The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Masashi Takaso - One of the best experts on this subject based on the ideXlab platform.
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Total en bloc spondylectomy of the eleventh Thoracic Vertebra following denosumab therapy for the treatment of a giant cell tumor.
Oncology Letters, 2017Co-Authors: Inoue, Takayuki Imura, Ryo Tazawa, Wataru Saito, Toshiyuki Nakazawa, Masayuki Miyagi, Masashi TakasoAbstract:: Although denosumab has been reported to induce effective clinical results with respect to tumor shrinkage in a short-term follow-up clinical study, total spondylectomy is recognized as the treatment of choice for eradicating giant cell tumors (GCTs) of the spine. The present study reports the case involving a GCT in the 11th Thoracic Vertebra complicated by idiopathic scoliosis and treated using total en bloc spondylectomy (TES) with preoperative denosumab therapy. A 35-year-old woman received preoperative denosumab therapy for 8 months, followed by surgery using a computed tomography (CT)-based navigation system that optimized accuracy by recognizing the area of the detached parietal pleura, the irregular border of the collapsed Vertebra, and the adjacent Vertebra. Complete en bloc resection of the Vertebra could be performed, suggesting denosumab can be an effective adjuvant therapy which can reduce the complexity of TES and CT-navigation system facilitated the safe use of this surgical method in a patient with idiopathic scoliosis.
Jinzeng Yang - One of the best experts on this subject based on the ideXlab platform.
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Transgenic over‐expression of growth differentiation factor 11 propeptide in skeleton results in transformation of the seventh cervical Vertebra into a Thoracic Vertebra
Molecular Reproduction and Development, 2010Co-Authors: Miyuri Kawasumi, Baoping Zhao, Stefan Moisyadi, Jinzeng YangAbstract:Growth differentiation factor 11 (GDF11) is one of the significant genes that control skeletal formation. Knockout of GDF11 function causes abnormal patterning of the anterior/posterior axial skeleton. The mRNA of GDF11 is initially translated to a precursor protein that undergoes a proteolytic cleavage to generate the C-terminal peptide or mature GDF11, and the N-terminal peptide named GDF11 propeptide. The propeptide can antagonize GDF11 activity in vitro. To investigate the effects of GDF11 propeptide on GDF11 function in vivo, we generated transgenic mice that over-express the propeptide cDNA in skeletal tissue. The transgenic mice showed formation of extra ribs on the seventh cervical Vertebra (C7) as a result of transformation of the C7 Vertebra into a Thoracic Vertebra. The GDF11 propeptide transgene mRNA was detected in tail tissue in embryos and was highly expressed in tail and calvaria bones after birth. A high frequency of C7 rib formation was noticed in the transgenic mouse line with a high level of transgene expression. The anterior boundaries of Hoxa-4 and Hoxa-5 mRNA in situ expressions showed cranial shifts from their normal preVertebra locations in transgenic embryos. These results demonstrated significant effects of GDF11 propeptide transgene on Vertebral formation, which are likely occurring through depressing GDF11 function and altered locations of Hoxa-4 and Hoxa-5 expression.
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transgenic over expression of growth differentiation factor 11 propeptide in skeleton results in transformation of the seventh cervical Vertebra into a Thoracic Vertebra
Molecular Reproduction and Development, 2010Co-Authors: Miyuri Kawasumi, Baoping Zhao, Stefan Moisyadi, Jinzeng YangAbstract:Growth differentiation factor 11 (GDF11) is one of the significant genes that control skeletal formation. Knockout of GDF11 function causes abnormal patterning of the anterior/posterior axial skeleton. The mRNA of GDF11 is initially translated to a precursor protein that undergoes a proteolytic cleavage to generate the C-terminal peptide or mature GDF11, and the N-terminal peptide named GDF11 propeptide. The propeptide can antagonize GDF11 activity in vitro. To investigate the effects of GDF11 propeptide on GDF11 function in vivo, we generated transgenic mice that over-express the propeptide cDNA in skeletal tissue. The transgenic mice showed formation of extra ribs on the seventh cervical Vertebra (C7) as a result of transformation of the C7 Vertebra into a Thoracic Vertebra. The GDF11 propeptide transgene mRNA was detected in tail tissue in embryos and was highly expressed in tail and calvaria bones after birth. A high frequency of C7 rib formation was noticed in the transgenic mouse line with a high level of transgene expression. The anterior boundaries of Hoxa-4 and Hoxa-5 mRNA in situ expressions showed cranial shifts from their normal preVertebra locations in transgenic embryos. These results demonstrated significant effects of GDF11 propeptide transgene on Vertebral formation, which are likely occurring through depressing GDF11 function and altered locations of Hoxa-4 and Hoxa-5 expression.
Inoue - One of the best experts on this subject based on the ideXlab platform.
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Total en bloc spondylectomy of the eleventh Thoracic Vertebra following denosumab therapy for the treatment of a giant cell tumor.
Oncology Letters, 2017Co-Authors: Inoue, Takayuki Imura, Ryo Tazawa, Wataru Saito, Toshiyuki Nakazawa, Masayuki Miyagi, Masashi TakasoAbstract:: Although denosumab has been reported to induce effective clinical results with respect to tumor shrinkage in a short-term follow-up clinical study, total spondylectomy is recognized as the treatment of choice for eradicating giant cell tumors (GCTs) of the spine. The present study reports the case involving a GCT in the 11th Thoracic Vertebra complicated by idiopathic scoliosis and treated using total en bloc spondylectomy (TES) with preoperative denosumab therapy. A 35-year-old woman received preoperative denosumab therapy for 8 months, followed by surgery using a computed tomography (CT)-based navigation system that optimized accuracy by recognizing the area of the detached parietal pleura, the irregular border of the collapsed Vertebra, and the adjacent Vertebra. Complete en bloc resection of the Vertebra could be performed, suggesting denosumab can be an effective adjuvant therapy which can reduce the complexity of TES and CT-navigation system facilitated the safe use of this surgical method in a patient with idiopathic scoliosis.
Jian Zhang - One of the best experts on this subject based on the ideXlab platform.
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Modified total en bloc spondylectomy for Thoracic Vertebra tumor through single posterior approach
Chinese Journal of Orthopaedics, 2010Co-Authors: Chang-an Guo, Zuo-qin Yan, Jian ZhangAbstract:Objective To investigate the practicability and safety of modified total en bloc spondyleetumy(MTES).Methods We had designed a series of novel surgical instruments for MTES inde-pendently,including saw cutter,disc puncture needle with sleeve,the saw leading clamp and protecting re-tractor.The traditional total en bloc spondylectomy(TES),which was reported by Tomita with"one step dis-section"from anteriorly to posteriorly,was modified into"two step dissection"from medially to exteriorly.Firstly,the desired cutting disc was punctured through the plane between dura mater spinalis and disc obliquely with 45°-60° to horizontal plane by using the disc puncture needle with sleeve in posterior-anterior direction.The needle and its sleeve were stopped by the protecting retractor,and then the needle was pulled out and a saw was inserted through the left sleeve.The tip of the inserted saw was led out to the same side by the leading clamp.The disc was cut by saw from medially to exteriorly.The neighboring disc was cut through same procedure.After a spine fixation rod was applied on this side,the residual discs on the oppo-site side were cut as previously described.Five patients with Thoracic Vertebra tumor were treated by using MTES technique through a single posterior approach.The etiology of the 5 patients included 1 case of osteo-lastoma,2 of giant cell tumor,1 of malignant angeioma,and 1 of metastasis of prostate carcinoma.Results MTES was performed successfully on all patients through a single posterior approach.The neurological deficit in all patients was not aggravated postoperatively.The neurological improvement was seen in 4 pa-tients.The average operative time was 7.6 h,and average blood loss was 1750 ml.No disruption of dural mater and the leakage of cerebrospinal fluid were found.No recurrence of tumor was observed at final follow-up.Conclusion MTES for Thoracic Vertebra tumor dissection through single posterior approach is technical-ly feasible.Compared with traditional TES,the practicability and safety of MTES has improved significantly. Key words: Thoracic Vertebrae; Spinal neoplasms; Surgical procedures,operative; Treatment outcome
Miyuri Kawasumi - One of the best experts on this subject based on the ideXlab platform.
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Transgenic over‐expression of growth differentiation factor 11 propeptide in skeleton results in transformation of the seventh cervical Vertebra into a Thoracic Vertebra
Molecular Reproduction and Development, 2010Co-Authors: Miyuri Kawasumi, Baoping Zhao, Stefan Moisyadi, Jinzeng YangAbstract:Growth differentiation factor 11 (GDF11) is one of the significant genes that control skeletal formation. Knockout of GDF11 function causes abnormal patterning of the anterior/posterior axial skeleton. The mRNA of GDF11 is initially translated to a precursor protein that undergoes a proteolytic cleavage to generate the C-terminal peptide or mature GDF11, and the N-terminal peptide named GDF11 propeptide. The propeptide can antagonize GDF11 activity in vitro. To investigate the effects of GDF11 propeptide on GDF11 function in vivo, we generated transgenic mice that over-express the propeptide cDNA in skeletal tissue. The transgenic mice showed formation of extra ribs on the seventh cervical Vertebra (C7) as a result of transformation of the C7 Vertebra into a Thoracic Vertebra. The GDF11 propeptide transgene mRNA was detected in tail tissue in embryos and was highly expressed in tail and calvaria bones after birth. A high frequency of C7 rib formation was noticed in the transgenic mouse line with a high level of transgene expression. The anterior boundaries of Hoxa-4 and Hoxa-5 mRNA in situ expressions showed cranial shifts from their normal preVertebra locations in transgenic embryos. These results demonstrated significant effects of GDF11 propeptide transgene on Vertebral formation, which are likely occurring through depressing GDF11 function and altered locations of Hoxa-4 and Hoxa-5 expression.
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transgenic over expression of growth differentiation factor 11 propeptide in skeleton results in transformation of the seventh cervical Vertebra into a Thoracic Vertebra
Molecular Reproduction and Development, 2010Co-Authors: Miyuri Kawasumi, Baoping Zhao, Stefan Moisyadi, Jinzeng YangAbstract:Growth differentiation factor 11 (GDF11) is one of the significant genes that control skeletal formation. Knockout of GDF11 function causes abnormal patterning of the anterior/posterior axial skeleton. The mRNA of GDF11 is initially translated to a precursor protein that undergoes a proteolytic cleavage to generate the C-terminal peptide or mature GDF11, and the N-terminal peptide named GDF11 propeptide. The propeptide can antagonize GDF11 activity in vitro. To investigate the effects of GDF11 propeptide on GDF11 function in vivo, we generated transgenic mice that over-express the propeptide cDNA in skeletal tissue. The transgenic mice showed formation of extra ribs on the seventh cervical Vertebra (C7) as a result of transformation of the C7 Vertebra into a Thoracic Vertebra. The GDF11 propeptide transgene mRNA was detected in tail tissue in embryos and was highly expressed in tail and calvaria bones after birth. A high frequency of C7 rib formation was noticed in the transgenic mouse line with a high level of transgene expression. The anterior boundaries of Hoxa-4 and Hoxa-5 mRNA in situ expressions showed cranial shifts from their normal preVertebra locations in transgenic embryos. These results demonstrated significant effects of GDF11 propeptide transgene on Vertebral formation, which are likely occurring through depressing GDF11 function and altered locations of Hoxa-4 and Hoxa-5 expression.