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Knut Wester - One of the best experts on this subject based on the ideXlab platform.
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Microarray-based gene expression profiling and DNA copy number variation analysis of Temporal Fossa arachnoid cysts
Cerebrospinal Fluid Research, 2010Co-Authors: Mads Aarhus, Christian A. Helland, Morten Lund-johansen, Knut Wester, Per M KnappskogAbstract:Background Intracranial arachnoid cysts (AC) are membranous sacs filled with CSF-like fluid that are commonly found in the Temporal Fossa. The majority of ACs are congenital. Typical symptoms are headache, dizziness, and dyscognition. Little is known about genes that contribute to the formation of the cyst membranes. Methods In order to identify differences in gene expression between normal arachnoid membrane (AM) and cyst membrane, we have performed a high-resolution mRNA microarray analysis. In addition we have screened DNA from AC samples for chromosomal duplications or deletions using DNA microarray-based copy number variation analysis. Results The transcriptome consisting of 33096 gene probes showed a near-complete similarity in expression between AC and AM samples. Only nine genes differed in expression between the two tissues: ASGR1, DPEP2, SOX9, SHROOM3, A2BP1, ATP10D, TRIML1, NMU were down regulated, whereas BEND5 was up regulated in the AC samples. Three of the AC samples had unreported human DNA copy number variations, all DNA gains. Conclusions Extending results of previous anatomical studies, the present study has identified a small subset of differentially expressed genes and DNA alterations in arachnoid cysts compared to normal arachnoid membrane.
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microarray based gene expression profiling and dna copy number variation analysis of Temporal Fossa arachnoid cysts
Cerebrospinal Fluid Research, 2010Co-Authors: Christian A. Helland, Knut Wester, Mads Aarhus, Per M Knappskog, Morten LundjohansenAbstract:Background Intracranial arachnoid cysts (AC) are membranous sacs filled with CSF-like fluid that are commonly found in the Temporal Fossa. The majority of ACs are congenital. Typical symptoms are headache, dizziness, and dyscognition. Little is known about genes that contribute to the formation of the cyst membranes.
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Microarray-based gene expression profiling and DNA copy number variation analysis of Temporal Fossa arachnoid cysts
Cerebrospinal Fluid Research, 2010Co-Authors: Mads Aarhus, Christian A. Helland, Morten Lund-johansen, Knut Wester, Per M KnappskogAbstract:Background Intracranial arachnoid cysts (AC) are membranous sacs filled with CSF-like fluid that are commonly found in the Temporal Fossa. The majority of ACs are congenital. Typical symptoms are headache, dizziness, and dyscognition. Little is known about genes that contribute to the formation of the cyst membranes. Methods In order to identify differences in gene expression between normal arachnoid membrane (AM) and cyst membrane, we have performed a high-resolution mRNA microarray analysis. In addition we have screened DNA from AC samples for chromosomal duplications or deletions using DNA microarray-based copy number variation analysis. Results The transcriptome consisting of 33096 gene probes showed a near-complete similarity in expression between AC and AM samples. Only nine genes differed in expression between the two tissues: ASGR1, DPEP2, SOX9, SHROOM3, A2BP1, ATP10D, TRIML1, NMU were down regulated, whereas BEND5 was up regulated in the AC samples. Three of the AC samples had unreported human DNA copy number variations, all DNA gains. Conclusions Extending results of previous anatomical studies, the present study has identified a small subset of differentially expressed genes and DNA alterations in arachnoid cysts compared to normal arachnoid membrane.
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Location, sidedness, and sex distribution of intracranial arachnoid cysts in a population-based sample.
Journal of neurosurgery, 2010Co-Authors: Christian A. Helland, Morten Lund-johansen, Knut WesterAbstract:Object The aim of this study was to examine the distribution of intracranial arachnoid cysts in a large and unselected patient population with special emphasis on sidedness and sex distribution. Methods In total, 299 patients with 305 arachnoid cysts were studied. These patients were consecutively referred to our department during a 20-year period from a well-defined geographical area with a stable population. Results There was a strong predilection (198 patients [66.2%]) for intracranial arachnoid cysts in the Temporal Fossa. Forty-two patients had cysts overlying the frontal convexity, 36 had cysts in the posterior Fossa, and 23 patients had cysts in other, different locations. Of 269 cysts with clearly unilateral distribution, 163 were located on the left side and 106 on the right side. This difference resulted from the marked preponderance of Temporal Fossa cysts on the left side (left-to-right ratio 2.5:1; p < 0.0001 [adjusted < 0.0005]). For cysts in the cerebellopontine angle (CPA), there was prepo...
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Intracranial arachnoid cysts – do they impair mental functions?
Journal of neurology, 2008Co-Authors: Knut WesterAbstract:Object Arachnoid cysts are benign, congenital malformations of the arachnoid with a predilection for the Temporal Fossa. Radiologically, most arachnoid cysts appear to be expansive lesions, and functional imaging has shown that arachnoid cysts may cause a reorganization of cortical functions.
Alfred B Watson - One of the best experts on this subject based on the ideXlab platform.
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imaging the Temporal Fossa
American Journal of Roentgenology, 1997Co-Authors: C E Swanson, L A Hayman, P J Diazmarchan, Alfred B WatsonAbstract:The purpose of our study was to delineate the interconnections in the Temporal Fossa that are visible on high-resolution clinical images.Thin-section MR images and CT scans of the Temporal Fossa in two normal volunteers were obtained in coronal and axial sections. MR images, CT scans, or both of 20 patients with demonstrable spread of disease were reviewed.The imaging studies of patients with disease proved more informative than images of the normal subject or the published anatomic and surgical descriptions of the Temporal Fossa. We recognized five discrete radiographically defined regions: the connective tissue layer, compartment of the superficial fat pad, compartment of the deep fat pad, compartment of the Temporal muscle (superior recess of the suprazygomatic masticator), and subperiosteal zone. Important, tortuous, and to our knowledge undescribed interconnections between the scalp, posterior neck, eyelid, face, and the suprazygomatic masticator were delineated.Imaging studies of the Temporal Fossa ...
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imaging the Temporal Fossa
Annual Meeting of the American Society of Neuroradiology, 1997Co-Authors: C E Swanson, L A Hayman, P J Diazmarchan, Alfred B WatsonAbstract:OBJECTIVE. The purpose of out study was to delineate the interconnections in the Temporal Fossa that are visible on high-resolution clinical images. SUBJECTS AND METHODS. Thin-section MR images and CT scans of the Temporal Fossa in two normal volunteers were obtained in coronal and axial sections, MR images. CT scans, or both of 20 patients with demonstrable spread of disease were reviewed. RESULTS. The imaging studies of patients with disease proved more informative than images of the normal subject or the published anatomic and surgical descriptions of the Temporal Fossa. We recognized five discrete radiographically defined regions: the connective tissue layer. compartment of the superficial fat pad, compartment of the deep fat pad, compartment of the Temporal muscle (superior recess of the suprazygomatic masticator). and subperiosteal zone. Important. tortuous. and to out knowledge undescribed interconnections between the scalp, posterior neck, eyelid. face, and the suprazygomatic masticator were delineated. CONCLUSION. Imaging studies of the Temporal Fossa can be used to formulate a clinically useful approach that simplifies the complex anatomy of the Temporal Fossa.
C E Swanson - One of the best experts on this subject based on the ideXlab platform.
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imaging the Temporal Fossa
American Journal of Roentgenology, 1997Co-Authors: C E Swanson, L A Hayman, P J Diazmarchan, Alfred B WatsonAbstract:The purpose of our study was to delineate the interconnections in the Temporal Fossa that are visible on high-resolution clinical images.Thin-section MR images and CT scans of the Temporal Fossa in two normal volunteers were obtained in coronal and axial sections. MR images, CT scans, or both of 20 patients with demonstrable spread of disease were reviewed.The imaging studies of patients with disease proved more informative than images of the normal subject or the published anatomic and surgical descriptions of the Temporal Fossa. We recognized five discrete radiographically defined regions: the connective tissue layer, compartment of the superficial fat pad, compartment of the deep fat pad, compartment of the Temporal muscle (superior recess of the suprazygomatic masticator), and subperiosteal zone. Important, tortuous, and to our knowledge undescribed interconnections between the scalp, posterior neck, eyelid, face, and the suprazygomatic masticator were delineated.Imaging studies of the Temporal Fossa ...
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imaging the Temporal Fossa
Annual Meeting of the American Society of Neuroradiology, 1997Co-Authors: C E Swanson, L A Hayman, P J Diazmarchan, Alfred B WatsonAbstract:OBJECTIVE. The purpose of out study was to delineate the interconnections in the Temporal Fossa that are visible on high-resolution clinical images. SUBJECTS AND METHODS. Thin-section MR images and CT scans of the Temporal Fossa in two normal volunteers were obtained in coronal and axial sections, MR images. CT scans, or both of 20 patients with demonstrable spread of disease were reviewed. RESULTS. The imaging studies of patients with disease proved more informative than images of the normal subject or the published anatomic and surgical descriptions of the Temporal Fossa. We recognized five discrete radiographically defined regions: the connective tissue layer. compartment of the superficial fat pad, compartment of the deep fat pad, compartment of the Temporal muscle (superior recess of the suprazygomatic masticator). and subperiosteal zone. Important. tortuous. and to out knowledge undescribed interconnections between the scalp, posterior neck, eyelid. face, and the suprazygomatic masticator were delineated. CONCLUSION. Imaging studies of the Temporal Fossa can be used to formulate a clinically useful approach that simplifies the complex anatomy of the Temporal Fossa.
Christian A. Helland - One of the best experts on this subject based on the ideXlab platform.
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microarray based gene expression profiling and dna copy number variation analysis of Temporal Fossa arachnoid cysts
Cerebrospinal Fluid Research, 2010Co-Authors: Christian A. Helland, Knut Wester, Mads Aarhus, Per M Knappskog, Morten LundjohansenAbstract:Background Intracranial arachnoid cysts (AC) are membranous sacs filled with CSF-like fluid that are commonly found in the Temporal Fossa. The majority of ACs are congenital. Typical symptoms are headache, dizziness, and dyscognition. Little is known about genes that contribute to the formation of the cyst membranes.
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Microarray-based gene expression profiling and DNA copy number variation analysis of Temporal Fossa arachnoid cysts
Cerebrospinal Fluid Research, 2010Co-Authors: Mads Aarhus, Christian A. Helland, Morten Lund-johansen, Knut Wester, Per M KnappskogAbstract:Background Intracranial arachnoid cysts (AC) are membranous sacs filled with CSF-like fluid that are commonly found in the Temporal Fossa. The majority of ACs are congenital. Typical symptoms are headache, dizziness, and dyscognition. Little is known about genes that contribute to the formation of the cyst membranes. Methods In order to identify differences in gene expression between normal arachnoid membrane (AM) and cyst membrane, we have performed a high-resolution mRNA microarray analysis. In addition we have screened DNA from AC samples for chromosomal duplications or deletions using DNA microarray-based copy number variation analysis. Results The transcriptome consisting of 33096 gene probes showed a near-complete similarity in expression between AC and AM samples. Only nine genes differed in expression between the two tissues: ASGR1, DPEP2, SOX9, SHROOM3, A2BP1, ATP10D, TRIML1, NMU were down regulated, whereas BEND5 was up regulated in the AC samples. Three of the AC samples had unreported human DNA copy number variations, all DNA gains. Conclusions Extending results of previous anatomical studies, the present study has identified a small subset of differentially expressed genes and DNA alterations in arachnoid cysts compared to normal arachnoid membrane.
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Microarray-based gene expression profiling and DNA copy number variation analysis of Temporal Fossa arachnoid cysts
Cerebrospinal Fluid Research, 2010Co-Authors: Mads Aarhus, Christian A. Helland, Morten Lund-johansen, Knut Wester, Per M KnappskogAbstract:Background Intracranial arachnoid cysts (AC) are membranous sacs filled with CSF-like fluid that are commonly found in the Temporal Fossa. The majority of ACs are congenital. Typical symptoms are headache, dizziness, and dyscognition. Little is known about genes that contribute to the formation of the cyst membranes. Methods In order to identify differences in gene expression between normal arachnoid membrane (AM) and cyst membrane, we have performed a high-resolution mRNA microarray analysis. In addition we have screened DNA from AC samples for chromosomal duplications or deletions using DNA microarray-based copy number variation analysis. Results The transcriptome consisting of 33096 gene probes showed a near-complete similarity in expression between AC and AM samples. Only nine genes differed in expression between the two tissues: ASGR1, DPEP2, SOX9, SHROOM3, A2BP1, ATP10D, TRIML1, NMU were down regulated, whereas BEND5 was up regulated in the AC samples. Three of the AC samples had unreported human DNA copy number variations, all DNA gains. Conclusions Extending results of previous anatomical studies, the present study has identified a small subset of differentially expressed genes and DNA alterations in arachnoid cysts compared to normal arachnoid membrane.
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Location, sidedness, and sex distribution of intracranial arachnoid cysts in a population-based sample.
Journal of neurosurgery, 2010Co-Authors: Christian A. Helland, Morten Lund-johansen, Knut WesterAbstract:Object The aim of this study was to examine the distribution of intracranial arachnoid cysts in a large and unselected patient population with special emphasis on sidedness and sex distribution. Methods In total, 299 patients with 305 arachnoid cysts were studied. These patients were consecutively referred to our department during a 20-year period from a well-defined geographical area with a stable population. Results There was a strong predilection (198 patients [66.2%]) for intracranial arachnoid cysts in the Temporal Fossa. Forty-two patients had cysts overlying the frontal convexity, 36 had cysts in the posterior Fossa, and 23 patients had cysts in other, different locations. Of 269 cysts with clearly unilateral distribution, 163 were located on the left side and 106 on the right side. This difference resulted from the marked preponderance of Temporal Fossa cysts on the left side (left-to-right ratio 2.5:1; p < 0.0001 [adjusted < 0.0005]). For cysts in the cerebellopontine angle (CPA), there was prepo...
P J Diazmarchan - One of the best experts on this subject based on the ideXlab platform.
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imaging the Temporal Fossa
American Journal of Roentgenology, 1997Co-Authors: C E Swanson, L A Hayman, P J Diazmarchan, Alfred B WatsonAbstract:The purpose of our study was to delineate the interconnections in the Temporal Fossa that are visible on high-resolution clinical images.Thin-section MR images and CT scans of the Temporal Fossa in two normal volunteers were obtained in coronal and axial sections. MR images, CT scans, or both of 20 patients with demonstrable spread of disease were reviewed.The imaging studies of patients with disease proved more informative than images of the normal subject or the published anatomic and surgical descriptions of the Temporal Fossa. We recognized five discrete radiographically defined regions: the connective tissue layer, compartment of the superficial fat pad, compartment of the deep fat pad, compartment of the Temporal muscle (superior recess of the suprazygomatic masticator), and subperiosteal zone. Important, tortuous, and to our knowledge undescribed interconnections between the scalp, posterior neck, eyelid, face, and the suprazygomatic masticator were delineated.Imaging studies of the Temporal Fossa ...
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imaging the Temporal Fossa
Annual Meeting of the American Society of Neuroradiology, 1997Co-Authors: C E Swanson, L A Hayman, P J Diazmarchan, Alfred B WatsonAbstract:OBJECTIVE. The purpose of out study was to delineate the interconnections in the Temporal Fossa that are visible on high-resolution clinical images. SUBJECTS AND METHODS. Thin-section MR images and CT scans of the Temporal Fossa in two normal volunteers were obtained in coronal and axial sections, MR images. CT scans, or both of 20 patients with demonstrable spread of disease were reviewed. RESULTS. The imaging studies of patients with disease proved more informative than images of the normal subject or the published anatomic and surgical descriptions of the Temporal Fossa. We recognized five discrete radiographically defined regions: the connective tissue layer. compartment of the superficial fat pad, compartment of the deep fat pad, compartment of the Temporal muscle (superior recess of the suprazygomatic masticator). and subperiosteal zone. Important. tortuous. and to out knowledge undescribed interconnections between the scalp, posterior neck, eyelid. face, and the suprazygomatic masticator were delineated. CONCLUSION. Imaging studies of the Temporal Fossa can be used to formulate a clinically useful approach that simplifies the complex anatomy of the Temporal Fossa.
