Technetium 99m

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Junji Konishi - One of the best experts on this subject based on the ideXlab platform.

  • Oxygen bubbling can improve the labelling of pentavalent Technetium-99m dimercaptosuccinic acid.
    European Journal of Nuclear Medicine and Molecular Imaging, 1995
    Co-Authors: Hisataka Kobayashi, Kazuko Horiuchi Suzuki, Harumi Sakahara, Akira Yokoyama, Junji Konishi
    Abstract:

    It has previously been reported that almost all of the trivalent Technetium-99m dimercaptosuccinic acid (99mTc (III) DMSA) present in the labelling product of pentavalent Technetium-99m DMSA (99mTc (V) DMSA) can be changed into99mTc (V) DMSA by bubbling with pure oxygen. We therefore performed studies in animals (mice) and humans to investigate the effect of such oxygen bubbling on the labelling efficiency of and on the renal uptake of99mTc. The method of labelling of99mTc (V) DMSA was that of Hirano. It was found that oxygen bubbling oxidized the contaminated99mTc (III) DMSA into99mTc (V) DMSA in vitro and decreased the uptake of radioactivity in the kidney in both animals and humans.

  • Intraosseous hemangiomatosis : Technetium-99m(V)dimercaptosuccinic acid and Technetium-99m-hydroxymethylene diphosphonate imaging
    The Journal of Nuclear Medicine, 1994
    Co-Authors: Hisataka Kobayashi, Mariko Hosono, Harumi Sakahara, Chohei Shigeno, Keigo Endo, Junji Konishi
    Abstract:

    We report a case of histologically proven intraosseous hemangiomatosis in which marked accumulation of pentavalent Technetium-99m-dimercaptosuccinic acid ( 99m Tc(V)DMSA) and Technetium-99m-hydroxymethylene diphosphonate ( 99m Tc-HMDP) was observed in the osteolytic hemangiomatous lesions

  • Technetium-99m-pyrophosphate uptake as an indicator of myocardial injury without infarct.
    Journal of nuclear medicine : official publication Society of Nuclear Medicine, 1994
    Co-Authors: Kazumi Okuda, Junji Konishi, Ryuji Nohara, Masatoshi Fujita, Nagara Tamaki, Shigetake Sasayama
    Abstract:

    Technetium-99m-pyrophosphate (PYP) is bound to calcium in necrotic myocardium and has been used clinically to evaluate myocardial infarction. Technetium-99m-PYP is also reported to accumulate in myocardium with unstable angina pectoris and it is speculated that severe ischemia with noninfarcted tissue may also increase uptake of 99mTc-PYP. In this paper, 99mTc-PYP uptake was determined in various models of myocardial ischemia of short duration to examine its applicability to the assessment of myocardial viability. In 23 open-chest dogs under anesthesia, models of ischemia-reperfusion of the left anterior descending artery (LAD) subjected to ischemia for 10, 30 or 60 min were produced. Wall motion was examined by echocardiography and myocardial blood flow was calculated using colored microspheres. Technetium-99m-PYP was injected after each ischemic intervention and reperfusion. Technetium-99m-PYP showed 1.18 +/- 0.009 in the uptake ratio (ischemic area/normal area) following 10-min ischemia (11 dogs). The uptake ratio following 30-min ischemia (8 dogs) showed a significantly higher increase than that following 10-min ischemia (4.09 +/- 1.75; p < 0.05), permitting in vivo and ex vivo imaging. After 60-min ischemia resulting in infarction (4 dogs), 99mTc-PYP uptake of the ischemic area showed an uptake ten times that of the normal area (transmural: 12.2 +/- 2.9, epicardium: 7.5 +/- 1.9, endocardium: 16.8 +/- 4.1). These findings indicate that since 99mTc-PYP accumulates in injured myocardium, its concurrent use with blood flow imaging is useful for the assessment of severity of ischemia, injured area and myocardial viability.

  • Scintigraphic Evaluation of Tenosynovial Giant Cell Tumor Using Technetium-99m(V)-Dimercaptosuccinic Acid
    The Journal of Nuclear Medicine, 1993
    Co-Authors: Hisataka Kobayashi, Harumi Sakahara, Yoshihiko Kotoura, Makoto Hosono, Makoto Shirato, Takao Yamamuro, Junji Konishi, Keigo Endo
    Abstract:

    Technetium-99m(V) dimercaptosuccinic acid (DMSA) and 67 Ga-cirtrate scintigraphy were performed in three patients with primary and recurrent tenosynovial giant-cell tumor (one localized type and two diffuse type). In all cases, 99m Tc(V)DMSA showed marked accumulation in all primary and recurrent tumors; however, 67 Ga-citrate showed no accumulation in any of the tumors. Technetium-99m(V)-DMSA scintigraphy was useful in detecting tenosynovial giant-cell tumor and in diagnosing recurrence of this tumor

  • Technetium-99m(V)dimercaptosuccinic acid uptake in intra-abdominal massive deposit of amyloid protein.
    The Journal of Nuclear Medicine, 1993
    Co-Authors: Hisataka Kobayashi, Keiko Shibuya, Shigeo Nomura, Harumi Sakahara, Takehisa Takagi, Takashi Kudoh, Tsuyoshi Itoh, Makoto Hosono, Keigo Endo, Junji Konishi
    Abstract:

    Technetium-99m(V)dimercaptosuccinic acid (DMSA) scintigraphy was performed in two patients with pathologically confirmed primary amyloidosis. Both patients had tumor-like deposits of AL-type amyloid in the abdomen. Marked uptake of the tracer by the amyloid deposits was noted. Technetium-99m-(V)DMSA scintigraphy appears to be useful in detecting the distribution of amyloid deposits and in determining the appropriate site for biopsy.

Hisataka Kobayashi - One of the best experts on this subject based on the ideXlab platform.

H Schicha - One of the best experts on this subject based on the ideXlab platform.

  • Technetium 99m mibi spect a highly sensitive diagnostic tool for localization of parathyroid adenomas
    Surgery, 2000
    Co-Authors: D Moka, Eberhard Voth, Markus Dietlein, Antonio Larenaavellaneda, H Schicha
    Abstract:

    Background: The aim of this study was to assess the value of Technetium 99m-MIBI scintigraphy using the single photon emission computed tomography (SPECT) technique for preoperative localization of smaller (≤ 1 g) parathyroid adenomas. Methods: A total of 92 patients (34 men, 58 women; mean age, 60 ± 13 years) with an established diagnosis of primary hyperparathyroidism and nondiagnostic ultrasonography (inclusion criteria) were scanned preoperatively. After a thyroid examination to check for other possible radionuclide-accumulating thyroid diseases, a planar Technetium 99m-pertechnetate/Technetium 99m-MIBI subtraction scintigraphy (15 minutes post injection) and tomographic images (120 minutes post injection) were acquired after intravenous injection of 740 MBq of Technetium 99m-MIBI and using a 3-head gamma camera (Picker Prism 3000). Sensitivity was defined by the ability to predict the correct site of a parathyroid adenoma. Results: All patients had parathyroid adenomas ≤ 1 g (53 patients, 0.5 -1.0 g; 39 patients, < 0.5 g). Correct localization of parathyroid adenomas to one side or the other was achieved in 87% of the patients using planar Technetium 99m-pertechnetate/Technetium 99m-MIBI subtraction scintigraphy. Sensitivity was increased to 95% by supplementary use of the SPECT technique and a 3-D display (volume-rendered reprojection for visualization). There was Technetium 99m-MIBI accumulation in 11 benign thyroid nodes, but none of the healthy parathyroid glands were shown on the scan. Conclusions: This study indicates that Technetium 99m-MIBI parathyroid scintigraphy is a sensitive and specific tool for topographic localization even of small parathyroid adenomas, especially with the use of SPECT. This method could help to improve the efficiency of parathyroidectomy (eg, by making unilateral exploration sufficient). (Surgery 2000;128:29-35.)

  • Technetium 99m-MIBI-SPECT: A highly sensitive diagnostic tool for localization of parathyroid adenomas.
    Surgery, 2000
    Co-Authors: D Moka, Eberhard Voth, Markus Dietlein, Antonio Larena-avellaneda, H Schicha
    Abstract:

    The aim of this study was to assess the value of Technetium 99m-MIBI scintigraphy using the single photon emission computed tomography (SPECT) technique for preoperative localization of smaller (</= 1 g) parathyroid adenomas. A total of 92 patients (34 men, 58 women; mean age, 60 +/- 13 years) with an established diagnosis of primary hyperparathyroidism and nondiagnostic ultrasonography (inclusion criteria) were scanned preoperatively. After a thyroid examination to check for other possible radionuclide-accumulating thyroid diseases, a planar Technetium 99m-pertechnetate/Technetium 99m-MIBI subtraction scintigraphy (15 minutes post injection) and tomographic images (120 minutes post injection) were acquired after intravenous injection of 740 MBq of Technetium 99m-MIBI and using a 3-head gamma camera (Picker Prism 3000). Sensitivity was defined by the ability to predict the correct site of a parathyroid adenoma. All patients had parathyroid adenomas </= 1 g (53 patients, 0.5 -1.0 g; 39 patients, < 0.5 g). Correct localization of parathyroid adenomas to one side or the other was achieved in 87% of the patients using planar Technetium 99m-pertechnetate/Technetium 99m-MIBI subtraction scintigraphy. Sensitivity was increased to 95% by supplementary use of the SPECT technique and a 3-D display (volume-rendered reprojection for visualization). There was Technetium 99m-MIBI accumulation in 11 benign thyroid nodes, but none of the healthy parathyroid glands were shown on the scan. This study indicates that Technetium 99m-MIBI parathyroid scintigraphy is a sensitive and specific tool for topographic localization even of small parathyroid adenomas, especially with the use of SPECT. This method could help to improve the efficiency of parathyroidectomy (eg, by making unilateral exploration sufficient).

Gyula Stotz - One of the best experts on this subject based on the ideXlab platform.

  • comparative scanning of thyroid nodules with Technetium 99m pertechnetate and Technetium 99m methoxyisobutylisonitrile
    European Journal of Nuclear Medicine and Molecular Imaging, 1993
    Co-Authors: Ivan Foldes, Annamaria Levay, Gyula Stotz
    Abstract:

    Thyroid imaging was performed using Technetium-99m methoxyisobutylisonitrile and Technetium-99m pertechnetate in 58 patients. The 99mTc-pertechnetate scans showed a total of 77 nodules: 60 cold, 13 hot and 4 of normal activity. There was no 99mTc-MIBI accumulation in 46.4% of 99mTc-pertechnetate cold nodules; 27 (45%) of these nodules showed 99mTc-MIBI uptake with the same intensity as the surrounding normal tissue, and five (8.6%) became hot with 99mTc-MIBI. Of the 99mTc-pertechnetate hot nodules 11 (84.6%) could not be differentiated from the normal extranodular tissue on the 99mTc-MIBI scan. The histopathology of 34 surgically removed nodules proved that increased, normal or decreased 99mTc-MIBI accumulation is not specific for thyroid malignancy and that the 99mTc-MIBI uptake depends mainly on the viability of thyroid tissue.

Osamu Yamamoto - One of the best experts on this subject based on the ideXlab platform.

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