The Experts below are selected from a list of 63 Experts worldwide ranked by ideXlab platform
S.j. Czuczwar - One of the best experts on this subject based on the ideXlab platform.
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Influence of aminophylline and 8-(p-sulfophenyl)Theophylline on the anticonvulsive action of diphenylhydantoin, phenobarbital, and valproate against maximal electroshock-induced convulsions in mice
Journal of Neural Transmission, 1993Co-Authors: Kinga K. Borowicz, Kozicka M, Zdzisław Kleinrok, S.j. CzuczwarAbstract:Aminophylline (Theophylline2·ethylenediamine) in the dose of 12.5 mg/kg (i.p.) was ineffective upon all antiepileptic drugs studied and at the higher dose of 25 mg/kg, impaired the anticonvulsant action of phenobarbital and valproate against maximal electroshock in mice. The protection offered by diphenylhydantoin was diminished by aminophylline at 50 mg/kg (0.238 mmol of anhydrous Theophylline/kg). In contrast, 8-(p-sulfophenyl)Theophylline (a Theophylline Derivative unable to cross the blood-brain barrier) in the dose of 80 mg/kg (0.238 mmol/kg) did not influence the protective activity of diphenylhydantoin, phenobarbital, and valproate.
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Influence of aminophylline and 8-(p-sulfophenyl)Theophylline on the anticonvulsive action of diphenylhydantoin, phenobarbital, and valproate against maximal electroshock-induced convulsions in mice
Journal of Neural Transmission General Section JNT, 1993Co-Authors: Kinga K. Borowicz, Zdzisław Kleinrok, M. Kozicka, S.j. CzuczwarAbstract:Aminophylline (Theophylline_2·ethylenediamine) in the dose of 12.5 mg/kg (i.p.) was ineffective upon all antiepileptic drugs studied and at the higher dose of 25 mg/kg, impaired the anticonvulsant action of phenobarbital and valproate against maximal electroshock in mice. The protection offered by diphenylhydantoin was diminished by aminophylline at 50 mg/kg (0.238 mmol of anhydrous Theophylline/kg). In contrast, 8-(p-sulfophenyl)Theophylline (a Theophylline Derivative unable to cross the blood-brain barrier) in the dose of 80 mg/kg (0.238 mmol/kg) did not influence the protective activity of diphenylhydantoin, phenobarbital, and valproate. It might be concluded that the aminophylline-induced impairment of the anticonvulsant action of common antiepileptic drugs results from the central effects of this methylxanthine.
Kinga K. Borowicz - One of the best experts on this subject based on the ideXlab platform.
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Influence of aminophylline and 8-(p-sulfophenyl)Theophylline on the anticonvulsive action of diphenylhydantoin, phenobarbital, and valproate against maximal electroshock-induced convulsions in mice
Journal of Neural Transmission, 1993Co-Authors: Kinga K. Borowicz, Kozicka M, Zdzisław Kleinrok, S.j. CzuczwarAbstract:Aminophylline (Theophylline2·ethylenediamine) in the dose of 12.5 mg/kg (i.p.) was ineffective upon all antiepileptic drugs studied and at the higher dose of 25 mg/kg, impaired the anticonvulsant action of phenobarbital and valproate against maximal electroshock in mice. The protection offered by diphenylhydantoin was diminished by aminophylline at 50 mg/kg (0.238 mmol of anhydrous Theophylline/kg). In contrast, 8-(p-sulfophenyl)Theophylline (a Theophylline Derivative unable to cross the blood-brain barrier) in the dose of 80 mg/kg (0.238 mmol/kg) did not influence the protective activity of diphenylhydantoin, phenobarbital, and valproate.
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Influence of aminophylline and 8-(p-sulfophenyl)Theophylline on the anticonvulsive action of diphenylhydantoin, phenobarbital, and valproate against maximal electroshock-induced convulsions in mice
Journal of Neural Transmission General Section JNT, 1993Co-Authors: Kinga K. Borowicz, Zdzisław Kleinrok, M. Kozicka, S.j. CzuczwarAbstract:Aminophylline (Theophylline_2·ethylenediamine) in the dose of 12.5 mg/kg (i.p.) was ineffective upon all antiepileptic drugs studied and at the higher dose of 25 mg/kg, impaired the anticonvulsant action of phenobarbital and valproate against maximal electroshock in mice. The protection offered by diphenylhydantoin was diminished by aminophylline at 50 mg/kg (0.238 mmol of anhydrous Theophylline/kg). In contrast, 8-(p-sulfophenyl)Theophylline (a Theophylline Derivative unable to cross the blood-brain barrier) in the dose of 80 mg/kg (0.238 mmol/kg) did not influence the protective activity of diphenylhydantoin, phenobarbital, and valproate. It might be concluded that the aminophylline-induced impairment of the anticonvulsant action of common antiepileptic drugs results from the central effects of this methylxanthine.
Ingjun Chen - One of the best experts on this subject based on the ideXlab platform.
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endothelium dependent and independent vasorelaxation by a Theophylline Derivative mcpt roles of cyclic nucleotides potassium channel opening and phosphodiesterase inhibition
Life Sciences, 2005Co-Authors: Yiching Lo, Hueihsia Tsou, Dengchyang Wu, Binnan Wu, Ingjun ChenAbstract:Abstract The vasorelaxation activities of MCPT, a newly synthesized xanthine Derivative, were investigated in this study. In phenylephrine (PE)-precontracted rat aortic rings with intact endothelium, MCPT caused a concentration-dependent relaxation, which was inhibited by endothelium removed. This relaxation was also reduced by the presence of nitric oxide synthase inhibitor L ω -nitro-L-arginine methylester (L-NAME, 100 μM), soluble guanylyl cyclase (sGC) inhibitors methylene blue (10 μM), 1 H-[1,2,4] oxidazolol [4,3-a] quinoxalin-1-one (ODQ, 1 μM), adenylyl cyclase (AC) blocker SQ 22536 (100 μM), ATP-sensitive K + channel blocker (K ATP ) glibenclamide (1 μM), a Ca 2+ activated K + channels blocker tetraethylammonium (TEA, 10 mM) and a voltage-dependent potassium channels blocker 4-aminopyridine (4-AP, 100 μM). The vasorelaxant effects of MCPT together with IBMX (0.5 μM) had an additive action. In PE-preconstricted endothelium-denuded aortic rings, the vasorelaxant effects of MCPT were attenuated by pretreatments with glibenclamide (1 μM), SQ 22536 (100 μM) or ODQ (1 μM), respectively. MCPT enhanced cAMP-dependent vasodilator isoprenaline- and NO donor/cGMP-dependent vasodilator sodium nitroprusside-induced relaxation activities in endothelium-denuded aortic rings. In A-10 cell and washed human platelets, MCPT induced a concentration-dependent increase in intracellular cyclic GMP and cyclic AMP levels. In phosphodiesterase assay, MCPT displayed inhibition effects on PDE 3, PDE 4 and PDE 5. The inhibition % were 52 ± 3.9, 32 ± 2.6 and 8 ± 1.1 respectively. The Western blot analysis on HUVEC indicated that MCPT increased the expression of eNOS. It is concluded that the vasorelaxation by MCPT may be mediated by the inhibition of phosphodiesterase, stimulation of NO/sGC/ cGMP and AC/cAMP pathways, and the opening of K + channels.
Zdzisław Kleinrok - One of the best experts on this subject based on the ideXlab platform.
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Influence of aminophylline and 8-(p-sulfophenyl)Theophylline on the anticonvulsive action of diphenylhydantoin, phenobarbital, and valproate against maximal electroshock-induced convulsions in mice
Journal of Neural Transmission, 1993Co-Authors: Kinga K. Borowicz, Kozicka M, Zdzisław Kleinrok, S.j. CzuczwarAbstract:Aminophylline (Theophylline2·ethylenediamine) in the dose of 12.5 mg/kg (i.p.) was ineffective upon all antiepileptic drugs studied and at the higher dose of 25 mg/kg, impaired the anticonvulsant action of phenobarbital and valproate against maximal electroshock in mice. The protection offered by diphenylhydantoin was diminished by aminophylline at 50 mg/kg (0.238 mmol of anhydrous Theophylline/kg). In contrast, 8-(p-sulfophenyl)Theophylline (a Theophylline Derivative unable to cross the blood-brain barrier) in the dose of 80 mg/kg (0.238 mmol/kg) did not influence the protective activity of diphenylhydantoin, phenobarbital, and valproate.
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Influence of aminophylline and 8-(p-sulfophenyl)Theophylline on the anticonvulsive action of diphenylhydantoin, phenobarbital, and valproate against maximal electroshock-induced convulsions in mice
Journal of Neural Transmission General Section JNT, 1993Co-Authors: Kinga K. Borowicz, Zdzisław Kleinrok, M. Kozicka, S.j. CzuczwarAbstract:Aminophylline (Theophylline_2·ethylenediamine) in the dose of 12.5 mg/kg (i.p.) was ineffective upon all antiepileptic drugs studied and at the higher dose of 25 mg/kg, impaired the anticonvulsant action of phenobarbital and valproate against maximal electroshock in mice. The protection offered by diphenylhydantoin was diminished by aminophylline at 50 mg/kg (0.238 mmol of anhydrous Theophylline/kg). In contrast, 8-(p-sulfophenyl)Theophylline (a Theophylline Derivative unable to cross the blood-brain barrier) in the dose of 80 mg/kg (0.238 mmol/kg) did not influence the protective activity of diphenylhydantoin, phenobarbital, and valproate. It might be concluded that the aminophylline-induced impairment of the anticonvulsant action of common antiepileptic drugs results from the central effects of this methylxanthine.
Jesús Hierrezuelo - One of the best experts on this subject based on the ideXlab platform.
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Characterization and stability of a bioactivated alumina nanomembrane for application in flow devices
Microporous and Mesoporous Materials, 2016Co-Authors: M.i. Vázquez, Jesús Hierrezuelo, V. Romero, J. Manuel López-romero, Juana Benavente, R. Romero, Rafael Contreras-cáceresAbstract:Abstract Surface modification of alumina nanomembrane (ANP) by Theophylline Derivative Theo 1 by dip-coating was successfully achieved. The hybrid material was characterized by SEM, XPS and confocal microscopy. The presence of Theo 1 on the ANP surface was established from salt diffusion and membrane potentials measurements. Changes in the electrical character and transport parameters of the modified sample, associated to Theo 1 deposition, were established. Stability of the material under diffusive flow was also ascertained. Moreover, as a result of Theo 1 bioactivation, streptavidin linkage to the ANP/Theo 1 -modified membrane was obtained, which is an indication of streptavidin capture.
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Membrane surface functionalization via Theophylline Derivative coating and streptavidin immobilization.
Colloids and Surfaces B: Biointerfaces, 2013Co-Authors: Jesús Hierrezuelo, V. Romero, Rodrigo Rico, Juana Benavente, J. Manuel López-romeroAbstract:Poly(vinylidene fluoride) (PVDF) and regenerated cellulose (RC) membranes were surface-modified by the adsorption of one adenosine receptor antagonist: the Theophylline-oligo(ethylene glycol)-alkene Derivative, Theo1. Surface modification was carried out by immersion of the membrane in a dichloromethane solution of Theo1 (PVDF + Theo1 and RC + Theo1 samples). Membrane surfaces with partial coverage by Theophylline and/or its inclusion in the membrane structures were studied by X-ray photoelectron spectroscopy (XPS), solid-state nuclear magnetic resonance (SNMR), impedance spectroscopy (IS) and contact angle (CA) measurements. The Theo1 orientation was inferred from the data. Streptavidin (SA) was immobilized onto the membrane/Theo1 hybrid material. The protein–Theophylline Theo1 interaction was visualized with bright field microscopy (BFM).
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Synthesis of Theophylline Derivatives and study of their activity as antagonists at adenosine receptors
Bioorganic & Medicinal Chemistry, 2010Co-Authors: Jesús Hierrezuelo, Rodrigo Rico, J. Manuel López-romero, José Brea, M. Isabel Loza, Manuel AlgarraAbstract:Abstract The synthesis of oligo(ethylene glycol)-alkene substituted Theophyllines in positions 7 and/or 8 is described. The binding activity at adenosine receptors of selected Derivatives was studied. Compound 2 showed high affinity for human A 2B receptor ( K i = 4.16 nM) with a selectivity K iA2A / K iA2B of 24.1, and a solubility in water of 1 mM. The alkenyl substituent in some of the Theophylline Derivatives allows for covalent attachment of them onto hydrogen-terminated silicon substrate surfaces via hydrosilylation. Alternatively, an azido group was incorporated to an oligo(ethylene glycol)Theophylline Derivative as an anchor for tethering the molecules on ethynyl presenting surfaces via click reaction.