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Chiahung Kao - One of the best experts on this subject based on the ideXlab platform.

  • compare fdg pet and Tc 99m Tetrofosmin spect to detect metastatic thyroid carcinoma1
    Academic Radiology, 2003
    Co-Authors: Yenkung Chen, Ruohfang Yen, Fengyuan Liu, Chiahung Kao
    Abstract:

    Rationale and Objectives. The effectiveness of 18-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) and technetium-99m Tetrofosmin (Tc-99m TF) single photon emission computed tomography (SPECT) of neck and chest was evaluated to detect metastatic lesions in well-differentiated thyroid carcinoma after nearly total thyroidectomy and radioiodine (I-131) treatment who present with elevated serum human thyroglobulin levels but negative I-131 whole body scan. Materials and Methods. Twenty-three patients with differentiated thyroid carcinoma who underwent nearly total thyroidectomy and I-131 treatments were included in this study. Results. All of the 23 patients had negative I-131 whole body scan and elevated human thyroglobulin levels under thyroid-stimulating hormone stimulation. Metastatic lesions were detected by FDG-PET in 20 patients, while Tc-99m TF SPECT revealed metastatic lesions in only 11 of the 20 patients. Both FDG-PET and Tc-99m TF SPECT failed to demonstrate miliary pulmonary metastases in two of the remaining three patients. The other patient did not show any lesion on FDG-PET, Tc-99m TF SPECT, chest computed tomography, or other imaging techniques. Conclusion. This study demonstrated that FDG-PET is more sensitive than Tc-99m TF SPECT to detect metastatic lesions in differentiated thyroid carcinoma with elevated human thyroglobulin but negative I-131 whole body scan. However, miliary pulmonary metastases could be missed by the both techniques.

  • detecting metastatic neck lymph nodes in papillary thyroid carcinoma by 18f 2 deoxyglucose positron emission tomography and Tc 99m Tetrofosmin single photon emission computed tomography
    Anticancer Research, 2003
    Co-Authors: Ruohfang Yen, Yehyou Shen, Chiahung Kao
    Abstract:

    The aim of this study was to evaluate the usefulness of 18-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) and technetium-99m Tetrofosmin (Tc-99m TF) single photon emission computed tomography (SPECT) to detect metastatic neck lymph nodes (LN) in papillary thyroid carcinoma (PTc) after total thyroidectomy and radioiodine-131 (I-131) treatments in patients with elevated serum human thyroglobulin (hTg) levels but negative I-131 whole body scan (WBS). Thirteen PTc patients underwent nearly total thyroidectomy and I-131 treatments with proven neck LN metastases were included in this study. All subjects had negative I-131 WBS and elevated hTg levels (hTg > or = 10 mu IU/ml) under thyroid-stimulating hormone (TSH) stimulation (TSH > or = 30 mu IU/ml). FDG-PET and Tc-99m TF SPECT were used to detect metastatic neck LN in PTc. FDG-PET could detect all of the 13 (100%) patients with metastatic neck LN, but Tc-99m TF SPECT revealed lesions in only 8 out of 13 (61.5%) patients (p < 0.05). This study demonstrated that FDG-PET is more sensitive than Tc-99m TF SPECT to detecting metastatic neck LN in PTc with elevated serum hTg levels but negative I-131 WBS.

Ruohfang Yen - One of the best experts on this subject based on the ideXlab platform.

  • compare fdg pet and Tc 99m Tetrofosmin spect to detect metastatic thyroid carcinoma1
    Academic Radiology, 2003
    Co-Authors: Yenkung Chen, Ruohfang Yen, Fengyuan Liu, Chiahung Kao
    Abstract:

    Rationale and Objectives. The effectiveness of 18-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) and technetium-99m Tetrofosmin (Tc-99m TF) single photon emission computed tomography (SPECT) of neck and chest was evaluated to detect metastatic lesions in well-differentiated thyroid carcinoma after nearly total thyroidectomy and radioiodine (I-131) treatment who present with elevated serum human thyroglobulin levels but negative I-131 whole body scan. Materials and Methods. Twenty-three patients with differentiated thyroid carcinoma who underwent nearly total thyroidectomy and I-131 treatments were included in this study. Results. All of the 23 patients had negative I-131 whole body scan and elevated human thyroglobulin levels under thyroid-stimulating hormone stimulation. Metastatic lesions were detected by FDG-PET in 20 patients, while Tc-99m TF SPECT revealed metastatic lesions in only 11 of the 20 patients. Both FDG-PET and Tc-99m TF SPECT failed to demonstrate miliary pulmonary metastases in two of the remaining three patients. The other patient did not show any lesion on FDG-PET, Tc-99m TF SPECT, chest computed tomography, or other imaging techniques. Conclusion. This study demonstrated that FDG-PET is more sensitive than Tc-99m TF SPECT to detect metastatic lesions in differentiated thyroid carcinoma with elevated human thyroglobulin but negative I-131 whole body scan. However, miliary pulmonary metastases could be missed by the both techniques.

  • detecting metastatic neck lymph nodes in papillary thyroid carcinoma by 18f 2 deoxyglucose positron emission tomography and Tc 99m Tetrofosmin single photon emission computed tomography
    Anticancer Research, 2003
    Co-Authors: Ruohfang Yen, Yehyou Shen, Chiahung Kao
    Abstract:

    The aim of this study was to evaluate the usefulness of 18-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) and technetium-99m Tetrofosmin (Tc-99m TF) single photon emission computed tomography (SPECT) to detect metastatic neck lymph nodes (LN) in papillary thyroid carcinoma (PTc) after total thyroidectomy and radioiodine-131 (I-131) treatments in patients with elevated serum human thyroglobulin (hTg) levels but negative I-131 whole body scan (WBS). Thirteen PTc patients underwent nearly total thyroidectomy and I-131 treatments with proven neck LN metastases were included in this study. All subjects had negative I-131 WBS and elevated hTg levels (hTg > or = 10 mu IU/ml) under thyroid-stimulating hormone (TSH) stimulation (TSH > or = 30 mu IU/ml). FDG-PET and Tc-99m TF SPECT were used to detect metastatic neck LN in PTc. FDG-PET could detect all of the 13 (100%) patients with metastatic neck LN, but Tc-99m TF SPECT revealed lesions in only 8 out of 13 (61.5%) patients (p < 0.05). This study demonstrated that FDG-PET is more sensitive than Tc-99m TF SPECT to detecting metastatic neck LN in PTc with elevated serum hTg levels but negative I-131 WBS.

Yen Ruoh-fang - One of the best experts on this subject based on the ideXlab platform.

  • Detection of Recurrent Nasopharyngeal Carcinomas after Radiotherapy with Technetium-99m Tetrofosmin Single Photon Emission Computed Tomography in Patients with Indeterminate Magnetic Resonance Imaging Findings
    2009
    Co-Authors: Yen Ruoh-fang
    Abstract:

    The aim of this study is to evaluate the effectiveness of technetium-99m Tetrofosmin (Tc-99m TF) single photon emission computed tomography (SPECT) of head and neck for detecting suspected recurrence of nasopharyngeal carcinomas( NPCs) when magnetic resonance imaging (MRI) findings are indeterminate. MRI was performed 4 months after radiotherapy and 26 NPC patients with indeterminate MR1 findings were included. MRI, Tc-99m TF SPECT, and biopsy were performed within 1 week. The final results were based on histopathologic findings and clinical follow-up for at least 6 months. For detecting recurrent NPC in indeterminate MRI findings, the sensitivity, specificity, and accuracy of Tc- 99m TF SPECT were 92.3%, 100 .0%, and 96.2%, respectively. Based on this result, we can suggest Tc-99m TF SPECT is effective to detect recurrent NPC when MRI findings are indeterminate. However, further studies including a larger NPC patient population are warranted to determine the exact role and clinical usefulness of Tc-99m TF SPECT to differentiate benign lesions and recurrent NPC when MRI findings are indeterminate

Yehyou Shen - One of the best experts on this subject based on the ideXlab platform.

  • detecting metastatic neck lymph nodes in papillary thyroid carcinoma by 18f 2 deoxyglucose positron emission tomography and Tc 99m Tetrofosmin single photon emission computed tomography
    Anticancer Research, 2003
    Co-Authors: Ruohfang Yen, Yehyou Shen, Chiahung Kao
    Abstract:

    The aim of this study was to evaluate the usefulness of 18-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) and technetium-99m Tetrofosmin (Tc-99m TF) single photon emission computed tomography (SPECT) to detect metastatic neck lymph nodes (LN) in papillary thyroid carcinoma (PTc) after total thyroidectomy and radioiodine-131 (I-131) treatments in patients with elevated serum human thyroglobulin (hTg) levels but negative I-131 whole body scan (WBS). Thirteen PTc patients underwent nearly total thyroidectomy and I-131 treatments with proven neck LN metastases were included in this study. All subjects had negative I-131 WBS and elevated hTg levels (hTg > or = 10 mu IU/ml) under thyroid-stimulating hormone (TSH) stimulation (TSH > or = 30 mu IU/ml). FDG-PET and Tc-99m TF SPECT were used to detect metastatic neck LN in PTc. FDG-PET could detect all of the 13 (100%) patients with metastatic neck LN, but Tc-99m TF SPECT revealed lesions in only 8 out of 13 (61.5%) patients (p < 0.05). This study demonstrated that FDG-PET is more sensitive than Tc-99m TF SPECT to detecting metastatic neck LN in PTc with elevated serum hTg levels but negative I-131 WBS.

Yenkung Chen - One of the best experts on this subject based on the ideXlab platform.

  • compare fdg pet and Tc 99m Tetrofosmin spect to detect metastatic thyroid carcinoma1
    Academic Radiology, 2003
    Co-Authors: Yenkung Chen, Ruohfang Yen, Fengyuan Liu, Chiahung Kao
    Abstract:

    Rationale and Objectives. The effectiveness of 18-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) and technetium-99m Tetrofosmin (Tc-99m TF) single photon emission computed tomography (SPECT) of neck and chest was evaluated to detect metastatic lesions in well-differentiated thyroid carcinoma after nearly total thyroidectomy and radioiodine (I-131) treatment who present with elevated serum human thyroglobulin levels but negative I-131 whole body scan. Materials and Methods. Twenty-three patients with differentiated thyroid carcinoma who underwent nearly total thyroidectomy and I-131 treatments were included in this study. Results. All of the 23 patients had negative I-131 whole body scan and elevated human thyroglobulin levels under thyroid-stimulating hormone stimulation. Metastatic lesions were detected by FDG-PET in 20 patients, while Tc-99m TF SPECT revealed metastatic lesions in only 11 of the 20 patients. Both FDG-PET and Tc-99m TF SPECT failed to demonstrate miliary pulmonary metastases in two of the remaining three patients. The other patient did not show any lesion on FDG-PET, Tc-99m TF SPECT, chest computed tomography, or other imaging techniques. Conclusion. This study demonstrated that FDG-PET is more sensitive than Tc-99m TF SPECT to detect metastatic lesions in differentiated thyroid carcinoma with elevated human thyroglobulin but negative I-131 whole body scan. However, miliary pulmonary metastases could be missed by the both techniques.