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H J Haubold - One of the best experts on this subject based on the ideXlab platform.
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united nations human space Technology Initiative hsti
Acta Astronautica, 2014Co-Authors: Mika Ochiai, Heike Steffens, Werner Balogh, H J Haubold, Mazlan OthmanAbstract:Abstract The Human Space Technology Initiative was launched in 2010 within the framework of the United Nations Programme on Space Applications implemented by the Office for Outer Space Affairs of the United Nations. It aims to involve more countries in activities related to human spaceflight and space exploration and to increase the benefits from the outcome of such activities through international cooperation, to make space exploration a truly international effort. The role of the Initiative in these efforts is to provide a platform to exchange information, foster collaboration between partners from spacefaring and non-spacefaring countries, and encourage emerging and developing countries to take part in space research and benefit from space applications. The Initiative organizes expert meetings and workshops annually to raise awareness of the current status of space exploration activities as well as of the benefits of utilizing human space Technology and its applications. The Initiative is also carrying out primary science activities including the Zero-Gravity Instrument Project and the Drop Tower Experiment Series aimed at promoting capacity-building activities in microgravity science and education, particularly in developing countries.
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THE UNITED NATIONS HUMAN SPACE Technology Initiative (HSTI) SCIENCE ACTIVITIES
arXiv: Popular Physics, 2012Co-Authors: Mika Ochiai, H J HauboldAbstract:The United Nations Human Space Technology Initiative (HSTI) aims at promoting international cooperation in human spaceflight and space exploration-related activities; creating awareness among countries on the benefits of utilizing human space Technology and its applications; and building capacity in microgravity education and research. HSTI has been conducting various scientific activities to promote microgravity education and research. The primary science activity is called 'Zero-gravity Instrument Distribution Project', in which one-axis clinostats will be distributed worldwide. The distribution project will provide unique opportunities for students and researchers to observe the growth of indigenous plants in their countries in a simulated microgravity condition and is expected to create a huge dataset of plant species with their responses to gravity.
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THE UNITED NATIONS HUMAN SPACE Technology Initiative (HSTI) ACTIVITY STATUS IN 2012
arXiv: Popular Physics, 2012Co-Authors: Mika Ochiai, H J HauboldAbstract:United Nations Office for Outer Space Affairs, Austria aimin.niu@unoosa.org hans.haubold@unoosa.org takao.doi@unoosa.org In 2010, the Human Space Technology Initiative (HSTI) was launched by the United Nations Office for Outer Space Affairs (UNOOSA) within the United Nations Programme on Space Applications. The Initiative aims at promoting international cooperation in human spaceflight and space exploration-related activities, creating awareness among countries on the benefits of utilizing human space Technology and its applications, and building capacity in microgravity education and research. HSTI has conducted a series of outreach activities and expert meetings bringing together participants from around the world. HSTI will also be implementing science and educational activities in relevant areas to raise the capacities, particularly in developing countries, in pursuit of the development goals of the United Nations, thus contributing to promoting the peaceful uses of outer space. I. INTRODUCTION More than 50 years have passed since Yuri Gagarin achieved the first human spaceflight on 12 April 1961, opening a new chapter of human endeavour in outer space. The years that followed saw the rapid development of space science and Technology in the realm of human presence in space, including the historic first Moon landing by Neil Armstrong on 20 July 1969, and the development of several space stations such as the Soviet Union’s Salyut and Mir and the U.S.’s Skylab programme on low Earth orbit. The first Apollo-Soyuz docking project was a significant step for furthering the collaborative human endeavour in space. In 1998, the construction of the International Space Station (ISS) began with the combined efforts of 15 nations [1]. With its size of 110 meters long, 74 meters wide, weighing almost 420 metric tons, the ISS offers unique and cooperative opportunities in both scientific and engineering projects. Humanity has maintained the multinational permanent human presence in outer space aboard the ISS, gaining new knowledge, technological innovation and creating invaluable assets for future generations. I.I United Nations Committee on the Peaceful Uses of Outer Space Back in 1959, the United Nations General Assembly established the Committee on the Peaceful Uses of Outer Space (COPUOS) in order to review the scope of international cooperation and to devise programmes in this field, undertaken under the United Nations’ auspices, as well as to encourage continued research and dissemination of information on outer space matters, and to study legal problems arising from the exploration of outer space [2]. With its two subsidiary bodies - the Scientific and Technical Subcommittee and the Legal Subcommittee, COPUOS deals with a wide range of issues concerning current and future activities in space, and reports to the General Assembly which adopts an annual resolution on international cooperation in the peaceful uses of outer space [3]. Several multilateral treaties have been adopted by the General Assembly to enable the orderly conduct of activities in outer space. The cornerstone of these governance instruments is the Treaty on Principles Governing the Activities of States in the Exploration and Use of Outer Space, including the Moon and Other Celestial Bodies, known as “Outer Space Treaty” of 1967 [4]. One of the other four treaties, the “Rescue Agreement” of 1968, requires States to assist an astronaut in case of accident, distress, emergency or unintended landing [5]. In 2011, the Declaration on the 50
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the united nations human space Technology Initiative hsti
arXiv: Space Physics, 2011Co-Authors: Mika Ochiai, H J Haubold, Ingrid Dietlein, Werner BaloghAbstract:The Human Space Technology Initiative (HSTI) has been launched under the framework of the United Nations Programme on Space Applications with its aims of promoting international cooperation in human spaceflight and space exploration-related activities; creating awareness among United Nations Member States on the benefits of utilizing human space Technology and its applications; and building capacity in microgravity education and research. The International Space Station (ISS), being operational with a permanent crew of six (6), is an unprecedented facility for research on science and Technology and can be regarded as one of the greatest resources for humankind to explore space. The HSTI seeks to promote human space Technology and to expand ISS utilization. This report describes the background, objectives, and current three-year work plan of HSTI which is composed of organizing expert meetings, seminars, and workshops as well as building capacity by distributing educational materials and zero-gravity experiment instruments.
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proposal for a united nations basic space Technology Initiative
Advances in Space Research, 2009Co-Authors: Werner Balogh, H J HauboldAbstract:The United Nations Programme on Space Applications, implemented by the United Nations Office for Outer Space Affairs, promotes the benefits of space-based solutions for sustainable economic and social development. The Programme assists Member States of the United Nations to establish indigenous capacities for the use of space Technology and its applications. In the past the Programme has primarily been focusing on the use of space applications and on basic space science activities. However, in recent years there has been a strong interest in a growing number of space-using countries to build space Technology capacities, for example, the ability to develop and operate small satellites. In reaction to this development, the United Nations in cooperation with the International Academy of Astronautics has been organizing annual workshops on small satellites in the service of developing countries. Space Technology related issues have also been addressed as part of various other activities of the Programme on Space Applications. Building on these experiences, the Office for Outer Space Affairs is now considering the launch of a new Initiative, preliminarily titled the United Nations Basic Space Technology Initiative (UNBSTI), to promote basic space Technology development. The Initiative would be implemented in the framework of the Programme on Space Applications and its aim would be to help building sustainable capacities for basic space Technology education and development, thereby advancing the operational use of space Technology and its applications.
Minna Lanz - One of the best experts on this subject based on the ideXlab platform.
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Pharmaceutical powder Technology — from art to science: the challenge of the FDA's Process Analytical Technology Initiative
Advanced Powder Technology, 2020Co-Authors: Hans Leuenberger, Minna LanzAbstract:Abstract —This paper describes with typical examples the state of art. The list of examples includes the problems of non-robust formulations and critical processes. The paper demonstrates the necessity and the challenge of the FDA's Process Analytical Technology Initiative, which is an important stimulus to develop a rigorous scientific framework in the area of pharmaceutical powder Technology. The paper suggests a kind of ‘road map’ to achieve as fast as possible the top of the ‘knowledge pyramid’. The road map includes the extensive use of a multivariate design of experiments, the use of artificial neural networks (ANN), the use of the laws of physical pharmacy and percolation theory, and, last but not least, tries to ‘translate’ the existing laws of physical chemistry into the area of pharmaceutical powder Technology, where we have the problem that the number of particles involved is much lower than the Avogadro number NA. For this reason it will be of interest to monitor closely the progress in nanoscience, especially in the area of mathematical modeling of the fascinating special physical properties of nanoparticles, which again consist of a finite number N of atoms, respectively molecules, with N ≪ N A .
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Pharmaceutical powder Technology - From art to science: The challenge of the FDA's process analytical Technology Initiative
Advanced Powder Technology, 2005Co-Authors: Hans Leuenberger, Minna LanzAbstract:—This paper describes with typical examples the state of art. The list of examples includes the problems of non-robust formulations and critical processes. The paper demonstrates the necessity and the challenge of the FDA's Process Analytical Technology Initiative, which is an important stimulus to develop a rigorous scientific framework in the area of pharmaceutical powder Technology. The paper suggests a kind of 'road map' to achieve as fast as possible the top of the 'knowledge pyramid'. The road map includes the extensive use of a multivariate design of experiments, the use of artificial neural networks (ANN), the use of the laws of physical pharmacy and percolation theory, and, last but not least, tries to 'translate' the existing laws of physical chemistry into the area of pharmaceutical powder Technology, where we have the problem that the number of particles involved is much lower than the Avogadro number N A . For this reason it will be of interest to monitor closely the progress in nanoscience, especially in the area of mathematical modeling of the fascinating special physical properties of nanoparticles, which again consist of a finite number N of atoms, respectively molecules, with N N A .
Hans Leuenberger - One of the best experts on this subject based on the ideXlab platform.
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Pharmaceutical powder Technology — from art to science: the challenge of the FDA's Process Analytical Technology Initiative
Advanced Powder Technology, 2020Co-Authors: Hans Leuenberger, Minna LanzAbstract:Abstract —This paper describes with typical examples the state of art. The list of examples includes the problems of non-robust formulations and critical processes. The paper demonstrates the necessity and the challenge of the FDA's Process Analytical Technology Initiative, which is an important stimulus to develop a rigorous scientific framework in the area of pharmaceutical powder Technology. The paper suggests a kind of ‘road map’ to achieve as fast as possible the top of the ‘knowledge pyramid’. The road map includes the extensive use of a multivariate design of experiments, the use of artificial neural networks (ANN), the use of the laws of physical pharmacy and percolation theory, and, last but not least, tries to ‘translate’ the existing laws of physical chemistry into the area of pharmaceutical powder Technology, where we have the problem that the number of particles involved is much lower than the Avogadro number NA. For this reason it will be of interest to monitor closely the progress in nanoscience, especially in the area of mathematical modeling of the fascinating special physical properties of nanoparticles, which again consist of a finite number N of atoms, respectively molecules, with N ≪ N A .
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From functional excipients towards drug carrier systems
Chimica Oggi-chemistry Today, 2006Co-Authors: Hans LeuenbergerAbstract:The paper describes the state of the art and actual trends in the area of pharmaceutical functional excipients, taking into account the impact of FDA's PAT (Process Analytical Technology) Initiative. The new requirements mean, that the formulator is requested to explain the specific choice and the functionality of the excipient. The formulator needs to have a clear "understanding of the formulation" and of the unit operations ("process understanding") used in the manufacturing process. The performance of functional excipients can only be assessed as a constituent of the specific formulation and unit operation. Special tools are necessary, such as the design of experiments, the use of artificial neural networks and the application of percolation theory for the design of dosage forms.
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Pharmaceutical powder Technology - From art to science: The challenge of the FDA's process analytical Technology Initiative
Advanced Powder Technology, 2005Co-Authors: Hans Leuenberger, Minna LanzAbstract:—This paper describes with typical examples the state of art. The list of examples includes the problems of non-robust formulations and critical processes. The paper demonstrates the necessity and the challenge of the FDA's Process Analytical Technology Initiative, which is an important stimulus to develop a rigorous scientific framework in the area of pharmaceutical powder Technology. The paper suggests a kind of 'road map' to achieve as fast as possible the top of the 'knowledge pyramid'. The road map includes the extensive use of a multivariate design of experiments, the use of artificial neural networks (ANN), the use of the laws of physical pharmacy and percolation theory, and, last but not least, tries to 'translate' the existing laws of physical chemistry into the area of pharmaceutical powder Technology, where we have the problem that the number of particles involved is much lower than the Avogadro number N A . For this reason it will be of interest to monitor closely the progress in nanoscience, especially in the area of mathematical modeling of the fascinating special physical properties of nanoparticles, which again consist of a finite number N of atoms, respectively molecules, with N N A .
Werner Balogh - One of the best experts on this subject based on the ideXlab platform.
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united nations human space Technology Initiative hsti
Acta Astronautica, 2014Co-Authors: Mika Ochiai, Heike Steffens, Werner Balogh, H J Haubold, Mazlan OthmanAbstract:Abstract The Human Space Technology Initiative was launched in 2010 within the framework of the United Nations Programme on Space Applications implemented by the Office for Outer Space Affairs of the United Nations. It aims to involve more countries in activities related to human spaceflight and space exploration and to increase the benefits from the outcome of such activities through international cooperation, to make space exploration a truly international effort. The role of the Initiative in these efforts is to provide a platform to exchange information, foster collaboration between partners from spacefaring and non-spacefaring countries, and encourage emerging and developing countries to take part in space research and benefit from space applications. The Initiative organizes expert meetings and workshops annually to raise awareness of the current status of space exploration activities as well as of the benefits of utilizing human space Technology and its applications. The Initiative is also carrying out primary science activities including the Zero-Gravity Instrument Project and the Drop Tower Experiment Series aimed at promoting capacity-building activities in microgravity science and education, particularly in developing countries.
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capacity building in space Technology development a new Initiative within the united nations programme on space applications
Space Policy, 2011Co-Authors: Werner BaloghAbstract:Abstract Since 1971 the UN Programme on Space Applications, implemented by the Office for Outer Space Affairs, has been organizing workshops, symposiums and expert meetings and providing training opportunities in the practical applications of space Technology. In 2009 the Office launched the Basic Space Technology Initiative (BSTI). The BSTI encompasses a range of activities in support of capacity building in space Technology development in response to the growing interest of academic and governmental organizations in many countries to establish basic, indigenous capabilities to develop nano- and small satellites. Considerations such as the education and training of experts, the creation of required testing and building infrastructure, opportunities for international cooperation and the applicable legal and regulatory frameworks are therefore of particular interest to these organizations. The BSTI aims to assist them with their efforts. This paper describes the origins of the Initiative, the activities that have been conducted to date and the work planned for 2011 and beyond.
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the united nations human space Technology Initiative hsti
arXiv: Space Physics, 2011Co-Authors: Mika Ochiai, H J Haubold, Ingrid Dietlein, Werner BaloghAbstract:The Human Space Technology Initiative (HSTI) has been launched under the framework of the United Nations Programme on Space Applications with its aims of promoting international cooperation in human spaceflight and space exploration-related activities; creating awareness among United Nations Member States on the benefits of utilizing human space Technology and its applications; and building capacity in microgravity education and research. The International Space Station (ISS), being operational with a permanent crew of six (6), is an unprecedented facility for research on science and Technology and can be regarded as one of the greatest resources for humankind to explore space. The HSTI seeks to promote human space Technology and to expand ISS utilization. This report describes the background, objectives, and current three-year work plan of HSTI which is composed of organizing expert meetings, seminars, and workshops as well as building capacity by distributing educational materials and zero-gravity experiment instruments.
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proposal for a united nations basic space Technology Initiative
Advances in Space Research, 2009Co-Authors: Werner Balogh, H J HauboldAbstract:The United Nations Programme on Space Applications, implemented by the United Nations Office for Outer Space Affairs, promotes the benefits of space-based solutions for sustainable economic and social development. The Programme assists Member States of the United Nations to establish indigenous capacities for the use of space Technology and its applications. In the past the Programme has primarily been focusing on the use of space applications and on basic space science activities. However, in recent years there has been a strong interest in a growing number of space-using countries to build space Technology capacities, for example, the ability to develop and operate small satellites. In reaction to this development, the United Nations in cooperation with the International Academy of Astronautics has been organizing annual workshops on small satellites in the service of developing countries. Space Technology related issues have also been addressed as part of various other activities of the Programme on Space Applications. Building on these experiences, the Office for Outer Space Affairs is now considering the launch of a new Initiative, preliminarily titled the United Nations Basic Space Technology Initiative (UNBSTI), to promote basic space Technology development. The Initiative would be implemented in the framework of the Programme on Space Applications and its aim would be to help building sustainable capacities for basic space Technology education and development, thereby advancing the operational use of space Technology and its applications.
Zheng Jian Li - One of the best experts on this subject based on the ideXlab platform.
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Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe
Biotechnology and Bioengineering, 2011Co-Authors: Nicholas R. Abu-absi, Maryann Ehly Cuellar, Brian M. Kenty, Michael C. Borys, Sivakesava Sakhamuri, David J. Strachan, Michael C. Hausladen, Zheng Jian LiAbstract:The FDA's process analytical Technology Initiative encourages drug manufacturers to apply innovative ideas to better understand their processes. There are many challenges to applying these techniques to monitor mammalian cell culture bioreactors for biologics manufacturing. These include the ability to monitor multiple components in complex medium formulations non-invasively and in-line. We report results that demonstrate, for the first time, the technical feasibility of the in-line application of Raman spectroscopy for monitoring a mammalian cell culture bioreactor. A Raman probe was used for the simultaneous prediction of culture parameters including glutamine, glutamate, glucose, lactate, ammonium, viable cell density, and total cell density.
