The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Stephen T. Holgate - One of the best experts on this subject based on the ideXlab platform.
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Effects of Theophylline on inflammatory cells and cytokines in asthmatic subjects: a placebo-controlled parallel group study.
The European respiratory journal, 1996Co-Authors: J.p. Finnerty, C. Lee, Susan J. Wilson, J. Madden, Ratko Djukanovic, Stephen T. HolgateAbstract:The anti-inflammatory effects of oral Theophylline on cells in bronchial biopsies of symptomatic atopic asthmatic subjects were investigated. Following a 2 week run-in period, asthmatic subjects were randomly assigned to either placebo (n=11) or Theophylline (n=15). Bronchial biopsies were taken at fibre-optic bronchoscopy at the beginning and end of a 6 week period, during which subjects took placebo or Theophylline medication at a dose intended to produce therapeutic concentrations. Nine of the placebo subjects and 12 of the Theophylline subjects completed the study. Improvement in asthma control was seen in the Theophylline-treated group. The mean (SD) Theophylline Blood Level at the end of the study was 10.9 (6.0) microg x mL-1. A significant decrease in interleukin (IL)4 expression from 1.38 to 1.04 cells x mm-2 (
Gordon L. Snider - One of the best experts on this subject based on the ideXlab platform.
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Theophylline in the ambulatory treatment of chronic obstructive lung disease: resolving a controversy.
Cleveland Clinic journal of medicine, 1993Co-Authors: Gordon L. SniderAbstract:BACKGROUND Recent reports of a high frequency of Theophylline toxicity, which usually occurs at Theophylline Blood Levels >20 μg/mL, coupled with the recent addition of metered-dose, inhaled anticholinergics to the beta-2 agonist inhalers already available for treatment of chronic obstructive pulmonary disease, has led some authors to suggest that Theophylline should no longer be used in the ambulatory management of this disease. OBJECTIVE The author suggests an alternate approach to Theophylline dosing as a means of resolving the current controversy. SUMMARY Because of the log-linear relationship between bronchodilation and Blood Level, little bronchodilator efficacy is lost by using a target therapeutic Theophylline Blood Level of 10 ± 2 μg/mL. This target provides a greater range between therapeutic and toxic Blood Levels than the 17 ± 2 μg/mL therapeutic target Blood Level that has also been recommended. CONCLUSIONS Because Theophylline has a different mode of action than the sympathomimetic or anticholinergic drugs, it continues to have a useful place in the ambulatory management of chronic obstructive pulmonary disease. Reports of Theophylline toxicity and the arrival of newer agents have caused some to advocate abandoning Theophylline for the treatment of COPD. An alternative is offered.
J.p. Finnerty - One of the best experts on this subject based on the ideXlab platform.
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Effects of Theophylline on inflammatory cells and cytokines in asthmatic subjects: a placebo-controlled parallel group study.
The European respiratory journal, 1996Co-Authors: J.p. Finnerty, C. Lee, Susan J. Wilson, J. Madden, Ratko Djukanovic, Stephen T. HolgateAbstract:The anti-inflammatory effects of oral Theophylline on cells in bronchial biopsies of symptomatic atopic asthmatic subjects were investigated. Following a 2 week run-in period, asthmatic subjects were randomly assigned to either placebo (n=11) or Theophylline (n=15). Bronchial biopsies were taken at fibre-optic bronchoscopy at the beginning and end of a 6 week period, during which subjects took placebo or Theophylline medication at a dose intended to produce therapeutic concentrations. Nine of the placebo subjects and 12 of the Theophylline subjects completed the study. Improvement in asthma control was seen in the Theophylline-treated group. The mean (SD) Theophylline Blood Level at the end of the study was 10.9 (6.0) microg x mL-1. A significant decrease in interleukin (IL)4 expression from 1.38 to 1.04 cells x mm-2 (
Ratko Djukanovic - One of the best experts on this subject based on the ideXlab platform.
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Effects of Theophylline on inflammatory cells and cytokines in asthmatic subjects: a placebo-controlled parallel group study.
The European respiratory journal, 1996Co-Authors: J.p. Finnerty, C. Lee, Susan J. Wilson, J. Madden, Ratko Djukanovic, Stephen T. HolgateAbstract:The anti-inflammatory effects of oral Theophylline on cells in bronchial biopsies of symptomatic atopic asthmatic subjects were investigated. Following a 2 week run-in period, asthmatic subjects were randomly assigned to either placebo (n=11) or Theophylline (n=15). Bronchial biopsies were taken at fibre-optic bronchoscopy at the beginning and end of a 6 week period, during which subjects took placebo or Theophylline medication at a dose intended to produce therapeutic concentrations. Nine of the placebo subjects and 12 of the Theophylline subjects completed the study. Improvement in asthma control was seen in the Theophylline-treated group. The mean (SD) Theophylline Blood Level at the end of the study was 10.9 (6.0) microg x mL-1. A significant decrease in interleukin (IL)4 expression from 1.38 to 1.04 cells x mm-2 (
J. Madden - One of the best experts on this subject based on the ideXlab platform.
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Effects of Theophylline on inflammatory cells and cytokines in asthmatic subjects: a placebo-controlled parallel group study.
The European respiratory journal, 1996Co-Authors: J.p. Finnerty, C. Lee, Susan J. Wilson, J. Madden, Ratko Djukanovic, Stephen T. HolgateAbstract:The anti-inflammatory effects of oral Theophylline on cells in bronchial biopsies of symptomatic atopic asthmatic subjects were investigated. Following a 2 week run-in period, asthmatic subjects were randomly assigned to either placebo (n=11) or Theophylline (n=15). Bronchial biopsies were taken at fibre-optic bronchoscopy at the beginning and end of a 6 week period, during which subjects took placebo or Theophylline medication at a dose intended to produce therapeutic concentrations. Nine of the placebo subjects and 12 of the Theophylline subjects completed the study. Improvement in asthma control was seen in the Theophylline-treated group. The mean (SD) Theophylline Blood Level at the end of the study was 10.9 (6.0) microg x mL-1. A significant decrease in interleukin (IL)4 expression from 1.38 to 1.04 cells x mm-2 (