The Experts below are selected from a list of 126 Experts worldwide ranked by ideXlab platform
Alfonso Leal-cerro - One of the best experts on this subject based on the ideXlab platform.
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Role of ketoconazole treatment in urinary-free cortisol-to-cortisone and tetrahydrocortisol-to-Tetrahydrocortisone ratios in nonectopic cushing’s syndrome
Endocrine, 2002Co-Authors: Pablo Stiefel, José S. García-morillo, Luis Jimenez, Encarnación Pamies, María Luisa Miranda, Joaquín Carneado, José Villar, Alfonso Leal-cerroAbstract:We hypothesized that in nonectopic Cushing syndrome there is an insufficient activity of type II (renal) 11β-hydroxysteroid dehydrogenase (11β-HSD2) that is related to cortisol excess, rather than to corticotropin (adrenocorticotropic hormone [ACTH]) levels. We measured plasma ACTH and urinary-free cortisol (UFF), urinary-free cortisone (UFE), tetrahydrocortisol (UTHF), and Tetrahydrocortisone (UTHE) in 24-h urine samples of 24 healthy subjects and 15 patients diagnosed with nonectopic Cushing syndrome. Then, in the group of patients, a new 24-h urine sample was collected after treatment with 800 mg daily of ketoconazole. The UFF/UFE and UTHF/UTHE ratios were calculated as an estimation of 11β-HSD2 activity. The patients had an increase in both the UFF/UFE (19.95±10.3 vs 5.78±4.72 nmol/24 h; p
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Role of ketoconazole treatment in urinary-free cortisol-to-cortisone and tetrahydrocortisol-to-Tetrahydrocortisone ratios in nonectopic Cushing's syndrome.
Endocrine, 2002Co-Authors: Pablo Stiefel, José S. García-morillo, Luis Jimenez, Encarnación Pamies, Joaquín Carneado, José Villar, María Miranda, Alfonso Leal-cerroAbstract:We hypothesized that in nonectopic Cushing syndrome there is an insufficient activity of type II (renal) 11β-hydroxysteroid dehydrogenase (11β-HSD2) that is related to cortisol excess, rather than to corticotropin (adrenocorticotropic hormone [ACTH]) levels. We measured plasma ACTH and urinary-free cortisol (UFF), urinary-free cortisone (UFE), tetrahydrocortisol (UTHF), and Tetrahydrocortisone (UTHE) in 24-h urine samples of 24 healthy subjects and 15 patients diagnosed with nonectopic Cushing syndrome. Then, in the group of patients, a new 24-h urine sample was collected after treatment with 800 mg daily of ketoconazole. The UFF/UFE and UTHF/UTHE ratios were calculated as an estimation of 11β-HSD2 activity. The patients had an increase in both the UFF/UFE (19.95±10.3 vs 5.78±4.72 nmol/24 h; p
Pablo Stiefel - One of the best experts on this subject based on the ideXlab platform.
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Role of ketoconazole treatment in urinary-free cortisol-to-cortisone and tetrahydrocortisol-to-Tetrahydrocortisone ratios in nonectopic cushing’s syndrome
Endocrine, 2002Co-Authors: Pablo Stiefel, José S. García-morillo, Luis Jimenez, Encarnación Pamies, María Luisa Miranda, Joaquín Carneado, José Villar, Alfonso Leal-cerroAbstract:We hypothesized that in nonectopic Cushing syndrome there is an insufficient activity of type II (renal) 11β-hydroxysteroid dehydrogenase (11β-HSD2) that is related to cortisol excess, rather than to corticotropin (adrenocorticotropic hormone [ACTH]) levels. We measured plasma ACTH and urinary-free cortisol (UFF), urinary-free cortisone (UFE), tetrahydrocortisol (UTHF), and Tetrahydrocortisone (UTHE) in 24-h urine samples of 24 healthy subjects and 15 patients diagnosed with nonectopic Cushing syndrome. Then, in the group of patients, a new 24-h urine sample was collected after treatment with 800 mg daily of ketoconazole. The UFF/UFE and UTHF/UTHE ratios were calculated as an estimation of 11β-HSD2 activity. The patients had an increase in both the UFF/UFE (19.95±10.3 vs 5.78±4.72 nmol/24 h; p
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Role of ketoconazole treatment in urinary-free cortisol-to-cortisone and tetrahydrocortisol-to-Tetrahydrocortisone ratios in nonectopic Cushing's syndrome.
Endocrine, 2002Co-Authors: Pablo Stiefel, José S. García-morillo, Luis Jimenez, Encarnación Pamies, Joaquín Carneado, José Villar, María Miranda, Alfonso Leal-cerroAbstract:We hypothesized that in nonectopic Cushing syndrome there is an insufficient activity of type II (renal) 11β-hydroxysteroid dehydrogenase (11β-HSD2) that is related to cortisol excess, rather than to corticotropin (adrenocorticotropic hormone [ACTH]) levels. We measured plasma ACTH and urinary-free cortisol (UFF), urinary-free cortisone (UFE), tetrahydrocortisol (UTHF), and Tetrahydrocortisone (UTHE) in 24-h urine samples of 24 healthy subjects and 15 patients diagnosed with nonectopic Cushing syndrome. Then, in the group of patients, a new 24-h urine sample was collected after treatment with 800 mg daily of ketoconazole. The UFF/UFE and UTHF/UTHE ratios were calculated as an estimation of 11β-HSD2 activity. The patients had an increase in both the UFF/UFE (19.95±10.3 vs 5.78±4.72 nmol/24 h; p
Joaquín Carneado - One of the best experts on this subject based on the ideXlab platform.
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Role of ketoconazole treatment in urinary-free cortisol-to-cortisone and tetrahydrocortisol-to-Tetrahydrocortisone ratios in nonectopic cushing’s syndrome
Endocrine, 2002Co-Authors: Pablo Stiefel, José S. García-morillo, Luis Jimenez, Encarnación Pamies, María Luisa Miranda, Joaquín Carneado, José Villar, Alfonso Leal-cerroAbstract:We hypothesized that in nonectopic Cushing syndrome there is an insufficient activity of type II (renal) 11β-hydroxysteroid dehydrogenase (11β-HSD2) that is related to cortisol excess, rather than to corticotropin (adrenocorticotropic hormone [ACTH]) levels. We measured plasma ACTH and urinary-free cortisol (UFF), urinary-free cortisone (UFE), tetrahydrocortisol (UTHF), and Tetrahydrocortisone (UTHE) in 24-h urine samples of 24 healthy subjects and 15 patients diagnosed with nonectopic Cushing syndrome. Then, in the group of patients, a new 24-h urine sample was collected after treatment with 800 mg daily of ketoconazole. The UFF/UFE and UTHF/UTHE ratios were calculated as an estimation of 11β-HSD2 activity. The patients had an increase in both the UFF/UFE (19.95±10.3 vs 5.78±4.72 nmol/24 h; p
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Role of ketoconazole treatment in urinary-free cortisol-to-cortisone and tetrahydrocortisol-to-Tetrahydrocortisone ratios in nonectopic Cushing's syndrome.
Endocrine, 2002Co-Authors: Pablo Stiefel, José S. García-morillo, Luis Jimenez, Encarnación Pamies, Joaquín Carneado, José Villar, María Miranda, Alfonso Leal-cerroAbstract:We hypothesized that in nonectopic Cushing syndrome there is an insufficient activity of type II (renal) 11β-hydroxysteroid dehydrogenase (11β-HSD2) that is related to cortisol excess, rather than to corticotropin (adrenocorticotropic hormone [ACTH]) levels. We measured plasma ACTH and urinary-free cortisol (UFF), urinary-free cortisone (UFE), tetrahydrocortisol (UTHF), and Tetrahydrocortisone (UTHE) in 24-h urine samples of 24 healthy subjects and 15 patients diagnosed with nonectopic Cushing syndrome. Then, in the group of patients, a new 24-h urine sample was collected after treatment with 800 mg daily of ketoconazole. The UFF/UFE and UTHF/UTHE ratios were calculated as an estimation of 11β-HSD2 activity. The patients had an increase in both the UFF/UFE (19.95±10.3 vs 5.78±4.72 nmol/24 h; p
Encarnación Pamies - One of the best experts on this subject based on the ideXlab platform.
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Role of ketoconazole treatment in urinary-free cortisol-to-cortisone and tetrahydrocortisol-to-Tetrahydrocortisone ratios in nonectopic cushing’s syndrome
Endocrine, 2002Co-Authors: Pablo Stiefel, José S. García-morillo, Luis Jimenez, Encarnación Pamies, María Luisa Miranda, Joaquín Carneado, José Villar, Alfonso Leal-cerroAbstract:We hypothesized that in nonectopic Cushing syndrome there is an insufficient activity of type II (renal) 11β-hydroxysteroid dehydrogenase (11β-HSD2) that is related to cortisol excess, rather than to corticotropin (adrenocorticotropic hormone [ACTH]) levels. We measured plasma ACTH and urinary-free cortisol (UFF), urinary-free cortisone (UFE), tetrahydrocortisol (UTHF), and Tetrahydrocortisone (UTHE) in 24-h urine samples of 24 healthy subjects and 15 patients diagnosed with nonectopic Cushing syndrome. Then, in the group of patients, a new 24-h urine sample was collected after treatment with 800 mg daily of ketoconazole. The UFF/UFE and UTHF/UTHE ratios were calculated as an estimation of 11β-HSD2 activity. The patients had an increase in both the UFF/UFE (19.95±10.3 vs 5.78±4.72 nmol/24 h; p
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Role of ketoconazole treatment in urinary-free cortisol-to-cortisone and tetrahydrocortisol-to-Tetrahydrocortisone ratios in nonectopic Cushing's syndrome.
Endocrine, 2002Co-Authors: Pablo Stiefel, José S. García-morillo, Luis Jimenez, Encarnación Pamies, Joaquín Carneado, José Villar, María Miranda, Alfonso Leal-cerroAbstract:We hypothesized that in nonectopic Cushing syndrome there is an insufficient activity of type II (renal) 11β-hydroxysteroid dehydrogenase (11β-HSD2) that is related to cortisol excess, rather than to corticotropin (adrenocorticotropic hormone [ACTH]) levels. We measured plasma ACTH and urinary-free cortisol (UFF), urinary-free cortisone (UFE), tetrahydrocortisol (UTHF), and Tetrahydrocortisone (UTHE) in 24-h urine samples of 24 healthy subjects and 15 patients diagnosed with nonectopic Cushing syndrome. Then, in the group of patients, a new 24-h urine sample was collected after treatment with 800 mg daily of ketoconazole. The UFF/UFE and UTHF/UTHE ratios were calculated as an estimation of 11β-HSD2 activity. The patients had an increase in both the UFF/UFE (19.95±10.3 vs 5.78±4.72 nmol/24 h; p
Luis Jimenez - One of the best experts on this subject based on the ideXlab platform.
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Role of ketoconazole treatment in urinary-free cortisol-to-cortisone and tetrahydrocortisol-to-Tetrahydrocortisone ratios in nonectopic cushing’s syndrome
Endocrine, 2002Co-Authors: Pablo Stiefel, José S. García-morillo, Luis Jimenez, Encarnación Pamies, María Luisa Miranda, Joaquín Carneado, José Villar, Alfonso Leal-cerroAbstract:We hypothesized that in nonectopic Cushing syndrome there is an insufficient activity of type II (renal) 11β-hydroxysteroid dehydrogenase (11β-HSD2) that is related to cortisol excess, rather than to corticotropin (adrenocorticotropic hormone [ACTH]) levels. We measured plasma ACTH and urinary-free cortisol (UFF), urinary-free cortisone (UFE), tetrahydrocortisol (UTHF), and Tetrahydrocortisone (UTHE) in 24-h urine samples of 24 healthy subjects and 15 patients diagnosed with nonectopic Cushing syndrome. Then, in the group of patients, a new 24-h urine sample was collected after treatment with 800 mg daily of ketoconazole. The UFF/UFE and UTHF/UTHE ratios were calculated as an estimation of 11β-HSD2 activity. The patients had an increase in both the UFF/UFE (19.95±10.3 vs 5.78±4.72 nmol/24 h; p
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Role of ketoconazole treatment in urinary-free cortisol-to-cortisone and tetrahydrocortisol-to-Tetrahydrocortisone ratios in nonectopic Cushing's syndrome.
Endocrine, 2002Co-Authors: Pablo Stiefel, José S. García-morillo, Luis Jimenez, Encarnación Pamies, Joaquín Carneado, José Villar, María Miranda, Alfonso Leal-cerroAbstract:We hypothesized that in nonectopic Cushing syndrome there is an insufficient activity of type II (renal) 11β-hydroxysteroid dehydrogenase (11β-HSD2) that is related to cortisol excess, rather than to corticotropin (adrenocorticotropic hormone [ACTH]) levels. We measured plasma ACTH and urinary-free cortisol (UFF), urinary-free cortisone (UFE), tetrahydrocortisol (UTHF), and Tetrahydrocortisone (UTHE) in 24-h urine samples of 24 healthy subjects and 15 patients diagnosed with nonectopic Cushing syndrome. Then, in the group of patients, a new 24-h urine sample was collected after treatment with 800 mg daily of ketoconazole. The UFF/UFE and UTHF/UTHE ratios were calculated as an estimation of 11β-HSD2 activity. The patients had an increase in both the UFF/UFE (19.95±10.3 vs 5.78±4.72 nmol/24 h; p
