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Cees A Visser - One of the best experts on this subject based on the ideXlab platform.

  • prediction of recovery of myocardial dysfunction after revascularization comparison of fluorine 18 fluorodeoxyglucose Thallium 201 spect Thallium 201 stress reinjection spect and dobutamine echocardiography
    Journal of the American College of Cardiology, 1996
    Co-Authors: Jan H Cornel, Frans C Visser, Paolo M Fioretti, Arthur Van Lingen, Ambroos E M Reijs, Eric Boersma, Gerrit J J Teule, Cees A Visser
    Abstract:

    Abstract Objectives. We compared three techniques to predict functional recovery after revascularization. Background. Recently, fluorine-18 (F-18) fluorodeoxyglucose in combination with single-photon emission computed tomography (SPECT) has been proposed to identify viable myocardium. Thallium-201 reinjection and low dose dobutamine echocardiography are used routinely for this purpose. Methods. Seventeen patients (mean [±SD] left ventricular ejection fraction 36 ± 11%) were studied. Regional and global ventricular function were evaluated before and 3 months after revascularization by echocardiography and radionuclide ventriculography, respectively. Myocardial F-18 fluorodeoxyglucose uptake (during hyperinsulinemic glucose clamping) was compared with rest perfusion assessed with early Thallium-201 SPECT. On a separate day, low dose dobutamine echocardiography and post-stress Thallium-201 reinjection SPECT were simultaneously performed. Results. The sensitivities for F-18 fluorodeoxyglucose/Thallium-201, Thallium-201 reinjection and low dose dobutamine echocardiography to assess recovery were 89%, 93% and 85%, respectively; specificities were 77%, 43% and 63%, respectively. Stepwise logistic regression indicated that F-18 fluorodeoxyglucose/Thallium-201 was the best predictor. In hypokinetic segments, the combination of F-18 fluorodeoxyglucose/Thallium-201 and low dose dobutamine echocardiography was the best predictor. Global function improved (left ventricular ejection fraction increased > 5%) in 6 patients and remained unchanged in 11. All three techniques correctly identified five of six patients with improvement. Fluorine-18 fluorodeoxyglucose/Thallium-201 identified all patients without improvement; low dose dobutamine echocardiography identified 9 of 11 without improvement; and Thallium-201 reinjection identified 6 of 11 patients without improvement. Conclusions. Fluorine-18 fluorodeoxyglucose/Thallium-201 SPECT was superior to the other techniques in assessing functional recovery. Integration of metabolic and functional data is necessary, particularly in hypokinesia, for optimal prediction of improvement of regional function.

  • Prediction of recovery of myocardial dysfunction after revascularization. Comparison of fluorine-18 fluorodeoxyglucose/Thallium-201 SPECT, Thallium-201 stress-reinjection SPECT and dobutamine echocardiography.
    Journal of the American College of Cardiology, 1996
    Co-Authors: Jan H Cornel, Frans C Visser, Paolo M Fioretti, Arthur Van Lingen, Ambroos E M Reijs, Eric Boersma, Gerrit J J Teule, Cees A Visser
    Abstract:

    Abstract Objectives. We compared three techniques to predict functional recovery after revascularization. Background. Recently, fluorine-18 (F-18) fluorodeoxyglucose in combination with single-photon emission computed tomography (SPECT) has been proposed to identify viable myocardium. Thallium-201 reinjection and low dose dobutamine echocardiography are used routinely for this purpose. Methods. Seventeen patients (mean [±SD] left ventricular ejection fraction 36 ± 11%) were studied. Regional and global ventricular function were evaluated before and 3 months after revascularization by echocardiography and radionuclide ventriculography, respectively. Myocardial F-18 fluorodeoxyglucose uptake (during hyperinsulinemic glucose clamping) was compared with rest perfusion assessed with early Thallium-201 SPECT. On a separate day, low dose dobutamine echocardiography and post-stress Thallium-201 reinjection SPECT were simultaneously performed. Results. The sensitivities for F-18 fluorodeoxyglucose/Thallium-201, Thallium-201 reinjection and low dose dobutamine echocardiography to assess recovery were 89%, 93% and 85%, respectively; specificities were 77%, 43% and 63%, respectively. Stepwise logistic regression indicated that F-18 fluorodeoxyglucose/Thallium-201 was the best predictor. In hypokinetic segments, the combination of F-18 fluorodeoxyglucose/Thallium-201 and low dose dobutamine echocardiography was the best predictor. Global function improved (left ventricular ejection fraction increased > 5%) in 6 patients and remained unchanged in 11. All three techniques correctly identified five of six patients with improvement. Fluorine-18 fluorodeoxyglucose/Thallium-201 identified all patients without improvement; low dose dobutamine echocardiography identified 9 of 11 without improvement; and Thallium-201 reinjection identified 6 of 11 patients without improvement. Conclusions. Fluorine-18 fluorodeoxyglucose/Thallium-201 SPECT was superior to the other techniques in assessing functional recovery. Integration of metabolic and functional data is necessary, particularly in hypokinesia, for optimal prediction of improvement of regional function.

Jan H Cornel - One of the best experts on this subject based on the ideXlab platform.

  • prediction of recovery of myocardial dysfunction after revascularization comparison of fluorine 18 fluorodeoxyglucose Thallium 201 spect Thallium 201 stress reinjection spect and dobutamine echocardiography
    Journal of the American College of Cardiology, 1996
    Co-Authors: Jan H Cornel, Frans C Visser, Paolo M Fioretti, Arthur Van Lingen, Ambroos E M Reijs, Eric Boersma, Gerrit J J Teule, Cees A Visser
    Abstract:

    Abstract Objectives. We compared three techniques to predict functional recovery after revascularization. Background. Recently, fluorine-18 (F-18) fluorodeoxyglucose in combination with single-photon emission computed tomography (SPECT) has been proposed to identify viable myocardium. Thallium-201 reinjection and low dose dobutamine echocardiography are used routinely for this purpose. Methods. Seventeen patients (mean [±SD] left ventricular ejection fraction 36 ± 11%) were studied. Regional and global ventricular function were evaluated before and 3 months after revascularization by echocardiography and radionuclide ventriculography, respectively. Myocardial F-18 fluorodeoxyglucose uptake (during hyperinsulinemic glucose clamping) was compared with rest perfusion assessed with early Thallium-201 SPECT. On a separate day, low dose dobutamine echocardiography and post-stress Thallium-201 reinjection SPECT were simultaneously performed. Results. The sensitivities for F-18 fluorodeoxyglucose/Thallium-201, Thallium-201 reinjection and low dose dobutamine echocardiography to assess recovery were 89%, 93% and 85%, respectively; specificities were 77%, 43% and 63%, respectively. Stepwise logistic regression indicated that F-18 fluorodeoxyglucose/Thallium-201 was the best predictor. In hypokinetic segments, the combination of F-18 fluorodeoxyglucose/Thallium-201 and low dose dobutamine echocardiography was the best predictor. Global function improved (left ventricular ejection fraction increased > 5%) in 6 patients and remained unchanged in 11. All three techniques correctly identified five of six patients with improvement. Fluorine-18 fluorodeoxyglucose/Thallium-201 identified all patients without improvement; low dose dobutamine echocardiography identified 9 of 11 without improvement; and Thallium-201 reinjection identified 6 of 11 patients without improvement. Conclusions. Fluorine-18 fluorodeoxyglucose/Thallium-201 SPECT was superior to the other techniques in assessing functional recovery. Integration of metabolic and functional data is necessary, particularly in hypokinesia, for optimal prediction of improvement of regional function.

  • Prediction of recovery of myocardial dysfunction after revascularization. Comparison of fluorine-18 fluorodeoxyglucose/Thallium-201 SPECT, Thallium-201 stress-reinjection SPECT and dobutamine echocardiography.
    Journal of the American College of Cardiology, 1996
    Co-Authors: Jan H Cornel, Frans C Visser, Paolo M Fioretti, Arthur Van Lingen, Ambroos E M Reijs, Eric Boersma, Gerrit J J Teule, Cees A Visser
    Abstract:

    Abstract Objectives. We compared three techniques to predict functional recovery after revascularization. Background. Recently, fluorine-18 (F-18) fluorodeoxyglucose in combination with single-photon emission computed tomography (SPECT) has been proposed to identify viable myocardium. Thallium-201 reinjection and low dose dobutamine echocardiography are used routinely for this purpose. Methods. Seventeen patients (mean [±SD] left ventricular ejection fraction 36 ± 11%) were studied. Regional and global ventricular function were evaluated before and 3 months after revascularization by echocardiography and radionuclide ventriculography, respectively. Myocardial F-18 fluorodeoxyglucose uptake (during hyperinsulinemic glucose clamping) was compared with rest perfusion assessed with early Thallium-201 SPECT. On a separate day, low dose dobutamine echocardiography and post-stress Thallium-201 reinjection SPECT were simultaneously performed. Results. The sensitivities for F-18 fluorodeoxyglucose/Thallium-201, Thallium-201 reinjection and low dose dobutamine echocardiography to assess recovery were 89%, 93% and 85%, respectively; specificities were 77%, 43% and 63%, respectively. Stepwise logistic regression indicated that F-18 fluorodeoxyglucose/Thallium-201 was the best predictor. In hypokinetic segments, the combination of F-18 fluorodeoxyglucose/Thallium-201 and low dose dobutamine echocardiography was the best predictor. Global function improved (left ventricular ejection fraction increased > 5%) in 6 patients and remained unchanged in 11. All three techniques correctly identified five of six patients with improvement. Fluorine-18 fluorodeoxyglucose/Thallium-201 identified all patients without improvement; low dose dobutamine echocardiography identified 9 of 11 without improvement; and Thallium-201 reinjection identified 6 of 11 patients without improvement. Conclusions. Fluorine-18 fluorodeoxyglucose/Thallium-201 SPECT was superior to the other techniques in assessing functional recovery. Integration of metabolic and functional data is necessary, particularly in hypokinesia, for optimal prediction of improvement of regional function.

Takayuki Shibutani - One of the best experts on this subject based on the ideXlab platform.

A Labbate - One of the best experts on this subject based on the ideXlab platform.

  • value of rest Thallium 201 technetium 99m sestamibi scans and dobutamine echocardiography for detecting myocardial viability
    American Journal of Cardiology, 1993
    Co-Authors: Paolo Marzullo, Oberdan Parodi, Gianmario Sambuceti, Barbara Reisenhofer, Eugenio Picano, A Distante, Alessia Gimelli, A Labbate
    Abstract:

    Abstract The relation between radioisotopic and echocardiographic markers of myocardial viability and postrevascularization recovery of function is still to be defined. To this purpose, 14 patients (11 men, 3 women, aged 35 to 64 years, mean 54 ± 7) with ventricular dysfunction were studied by a multiparametric approach. Each patient underwent, on separate days, rest Thallium-201 and technetium-99m sestamibi scintigraphy, dobutamine echocardiography and coronary angiography. Coronary angiography was analyzed by a quantitative approach. Thallium uptake at rest was quantified from planar early (10-minute) and delayed (16-hour) Thallium-201 images and expressed as a percentage of maximal activity in each projection using a 13-segment model. Sestamibi uptake was expressed in the same way. Dobutamine (up to 10 μg/kg/min) echocardiography was analyzed using a score index ranging from 1 (normokinesia) to 4 (dyskinesia) and a similar segmental model. Before revascularization 50 segments were grouped as normal (coronary stenosis 50% coronary stenosis, 57 had normal wall motion (group 2) and 75 showed regional dyssynergies (group 3). Early and delayed Thallium-201 regional percent activities did not differ in group 1 and in group 2 but were significantly less in group 3 segments. Sestamibi percent activity was more in group 1 and significantly reduced both in group 2 and 3 segments. Segments with improved wall motion after dobutamine had more early, delayed Thallium-201 and sestamibi percent activities than unresponsive segments. Postrevascularization echocardiography was performed in all patients. Delayed Thallium-201 scans and dobutamine echocardiography showed good sensitivity and specificity in detecting viable myocardium. It is concluded that: (1) rest-injected, delayed Thallium-201 scan provides a good preoperative characterization of viable myocardium; (2) sestamibi does not differentiate dyssynergic from normal segments in territories supplied by stenotic coronary arteries; and (3) dobutamine echocardiography is similar to delayed Thallium-201 scintigraphy in predicting myocardial viability.

Mario S. Verani - One of the best experts on this subject based on the ideXlab platform.

  • Adenosine Thallium 201 myocardial perfusion scintigraphy.
    American heart journal, 1991
    Co-Authors: Mario S. Verani
    Abstract:

    Pharmacologic coronary vasodilation as an adjunct to myocardial perfusion imaging has become increasingly important in the evaluation of patients with coronary artery disease, in view of the large number of patients who cannot perform an adequate exercise test or in whom contraindications render exercise inappropriate. Adenosine is a very potent coronary vasodilator and when combined with Thallium 201 scintigraphy produces images of high quality, with the added advantages of a very short half-life (less than 10 seconds) and the ability to adjust the dose during the infusion, which may enhance safety and curtail the duration of side effects. The reported sensitivity and specificity of adenosine Thallium 201 scintigraphy for the detection of coronary artery disease are high and at least comparable with imaging after exercise or dipyridamole administration.

  • Adenosine Thallium 201 myocardial perfusion scintigraphy
    American Heart Journal, 1991
    Co-Authors: Mario S. Verani
    Abstract:

    Pharmacologic coronary vasodilation as an adjunct to myocardial perfusion imaging has become increasingly important in the evaluation of patients with coronary artery disease, in view of the large number of patients who cannot perform an adequate exercise test or in whom contraindications render exercise inappropriate. Adenosine is a very potent coronary vasodilator and when combined with Thallium 201 scintigraphy produces images of high quality, with the added advantages of a very short half-life (