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Srecko R Trifunovic - One of the best experts on this subject based on the ideXlab platform.
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antibacterial and antibiofilm screening of new platinum iv complexes with some s alkyl derivatives of Thiosalicylic Acid
Kragujevac Journal of Science, 2017Co-Authors: Ivana D Radojevic, Milos Nikolic, Marina Mijajlovic, Srecko R Trifunovic, Ljiljana R Comic, Sava Vasic, Gordana P RadicAbstract:The influence of 5 new Platinum(IV) (Pt(IV)) complexes with S-alkyl derivatives of Thiosalicylic Acid (C1-benzyl, C2-methyl, C3-ethyl, C4-propyl and C5- butyl) was studied on 16 strains of bacteria. Antibacterial activity was tested using microdilution method with resazurin while antibiofilm activity was observed by tissue culture plate method, using doxycycline as a positive control. The results were expressed as minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and biofilm inhibitory concentration (BIC). The best result on Gram positive bacteria exhibited C1 and MIC was <7.81μg/ml against Staphylococcus aureus ATCC 25923. Bifidobacterium animalis subsp. lactis (probiotic) was sensitive to C2 (MIC at 15.625 μg/ml). The highest sensitivity of Gram negative bacteria was observed in Escherichia coli ATCC 25922 treated with C1, C2, C3 and C4, in Proteus mirabilis ATCC 12453 treated with C1, and in Pseudomonas aeruginosa treated with C2, C3 and C5 (all MICs at 250 μg/ml). The C2 complex were more efficient as antibiofilm agents and the best results were obtained with C2 acting against S. aureus and S. aureus ATCC 25923 biofilms. In conclusion, we noticed that the tested compounds exhibited promising properties as antibacterial and antibiofilm agents.
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cytotoxicity of copper ii complexes with some s alkyl derivatives of Thiosalicylic Acid crystal structure of the binuclear copper ii complex with s ethyl derivative of Thiosalicylic Acid
Journal of Molecular Structure, 2016Co-Authors: Milos Nikolic, Aleksandar Arsenijevic, Jelena Milovanovic, Zoran Ratkovic, Marina Mijajlovic, Verica V Jevtic, Slađana B Novakovic, Goran A Bogdanovic, Bojana Stojanovic, Srecko R TrifunovicAbstract:Abstract The spectroscopically predicted structure of the obtained copper(II)-complex with S-ethyl derivative of Thiosalicylic Acid was confirmed by X-ray structural study and compared to previously reported crystal structure of the Cu complex with S-methyl derivative. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. Cytotoxic effects of S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) and butyl (L5)) derivatives of Thiosalicylic Acid and the corresponding binuclear copper(II)-complexes on murine colon carcinoma cell lines, CT26 and CT26.CL25 and human colon carcinoma cell line HCT-116 were reported here. The analysis of cancer cell viability showed that all the tested complexes had low cytotoxic effect on murine colon carcinoma cell lines, but several times higher cytotoxicity on normal human colon carcinoma cells.
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cytotoxicity of palladium ii complexes with some alkyl derivates of Thiosalicylic Acid crystal structure of the bis s butyl thiosalicylate palladium ii complex pd s bu thiosal 2
Polyhedron, 2015Co-Authors: Marina Mijajlovic, Nebojsa Arsenijevic, Zoran Ratkovic, Milos Nikolic, Verica V Jevtic, Slađana B Novakovic, Goran A Bogdanovic, Bojana Simovic Markovic, Vladislav Volarevic, Srecko R TrifunovicAbstract:Abstract The spectroscopically predicted structure of the obtained bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)2], was confirmed by an X-ray structural study. The asymmetric unit of [Pd(S-bu-thiosal)2] consists of neutral complex molecules, where the Pd(II) ion is placed in a cis-square-planar coordination environment formed by O and S atoms of two deprotonated S-butyl-Thiosalicylic Acid ligands. The cytotoxic effects of the S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) and butyl (L5)) derivatives of Thiosalicylic Acid and the corresponding palladium(II) complexes are reported here. The analysis of cancer cell viability showed that all the tested complexes are cytotoxic to human colon carcinoma cells (HCT-116 and CaCo-2) and human lung carcinoma epithelial cells (A549). The antitumor activities of the above mentioned Pd(II) complexes are higher in comparison to the corresponding ligands.
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synthesis characterization and antimicrobial activity of copper ii complexes with some s alkyl derivatives of Thiosalicylic Acid crystal structure of the binuclear copper ii complex with s methyl derivative of Thiosalicylic Acid
Polyhedron, 2014Co-Authors: Milos Nikolic, Zoran Ratkovic, Marina Mijajlovic, Verica V Jevtic, Slađana B Novakovic, Goran A Bogdanovic, Ivana D Radojevic, Srecko R Trifunovic, Ljiljana R Comic, Gordana P RadicAbstract:Abstract The five new copper(II) complexes with some S-alkyl derivatives of Thiosalicylic Acid (alkyl = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4), butyl (L5)) have been synthesized and characterized by microanalysis and infrared spectra. The spectroscopically predicted structure of the obtained binuclear copper(II) complex with S-methyl derivative of Thiosalicylic Acid was confirmed by X-ray analysis. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. The compound crystallizes with two binuclear Cu(II) complex molecules in the asymmetric unit. Both molecules have typical paddle-wheel structure with apical positions occupied by water molecules. The independent molecules showed slight difference in configuration mainly reflected in the different orientation of the phenyl rings relating to their carboxylate groups. Antimicrobial activity of these complexes was tested by microdilution method and both minimal inhibitory and microbicidal concentration were determined. The intensity of the antimicrobial activity varied depending on the species of microorganism and the compound type. In general, the activity of the complexes was higher than or similar to the corresponding ligands. All the tested complexes demonstrated moderate or selective antibacterial activity and low antifungal activity.
Zoran Ratkovic - One of the best experts on this subject based on the ideXlab platform.
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synthesis characterization and cytotoxic activity of binuclear copper ii complexes with some s isoalkyl derivatives of Thiosalicylic Acid crystal structure of the binuclear copper ii complex with s isopropyl derivative of Thiosalicylic Acid
Journal of Inorganic Biochemistry, 2020Co-Authors: Jelena Dimitrijevic, Aleksandar Arsenijevic, Marija Milovanovic, Nebojsa Arsenijevic, Jelena Milovanovic, Ana S Stankovic, Andriana M Bukonjic, Dusan Lj Tomovic, Zoran Ratkovic, Ivan PotocňakAbstract:Abstract Isoalkyl (isoalkyl = isopropyl-(L1), isobutyl-(L2) and isoamyl-(L3)) derivatives of Thiosalicylic Acid (TSA) were prepared by alkylation of TSA with corresponding isoalkyl-chlorides in the alkaline water-ethanol solution. The new free copper(II)-complexes with corresponding S-isoalkyl derivatives of TSA (C1-copper(II)-complex with S-isopropyl derivative of Thiosalicylic Acid, C2-copper(II)-complex with S-isobutyl derivative of Thiosalicylic Acid and C3-copper(II)-complex with S-isoamyl derivative of Thiosalicylic Acid) have been synthesized by direct reaction of copper(II)-nitrate with ligand precursor and then characterized by microanalysis, infrared spectra (IR) and EPR (electron paramagnetic resonance) spectra. The spectroscopically predicted structure of the obtained binuclear copper(II)-complex with S-isopropyl derivative of Thiosalicylic Acid was confirmed by X-ray analysis. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. Newly synthesized precursors S-isoalkyl derivatives of Thiosalicylic Acid and corresponding copper(II)-complexes moderately reduced viability of human and murine lung cancer cells, they showed similar cytotoxic effect on human colorectal cancer cells as cisplatin and lower cytotoxic effect than cisplatin toward normal fibroblasts, evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) colorimetric technique. All new complexes exhibited apoptotic effect toward lung cancer cells, stronger than cisplatin, whereas only C3 induced significant apoptosis of colorectal cancer cells. Complex C1 showed significant antiproliferative effect against murine lung cancer cells, LLC1, while C2 reduced expression of Ki67 in human colorectal cancer cells. All tested complexes induced cell cycle arrest of HCT116 cells in G2/M phase.
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DNA binding and antitumor activities of platinum(IV) and zinc(II) complexes with some S-alkyl derivatives of Thiosalicylic Acid
Transition Metal Chemistry, 2018Co-Authors: Zana Besser Silconi, Jelena Milovanovic, Zoran Ratkovic, Milos Nikolic, Marina Mijajlovic, Gordana Radić, Sasa Benazic, Milena Jurisevic, Dragana Djordjevic, Snezana RadisavljevicAbstract:A series of complexes of platinum(IV) ( C1 – C5 ) and zinc(II) ( C6 – C10 ) with S-alkyl derivatives of Thiosalicylic Acid were prepared and characterized. The interactions of the complexes with calf thymus DNA were analyzed by absorption (UV–Vis) and emission spectral studies (ethidium bromide displacement studies). The cytotoxic activities of complexes C1 – C10 were determined against mouse B cell lymphocytic leukemia cells (BCL1), human B-prolymphocytic leukemia (JVM-13), mouse mammary carcinoma cells (4T1), and human mammary carcinoma cells (MDA-MB-468) and compared to the activities of the free ligand precursors and cisplatin. The cytotoxicities of the platinum(IV) and zinc(II) complexes toward mouse tumor cell lines were higher compared with their effects on human tumor cell lines. The zinc(II) complex C9 showed the highest antitumor activity toward the tested human cell lines, while the platinum(IV) complex C4 exhibited the highest antitumor activity toward mouse BCL1 and 4T1 cells. Both C4 and C9 have ligands derived from S-propyl Thiosalicylic Acid.
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antibacterial antibiofilm and antioxidant screening of copper ii complexes with some s alkyl derivatives of Thiosalicylic Acid crystal structure of the binuclear copper ii complex with s propyl derivative of Thiosalicylic Acid
Journal of Molecular Structure, 2017Co-Authors: Andriana M Bukonjic, Dusan Lj Tomovic, Zoran Ratkovic, Milos Nikolic, Marina Mijajlovic, Verica V Jevtic, Slađana B Novakovic, Goran A Bogdanovic, Ivana D Radojevic, Jovana Z MaksimovicAbstract:Abstract The spectroscopically predicted structure of the obtained copper(II)-complex with S-propyl derivative of Thiosalicylic Acid was confirmed by X-ray structural study. The binuclear copper(II)-complex with S-propyl derivative of Thiosalicylic Acid crystallized in two polymorphic forms with main structural difference in the orientation of phenyl rings relative to corresponding carboxylate groups. The antibacterial activity was tested determining the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) by using microdilution method. The influence on bacterial biofilm formation was determined by tissue culture plate method. In general, the copper(II)-complexes manifested a selective and moderate activity. The most sensitive bacteria to the effects of Cu(II)-complexes was a clinical isolate of Pseudomonas aeruginosa. For this bacteria MIC and biofilm inhibitory concentration (BIC) values for all tested complexes were in the range or better than the positive control, doxycycline. Also, for the established biofilm of clinical isolate Staphylococcus aureus, BIC values for the copper(II)-complex with S-ethyl derivative of Thiosalicylic Acid,[Cu2(S-et-thiosal)4(H2O)2] (C3) and copper(II)-complex with S-butyl derivative of Thiosalicylic Acid, [Cu2(S-bu-thiosal)4(H2O)2] (C5) were in range or better than the positive control. All the complexes acted better against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus aureus ATCC 25923) than Gram-negative bacteria (Proteus mirabilis ATCC 12453, Pseudomonas aeruginosa, and P. aeruginosa ATCC 27855). The complexes showed weak antioxidative properties tested by two methods (1,1-diphenyl-2-picrylhydrazyl (DPPH) and reducing power assay).
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cytotoxicity of copper ii complexes with some s alkyl derivatives of Thiosalicylic Acid crystal structure of the binuclear copper ii complex with s ethyl derivative of Thiosalicylic Acid
Journal of Molecular Structure, 2016Co-Authors: Milos Nikolic, Aleksandar Arsenijevic, Jelena Milovanovic, Zoran Ratkovic, Marina Mijajlovic, Verica V Jevtic, Slađana B Novakovic, Goran A Bogdanovic, Bojana Stojanovic, Srecko R TrifunovicAbstract:Abstract The spectroscopically predicted structure of the obtained copper(II)-complex with S-ethyl derivative of Thiosalicylic Acid was confirmed by X-ray structural study and compared to previously reported crystal structure of the Cu complex with S-methyl derivative. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. Cytotoxic effects of S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) and butyl (L5)) derivatives of Thiosalicylic Acid and the corresponding binuclear copper(II)-complexes on murine colon carcinoma cell lines, CT26 and CT26.CL25 and human colon carcinoma cell line HCT-116 were reported here. The analysis of cancer cell viability showed that all the tested complexes had low cytotoxic effect on murine colon carcinoma cell lines, but several times higher cytotoxicity on normal human colon carcinoma cells.
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cytotoxicity of palladium ii complexes with some alkyl derivates of Thiosalicylic Acid crystal structure of the bis s butyl thiosalicylate palladium ii complex pd s bu thiosal 2
Polyhedron, 2015Co-Authors: Marina Mijajlovic, Nebojsa Arsenijevic, Zoran Ratkovic, Milos Nikolic, Verica V Jevtic, Slađana B Novakovic, Goran A Bogdanovic, Bojana Simovic Markovic, Vladislav Volarevic, Srecko R TrifunovicAbstract:Abstract The spectroscopically predicted structure of the obtained bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)2], was confirmed by an X-ray structural study. The asymmetric unit of [Pd(S-bu-thiosal)2] consists of neutral complex molecules, where the Pd(II) ion is placed in a cis-square-planar coordination environment formed by O and S atoms of two deprotonated S-butyl-Thiosalicylic Acid ligands. The cytotoxic effects of the S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) and butyl (L5)) derivatives of Thiosalicylic Acid and the corresponding palladium(II) complexes are reported here. The analysis of cancer cell viability showed that all the tested complexes are cytotoxic to human colon carcinoma cells (HCT-116 and CaCo-2) and human lung carcinoma epithelial cells (A549). The antitumor activities of the above mentioned Pd(II) complexes are higher in comparison to the corresponding ligands.
Marina Mijajlovic - One of the best experts on this subject based on the ideXlab platform.
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DNA binding and antitumor activities of platinum(IV) and zinc(II) complexes with some S-alkyl derivatives of Thiosalicylic Acid
Transition Metal Chemistry, 2018Co-Authors: Zana Besser Silconi, Jelena Milovanovic, Zoran Ratkovic, Milos Nikolic, Marina Mijajlovic, Gordana Radić, Sasa Benazic, Milena Jurisevic, Dragana Djordjevic, Snezana RadisavljevicAbstract:A series of complexes of platinum(IV) ( C1 – C5 ) and zinc(II) ( C6 – C10 ) with S-alkyl derivatives of Thiosalicylic Acid were prepared and characterized. The interactions of the complexes with calf thymus DNA were analyzed by absorption (UV–Vis) and emission spectral studies (ethidium bromide displacement studies). The cytotoxic activities of complexes C1 – C10 were determined against mouse B cell lymphocytic leukemia cells (BCL1), human B-prolymphocytic leukemia (JVM-13), mouse mammary carcinoma cells (4T1), and human mammary carcinoma cells (MDA-MB-468) and compared to the activities of the free ligand precursors and cisplatin. The cytotoxicities of the platinum(IV) and zinc(II) complexes toward mouse tumor cell lines were higher compared with their effects on human tumor cell lines. The zinc(II) complex C9 showed the highest antitumor activity toward the tested human cell lines, while the platinum(IV) complex C4 exhibited the highest antitumor activity toward mouse BCL1 and 4T1 cells. Both C4 and C9 have ligands derived from S-propyl Thiosalicylic Acid.
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antibacterial antibiofilm and antioxidant screening of copper ii complexes with some s alkyl derivatives of Thiosalicylic Acid crystal structure of the binuclear copper ii complex with s propyl derivative of Thiosalicylic Acid
Journal of Molecular Structure, 2017Co-Authors: Andriana M Bukonjic, Dusan Lj Tomovic, Zoran Ratkovic, Milos Nikolic, Marina Mijajlovic, Verica V Jevtic, Slađana B Novakovic, Goran A Bogdanovic, Ivana D Radojevic, Jovana Z MaksimovicAbstract:Abstract The spectroscopically predicted structure of the obtained copper(II)-complex with S-propyl derivative of Thiosalicylic Acid was confirmed by X-ray structural study. The binuclear copper(II)-complex with S-propyl derivative of Thiosalicylic Acid crystallized in two polymorphic forms with main structural difference in the orientation of phenyl rings relative to corresponding carboxylate groups. The antibacterial activity was tested determining the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) by using microdilution method. The influence on bacterial biofilm formation was determined by tissue culture plate method. In general, the copper(II)-complexes manifested a selective and moderate activity. The most sensitive bacteria to the effects of Cu(II)-complexes was a clinical isolate of Pseudomonas aeruginosa. For this bacteria MIC and biofilm inhibitory concentration (BIC) values for all tested complexes were in the range or better than the positive control, doxycycline. Also, for the established biofilm of clinical isolate Staphylococcus aureus, BIC values for the copper(II)-complex with S-ethyl derivative of Thiosalicylic Acid,[Cu2(S-et-thiosal)4(H2O)2] (C3) and copper(II)-complex with S-butyl derivative of Thiosalicylic Acid, [Cu2(S-bu-thiosal)4(H2O)2] (C5) were in range or better than the positive control. All the complexes acted better against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus aureus ATCC 25923) than Gram-negative bacteria (Proteus mirabilis ATCC 12453, Pseudomonas aeruginosa, and P. aeruginosa ATCC 27855). The complexes showed weak antioxidative properties tested by two methods (1,1-diphenyl-2-picrylhydrazyl (DPPH) and reducing power assay).
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antibacterial and antibiofilm screening of new platinum iv complexes with some s alkyl derivatives of Thiosalicylic Acid
Kragujevac Journal of Science, 2017Co-Authors: Ivana D Radojevic, Milos Nikolic, Marina Mijajlovic, Srecko R Trifunovic, Ljiljana R Comic, Sava Vasic, Gordana P RadicAbstract:The influence of 5 new Platinum(IV) (Pt(IV)) complexes with S-alkyl derivatives of Thiosalicylic Acid (C1-benzyl, C2-methyl, C3-ethyl, C4-propyl and C5- butyl) was studied on 16 strains of bacteria. Antibacterial activity was tested using microdilution method with resazurin while antibiofilm activity was observed by tissue culture plate method, using doxycycline as a positive control. The results were expressed as minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and biofilm inhibitory concentration (BIC). The best result on Gram positive bacteria exhibited C1 and MIC was <7.81μg/ml against Staphylococcus aureus ATCC 25923. Bifidobacterium animalis subsp. lactis (probiotic) was sensitive to C2 (MIC at 15.625 μg/ml). The highest sensitivity of Gram negative bacteria was observed in Escherichia coli ATCC 25922 treated with C1, C2, C3 and C4, in Proteus mirabilis ATCC 12453 treated with C1, and in Pseudomonas aeruginosa treated with C2, C3 and C5 (all MICs at 250 μg/ml). The C2 complex were more efficient as antibiofilm agents and the best results were obtained with C2 acting against S. aureus and S. aureus ATCC 25923 biofilms. In conclusion, we noticed that the tested compounds exhibited promising properties as antibacterial and antibiofilm agents.
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cytotoxicity of copper ii complexes with some s alkyl derivatives of Thiosalicylic Acid crystal structure of the binuclear copper ii complex with s ethyl derivative of Thiosalicylic Acid
Journal of Molecular Structure, 2016Co-Authors: Milos Nikolic, Aleksandar Arsenijevic, Jelena Milovanovic, Zoran Ratkovic, Marina Mijajlovic, Verica V Jevtic, Slađana B Novakovic, Goran A Bogdanovic, Bojana Stojanovic, Srecko R TrifunovicAbstract:Abstract The spectroscopically predicted structure of the obtained copper(II)-complex with S-ethyl derivative of Thiosalicylic Acid was confirmed by X-ray structural study and compared to previously reported crystal structure of the Cu complex with S-methyl derivative. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. Cytotoxic effects of S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) and butyl (L5)) derivatives of Thiosalicylic Acid and the corresponding binuclear copper(II)-complexes on murine colon carcinoma cell lines, CT26 and CT26.CL25 and human colon carcinoma cell line HCT-116 were reported here. The analysis of cancer cell viability showed that all the tested complexes had low cytotoxic effect on murine colon carcinoma cell lines, but several times higher cytotoxicity on normal human colon carcinoma cells.
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cytotoxicity of palladium ii complexes with some alkyl derivates of Thiosalicylic Acid crystal structure of the bis s butyl thiosalicylate palladium ii complex pd s bu thiosal 2
Polyhedron, 2015Co-Authors: Marina Mijajlovic, Nebojsa Arsenijevic, Zoran Ratkovic, Milos Nikolic, Verica V Jevtic, Slađana B Novakovic, Goran A Bogdanovic, Bojana Simovic Markovic, Vladislav Volarevic, Srecko R TrifunovicAbstract:Abstract The spectroscopically predicted structure of the obtained bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)2], was confirmed by an X-ray structural study. The asymmetric unit of [Pd(S-bu-thiosal)2] consists of neutral complex molecules, where the Pd(II) ion is placed in a cis-square-planar coordination environment formed by O and S atoms of two deprotonated S-butyl-Thiosalicylic Acid ligands. The cytotoxic effects of the S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) and butyl (L5)) derivatives of Thiosalicylic Acid and the corresponding palladium(II) complexes are reported here. The analysis of cancer cell viability showed that all the tested complexes are cytotoxic to human colon carcinoma cells (HCT-116 and CaCo-2) and human lung carcinoma epithelial cells (A549). The antitumor activities of the above mentioned Pd(II) complexes are higher in comparison to the corresponding ligands.
Milos Nikolic - One of the best experts on this subject based on the ideXlab platform.
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DNA binding and antitumor activities of platinum(IV) and zinc(II) complexes with some S-alkyl derivatives of Thiosalicylic Acid
Transition Metal Chemistry, 2018Co-Authors: Zana Besser Silconi, Jelena Milovanovic, Zoran Ratkovic, Milos Nikolic, Marina Mijajlovic, Gordana Radić, Sasa Benazic, Milena Jurisevic, Dragana Djordjevic, Snezana RadisavljevicAbstract:A series of complexes of platinum(IV) ( C1 – C5 ) and zinc(II) ( C6 – C10 ) with S-alkyl derivatives of Thiosalicylic Acid were prepared and characterized. The interactions of the complexes with calf thymus DNA were analyzed by absorption (UV–Vis) and emission spectral studies (ethidium bromide displacement studies). The cytotoxic activities of complexes C1 – C10 were determined against mouse B cell lymphocytic leukemia cells (BCL1), human B-prolymphocytic leukemia (JVM-13), mouse mammary carcinoma cells (4T1), and human mammary carcinoma cells (MDA-MB-468) and compared to the activities of the free ligand precursors and cisplatin. The cytotoxicities of the platinum(IV) and zinc(II) complexes toward mouse tumor cell lines were higher compared with their effects on human tumor cell lines. The zinc(II) complex C9 showed the highest antitumor activity toward the tested human cell lines, while the platinum(IV) complex C4 exhibited the highest antitumor activity toward mouse BCL1 and 4T1 cells. Both C4 and C9 have ligands derived from S-propyl Thiosalicylic Acid.
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antibacterial antibiofilm and antioxidant screening of copper ii complexes with some s alkyl derivatives of Thiosalicylic Acid crystal structure of the binuclear copper ii complex with s propyl derivative of Thiosalicylic Acid
Journal of Molecular Structure, 2017Co-Authors: Andriana M Bukonjic, Dusan Lj Tomovic, Zoran Ratkovic, Milos Nikolic, Marina Mijajlovic, Verica V Jevtic, Slađana B Novakovic, Goran A Bogdanovic, Ivana D Radojevic, Jovana Z MaksimovicAbstract:Abstract The spectroscopically predicted structure of the obtained copper(II)-complex with S-propyl derivative of Thiosalicylic Acid was confirmed by X-ray structural study. The binuclear copper(II)-complex with S-propyl derivative of Thiosalicylic Acid crystallized in two polymorphic forms with main structural difference in the orientation of phenyl rings relative to corresponding carboxylate groups. The antibacterial activity was tested determining the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) by using microdilution method. The influence on bacterial biofilm formation was determined by tissue culture plate method. In general, the copper(II)-complexes manifested a selective and moderate activity. The most sensitive bacteria to the effects of Cu(II)-complexes was a clinical isolate of Pseudomonas aeruginosa. For this bacteria MIC and biofilm inhibitory concentration (BIC) values for all tested complexes were in the range or better than the positive control, doxycycline. Also, for the established biofilm of clinical isolate Staphylococcus aureus, BIC values for the copper(II)-complex with S-ethyl derivative of Thiosalicylic Acid,[Cu2(S-et-thiosal)4(H2O)2] (C3) and copper(II)-complex with S-butyl derivative of Thiosalicylic Acid, [Cu2(S-bu-thiosal)4(H2O)2] (C5) were in range or better than the positive control. All the complexes acted better against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus aureus ATCC 25923) than Gram-negative bacteria (Proteus mirabilis ATCC 12453, Pseudomonas aeruginosa, and P. aeruginosa ATCC 27855). The complexes showed weak antioxidative properties tested by two methods (1,1-diphenyl-2-picrylhydrazyl (DPPH) and reducing power assay).
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antibacterial and antibiofilm screening of new platinum iv complexes with some s alkyl derivatives of Thiosalicylic Acid
Kragujevac Journal of Science, 2017Co-Authors: Ivana D Radojevic, Milos Nikolic, Marina Mijajlovic, Srecko R Trifunovic, Ljiljana R Comic, Sava Vasic, Gordana P RadicAbstract:The influence of 5 new Platinum(IV) (Pt(IV)) complexes with S-alkyl derivatives of Thiosalicylic Acid (C1-benzyl, C2-methyl, C3-ethyl, C4-propyl and C5- butyl) was studied on 16 strains of bacteria. Antibacterial activity was tested using microdilution method with resazurin while antibiofilm activity was observed by tissue culture plate method, using doxycycline as a positive control. The results were expressed as minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and biofilm inhibitory concentration (BIC). The best result on Gram positive bacteria exhibited C1 and MIC was <7.81μg/ml against Staphylococcus aureus ATCC 25923. Bifidobacterium animalis subsp. lactis (probiotic) was sensitive to C2 (MIC at 15.625 μg/ml). The highest sensitivity of Gram negative bacteria was observed in Escherichia coli ATCC 25922 treated with C1, C2, C3 and C4, in Proteus mirabilis ATCC 12453 treated with C1, and in Pseudomonas aeruginosa treated with C2, C3 and C5 (all MICs at 250 μg/ml). The C2 complex were more efficient as antibiofilm agents and the best results were obtained with C2 acting against S. aureus and S. aureus ATCC 25923 biofilms. In conclusion, we noticed that the tested compounds exhibited promising properties as antibacterial and antibiofilm agents.
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cytotoxicity of copper ii complexes with some s alkyl derivatives of Thiosalicylic Acid crystal structure of the binuclear copper ii complex with s ethyl derivative of Thiosalicylic Acid
Journal of Molecular Structure, 2016Co-Authors: Milos Nikolic, Aleksandar Arsenijevic, Jelena Milovanovic, Zoran Ratkovic, Marina Mijajlovic, Verica V Jevtic, Slađana B Novakovic, Goran A Bogdanovic, Bojana Stojanovic, Srecko R TrifunovicAbstract:Abstract The spectroscopically predicted structure of the obtained copper(II)-complex with S-ethyl derivative of Thiosalicylic Acid was confirmed by X-ray structural study and compared to previously reported crystal structure of the Cu complex with S-methyl derivative. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. Cytotoxic effects of S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) and butyl (L5)) derivatives of Thiosalicylic Acid and the corresponding binuclear copper(II)-complexes on murine colon carcinoma cell lines, CT26 and CT26.CL25 and human colon carcinoma cell line HCT-116 were reported here. The analysis of cancer cell viability showed that all the tested complexes had low cytotoxic effect on murine colon carcinoma cell lines, but several times higher cytotoxicity on normal human colon carcinoma cells.
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cytotoxicity of palladium ii complexes with some alkyl derivates of Thiosalicylic Acid crystal structure of the bis s butyl thiosalicylate palladium ii complex pd s bu thiosal 2
Polyhedron, 2015Co-Authors: Marina Mijajlovic, Nebojsa Arsenijevic, Zoran Ratkovic, Milos Nikolic, Verica V Jevtic, Slađana B Novakovic, Goran A Bogdanovic, Bojana Simovic Markovic, Vladislav Volarevic, Srecko R TrifunovicAbstract:Abstract The spectroscopically predicted structure of the obtained bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)2], was confirmed by an X-ray structural study. The asymmetric unit of [Pd(S-bu-thiosal)2] consists of neutral complex molecules, where the Pd(II) ion is placed in a cis-square-planar coordination environment formed by O and S atoms of two deprotonated S-butyl-Thiosalicylic Acid ligands. The cytotoxic effects of the S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) and butyl (L5)) derivatives of Thiosalicylic Acid and the corresponding palladium(II) complexes are reported here. The analysis of cancer cell viability showed that all the tested complexes are cytotoxic to human colon carcinoma cells (HCT-116 and CaCo-2) and human lung carcinoma epithelial cells (A549). The antitumor activities of the above mentioned Pd(II) complexes are higher in comparison to the corresponding ligands.
Slađana B Novakovic - One of the best experts on this subject based on the ideXlab platform.
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antibacterial antibiofilm and antioxidant screening of copper ii complexes with some s alkyl derivatives of Thiosalicylic Acid crystal structure of the binuclear copper ii complex with s propyl derivative of Thiosalicylic Acid
Journal of Molecular Structure, 2017Co-Authors: Andriana M Bukonjic, Dusan Lj Tomovic, Zoran Ratkovic, Milos Nikolic, Marina Mijajlovic, Verica V Jevtic, Slađana B Novakovic, Goran A Bogdanovic, Ivana D Radojevic, Jovana Z MaksimovicAbstract:Abstract The spectroscopically predicted structure of the obtained copper(II)-complex with S-propyl derivative of Thiosalicylic Acid was confirmed by X-ray structural study. The binuclear copper(II)-complex with S-propyl derivative of Thiosalicylic Acid crystallized in two polymorphic forms with main structural difference in the orientation of phenyl rings relative to corresponding carboxylate groups. The antibacterial activity was tested determining the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) by using microdilution method. The influence on bacterial biofilm formation was determined by tissue culture plate method. In general, the copper(II)-complexes manifested a selective and moderate activity. The most sensitive bacteria to the effects of Cu(II)-complexes was a clinical isolate of Pseudomonas aeruginosa. For this bacteria MIC and biofilm inhibitory concentration (BIC) values for all tested complexes were in the range or better than the positive control, doxycycline. Also, for the established biofilm of clinical isolate Staphylococcus aureus, BIC values for the copper(II)-complex with S-ethyl derivative of Thiosalicylic Acid,[Cu2(S-et-thiosal)4(H2O)2] (C3) and copper(II)-complex with S-butyl derivative of Thiosalicylic Acid, [Cu2(S-bu-thiosal)4(H2O)2] (C5) were in range or better than the positive control. All the complexes acted better against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus aureus ATCC 25923) than Gram-negative bacteria (Proteus mirabilis ATCC 12453, Pseudomonas aeruginosa, and P. aeruginosa ATCC 27855). The complexes showed weak antioxidative properties tested by two methods (1,1-diphenyl-2-picrylhydrazyl (DPPH) and reducing power assay).
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cytotoxicity of copper ii complexes with some s alkyl derivatives of Thiosalicylic Acid crystal structure of the binuclear copper ii complex with s ethyl derivative of Thiosalicylic Acid
Journal of Molecular Structure, 2016Co-Authors: Milos Nikolic, Aleksandar Arsenijevic, Jelena Milovanovic, Zoran Ratkovic, Marina Mijajlovic, Verica V Jevtic, Slađana B Novakovic, Goran A Bogdanovic, Bojana Stojanovic, Srecko R TrifunovicAbstract:Abstract The spectroscopically predicted structure of the obtained copper(II)-complex with S-ethyl derivative of Thiosalicylic Acid was confirmed by X-ray structural study and compared to previously reported crystal structure of the Cu complex with S-methyl derivative. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. Cytotoxic effects of S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) and butyl (L5)) derivatives of Thiosalicylic Acid and the corresponding binuclear copper(II)-complexes on murine colon carcinoma cell lines, CT26 and CT26.CL25 and human colon carcinoma cell line HCT-116 were reported here. The analysis of cancer cell viability showed that all the tested complexes had low cytotoxic effect on murine colon carcinoma cell lines, but several times higher cytotoxicity on normal human colon carcinoma cells.
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cytotoxicity of palladium ii complexes with some alkyl derivates of Thiosalicylic Acid crystal structure of the bis s butyl thiosalicylate palladium ii complex pd s bu thiosal 2
Polyhedron, 2015Co-Authors: Marina Mijajlovic, Nebojsa Arsenijevic, Zoran Ratkovic, Milos Nikolic, Verica V Jevtic, Slađana B Novakovic, Goran A Bogdanovic, Bojana Simovic Markovic, Vladislav Volarevic, Srecko R TrifunovicAbstract:Abstract The spectroscopically predicted structure of the obtained bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)2], was confirmed by an X-ray structural study. The asymmetric unit of [Pd(S-bu-thiosal)2] consists of neutral complex molecules, where the Pd(II) ion is placed in a cis-square-planar coordination environment formed by O and S atoms of two deprotonated S-butyl-Thiosalicylic Acid ligands. The cytotoxic effects of the S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) and butyl (L5)) derivatives of Thiosalicylic Acid and the corresponding palladium(II) complexes are reported here. The analysis of cancer cell viability showed that all the tested complexes are cytotoxic to human colon carcinoma cells (HCT-116 and CaCo-2) and human lung carcinoma epithelial cells (A549). The antitumor activities of the above mentioned Pd(II) complexes are higher in comparison to the corresponding ligands.
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synthesis characterization and antimicrobial activity of copper ii complexes with some s alkyl derivatives of Thiosalicylic Acid crystal structure of the binuclear copper ii complex with s methyl derivative of Thiosalicylic Acid
Polyhedron, 2014Co-Authors: Milos Nikolic, Zoran Ratkovic, Marina Mijajlovic, Verica V Jevtic, Slađana B Novakovic, Goran A Bogdanovic, Ivana D Radojevic, Srecko R Trifunovic, Ljiljana R Comic, Gordana P RadicAbstract:Abstract The five new copper(II) complexes with some S-alkyl derivatives of Thiosalicylic Acid (alkyl = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4), butyl (L5)) have been synthesized and characterized by microanalysis and infrared spectra. The spectroscopically predicted structure of the obtained binuclear copper(II) complex with S-methyl derivative of Thiosalicylic Acid was confirmed by X-ray analysis. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. The compound crystallizes with two binuclear Cu(II) complex molecules in the asymmetric unit. Both molecules have typical paddle-wheel structure with apical positions occupied by water molecules. The independent molecules showed slight difference in configuration mainly reflected in the different orientation of the phenyl rings relating to their carboxylate groups. Antimicrobial activity of these complexes was tested by microdilution method and both minimal inhibitory and microbicidal concentration were determined. The intensity of the antimicrobial activity varied depending on the species of microorganism and the compound type. In general, the activity of the complexes was higher than or similar to the corresponding ligands. All the tested complexes demonstrated moderate or selective antibacterial activity and low antifungal activity.
