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P. Roversi - One of the best experts on this subject based on the ideXlab platform.
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isothiazoles part vi cycloaddition of azides to isothiazole dioxides synthesis of thiadiazabicyclo 3 1 0 hexene Derivatives and their thermal rearrangement to thiazete dioxides 1 2 6 Thiadiazine dioxides and pyrazoles
Tetrahedron, 1996Co-Authors: F. Clerici, F. Galletti, D. Pocar, P. RoversiAbstract:Abstract 3-Diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide ( 1 ) was made to react with arylalkyl- and arylazides 2 . Cycloadducts 3 , which could be isolated in some cases, afforded N-arylalkyl- or N-aryl-thiadiazabicyclo[3.1.0]hexene Derivatives 4 through N 2 -elimination. Thermal rearrangements of N-aryl- and N-β-phenylethyl substituted compounds 4b-e , produced Derivatives of 1,2-thiazete 1,1-dioxide 5 , 1,2,6-Thiadiazine 1,1-dioxide 6 and pyrazole 7 . The reaction can be optimized to afford compounds 6 in synthetically useful yield. In the case of N-benzyl-thiadiazabicyclo[3.1.0]hexene Derivative 4a the different substitution on the aziridine nitrogen produced a different reaction course, affording the Thiadiazine Derivative 6a and the pyrimidine Derivative 8 .
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Isothiazoles. Part VI.1 Cycloaddition of azides to isothiazole dioxides: Synthesis of thiadiazabicyclo[3.1.0]hexene Derivatives and their thermal rearrangement to thiazete dioxides, 1,2,6-Thiadiazine dioxides and pyrazoles
'Elsevier BV', 1996Co-Authors: F. Clerici, F. Galletti, D. Pocar, P. RoversiAbstract:3-Diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide (1) was made to react with arylalkyl-and arylazides 2. Cycloadducts 3, which could be isolated in some cases, afforded N-arylalkyl-or N-aryl-thiadiazabicyclo[3.1.0]hexene Derivatives 4 through N2-elimination. Thermal rearrangements of N-aryl-and N-\u3b2-phenylethyl substituted compounds 4b-e, produced Derivatives of 1,2-thiazete 1,1-dioxide 5, 1,2,6-Thiadiazine 1,1-dioxide 6 and pyrazole 7. The reaction can be optimized to afford compounds 6 in synthetically useful yield. In the case of N-benzyl-thiadiazabicyclo[3.1.0]hexene Derivative 4a the different substitution on the aziridine nitrogen produced a different reaction course, affording the Thiadiazine Derivative 6a and the pyrimidine Derivative 8. Copyright \ua9 1996 Elsevier Science Ltd
F. Clerici - One of the best experts on this subject based on the ideXlab platform.
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isothiazoles part vi cycloaddition of azides to isothiazole dioxides synthesis of thiadiazabicyclo 3 1 0 hexene Derivatives and their thermal rearrangement to thiazete dioxides 1 2 6 Thiadiazine dioxides and pyrazoles
Tetrahedron, 1996Co-Authors: F. Clerici, F. Galletti, D. Pocar, P. RoversiAbstract:Abstract 3-Diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide ( 1 ) was made to react with arylalkyl- and arylazides 2 . Cycloadducts 3 , which could be isolated in some cases, afforded N-arylalkyl- or N-aryl-thiadiazabicyclo[3.1.0]hexene Derivatives 4 through N 2 -elimination. Thermal rearrangements of N-aryl- and N-β-phenylethyl substituted compounds 4b-e , produced Derivatives of 1,2-thiazete 1,1-dioxide 5 , 1,2,6-Thiadiazine 1,1-dioxide 6 and pyrazole 7 . The reaction can be optimized to afford compounds 6 in synthetically useful yield. In the case of N-benzyl-thiadiazabicyclo[3.1.0]hexene Derivative 4a the different substitution on the aziridine nitrogen produced a different reaction course, affording the Thiadiazine Derivative 6a and the pyrimidine Derivative 8 .
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Isothiazoles. Part VI.1 Cycloaddition of azides to isothiazole dioxides: Synthesis of thiadiazabicyclo[3.1.0]hexene Derivatives and their thermal rearrangement to thiazete dioxides, 1,2,6-Thiadiazine dioxides and pyrazoles
'Elsevier BV', 1996Co-Authors: F. Clerici, F. Galletti, D. Pocar, P. RoversiAbstract:3-Diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide (1) was made to react with arylalkyl-and arylazides 2. Cycloadducts 3, which could be isolated in some cases, afforded N-arylalkyl-or N-aryl-thiadiazabicyclo[3.1.0]hexene Derivatives 4 through N2-elimination. Thermal rearrangements of N-aryl-and N-\u3b2-phenylethyl substituted compounds 4b-e, produced Derivatives of 1,2-thiazete 1,1-dioxide 5, 1,2,6-Thiadiazine 1,1-dioxide 6 and pyrazole 7. The reaction can be optimized to afford compounds 6 in synthetically useful yield. In the case of N-benzyl-thiadiazabicyclo[3.1.0]hexene Derivative 4a the different substitution on the aziridine nitrogen produced a different reaction course, affording the Thiadiazine Derivative 6a and the pyrimidine Derivative 8. Copyright \ua9 1996 Elsevier Science Ltd
F. Galletti - One of the best experts on this subject based on the ideXlab platform.
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isothiazoles part vi cycloaddition of azides to isothiazole dioxides synthesis of thiadiazabicyclo 3 1 0 hexene Derivatives and their thermal rearrangement to thiazete dioxides 1 2 6 Thiadiazine dioxides and pyrazoles
Tetrahedron, 1996Co-Authors: F. Clerici, F. Galletti, D. Pocar, P. RoversiAbstract:Abstract 3-Diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide ( 1 ) was made to react with arylalkyl- and arylazides 2 . Cycloadducts 3 , which could be isolated in some cases, afforded N-arylalkyl- or N-aryl-thiadiazabicyclo[3.1.0]hexene Derivatives 4 through N 2 -elimination. Thermal rearrangements of N-aryl- and N-β-phenylethyl substituted compounds 4b-e , produced Derivatives of 1,2-thiazete 1,1-dioxide 5 , 1,2,6-Thiadiazine 1,1-dioxide 6 and pyrazole 7 . The reaction can be optimized to afford compounds 6 in synthetically useful yield. In the case of N-benzyl-thiadiazabicyclo[3.1.0]hexene Derivative 4a the different substitution on the aziridine nitrogen produced a different reaction course, affording the Thiadiazine Derivative 6a and the pyrimidine Derivative 8 .
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Isothiazoles. Part VI.1 Cycloaddition of azides to isothiazole dioxides: Synthesis of thiadiazabicyclo[3.1.0]hexene Derivatives and their thermal rearrangement to thiazete dioxides, 1,2,6-Thiadiazine dioxides and pyrazoles
'Elsevier BV', 1996Co-Authors: F. Clerici, F. Galletti, D. Pocar, P. RoversiAbstract:3-Diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide (1) was made to react with arylalkyl-and arylazides 2. Cycloadducts 3, which could be isolated in some cases, afforded N-arylalkyl-or N-aryl-thiadiazabicyclo[3.1.0]hexene Derivatives 4 through N2-elimination. Thermal rearrangements of N-aryl-and N-\u3b2-phenylethyl substituted compounds 4b-e, produced Derivatives of 1,2-thiazete 1,1-dioxide 5, 1,2,6-Thiadiazine 1,1-dioxide 6 and pyrazole 7. The reaction can be optimized to afford compounds 6 in synthetically useful yield. In the case of N-benzyl-thiadiazabicyclo[3.1.0]hexene Derivative 4a the different substitution on the aziridine nitrogen produced a different reaction course, affording the Thiadiazine Derivative 6a and the pyrimidine Derivative 8. Copyright \ua9 1996 Elsevier Science Ltd
D. Pocar - One of the best experts on this subject based on the ideXlab platform.
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isothiazoles part vi cycloaddition of azides to isothiazole dioxides synthesis of thiadiazabicyclo 3 1 0 hexene Derivatives and their thermal rearrangement to thiazete dioxides 1 2 6 Thiadiazine dioxides and pyrazoles
Tetrahedron, 1996Co-Authors: F. Clerici, F. Galletti, D. Pocar, P. RoversiAbstract:Abstract 3-Diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide ( 1 ) was made to react with arylalkyl- and arylazides 2 . Cycloadducts 3 , which could be isolated in some cases, afforded N-arylalkyl- or N-aryl-thiadiazabicyclo[3.1.0]hexene Derivatives 4 through N 2 -elimination. Thermal rearrangements of N-aryl- and N-β-phenylethyl substituted compounds 4b-e , produced Derivatives of 1,2-thiazete 1,1-dioxide 5 , 1,2,6-Thiadiazine 1,1-dioxide 6 and pyrazole 7 . The reaction can be optimized to afford compounds 6 in synthetically useful yield. In the case of N-benzyl-thiadiazabicyclo[3.1.0]hexene Derivative 4a the different substitution on the aziridine nitrogen produced a different reaction course, affording the Thiadiazine Derivative 6a and the pyrimidine Derivative 8 .
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Isothiazoles. Part VI.1 Cycloaddition of azides to isothiazole dioxides: Synthesis of thiadiazabicyclo[3.1.0]hexene Derivatives and their thermal rearrangement to thiazete dioxides, 1,2,6-Thiadiazine dioxides and pyrazoles
'Elsevier BV', 1996Co-Authors: F. Clerici, F. Galletti, D. Pocar, P. RoversiAbstract:3-Diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide (1) was made to react with arylalkyl-and arylazides 2. Cycloadducts 3, which could be isolated in some cases, afforded N-arylalkyl-or N-aryl-thiadiazabicyclo[3.1.0]hexene Derivatives 4 through N2-elimination. Thermal rearrangements of N-aryl-and N-\u3b2-phenylethyl substituted compounds 4b-e, produced Derivatives of 1,2-thiazete 1,1-dioxide 5, 1,2,6-Thiadiazine 1,1-dioxide 6 and pyrazole 7. The reaction can be optimized to afford compounds 6 in synthetically useful yield. In the case of N-benzyl-thiadiazabicyclo[3.1.0]hexene Derivative 4a the different substitution on the aziridine nitrogen produced a different reaction course, affording the Thiadiazine Derivative 6a and the pyrimidine Derivative 8. Copyright \ua9 1996 Elsevier Science Ltd
Dotsenko V. - One of the best experts on this subject based on the ideXlab platform.
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The effect of Derivatives of tetrahydropyrido[2,1-b][1,3,5] Thiadiazine on hematologic indices of rats with subacute parotitis
2020Co-Authors: Bybik E. Y., Frolov K. A., Yaroshevskaya O. G., Demenko A., Dotsenko V.Abstract:Objective: to study the indices characterizing the red and white hematopoiesis in a clinical blood examination in animals with a simulated inflammation process against a background of pharmacocorrection with original Thiadiazine Derivative
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Study of analeptic activity of tetrahydropyrido [2,1-b] [1,3,5] tiadiazine Derivatives
'Belgorod National Research University', 2017Co-Authors: Yu E Bibik, Saphonova A. A., Yeryomin A., Frolov K. A., Dotsenko V.Abstract:Our goal is to conduct an investigation of the analeptic activity of the tetrahydropyrido [2,1-b] [1, 3, 5] Thiadiazine Derivative group. Biological studies were carried out on 78 white pedigreed mature sexually transmitted rats of both sexes weighing 230-270 g in the autumn-winter period. The test substances were administered intragastrically at a dose of 5 mg/kg 1 hour prior to the induction of anesthesia. Animals of the control group received thiopental sodium at a dose of 70 mg/kg. As the reference preparation, sodium caffeinebenzoate was used intraperitoneally at a dose of 10 mg/k