The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Scott J. Montain - One of the best experts on this subject based on the ideXlab platform.
-
a simple and valid method to determine thermoregulatory sweating Threshold and sensitivity
Journal of Applied Physiology, 2009Co-Authors: Samuel N Cheuvront, Michael N. Sawka, Shawn E Bearden, Robert W Kenefick, Brett R Ely, David W Degroot, Scott J. MontainAbstract:Sweating Threshold Temperature and sweating sensitivity responses are measured to evaluate thermoregulatory control. However, analytic approaches vary, and no standardized methodology has been vali...
-
Control of thermoregulatory sweating is altered by hydration level and exercise intensity
Journal of Applied Physiology, 1995Co-Authors: Scott J. Montain, William A. Latzka, Michael N. SawkaAbstract:The purpose of this study was to examine the thermoregulatory sweating control parameters of Threshold Temperature and sensitivity to determine whether 1) these variables were altered by hypohydration level and exercise intensity and 2) these alterations, if present, were additive and independent. Nine heat-acclimated men completed a matrix of nine trials: three exercise intensities of 25, 45, and 65% maximal O2 uptake and three hydration levels, i.e., euhydration and hypohydration (Hy) at 3 and 5% of body weight. During each trial, subjects attempted 50 min of treadmill exercise in a warm room (30 degrees C dry bulb, 50% relative humidity) while esophageal Temperature and upper arm sweating rate were continuously measured. Hypohydration was achieved by exercise and fluid restriction the day preceding the trials. The following new findings were made: 1) Threshold Temperature increased in graded manner with hypohydration level (approximately 0.06 degree C/% Hy); 2) sensitivity decreased in a graded manner with hypohydration level (approximately 0.06 units/%Hy); 3) Threshold Temperature was not altered by exercise intensity; and 4) sensitivity increased from low- to moderate- and high-intensity exercise. We conclude that both hypohydration level and exercise intensity produce independent effects on control of thermoregulatory sweating.
Kazue Mizumura - One of the best experts on this subject based on the ideXlab platform.
-
bradykinin lowers the Threshold Temperature for heat activation of vanilloid receptor 1
Journal of Neurophysiology, 2002Co-Authors: Takeshi Sugiura, Makoto Tominaga, Hirotada Katsuya, Kazue MizumuraAbstract:Bradykinin (BK) is an inflammatory mediator that plays a pivotal role in pain and hyperalgesia to heat in inflamed tissues by exciting nociceptors and sensitizing them to heat through activation of protein kinase C (PKC). It has been suggested that the capsaicin receptor (VR1), a nociceptor-specific cation channel sensitive to noxious heat, protons, and capsaicin, is a channel that is modified by BK in these effects. In this study, we examined how BK modulates the activity of VR1. We measured VR1 currents using the patch-clamp technique in human embryonic kidney-derived (HEK293) cells expressing VR1 and B2 BK receptor. We found that BK lowered the Threshold Temperature for activation of VR1 currents in HEK cells down to well below the physiological body Temperature in a concentration-dependent manner through PKC activation. We also demonstrated that in capsaicin-sensitive dorsal root ganglion (DRG) neurons the activation Threshold of heat-induced current, which is considered to be VR-1 mediated, was lowered by BK and that this effect was also mediated by PKC. These data further support the supposition that modulation of VR1 is a mechanism for the BK-induced excitation of nociceptors and their sensitization to heat.
-
bradykinin lowers the Threshold Temperature for heat activation of vanilloid receptor 1
Journal of Neurophysiology, 2002Co-Authors: Takeshi Sugiura, Makoto Tominaga, Hirotada Katsuya, Kazue MizumuraAbstract:Bradykinin (BK) is an inflammatory mediator that plays a pivotal role in pain and hyperalgesia to heat in inflamed tissues by exciting nociceptors and sensitizing them to heat through activation of...
Takeshi Sugiura - One of the best experts on this subject based on the ideXlab platform.
-
bradykinin lowers the Threshold Temperature for heat activation of vanilloid receptor 1
Journal of Neurophysiology, 2002Co-Authors: Takeshi Sugiura, Makoto Tominaga, Hirotada Katsuya, Kazue MizumuraAbstract:Bradykinin (BK) is an inflammatory mediator that plays a pivotal role in pain and hyperalgesia to heat in inflamed tissues by exciting nociceptors and sensitizing them to heat through activation of protein kinase C (PKC). It has been suggested that the capsaicin receptor (VR1), a nociceptor-specific cation channel sensitive to noxious heat, protons, and capsaicin, is a channel that is modified by BK in these effects. In this study, we examined how BK modulates the activity of VR1. We measured VR1 currents using the patch-clamp technique in human embryonic kidney-derived (HEK293) cells expressing VR1 and B2 BK receptor. We found that BK lowered the Threshold Temperature for activation of VR1 currents in HEK cells down to well below the physiological body Temperature in a concentration-dependent manner through PKC activation. We also demonstrated that in capsaicin-sensitive dorsal root ganglion (DRG) neurons the activation Threshold of heat-induced current, which is considered to be VR-1 mediated, was lowered by BK and that this effect was also mediated by PKC. These data further support the supposition that modulation of VR1 is a mechanism for the BK-induced excitation of nociceptors and their sensitization to heat.
-
bradykinin lowers the Threshold Temperature for heat activation of vanilloid receptor 1
Journal of Neurophysiology, 2002Co-Authors: Takeshi Sugiura, Makoto Tominaga, Hirotada Katsuya, Kazue MizumuraAbstract:Bradykinin (BK) is an inflammatory mediator that plays a pivotal role in pain and hyperalgesia to heat in inflamed tissues by exciting nociceptors and sensitizing them to heat through activation of...
Xiaoguang Wang - One of the best experts on this subject based on the ideXlab platform.
-
Threshold Temperature for pairwise and many particle thermal entanglement in the isotropic heisenberg model
Physical Review A, 2002Co-Authors: Xiaoguang WangAbstract:We study the Threshold Temperature for pairwise thermal entanglement in the spin-1/2 isotropic Heisenberg model up to 11 spins and find that the Threshold Temperature for odd and even number of qubits approaches the thermal dynamical limit from below and above, respectively. The Threshold Temperature in the thermodynamical limit is estimated. We investigate the many-particle entanglement in both the ground states and the thermal states of the model up to 11 spins, and find that the ground state in the four-qubit model is a four-particle entangled state and the corresponding thermal state is also a four-particle entangled state before a Threshold Temperature.
Michael N. Sawka - One of the best experts on this subject based on the ideXlab platform.
-
a simple and valid method to determine thermoregulatory sweating Threshold and sensitivity
Journal of Applied Physiology, 2009Co-Authors: Samuel N Cheuvront, Michael N. Sawka, Shawn E Bearden, Robert W Kenefick, Brett R Ely, David W Degroot, Scott J. MontainAbstract:Sweating Threshold Temperature and sweating sensitivity responses are measured to evaluate thermoregulatory control. However, analytic approaches vary, and no standardized methodology has been vali...
-
Control of thermoregulatory sweating is altered by hydration level and exercise intensity
Journal of Applied Physiology, 1995Co-Authors: Scott J. Montain, William A. Latzka, Michael N. SawkaAbstract:The purpose of this study was to examine the thermoregulatory sweating control parameters of Threshold Temperature and sensitivity to determine whether 1) these variables were altered by hypohydration level and exercise intensity and 2) these alterations, if present, were additive and independent. Nine heat-acclimated men completed a matrix of nine trials: three exercise intensities of 25, 45, and 65% maximal O2 uptake and three hydration levels, i.e., euhydration and hypohydration (Hy) at 3 and 5% of body weight. During each trial, subjects attempted 50 min of treadmill exercise in a warm room (30 degrees C dry bulb, 50% relative humidity) while esophageal Temperature and upper arm sweating rate were continuously measured. Hypohydration was achieved by exercise and fluid restriction the day preceding the trials. The following new findings were made: 1) Threshold Temperature increased in graded manner with hypohydration level (approximately 0.06 degree C/% Hy); 2) sensitivity decreased in a graded manner with hypohydration level (approximately 0.06 units/%Hy); 3) Threshold Temperature was not altered by exercise intensity; and 4) sensitivity increased from low- to moderate- and high-intensity exercise. We conclude that both hypohydration level and exercise intensity produce independent effects on control of thermoregulatory sweating.
