The Experts below are selected from a list of 472005 Experts worldwide ranked by ideXlab platform
Xiongwei Deng - One of the best experts on this subject based on the ideXlab platform.
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mesoporous silica coated polydopamine functionalized reduced graphene oxide for synergistic targeted chemo photothermal Therapy
ACS Applied Materials & Interfaces, 2017Co-Authors: Leihou Shao, Ruirui Zhang, Caiyan Zhao, Xiongwei DengAbstract:The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-photothermal Therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the photothermal Effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-photothermal Therapy Effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA...
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mesoporous silica coated polydopamine functionalized reduced graphene oxide for synergistic targeted chemo photothermal Therapy
ACS Applied Materials & Interfaces, 2017Co-Authors: Leihou Shao, Ruirui Zhang, Caiyan Zhao, Xiongwei DengAbstract:The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-photothermal Therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the photothermal Effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-photothermal Therapy Effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA exhibits good dispersibility, excellent photothermal property, remarkable tumor cell killing efficiency, and specificity to target tumor cells. In vivo antitumor experiments further demonstrated that pRGO@MS(DOX)-HA could exhibit an excellent synergistic antitumor efficacy, which is much more distinct than any monoTherapy. This work presents a novel nanoplatform which could load chemoTherapy drugs with high efficiency and be used as light-mediated photothermal cancer Therapy agent.
Caiyan Zhao - One of the best experts on this subject based on the ideXlab platform.
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mesoporous silica coated polydopamine functionalized reduced graphene oxide for synergistic targeted chemo photothermal Therapy
ACS Applied Materials & Interfaces, 2017Co-Authors: Leihou Shao, Ruirui Zhang, Caiyan Zhao, Xiongwei DengAbstract:The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-photothermal Therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the photothermal Effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-photothermal Therapy Effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA...
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mesoporous silica coated polydopamine functionalized reduced graphene oxide for synergistic targeted chemo photothermal Therapy
ACS Applied Materials & Interfaces, 2017Co-Authors: Leihou Shao, Ruirui Zhang, Caiyan Zhao, Xiongwei DengAbstract:The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-photothermal Therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the photothermal Effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-photothermal Therapy Effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA exhibits good dispersibility, excellent photothermal property, remarkable tumor cell killing efficiency, and specificity to target tumor cells. In vivo antitumor experiments further demonstrated that pRGO@MS(DOX)-HA could exhibit an excellent synergistic antitumor efficacy, which is much more distinct than any monoTherapy. This work presents a novel nanoplatform which could load chemoTherapy drugs with high efficiency and be used as light-mediated photothermal cancer Therapy agent.
Leihou Shao - One of the best experts on this subject based on the ideXlab platform.
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mesoporous silica coated polydopamine functionalized reduced graphene oxide for synergistic targeted chemo photothermal Therapy
ACS Applied Materials & Interfaces, 2017Co-Authors: Leihou Shao, Ruirui Zhang, Caiyan Zhao, Xiongwei DengAbstract:The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-photothermal Therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the photothermal Effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-photothermal Therapy Effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA...
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mesoporous silica coated polydopamine functionalized reduced graphene oxide for synergistic targeted chemo photothermal Therapy
ACS Applied Materials & Interfaces, 2017Co-Authors: Leihou Shao, Ruirui Zhang, Caiyan Zhao, Xiongwei DengAbstract:The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-photothermal Therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the photothermal Effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-photothermal Therapy Effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA exhibits good dispersibility, excellent photothermal property, remarkable tumor cell killing efficiency, and specificity to target tumor cells. In vivo antitumor experiments further demonstrated that pRGO@MS(DOX)-HA could exhibit an excellent synergistic antitumor efficacy, which is much more distinct than any monoTherapy. This work presents a novel nanoplatform which could load chemoTherapy drugs with high efficiency and be used as light-mediated photothermal cancer Therapy agent.
Ruirui Zhang - One of the best experts on this subject based on the ideXlab platform.
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mesoporous silica coated polydopamine functionalized reduced graphene oxide for synergistic targeted chemo photothermal Therapy
ACS Applied Materials & Interfaces, 2017Co-Authors: Leihou Shao, Ruirui Zhang, Caiyan Zhao, Xiongwei DengAbstract:The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-photothermal Therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the photothermal Effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-photothermal Therapy Effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA...
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mesoporous silica coated polydopamine functionalized reduced graphene oxide for synergistic targeted chemo photothermal Therapy
ACS Applied Materials & Interfaces, 2017Co-Authors: Leihou Shao, Ruirui Zhang, Caiyan Zhao, Xiongwei DengAbstract:The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-photothermal Therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the photothermal Effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-photothermal Therapy Effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA exhibits good dispersibility, excellent photothermal property, remarkable tumor cell killing efficiency, and specificity to target tumor cells. In vivo antitumor experiments further demonstrated that pRGO@MS(DOX)-HA could exhibit an excellent synergistic antitumor efficacy, which is much more distinct than any monoTherapy. This work presents a novel nanoplatform which could load chemoTherapy drugs with high efficiency and be used as light-mediated photothermal cancer Therapy agent.
T B Kirk - One of the best experts on this subject based on the ideXlab platform.
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construction of a high efficiency drug and gene co delivery system for cancer Therapy from a ph sensitive supramolecular inclusion between oligoethylenimine graft β cyclodextrin and hyperbranched polyglycerol derivative
ACS Applied Materials & Interfaces, 2018Co-Authors: Xiaoyan Zhou, T B Kirk, Wei XueAbstract:Introducing genes into drug-delivery system for a combined Therapy has become a promising strategy for cancer treatment. However, improving the in vivo Therapy Effect resulted from the high deliver...
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construction of a high efficiency drug and gene co delivery system for cancer Therapy from a ph sensitive supramolecular inclusion between oligoethylenimine graft β cyclodextrin and hyperbranched polyglycerol derivative
ACS Applied Materials & Interfaces, 2018Co-Authors: Xiaoyan Zhou, Lanqin Xu, Jiake Xu, Jianping Wu, T B KirkAbstract:Introducing genes into drug-delivery system for a combined Therapy has become a promising strategy for cancer treatment. However, improving the in vivo Therapy Effect resulted from the high delivery efficiency, low toxicity, and good stability in the blood remains a challenge. For this purpose, the supramolecular inclusion was considered to construct a high-efficiency drug and gene co-delivery system in this work. The oligoethylenimine-conjugated β-cyclodextrin (β-CD-PEI600) and benzimidazole-modified four-arm-polycaprolactone-initiated hyperbranched polyglycerol (PCL-HPG-BM) were synthesized as the host and guest molecules, respectively, and then the co-delivery carrier of PCL-HPG-PEI600 was formed from the pH-mediated inclusion interaction between β-CD and BM. PCL-HPG-PEI600 showed the improved drug (doxorubicin, DOX) and gene (MMP-9 shRNA plasmid, pMMP-9) delivery ability in vivo, and their cellular uptake and intracellular delivery were investigated. Particularly, PCL-HPG-PEI600 showed excellent pMMP-...
