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Jeffrey M. Hausdorff - One of the best experts on this subject based on the ideXlab platform.

  • Impact of sub-Thalamic Nucleus deep brain stimulation on dual tasking gait in Parkinson’s disease
    Journal of Neuroengineering and Rehabilitation, 2013
    Co-Authors: Eliraz Seri-fainshtat, Zvi Israel, Aner Weiss, Jeffrey M. Hausdorff
    Abstract:

    The beneficial effects of bilateral sub-Thalamic Nucleus deep brain stimulation on motor function and gait in advanced Parkinson’s disease are established. Less is known about the effect of stimulation on cognitive function and the capacity to walk while dual tasking, an ability that has been related to fall risk. Everyday walking takes place in complex environments that often require multi-tasking. Hence, dual tasking gait performance reflects everyday ambulation as well as gait automaticity. The purpose of this study was to examine the impact of sub-Thalamic Nucleus deep brain stimulation on dual task walking in patients with advanced Parkinson’s disease. Gait was assessed using a performance-based test and by quantifying single-task and dual task walking conditions in 28 patients with advanced Parkinson’s disease. These tests were conducted in 4 conditions: “OFF” medication, with the stimulator turned on and off, and “ON” medication, with the stimulator turned on and off. A previously validated, computerized neuro-psychological battery assessed executive function, attention and memory “OFF” and “ON” deep brain stimulation, after subjects took their anti-Parkinsonian medications. Stimulation improved motor function and the spatiotemporal parameters of gait (e.g., gait speed) during both single-task and dual task walking conditions. Attention improved, but executive function did not. The dual task effect on gait did not change in response to stimulation. For example, during serial 3 subtractions, gait speed was reduced by -0.20 ± 0.14 m/sec while OFF DBS and OFF meds and by -0.22 ± 0.14 m/sec when the DBS was turned on (p = 0.648). Similarly, ON medication, serial 3 subtractions reduced gait speed by -0.20 ± 0.16 m/sec OFF DBS and by -0.22 ± 0.09 m/sec ON DBS (p = 0.543). Bilateral sub-Thalamic Nucleus deep brain stimulation improves motor symptoms, certain features of gait and even some aspects of cognitive function. However, stimulation apparently fails to reduce the negative impact of a dual task on walking abilities. These findings provide new insight into the effects of deep brain stimulation on gait during cognitively challenging conditions and everyday walking.

  • impact of sub Thalamic Nucleus deep brain stimulation on dual tasking gait in parkinson s disease
    Journal of Neuroengineering and Rehabilitation, 2013
    Co-Authors: Eliraz Serifainshtat, Zvi Israel, Aner Weiss, Jeffrey M. Hausdorff
    Abstract:

    The beneficial effects of bilateral sub-Thalamic Nucleus deep brain stimulation on motor function and gait in advanced Parkinson’s disease are established. Less is known about the effect of stimulation on cognitive function and the capacity to walk while dual tasking, an ability that has been related to fall risk. Everyday walking takes place in complex environments that often require multi-tasking. Hence, dual tasking gait performance reflects everyday ambulation as well as gait automaticity. The purpose of this study was to examine the impact of sub-Thalamic Nucleus deep brain stimulation on dual task walking in patients with advanced Parkinson’s disease. Gait was assessed using a performance-based test and by quantifying single-task and dual task walking conditions in 28 patients with advanced Parkinson’s disease. These tests were conducted in 4 conditions: “OFF” medication, with the stimulator turned on and off, and “ON” medication, with the stimulator turned on and off. A previously validated, computerized neuro-psychological battery assessed executive function, attention and memory “OFF” and “ON” deep brain stimulation, after subjects took their anti-Parkinsonian medications. Stimulation improved motor function and the spatiotemporal parameters of gait (e.g., gait speed) during both single-task and dual task walking conditions. Attention improved, but executive function did not. The dual task effect on gait did not change in response to stimulation. For example, during serial 3 subtractions, gait speed was reduced by -0.20 ± 0.14 m/sec while OFF DBS and OFF meds and by -0.22 ± 0.14 m/sec when the DBS was turned on (p = 0.648). Similarly, ON medication, serial 3 subtractions reduced gait speed by -0.20 ± 0.16 m/sec OFF DBS and by -0.22 ± 0.09 m/sec ON DBS (p = 0.543). Bilateral sub-Thalamic Nucleus deep brain stimulation improves motor symptoms, certain features of gait and even some aspects of cognitive function. However, stimulation apparently fails to reduce the negative impact of a dual task on walking abilities. These findings provide new insight into the effects of deep brain stimulation on gait during cognitively challenging conditions and everyday walking.

Andres M. Lozano - One of the best experts on this subject based on the ideXlab platform.

  • Bilateral Anterior Thalamic Nucleus Lesions Are Not Protective against Seizures in Chronic Pilocarpine Epileptic Rats
    Stereotactic and Functional Neurosurgery, 2009
    Co-Authors: Clement Hamani, Flavio I.s. Ewerton, Flávia Marcolin De Almeida, Saulo M. Bonilha, Luciene Covolan, Clarissa F. Cavarsan, Gerson Ballester, Luiz E. Mello, Andres M. Lozano
    Abstract:

    Aims: To investigate whether anterior Thalamic Nucleus (AN) lesions are protective against spontaneous recurrent seizures in the chronic phase of the pilocarpine model of epilepsy.

  • bilateral anterior Thalamic Nucleus lesions and high frequency stimulation are protective against pilocarpine induced seizures and status epilepticus
    Neurosurgery, 2004
    Co-Authors: Clement Hamani, Flavio I.s. Ewerton, Saulo M. Bonilha, Gerson Ballester, Luiz E. Mello, Andres M. Lozano
    Abstract:

    OBJECTIVE: The thalamus is thought to play an important role in secondary generalization of seizures. The aim of the present study was to investigate the influence of anterior Thalamic Nucleus lesions and high-frequency stimulation in the pilocarpine model of secondarily generalized selzures in rats. METHODS: Adult Wistar rats underwent unilateral (n = 7) or bilateral anterior Nucleus thalamotomies (n = 10), or unilateral (n = 4) or bilateral (n = 9) anterior Thalamic Nucleus stimulation through implanted electrodes. Control animals (n = 9) received bilateral implants but no stimulation. Seven days after these procedures, animals were provided pilocarpine (320 mg/kg intraperitoneally) to induce seizures and status epilepticus (SE). Electrographic recordings from hippocampal and cortical electrodes were evaluated, and ictal behavior was assessed. RESULTS: In the control group, 67% of the animals developed SE 15.3 ± 8.8 minutes after pilocarpine administration. Neither unilateral anterior Nucleus lesions nor stimulation significantly reduced the propensity or latency for developing seizures and SE. Thalamic stimulation did not prevent SE (observed in 56% of the animals), but it significantly prolonged the latency to its development (48.4 ± 17,7 min, P = 0.02). Strikingly, no animal with bilateral anterior Nucleus thalamotomies developed seizures or SE with pilocarpine. CONCLUSION: Bilateral anterior Thalamic nuclear complex stimulation and thalamotomies were protective against SE induced by pilocarpine.

  • bilateral anterior Thalamic Nucleus lesions and high frequency stimulation are protective against pilocarpine induced seizures and status epilepticus
    Neurosurgery, 2004
    Co-Authors: Clement Hamani, Flavio I.s. Ewerton, Saulo M. Bonilha, Gerson Ballester, Luiz E. Mello, Andres M. Lozano
    Abstract:

    OBJECTIVE: The thalamus is thought to play an important role in secondary generalization of seizures. The aim of the present study was to investigate the influence of anterior Thalamic Nucleus lesions and high-frequency stimulation in the pilocarpine model of secondarily generalized seizures in rats. METHODS: Adult Wistar rats underwent unilateral (n = 7) or bilateral anterior Nucleus thalamotomies (n = 10), or unilateral (n = 4) or bilateral (n = 9) anterior Thalamic Nucleus stimulation through implanted electrodes. Control animals (n = 9) received bilateral implants but no stimulation. Seven days after these procedures, animals were provided pilocarpine (320 mg/kg intraperitoneally) to induce seizures and status epilepticus (SE). Electrographic recordings from hippocampal and cortical electrodes were evaluated, and ictal behavior was assessed. RESULTS: In the control group, 67% of the animals developed SE 15.3 +/- 8.8 minutes after pilocarpine administration. Neither unilateral anterior Nucleus lesions nor stimulation significantly reduced the propensity or latency for developing seizures and SE. Bilateral Thalamic stimulation did not prevent SE (observed in 56% of the animals), but it significantly prolonged the latency to its development (48.4 +/- 17.7 min, P = 0.02). Strikingly, no animal with bilateral anterior Nucleus thalamotomies developed seizures or SE with pilocarpine. CONCLUSION: Bilateral anterior Thalamic nuclear complex stimulation and thalamotomies were protective against SE induced by pilocarpine.

Clement Hamani - One of the best experts on this subject based on the ideXlab platform.

  • Bilateral Anterior Thalamic Nucleus Lesions Are Not Protective against Seizures in Chronic Pilocarpine Epileptic Rats
    Stereotactic and Functional Neurosurgery, 2009
    Co-Authors: Clement Hamani, Flavio I.s. Ewerton, Flávia Marcolin De Almeida, Saulo M. Bonilha, Luciene Covolan, Clarissa F. Cavarsan, Gerson Ballester, Luiz E. Mello, Andres M. Lozano
    Abstract:

    Aims: To investigate whether anterior Thalamic Nucleus (AN) lesions are protective against spontaneous recurrent seizures in the chronic phase of the pilocarpine model of epilepsy.

  • bilateral anterior Thalamic Nucleus lesions and high frequency stimulation are protective against pilocarpine induced seizures and status epilepticus
    Neurosurgery, 2004
    Co-Authors: Clement Hamani, Flavio I.s. Ewerton, Saulo M. Bonilha, Gerson Ballester, Luiz E. Mello, Andres M. Lozano
    Abstract:

    OBJECTIVE: The thalamus is thought to play an important role in secondary generalization of seizures. The aim of the present study was to investigate the influence of anterior Thalamic Nucleus lesions and high-frequency stimulation in the pilocarpine model of secondarily generalized selzures in rats. METHODS: Adult Wistar rats underwent unilateral (n = 7) or bilateral anterior Nucleus thalamotomies (n = 10), or unilateral (n = 4) or bilateral (n = 9) anterior Thalamic Nucleus stimulation through implanted electrodes. Control animals (n = 9) received bilateral implants but no stimulation. Seven days after these procedures, animals were provided pilocarpine (320 mg/kg intraperitoneally) to induce seizures and status epilepticus (SE). Electrographic recordings from hippocampal and cortical electrodes were evaluated, and ictal behavior was assessed. RESULTS: In the control group, 67% of the animals developed SE 15.3 ± 8.8 minutes after pilocarpine administration. Neither unilateral anterior Nucleus lesions nor stimulation significantly reduced the propensity or latency for developing seizures and SE. Thalamic stimulation did not prevent SE (observed in 56% of the animals), but it significantly prolonged the latency to its development (48.4 ± 17,7 min, P = 0.02). Strikingly, no animal with bilateral anterior Nucleus thalamotomies developed seizures or SE with pilocarpine. CONCLUSION: Bilateral anterior Thalamic nuclear complex stimulation and thalamotomies were protective against SE induced by pilocarpine.

  • bilateral anterior Thalamic Nucleus lesions and high frequency stimulation are protective against pilocarpine induced seizures and status epilepticus
    Neurosurgery, 2004
    Co-Authors: Clement Hamani, Flavio I.s. Ewerton, Saulo M. Bonilha, Gerson Ballester, Luiz E. Mello, Andres M. Lozano
    Abstract:

    OBJECTIVE: The thalamus is thought to play an important role in secondary generalization of seizures. The aim of the present study was to investigate the influence of anterior Thalamic Nucleus lesions and high-frequency stimulation in the pilocarpine model of secondarily generalized seizures in rats. METHODS: Adult Wistar rats underwent unilateral (n = 7) or bilateral anterior Nucleus thalamotomies (n = 10), or unilateral (n = 4) or bilateral (n = 9) anterior Thalamic Nucleus stimulation through implanted electrodes. Control animals (n = 9) received bilateral implants but no stimulation. Seven days after these procedures, animals were provided pilocarpine (320 mg/kg intraperitoneally) to induce seizures and status epilepticus (SE). Electrographic recordings from hippocampal and cortical electrodes were evaluated, and ictal behavior was assessed. RESULTS: In the control group, 67% of the animals developed SE 15.3 +/- 8.8 minutes after pilocarpine administration. Neither unilateral anterior Nucleus lesions nor stimulation significantly reduced the propensity or latency for developing seizures and SE. Bilateral Thalamic stimulation did not prevent SE (observed in 56% of the animals), but it significantly prolonged the latency to its development (48.4 +/- 17.7 min, P = 0.02). Strikingly, no animal with bilateral anterior Nucleus thalamotomies developed seizures or SE with pilocarpine. CONCLUSION: Bilateral anterior Thalamic nuclear complex stimulation and thalamotomies were protective against SE induced by pilocarpine.

Eliraz Serifainshtat - One of the best experts on this subject based on the ideXlab platform.

  • impact of sub Thalamic Nucleus deep brain stimulation on dual tasking gait in parkinson s disease
    Journal of Neuroengineering and Rehabilitation, 2013
    Co-Authors: Eliraz Serifainshtat, Zvi Israel, Aner Weiss, Jeffrey M. Hausdorff
    Abstract:

    The beneficial effects of bilateral sub-Thalamic Nucleus deep brain stimulation on motor function and gait in advanced Parkinson’s disease are established. Less is known about the effect of stimulation on cognitive function and the capacity to walk while dual tasking, an ability that has been related to fall risk. Everyday walking takes place in complex environments that often require multi-tasking. Hence, dual tasking gait performance reflects everyday ambulation as well as gait automaticity. The purpose of this study was to examine the impact of sub-Thalamic Nucleus deep brain stimulation on dual task walking in patients with advanced Parkinson’s disease. Gait was assessed using a performance-based test and by quantifying single-task and dual task walking conditions in 28 patients with advanced Parkinson’s disease. These tests were conducted in 4 conditions: “OFF” medication, with the stimulator turned on and off, and “ON” medication, with the stimulator turned on and off. A previously validated, computerized neuro-psychological battery assessed executive function, attention and memory “OFF” and “ON” deep brain stimulation, after subjects took their anti-Parkinsonian medications. Stimulation improved motor function and the spatiotemporal parameters of gait (e.g., gait speed) during both single-task and dual task walking conditions. Attention improved, but executive function did not. The dual task effect on gait did not change in response to stimulation. For example, during serial 3 subtractions, gait speed was reduced by -0.20 ± 0.14 m/sec while OFF DBS and OFF meds and by -0.22 ± 0.14 m/sec when the DBS was turned on (p = 0.648). Similarly, ON medication, serial 3 subtractions reduced gait speed by -0.20 ± 0.16 m/sec OFF DBS and by -0.22 ± 0.09 m/sec ON DBS (p = 0.543). Bilateral sub-Thalamic Nucleus deep brain stimulation improves motor symptoms, certain features of gait and even some aspects of cognitive function. However, stimulation apparently fails to reduce the negative impact of a dual task on walking abilities. These findings provide new insight into the effects of deep brain stimulation on gait during cognitively challenging conditions and everyday walking.

Flavio I.s. Ewerton - One of the best experts on this subject based on the ideXlab platform.

  • Bilateral Anterior Thalamic Nucleus Lesions Are Not Protective against Seizures in Chronic Pilocarpine Epileptic Rats
    Stereotactic and Functional Neurosurgery, 2009
    Co-Authors: Clement Hamani, Flavio I.s. Ewerton, Flávia Marcolin De Almeida, Saulo M. Bonilha, Luciene Covolan, Clarissa F. Cavarsan, Gerson Ballester, Luiz E. Mello, Andres M. Lozano
    Abstract:

    Aims: To investigate whether anterior Thalamic Nucleus (AN) lesions are protective against spontaneous recurrent seizures in the chronic phase of the pilocarpine model of epilepsy.

  • bilateral anterior Thalamic Nucleus lesions and high frequency stimulation are protective against pilocarpine induced seizures and status epilepticus
    Neurosurgery, 2004
    Co-Authors: Clement Hamani, Flavio I.s. Ewerton, Saulo M. Bonilha, Gerson Ballester, Luiz E. Mello, Andres M. Lozano
    Abstract:

    OBJECTIVE: The thalamus is thought to play an important role in secondary generalization of seizures. The aim of the present study was to investigate the influence of anterior Thalamic Nucleus lesions and high-frequency stimulation in the pilocarpine model of secondarily generalized selzures in rats. METHODS: Adult Wistar rats underwent unilateral (n = 7) or bilateral anterior Nucleus thalamotomies (n = 10), or unilateral (n = 4) or bilateral (n = 9) anterior Thalamic Nucleus stimulation through implanted electrodes. Control animals (n = 9) received bilateral implants but no stimulation. Seven days after these procedures, animals were provided pilocarpine (320 mg/kg intraperitoneally) to induce seizures and status epilepticus (SE). Electrographic recordings from hippocampal and cortical electrodes were evaluated, and ictal behavior was assessed. RESULTS: In the control group, 67% of the animals developed SE 15.3 ± 8.8 minutes after pilocarpine administration. Neither unilateral anterior Nucleus lesions nor stimulation significantly reduced the propensity or latency for developing seizures and SE. Thalamic stimulation did not prevent SE (observed in 56% of the animals), but it significantly prolonged the latency to its development (48.4 ± 17,7 min, P = 0.02). Strikingly, no animal with bilateral anterior Nucleus thalamotomies developed seizures or SE with pilocarpine. CONCLUSION: Bilateral anterior Thalamic nuclear complex stimulation and thalamotomies were protective against SE induced by pilocarpine.

  • bilateral anterior Thalamic Nucleus lesions and high frequency stimulation are protective against pilocarpine induced seizures and status epilepticus
    Neurosurgery, 2004
    Co-Authors: Clement Hamani, Flavio I.s. Ewerton, Saulo M. Bonilha, Gerson Ballester, Luiz E. Mello, Andres M. Lozano
    Abstract:

    OBJECTIVE: The thalamus is thought to play an important role in secondary generalization of seizures. The aim of the present study was to investigate the influence of anterior Thalamic Nucleus lesions and high-frequency stimulation in the pilocarpine model of secondarily generalized seizures in rats. METHODS: Adult Wistar rats underwent unilateral (n = 7) or bilateral anterior Nucleus thalamotomies (n = 10), or unilateral (n = 4) or bilateral (n = 9) anterior Thalamic Nucleus stimulation through implanted electrodes. Control animals (n = 9) received bilateral implants but no stimulation. Seven days after these procedures, animals were provided pilocarpine (320 mg/kg intraperitoneally) to induce seizures and status epilepticus (SE). Electrographic recordings from hippocampal and cortical electrodes were evaluated, and ictal behavior was assessed. RESULTS: In the control group, 67% of the animals developed SE 15.3 +/- 8.8 minutes after pilocarpine administration. Neither unilateral anterior Nucleus lesions nor stimulation significantly reduced the propensity or latency for developing seizures and SE. Bilateral Thalamic stimulation did not prevent SE (observed in 56% of the animals), but it significantly prolonged the latency to its development (48.4 +/- 17.7 min, P = 0.02). Strikingly, no animal with bilateral anterior Nucleus thalamotomies developed seizures or SE with pilocarpine. CONCLUSION: Bilateral anterior Thalamic nuclear complex stimulation and thalamotomies were protective against SE induced by pilocarpine.