The Experts below are selected from a list of 126 Experts worldwide ranked by ideXlab platform
Sacide Pehlivan - One of the best experts on this subject based on the ideXlab platform.
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investigation of tnf alpha tgf beta 1 il 10 il 6 ifn gamma mbl gpia and il1a gene polymorphisms in patients with idiopathic thrombocytopenic purpura
Platelets, 2011Co-Authors: Mustafa Pehlivan, Vahap Okan, Tugce Sever, Mustafa Yilmaz, T Babacan, Oguzkan S Balci, Sacide PehlivanAbstract:Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by the presence of autoantibodies developing against Thrombocyte Membrane glycoproteins (GPs), such as GPIIa/IIIa and GPIb/IX. Single nucleotide polymorphisms (SNPs) of inflammatory cytokine genes were investigated in 71 patients with chronic ITP and 71 healthy controls, and they were compared with the clinical parameters. The polymorphisms in the SNPs were investigated with the polymerase chain reaction, polymerase chain reaction with sequence specific primer, and polymerase chain reaction-restriction fragment length polymorphism methods. It was found that the high expression of TNF-alpha (−308) AG phenotype significantly increased in cases with ITP (odds ratio, OR: 0.318, 95% confidence intervals, CI: 0.103–0.987, p < 0.05). TT genotype in TGF-beta 1 (codon 10) significantly decreased in ITP in comparison with the controls (OR: 0.342, 95% CI: 0.149–0.787, p = 0.016). IFN-gamma (+874) TT genotype was detected to be high in cases...
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Investigation of TNF-alpha, TGF-beta 1, IL-10, IL-6, IFN-gamma, MBL, GPIA, and IL1A gene polymorphisms in patients with idiopathic thrombocytopenic purpura
Platelets, 2011Co-Authors: Mustafa Pehlivan, Vahap Okan, Tugce Sever, S. Oguzkan Balci, Mustafa Yilmaz, T Babacan, Sacide PehlivanAbstract:Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by the presence of autoantibodies developing against Thrombocyte Membrane glycoproteins (GPs), such as GPIIa/IIIa and GPIb/IX. Single nucleotide polymorphisms (SNPs) of inflammatory cytokine genes were investigated in 71 patients with chronic ITP and 71 healthy controls, and they were compared with the clinical parameters. The polymorphisms in the SNPs were investigated with the polymerase chain reaction, polymerase chain reaction with sequence specific primer, and polymerase chain reaction-restriction fragment length polymorphism methods. It was found that the high expression of TNF-alpha (−308) AG phenotype significantly increased in cases with ITP (odds ratio, OR: 0.318, 95% confidence intervals, CI: 0.103–0.987, p
Mustafa Pehlivan - One of the best experts on this subject based on the ideXlab platform.
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investigation of tnf alpha tgf beta 1 il 10 il 6 ifn gamma mbl gpia and il1a gene polymorphisms in patients with idiopathic thrombocytopenic purpura
Platelets, 2011Co-Authors: Mustafa Pehlivan, Vahap Okan, Tugce Sever, Mustafa Yilmaz, T Babacan, Oguzkan S Balci, Sacide PehlivanAbstract:Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by the presence of autoantibodies developing against Thrombocyte Membrane glycoproteins (GPs), such as GPIIa/IIIa and GPIb/IX. Single nucleotide polymorphisms (SNPs) of inflammatory cytokine genes were investigated in 71 patients with chronic ITP and 71 healthy controls, and they were compared with the clinical parameters. The polymorphisms in the SNPs were investigated with the polymerase chain reaction, polymerase chain reaction with sequence specific primer, and polymerase chain reaction-restriction fragment length polymorphism methods. It was found that the high expression of TNF-alpha (−308) AG phenotype significantly increased in cases with ITP (odds ratio, OR: 0.318, 95% confidence intervals, CI: 0.103–0.987, p < 0.05). TT genotype in TGF-beta 1 (codon 10) significantly decreased in ITP in comparison with the controls (OR: 0.342, 95% CI: 0.149–0.787, p = 0.016). IFN-gamma (+874) TT genotype was detected to be high in cases...
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Investigation of TNF-alpha, TGF-beta 1, IL-10, IL-6, IFN-gamma, MBL, GPIA, and IL1A gene polymorphisms in patients with idiopathic thrombocytopenic purpura
Platelets, 2011Co-Authors: Mustafa Pehlivan, Vahap Okan, Tugce Sever, S. Oguzkan Balci, Mustafa Yilmaz, T Babacan, Sacide PehlivanAbstract:Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by the presence of autoantibodies developing against Thrombocyte Membrane glycoproteins (GPs), such as GPIIa/IIIa and GPIb/IX. Single nucleotide polymorphisms (SNPs) of inflammatory cytokine genes were investigated in 71 patients with chronic ITP and 71 healthy controls, and they were compared with the clinical parameters. The polymorphisms in the SNPs were investigated with the polymerase chain reaction, polymerase chain reaction with sequence specific primer, and polymerase chain reaction-restriction fragment length polymorphism methods. It was found that the high expression of TNF-alpha (−308) AG phenotype significantly increased in cases with ITP (odds ratio, OR: 0.318, 95% confidence intervals, CI: 0.103–0.987, p
Tugce Sever - One of the best experts on this subject based on the ideXlab platform.
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investigation of tnf alpha tgf beta 1 il 10 il 6 ifn gamma mbl gpia and il1a gene polymorphisms in patients with idiopathic thrombocytopenic purpura
Platelets, 2011Co-Authors: Mustafa Pehlivan, Vahap Okan, Tugce Sever, Mustafa Yilmaz, T Babacan, Oguzkan S Balci, Sacide PehlivanAbstract:Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by the presence of autoantibodies developing against Thrombocyte Membrane glycoproteins (GPs), such as GPIIa/IIIa and GPIb/IX. Single nucleotide polymorphisms (SNPs) of inflammatory cytokine genes were investigated in 71 patients with chronic ITP and 71 healthy controls, and they were compared with the clinical parameters. The polymorphisms in the SNPs were investigated with the polymerase chain reaction, polymerase chain reaction with sequence specific primer, and polymerase chain reaction-restriction fragment length polymorphism methods. It was found that the high expression of TNF-alpha (−308) AG phenotype significantly increased in cases with ITP (odds ratio, OR: 0.318, 95% confidence intervals, CI: 0.103–0.987, p < 0.05). TT genotype in TGF-beta 1 (codon 10) significantly decreased in ITP in comparison with the controls (OR: 0.342, 95% CI: 0.149–0.787, p = 0.016). IFN-gamma (+874) TT genotype was detected to be high in cases...
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Investigation of TNF-alpha, TGF-beta 1, IL-10, IL-6, IFN-gamma, MBL, GPIA, and IL1A gene polymorphisms in patients with idiopathic thrombocytopenic purpura
Platelets, 2011Co-Authors: Mustafa Pehlivan, Vahap Okan, Tugce Sever, S. Oguzkan Balci, Mustafa Yilmaz, T Babacan, Sacide PehlivanAbstract:Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by the presence of autoantibodies developing against Thrombocyte Membrane glycoproteins (GPs), such as GPIIa/IIIa and GPIb/IX. Single nucleotide polymorphisms (SNPs) of inflammatory cytokine genes were investigated in 71 patients with chronic ITP and 71 healthy controls, and they were compared with the clinical parameters. The polymorphisms in the SNPs were investigated with the polymerase chain reaction, polymerase chain reaction with sequence specific primer, and polymerase chain reaction-restriction fragment length polymorphism methods. It was found that the high expression of TNF-alpha (−308) AG phenotype significantly increased in cases with ITP (odds ratio, OR: 0.318, 95% confidence intervals, CI: 0.103–0.987, p
T Babacan - One of the best experts on this subject based on the ideXlab platform.
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investigation of tnf alpha tgf beta 1 il 10 il 6 ifn gamma mbl gpia and il1a gene polymorphisms in patients with idiopathic thrombocytopenic purpura
Platelets, 2011Co-Authors: Mustafa Pehlivan, Vahap Okan, Tugce Sever, Mustafa Yilmaz, T Babacan, Oguzkan S Balci, Sacide PehlivanAbstract:Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by the presence of autoantibodies developing against Thrombocyte Membrane glycoproteins (GPs), such as GPIIa/IIIa and GPIb/IX. Single nucleotide polymorphisms (SNPs) of inflammatory cytokine genes were investigated in 71 patients with chronic ITP and 71 healthy controls, and they were compared with the clinical parameters. The polymorphisms in the SNPs were investigated with the polymerase chain reaction, polymerase chain reaction with sequence specific primer, and polymerase chain reaction-restriction fragment length polymorphism methods. It was found that the high expression of TNF-alpha (−308) AG phenotype significantly increased in cases with ITP (odds ratio, OR: 0.318, 95% confidence intervals, CI: 0.103–0.987, p < 0.05). TT genotype in TGF-beta 1 (codon 10) significantly decreased in ITP in comparison with the controls (OR: 0.342, 95% CI: 0.149–0.787, p = 0.016). IFN-gamma (+874) TT genotype was detected to be high in cases...
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Investigation of TNF-alpha, TGF-beta 1, IL-10, IL-6, IFN-gamma, MBL, GPIA, and IL1A gene polymorphisms in patients with idiopathic thrombocytopenic purpura
Platelets, 2011Co-Authors: Mustafa Pehlivan, Vahap Okan, Tugce Sever, S. Oguzkan Balci, Mustafa Yilmaz, T Babacan, Sacide PehlivanAbstract:Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by the presence of autoantibodies developing against Thrombocyte Membrane glycoproteins (GPs), such as GPIIa/IIIa and GPIb/IX. Single nucleotide polymorphisms (SNPs) of inflammatory cytokine genes were investigated in 71 patients with chronic ITP and 71 healthy controls, and they were compared with the clinical parameters. The polymorphisms in the SNPs were investigated with the polymerase chain reaction, polymerase chain reaction with sequence specific primer, and polymerase chain reaction-restriction fragment length polymorphism methods. It was found that the high expression of TNF-alpha (−308) AG phenotype significantly increased in cases with ITP (odds ratio, OR: 0.318, 95% confidence intervals, CI: 0.103–0.987, p
Mustafa Yilmaz - One of the best experts on this subject based on the ideXlab platform.
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investigation of tnf alpha tgf beta 1 il 10 il 6 ifn gamma mbl gpia and il1a gene polymorphisms in patients with idiopathic thrombocytopenic purpura
Platelets, 2011Co-Authors: Mustafa Pehlivan, Vahap Okan, Tugce Sever, Mustafa Yilmaz, T Babacan, Oguzkan S Balci, Sacide PehlivanAbstract:Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by the presence of autoantibodies developing against Thrombocyte Membrane glycoproteins (GPs), such as GPIIa/IIIa and GPIb/IX. Single nucleotide polymorphisms (SNPs) of inflammatory cytokine genes were investigated in 71 patients with chronic ITP and 71 healthy controls, and they were compared with the clinical parameters. The polymorphisms in the SNPs were investigated with the polymerase chain reaction, polymerase chain reaction with sequence specific primer, and polymerase chain reaction-restriction fragment length polymorphism methods. It was found that the high expression of TNF-alpha (−308) AG phenotype significantly increased in cases with ITP (odds ratio, OR: 0.318, 95% confidence intervals, CI: 0.103–0.987, p < 0.05). TT genotype in TGF-beta 1 (codon 10) significantly decreased in ITP in comparison with the controls (OR: 0.342, 95% CI: 0.149–0.787, p = 0.016). IFN-gamma (+874) TT genotype was detected to be high in cases...
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Investigation of TNF-alpha, TGF-beta 1, IL-10, IL-6, IFN-gamma, MBL, GPIA, and IL1A gene polymorphisms in patients with idiopathic thrombocytopenic purpura
Platelets, 2011Co-Authors: Mustafa Pehlivan, Vahap Okan, Tugce Sever, S. Oguzkan Balci, Mustafa Yilmaz, T Babacan, Sacide PehlivanAbstract:Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by the presence of autoantibodies developing against Thrombocyte Membrane glycoproteins (GPs), such as GPIIa/IIIa and GPIb/IX. Single nucleotide polymorphisms (SNPs) of inflammatory cytokine genes were investigated in 71 patients with chronic ITP and 71 healthy controls, and they were compared with the clinical parameters. The polymorphisms in the SNPs were investigated with the polymerase chain reaction, polymerase chain reaction with sequence specific primer, and polymerase chain reaction-restriction fragment length polymorphism methods. It was found that the high expression of TNF-alpha (−308) AG phenotype significantly increased in cases with ITP (odds ratio, OR: 0.318, 95% confidence intervals, CI: 0.103–0.987, p