The Experts below are selected from a list of 75405 Experts worldwide ranked by ideXlab platform
Simon J Graham - One of the best experts on this subject based on the ideXlab platform.
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a novel tablet computer Platform for advanced language mapping during awake craniotomy procedures
Journal of Neurosurgery, 2016Co-Authors: Melanie Morrison, Marco M Garavaglia, Laleh Golestanirad, Gregory M T Hare, Michael D Cusimano, Tom A Schweizer, Simon J GrahamAbstract:A computerized Platform has been developed to enhance behavioral Testing during intraoperative language mapping in awake craniotomy procedures. The system is uniquely compatible with the environmental demands of both the operating room and preoperative functional MRI (fMRI), thus providing standardized Testing toward improving spatial agreement between the 2 brain mapping techniques. Details of the Platform architecture, its advantages over traditional Testing methods, and its use for language mapping are described. Four illustrative cases demonstrate the efficacy of using the Testing Platform to administer sophisticated language paradigms, and the spatial agreement between intraoperative mapping and preoperative fMRI results. The Testing Platform substantially improved the ability of the surgeon to detect and characterize language deficits. Use of a written word generation task to assess language production helped confirm areas of speech apraxia and speech arrest that were inadequately characterized or m...
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a novel tablet computer Platform for advanced language mapping during awake craniotomy procedures
Journal of Neurosurgery, 2016Co-Authors: Melanie Morrison, Marco M Garavaglia, Laleh Golestanirad, Gregory M T Hare, Michael D Cusimano, Tom A Schweizer, Fred Tam, Sunit Das, Simon J GrahamAbstract:A computerized Platform has been developed to enhance behavioral Testing during intraoperative language mapping in awake craniotomy procedures. The system is uniquely compatible with the environmental demands of both the operating room and preoperative functional MRI (fMRI), thus providing standardized Testing toward improving spatial agreement between the 2 brain mapping techniques. Details of the Platform architecture, its advantages over traditional Testing methods, and its use for language mapping are described. Four illustrative cases demonstrate the efficacy of using the Testing Platform to administer sophisticated language paradigms, and the spatial agreement between intraoperative mapping and preoperative fMRI results. The Testing Platform substantially improved the ability of the surgeon to detect and characterize language deficits. Use of a written word generation task to assess language production helped confirm areas of speech apraxia and speech arrest that were inadequately characterized or missed with the use of traditional paradigms, respectively. Preoperative fMRI of the analogous writing task was also assistive, displaying excellent spatial agreement with intraoperative mapping in all 4 cases. Sole use of traditional Testing paradigms can be limiting during awake craniotomy procedures. Comprehensive assessment of language function will require additional use of more sophisticated and ecologically valid Testing paradigms. The Platform presented here provides a means to do so.
Xinyu Liu - One of the best experts on this subject based on the ideXlab platform.
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speeds a portable serological Testing Platform for rapid electrochemical detection of sars cov 2 antibodies
Biosensors and Bioelectronics, 2021Co-Authors: Ran Peng, Yueyue Pan, Zhen Qin, James M Rini, Xinyu LiuAbstract:Abstract The COVID-19 pandemic has resulted in a worldwide health crisis. Rapid diagnosis, new therapeutics and effective vaccines will all be required to stop the spread of COVID-19. Quantitative evaluation of serum antibody levels against the SARS-CoV-2 virus provides a means of monitoring a patient's immune response to a natural viral infection or vaccination, as well as evidence of a prior infection. In this paper, a portable and low-cost electrochemical immunosensor is developed for the rapid and accurate quantification of SARS-CoV-2 serum antibodies. The immunosensor is capable of quantifying the concentrations of immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies against the SARS-CoV-2 spike protein in human serum. For IgG and IgM, it provides measurements in the range of 10.1 ng/mL − 60 μg/mL and 1.64 ng/mL − 50 μg/mL, respectively, and both antibodies can be assayed in 13 min. We also developed device stabilization and storage strategies to achieve stable performance of the immunosensor within 24-week storage at room temperature. We evaluated the performance of the immunosensor using COVID-19 patient serum samples collected at different time points after symptom onset. The rapid and sensitive detection of IgG and IgM provided by our immunosensor fulfills the need of rapid COVID-19 serology Testing for both point-of-care diagnosis and population immunity screening.
Melanie Morrison - One of the best experts on this subject based on the ideXlab platform.
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a novel tablet computer Platform for advanced language mapping during awake craniotomy procedures
Journal of Neurosurgery, 2016Co-Authors: Melanie Morrison, Marco M Garavaglia, Laleh Golestanirad, Gregory M T Hare, Michael D Cusimano, Tom A Schweizer, Simon J GrahamAbstract:A computerized Platform has been developed to enhance behavioral Testing during intraoperative language mapping in awake craniotomy procedures. The system is uniquely compatible with the environmental demands of both the operating room and preoperative functional MRI (fMRI), thus providing standardized Testing toward improving spatial agreement between the 2 brain mapping techniques. Details of the Platform architecture, its advantages over traditional Testing methods, and its use for language mapping are described. Four illustrative cases demonstrate the efficacy of using the Testing Platform to administer sophisticated language paradigms, and the spatial agreement between intraoperative mapping and preoperative fMRI results. The Testing Platform substantially improved the ability of the surgeon to detect and characterize language deficits. Use of a written word generation task to assess language production helped confirm areas of speech apraxia and speech arrest that were inadequately characterized or m...
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a novel tablet computer Platform for advanced language mapping during awake craniotomy procedures
Journal of Neurosurgery, 2016Co-Authors: Melanie Morrison, Marco M Garavaglia, Laleh Golestanirad, Gregory M T Hare, Michael D Cusimano, Tom A Schweizer, Fred Tam, Sunit Das, Simon J GrahamAbstract:A computerized Platform has been developed to enhance behavioral Testing during intraoperative language mapping in awake craniotomy procedures. The system is uniquely compatible with the environmental demands of both the operating room and preoperative functional MRI (fMRI), thus providing standardized Testing toward improving spatial agreement between the 2 brain mapping techniques. Details of the Platform architecture, its advantages over traditional Testing methods, and its use for language mapping are described. Four illustrative cases demonstrate the efficacy of using the Testing Platform to administer sophisticated language paradigms, and the spatial agreement between intraoperative mapping and preoperative fMRI results. The Testing Platform substantially improved the ability of the surgeon to detect and characterize language deficits. Use of a written word generation task to assess language production helped confirm areas of speech apraxia and speech arrest that were inadequately characterized or missed with the use of traditional paradigms, respectively. Preoperative fMRI of the analogous writing task was also assistive, displaying excellent spatial agreement with intraoperative mapping in all 4 cases. Sole use of traditional Testing paradigms can be limiting during awake craniotomy procedures. Comprehensive assessment of language function will require additional use of more sophisticated and ecologically valid Testing paradigms. The Platform presented here provides a means to do so.
Michael Y Sha - One of the best experts on this subject based on the ideXlab platform.
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a high throughput anti sars cov 2 igg Testing Platform for covid 19
Journal of Virological Methods, 2021Co-Authors: Eric Chu, Dayu Zhang, Aiguo Zhang, Michael Y ShaAbstract:Abstract Background Serology tests for detecting the antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can identify previous infection and help to confirm the presence of current infection. Objective The aim of this study was to evaluate the performances of a newly developed high throughput immunoassay for anti-SARS-CoV-2 IgG antibody detection. Results Clinical agreement studies were performed in 107 COVID-19 patient serum samples and 226 negative donor serum/plasma samples. Positive percent agreement (PPA) was 46.15 % (95 % CI: 19.22 % ∼74.87 %), 61.54 % (95 % CI: 31.58 % ∼86.14 %), and 97.53 % (95 % CI: 91.36 % ∼99.70 %) for samples collected on 0−7 days, 8−14 days, and ≥15 days from symptom onset, respectively. Negative Percent Agreement (NPA) was 98.23 % (95 % CI: 95.53 % ∼99.52 %). No cross-reactivity was observed to patient samples positive for IgG antibodies against the following pathogens: HIV, HAV, HBV, RSV, CMV, EBV, Rubella, Influenza A, and Influenza B. Hemoglobin (200 mg/dL), bilirubin (2 mg/dL) and EDTA (10 mM) showed no significant interfering effect on this assay. Conclusion An anti-SARS-CoV-2 IgG antibody assay with high sensitivity and specificity has been developed. With the high throughput, this assay will speed up anti-SARS-CoV-2 IgG Testing.
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a high throughput anti sars cov 2 igg Testing Platform for covid 19
medRxiv, 2020Co-Authors: Eric Chu, Dayu Zhang, Aiguo Zhang, Michael Y ShaAbstract:Background: Serology tests for detecting the antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can identify previous infection and help to confirm the presence of current infection. Objective: The aim of this study was to evaluate the performances of a newly developed high throughput immunoassay for anti-SARS-CoV-2 IgG antibody detection. Results: Clinical agreement studies were performed in 77 COVID-19 patient serum samples and 226 negative donor serum/plasma samples. Positive percent agreement (PPA) was 42.86% (95% CI: 9.90% to 81.59%), 55.56% (95% CI: 21.20% to 86.30%), and 96.72% (95% CI: 88.65% to 99.60%) for samples collected on 0-7 days, 8-14 days, and ≥15 days from symptom onset, respectively. Negative Percent Agreement (NPA) was 98.23% (95% CI: 95.53% to 99.52%). No cross-reactivity was observed to patient samples positive for IgG antibodies against the following pathogens: HIV, HAV, HBV, RSV, CMV, EBV, Rubella, Influenza A, and Influenza B. Hemoglobin (200 mg/dL), bilirubin (2 mg/dL) and EDTA (10 mM) showed no significant interfering effect on this assay. Conclusion: An anti-SARS-CoV-2 IgG antibody assay with high sensitivity and specificity has been developed. With the high throughput, this assay will speed up the anti-SARS-CoV-2 IgG Testing.
Ran Peng - One of the best experts on this subject based on the ideXlab platform.
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speeds a portable serological Testing Platform for rapid electrochemical detection of sars cov 2 antibodies
Biosensors and Bioelectronics, 2021Co-Authors: Ran Peng, Yueyue Pan, Zhen Qin, James M Rini, Xinyu LiuAbstract:Abstract The COVID-19 pandemic has resulted in a worldwide health crisis. Rapid diagnosis, new therapeutics and effective vaccines will all be required to stop the spread of COVID-19. Quantitative evaluation of serum antibody levels against the SARS-CoV-2 virus provides a means of monitoring a patient's immune response to a natural viral infection or vaccination, as well as evidence of a prior infection. In this paper, a portable and low-cost electrochemical immunosensor is developed for the rapid and accurate quantification of SARS-CoV-2 serum antibodies. The immunosensor is capable of quantifying the concentrations of immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies against the SARS-CoV-2 spike protein in human serum. For IgG and IgM, it provides measurements in the range of 10.1 ng/mL − 60 μg/mL and 1.64 ng/mL − 50 μg/mL, respectively, and both antibodies can be assayed in 13 min. We also developed device stabilization and storage strategies to achieve stable performance of the immunosensor within 24-week storage at room temperature. We evaluated the performance of the immunosensor using COVID-19 patient serum samples collected at different time points after symptom onset. The rapid and sensitive detection of IgG and IgM provided by our immunosensor fulfills the need of rapid COVID-19 serology Testing for both point-of-care diagnosis and population immunity screening.
