The Experts below are selected from a list of 8601 Experts worldwide ranked by ideXlab platform

Jasreen Kaur - One of the best experts on this subject based on the ideXlab platform.

  • toxicological evaluation of metal oxide nanoparticles and mixed exposures at low doses using zebra fish and THP1 Cell Line
    2019
    Co-Authors: Jasreen Kaur, Madhu Khatri, Sanjeev Puri
    Abstract:

    Metal and metal oxide nanoparticles are being used in different industries now‐a‐days leading to their unavoidable exposure to humans and animals. In the present study, toxicological testing was done using nanoparticles of copper oxide, cerium oxide and their mixture (1:1 ratio) on zebra fish embryos and THP‐1 Cell Line. Zebrafish embryos were exposed to 0.01 μg/ml to 50 μg/ml concentrations of dispersed nanoparticles using a 96 well plate and their effects were studied at different hours post fertilization (hpf) i.e. 0 hpf, 24 hpf, 48 hpf, 72 hpf and 96 hpf respectively. Results showed that copper oxide nanoparticles has drastic effects on the morphology and physiology of zebra fish whereas cerium oxide nanoparticles and mixture of these nanoparticles did not show much of the effects. Comparable results were obtained from in vitro study using human monocyte Cell Line (THP‐1). It is concluded that these nanoparticles may cause toxicological effects to humans and environment.

Sanjeev Puri - One of the best experts on this subject based on the ideXlab platform.

  • toxicological evaluation of metal oxide nanoparticles and mixed exposures at low doses using zebra fish and THP1 Cell Line
    2019
    Co-Authors: Jasreen Kaur, Madhu Khatri, Sanjeev Puri
    Abstract:

    Metal and metal oxide nanoparticles are being used in different industries now‐a‐days leading to their unavoidable exposure to humans and animals. In the present study, toxicological testing was done using nanoparticles of copper oxide, cerium oxide and their mixture (1:1 ratio) on zebra fish embryos and THP‐1 Cell Line. Zebrafish embryos were exposed to 0.01 μg/ml to 50 μg/ml concentrations of dispersed nanoparticles using a 96 well plate and their effects were studied at different hours post fertilization (hpf) i.e. 0 hpf, 24 hpf, 48 hpf, 72 hpf and 96 hpf respectively. Results showed that copper oxide nanoparticles has drastic effects on the morphology and physiology of zebra fish whereas cerium oxide nanoparticles and mixture of these nanoparticles did not show much of the effects. Comparable results were obtained from in vitro study using human monocyte Cell Line (THP‐1). It is concluded that these nanoparticles may cause toxicological effects to humans and environment.

Madhu Khatri - One of the best experts on this subject based on the ideXlab platform.

  • toxicological evaluation of metal oxide nanoparticles and mixed exposures at low doses using zebra fish and THP1 Cell Line
    2019
    Co-Authors: Jasreen Kaur, Madhu Khatri, Sanjeev Puri
    Abstract:

    Metal and metal oxide nanoparticles are being used in different industries now‐a‐days leading to their unavoidable exposure to humans and animals. In the present study, toxicological testing was done using nanoparticles of copper oxide, cerium oxide and their mixture (1:1 ratio) on zebra fish embryos and THP‐1 Cell Line. Zebrafish embryos were exposed to 0.01 μg/ml to 50 μg/ml concentrations of dispersed nanoparticles using a 96 well plate and their effects were studied at different hours post fertilization (hpf) i.e. 0 hpf, 24 hpf, 48 hpf, 72 hpf and 96 hpf respectively. Results showed that copper oxide nanoparticles has drastic effects on the morphology and physiology of zebra fish whereas cerium oxide nanoparticles and mixture of these nanoparticles did not show much of the effects. Comparable results were obtained from in vitro study using human monocyte Cell Line (THP‐1). It is concluded that these nanoparticles may cause toxicological effects to humans and environment.

Frungieri, Monica Beatriz - One of the best experts on this subject based on the ideXlab platform.

  • β-adrenergic receptors in the up-regulation of COX2 expression and prostaglandin production in testicular macrophages: Possible relevance to male idiopathic infertility
    2019
    Co-Authors: Matzkin, Maria Eugenia, Riviere Eugenia, Rossi, Soledad Paola, Ponzio Roberto, Puigdomenech Elisa, Levalle Oscar, Terradas Claudio, Calandra, Ricardo Saul, Mayerhofer Artur, Frungieri, Monica Beatriz
    Abstract:

    Catecholaminergic neuronal elements (CNE) and macrophages (MACs) are increased in testes of patients withidiopathic infertility. Now, we describe an anatomical proximity between CNE and MACs, expression of specificα- and β-adrenergic receptors (ADRs) subtypes in MACs, and a positive correlation between the number of MACsand cyclooxygenase (COX2) expression - key enzyme in prostaglandin (PG) synthesis and an inflammatorymarker - in testes of infertile men. To examine a potential effect of adrenergic input on COX2 expression, we usedtwo additional experimental models: non-testicular human MACs (THP1 Cell Line) and non-human testicularMACs purified from adult Syrian hamsters. We found that epinephrine and norepinephrine up-regulate COX2expression and PGD2 production through β1-and β2-ADRs.Our results demonstrate the existence of a yet unknown link between CNE and MACs in the human testis thatcould trigger inflammation and tissue homeostatic dysregulation associated with pathogenesis or maintenance of infertility states.Fil: Matzkin, Maria Eugenia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Riviere, Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires; ArgentinaFil: Rossi, Soledad Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaFil: Ponzio, Roberto. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Puigdomenech, Elisa. Instituto Médico IPREFER; ArgentinaFil: Levalle, Oscar. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Carlos Durand.; ArgentinaFil: Terradas, Claudio. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Carlos Durand.; ArgentinaFil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Mayerhofer, Artur. Ludwig Maximilians Universitat; AlemaniaFil: Frungieri, Monica Beatriz. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentin

  • β-adrenergic receptors in the up-regulation of COX2 expression and prostaglandin production in testicular macrophages: possible relevance to male idiopathic infertility
    2019
    Co-Authors: Matzkin, Maria Eugenia, Riviere Eugenia, Rossi, Soledad Paola, Ponzio Roberto, Puigdomenech Elisa, Levalle Oscar, Terradas Claudio, Calandra, Ricardo Saul, Mayerhofer Artur, Frungieri, Monica Beatriz
    Abstract:

    Catecholaminergic neuronal elements (CNE) and macrophages (MACs) are increased in testes of patients with idiopathic infertility. Now, we describe an anatomical proximity between CNE and MACs, expression of specific α- and β-adrenergic receptors (ADRs) subtypes in MACs, and a positive correlation between the number of MACs and cyclooxygenase (COX2) expression - key enzyme in prostaglandin (PG) synthesis and an inflammatory marker - in testes of infertile men. To examine a potential effect of adrenergic input on COX2 expression, we used two additional experimental models: non-testicular human MACs (THP1 Cell Line) and non-human testicular MACs purified from adult Syrian hamsters. We found that epinephrine and norepinephrine up-regulate COX2 expression and PGD2 production through β1-and β2-ADRs. Our results demonstrate the existence of a yet unknown link between CNE and MACs in the human testis that could trigger inflammation and tissue homeostatic dysregulation associated with pathogenesis or maintenance of infertility states.Fil: Matzkin, Maria Eugenia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Riviere, Eugenia. Universidad de Buenos Aires. Ciclo Básico Común; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rossi, Soledad Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaFil: Ponzio, Roberto. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Puigdomenech, Elisa. Instituto Médico PREFER; ArgentinaFil: Levalle, Oscar. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Carlos Durand.; ArgentinaFil: Terradas, Claudio. Instituto de Alta Complejidad San Isidro; Argentina. Instituto Médico PREFER; Argentina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Carlos Durand.; ArgentinaFil: Calandra, Ricardo Saúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Mayerhofer, Artur. Ludwig Maximilians Universitat; AlemaniaFil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Ciclo Básico Común; Argentin

Matzkin, Maria Eugenia - One of the best experts on this subject based on the ideXlab platform.

  • β-adrenergic receptors in the up-regulation of COX2 expression and prostaglandin production in testicular macrophages: Possible relevance to male idiopathic infertility
    2019
    Co-Authors: Matzkin, Maria Eugenia, Riviere Eugenia, Rossi, Soledad Paola, Ponzio Roberto, Puigdomenech Elisa, Levalle Oscar, Terradas Claudio, Calandra, Ricardo Saul, Mayerhofer Artur, Frungieri, Monica Beatriz
    Abstract:

    Catecholaminergic neuronal elements (CNE) and macrophages (MACs) are increased in testes of patients withidiopathic infertility. Now, we describe an anatomical proximity between CNE and MACs, expression of specificα- and β-adrenergic receptors (ADRs) subtypes in MACs, and a positive correlation between the number of MACsand cyclooxygenase (COX2) expression - key enzyme in prostaglandin (PG) synthesis and an inflammatorymarker - in testes of infertile men. To examine a potential effect of adrenergic input on COX2 expression, we usedtwo additional experimental models: non-testicular human MACs (THP1 Cell Line) and non-human testicularMACs purified from adult Syrian hamsters. We found that epinephrine and norepinephrine up-regulate COX2expression and PGD2 production through β1-and β2-ADRs.Our results demonstrate the existence of a yet unknown link between CNE and MACs in the human testis thatcould trigger inflammation and tissue homeostatic dysregulation associated with pathogenesis or maintenance of infertility states.Fil: Matzkin, Maria Eugenia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Riviere, Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires; ArgentinaFil: Rossi, Soledad Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaFil: Ponzio, Roberto. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Puigdomenech, Elisa. Instituto Médico IPREFER; ArgentinaFil: Levalle, Oscar. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Carlos Durand.; ArgentinaFil: Terradas, Claudio. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Carlos Durand.; ArgentinaFil: Calandra, Ricardo Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Mayerhofer, Artur. Ludwig Maximilians Universitat; AlemaniaFil: Frungieri, Monica Beatriz. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentin

  • β-adrenergic receptors in the up-regulation of COX2 expression and prostaglandin production in testicular macrophages: possible relevance to male idiopathic infertility
    2019
    Co-Authors: Matzkin, Maria Eugenia, Riviere Eugenia, Rossi, Soledad Paola, Ponzio Roberto, Puigdomenech Elisa, Levalle Oscar, Terradas Claudio, Calandra, Ricardo Saul, Mayerhofer Artur, Frungieri, Monica Beatriz
    Abstract:

    Catecholaminergic neuronal elements (CNE) and macrophages (MACs) are increased in testes of patients with idiopathic infertility. Now, we describe an anatomical proximity between CNE and MACs, expression of specific α- and β-adrenergic receptors (ADRs) subtypes in MACs, and a positive correlation between the number of MACs and cyclooxygenase (COX2) expression - key enzyme in prostaglandin (PG) synthesis and an inflammatory marker - in testes of infertile men. To examine a potential effect of adrenergic input on COX2 expression, we used two additional experimental models: non-testicular human MACs (THP1 Cell Line) and non-human testicular MACs purified from adult Syrian hamsters. We found that epinephrine and norepinephrine up-regulate COX2 expression and PGD2 production through β1-and β2-ADRs. Our results demonstrate the existence of a yet unknown link between CNE and MACs in the human testis that could trigger inflammation and tissue homeostatic dysregulation associated with pathogenesis or maintenance of infertility states.Fil: Matzkin, Maria Eugenia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Riviere, Eugenia. Universidad de Buenos Aires. Ciclo Básico Común; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rossi, Soledad Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; ArgentinaFil: Ponzio, Roberto. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Puigdomenech, Elisa. Instituto Médico PREFER; ArgentinaFil: Levalle, Oscar. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Carlos Durand.; ArgentinaFil: Terradas, Claudio. Instituto de Alta Complejidad San Isidro; Argentina. Instituto Médico PREFER; Argentina. Gobierno de la Ciudad Autonoma de Buenos Aires. Hospital General de Agudos Carlos Durand.; ArgentinaFil: Calandra, Ricardo Saúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Mayerhofer, Artur. Ludwig Maximilians Universitat; AlemaniaFil: Frungieri, Monica Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Ciclo Básico Común; Argentin