maddahi, Guido GermanoAbstract:Objectives. This study assessed the validity of a novel approach to myocardial perfusion scintigraphy that provides the opportunity to avoid the drawbacks of standard same-day rest/stress Technetium-99m sestamibi myocardial perfusion studies by using separate-acquisition dual-isotope rest thallium-201 and exercise Technetium-99m sestamibi single-photon emisson computed tomography (SPECT). Background. Standard seme-day rest/stress Technetium-99m sestamibi myocardial perfusion studies are cumbersome, associated with a potential decrease in perceived stress defect severity compared with thallium-201 due to the presence of rest Technetium-99m sestamibi and may be enable to differentiate hibernating from infarcted myocardium. Methods. The dual-isotope procedure was performed in 63 patients without previous myocardial infarction undergoing coronary angiography to evaluate sensitivity and specificity for coronary artery disease and in 107 patients with a low (<5%) likelihood of coronary artery disease to evaluate normalcy rate. To validate defect reversibility, the dual-isotope SPECT study was compared with stress/rest Technetium-99m sestamibi SPECT studies in a separate group of 31 patients with previous documented myocardial infarction who underwent a rest Technetium-99m sestamibi study in addition to the dual-isotope SPECT study. Results. In angiographic correlations, dual-isotope SPECT demonstrated high sensitivity for detecting patients with ≥50% stenosis (91 %, 55 patients) and ≥70% stenosis (96%, 52 patients). In a small group of patients, high specificity was also observed (75% for <50% stenosis [8 patients] and 82% for <70% stenosis [11 patients]). A very high normalcy rate of 95% was also found. In the patient group assessed for defect reversibility, in zones with no previous myocardial infarction, segmental agreement for defect type between rest thallium-201 and rest Technetium-99m sestamibi studies was 97% (kappa = 0.79, p < 0.001). In myocardial infarct zones, segmental agreement for defect type was 98% (kappa = 0.93, p < 0.001). Image quality was generally good to excellent. Conclusions. Our findings demonstrate that separate-acquisition dual-isotope myocardial perfusion SPECT is accurate for coronary artery disease detection, correlates well with reststress sestamibi studies for assessment of defect reversibility and results in good to excellent image quality. This approach provides an excellent method for the combined assessment of stress myocardial perfusion and myocardial viability.
Guido Germano - One of the best experts on this subject based on the ideXlab platform.
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separate acquisition rest thallium 201 stress technetium 99m sestamibi dual isotope myocardial perfusion single photon emission computed tomography a clinical validation study
Journal of the American College of Cardiology, 1993Co-Authors: Daniel S Berman, Hosen Kiat, John D Friedman, Fan Ping Wang, Kenneth Van Train, Lisa Matzer, Jamshid Maddahi, Guido GermanoAbstract:Objectives. This study assessed the validity of a novel approach to myocardial perfusion scintigraphy that provides the opportunity to avoid the drawbacks of standard same-day rest/stress Technetium-99m sestamibi myocardial perfusion studies by using separate-acquisition dual-isotope rest thallium-201 and exercise Technetium-99m sestamibi single-photon emisson computed tomography (SPECT). Background. Standard seme-day rest/stress Technetium-99m sestamibi myocardial perfusion studies are cumbersome, associated with a potential decrease in perceived stress defect severity compared with thallium-201 due to the presence of rest Technetium-99m sestamibi and may be enable to differentiate hibernating from infarcted myocardium. Methods. The dual-isotope procedure was performed in 63 patients without previous myocardial infarction undergoing coronary angiography to evaluate sensitivity and specificity for coronary artery disease and in 107 patients with a low (<5%) likelihood of coronary artery disease to evaluate normalcy rate. To validate defect reversibility, the dual-isotope SPECT study was compared with stress/rest Technetium-99m sestamibi SPECT studies in a separate group of 31 patients with previous documented myocardial infarction who underwent a rest Technetium-99m sestamibi study in addition to the dual-isotope SPECT study. Results. In angiographic correlations, dual-isotope SPECT demonstrated high sensitivity for detecting patients with ≥50% stenosis (91 %, 55 patients) and ≥70% stenosis (96%, 52 patients). In a small group of patients, high specificity was also observed (75% for <50% stenosis [8 patients] and 82% for <70% stenosis [11 patients]). A very high normalcy rate of 95% was also found. In the patient group assessed for defect reversibility, in zones with no previous myocardial infarction, segmental agreement for defect type between rest thallium-201 and rest Technetium-99m sestamibi studies was 97% (kappa = 0.79, p < 0.001). In myocardial infarct zones, segmental agreement for defect type was 98% (kappa = 0.93, p < 0.001). Image quality was generally good to excellent. Conclusions. Our findings demonstrate that separate-acquisition dual-isotope myocardial perfusion SPECT is accurate for coronary artery disease detection, correlates well with reststress sestamibi studies for assessment of defect reversibility and results in good to excellent image quality. This approach provides an excellent method for the combined assessment of stress myocardial perfusion and myocardial viability.
Babar Rashid Zargar - One of the best experts on this subject based on the ideXlab platform.
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Intrathymic parathyroid adenoma
Indian Journal of Thoracic and Cardiovascular Surgery, 2011Co-Authors: Nadeem Ul Nazeer Kawoosa, Babar Rashid ZargarAbstract:Intrathymic parathyroid adenoma is a rare cause of persistent primary hyperparathyroidism. We encountered a case of intrathymic parathyroid adenoma, detected by computed tomographic scan and confirmed by Technetium-99 (Tc-99) Sestamibi scan and histology. The surgical approach included a median sternotomy and a large intrathymic parathyroid adenoma was identified and excised through the sternotomy. In this case, Tc-99 Sestamibi scan successfully localized a persistant abnormal tracer uptake in the mediastinum suggestive of mediastinal parathyroid adenoma. Although not recommended for routine preoperative evaluation, scintigraphy can be useful in the preoperative localization of ectopic parathyroid adenomas.
Ishac Cohen - One of the best experts on this subject based on the ideXlab platform.
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diagnostic accuracy of gated tc 99m sestamibi stress myocardial perfusion spect with combined supine and prone acquisitions to detect coronary artery disease in obese and nonobese patients
Journal of Nuclear Cardiology, 2006Co-Authors: Daniel S Berman, Xingping Kang, Hidetaka Nishina, Piotr J Slomka, Leslee J Shaw, Sean W Hayes, Ishac CohenAbstract:Background The diagnostic value of gated myocardial perfusion single-photon emission computed tomography (MPS) with combined supine and prone acquisitions to detect coronary artery disease (CAD) in obese and nonobese patients has not been defined. Methods and Results We studied 1511 patients without prior myocardial infarction or coronary revascularization who either had coronary angiography within 3 months of MPS (n = 785) or had a low pretest likelihood of CAD (n = 726). All patients underwent rest thallium 201/gated exercise or adenosine stress technetium 99m sestamibi MPS in both the supine and prone positions. According to body mass index (BMI), patients were categorized as normal weight (BMI of 18.5-24.9 kg/m2), overweight (BMI of 25.0-29.9 kg/m2), or obese (BMI ≥30.0 kg/m2). There were no significant differences in stress, fixed, or ischemic defects among patients in different weight categories. The sensitivity of MPS was 85%, 86%, and 89% for detecting patients with 50% or greater coronary stenosis and 89%, 91%, and 92% for detecting those with 70% or greater coronary stenosis in the normal-weight, overweight, and obese groups, respectively. Normalcy rates were nearly identical among the 3 weight groups (99%, 98%, and 99%, respectively). Multivariate logistic regression analysis further confirmed that BMI was a nonsignificant predictor for the detection of CAD. In a subset of 290 patients, automated quantitative MPS analysis confirmed that combined supine and prone MPS increased specificity (86%) in identifying CAD, without a significant reduction in sensitivity (83% for ≥50% stenosis and 88% for ≥70% stenosis). Conclusion The findings of this study suggest that MPS performed with gating and combined supine and prone acquisitions without attenuation correction had a similar diagnostic accuracy for the detection of CAD in normal-weight, overweight, and obese patients.
Koichi Tokuuye - One of the best experts on this subject based on the ideXlab platform.
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measuring hepatic functional reserve using low temporal resolution gd eob dtpa dynamic contrast enhanced mri a preliminary study comparing galactosyl human serum albumin scintigraphy with indocyanine green retention
European Radiology, 2014Co-Authors: Kazuhiro Saito, Joseph R Ledsam, Steven Sourbron, Tsuyoshi Hashimoto, Yoichi Araki, Soichi Akata, Koichi TokuuyeAbstract:Objective To investigate if tracer kinetic modelling of low temporal resolution dynamic contrast-enhanced (DCE) MRI with Gd-EOB-DTPA could replace Technetium-99 m galactosyl human serum albumin (GSA) single positron emission computed tomography (SPECT) and indocyanine green (ICG) retention for the measurement of liver functional reserve.
