The Experts below are selected from a list of 43473 Experts worldwide ranked by ideXlab platform
James N. George - One of the best experts on this subject based on the ideXlab platform.
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Hereditary Thrombotic Thrombocytopenic Purpura.
The New England journal of medicine, 2019Co-Authors: Johanna A. Kremer Hovinga, James N. GeorgeAbstract:Hereditary Thrombotic Thrombocytopenic Purpura Hereditary thrombotic Thrombocytopenic Purpura is an autosomal recessive disorder caused by the absence of a functional protease (ADAMTS13) that proce...
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The association of pregnancy with thrombotic Thrombocytopenic Purpura-hemolytic uremic syndrome.
Current opinion in hematology, 2003Co-Authors: James N. GeorgeAbstract:Thrombotic Thrombocytopenic Purpura-hemolytic uremic syndrome occurs more commonly in women and among women is commonly associated with pregnancy. Case series of thrombotic Thrombocytopenic Purpura-hemolytic uremic syndrome from 1964 to 2002 were reviewed (1) to document the reports of occurrence of thrombotic Thrombocytopenic Purpura-hemolytic uremic syndrome during pregnancy and (2) to search for reports of women with congenital or familial thrombotic Thrombocytopenic Purpura-hemolytic uremic syndrome who were initially diagnosed during their first pregnancy. The time during pregnancy with greatest risk for development of thrombotic Thrombocytopenic Purpura-hemolytic uremic syndrome is near term and during the postpartum period. This is also the time of greatest risk for thrombotic events and for the occurrence of other pregnancy-related syndromes: preeclampsia, eclampsia, and hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. These other syndromes may also be associated with thrombocytopenia, microangiopathic hemolytic anemia, neurologic symptoms, and renal insufficiency, making their distinction from thrombotic Thrombocytopenic Purpura-hemolytic uremic syndrome difficult or impossible. The occurrence of preeclampsia and related syndromes, the hypercoaguable state that occurs in late pregnancy and postpartum, and the progressively decreasing concentration of ADAMTS13 that occurs during late pregnancy may combine to increase the risk for occurrence of thrombotic Thrombocytopenic Purpura-hemolytic uremic syndrome.
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Diagnosis, clinical course, and management of idiopathic Thrombocytopenic Purpura.
Current opinion in hematology, 1996Co-Authors: James N. GeorgeAbstract:Idiopathic Thrombocytopenic Purpura is a common acquired bleeding disorder. However, the diagnosis is often uncertain because there are no specific tests that define idiopathic Thrombocytopenic Purpura, and management decisions are often difficult because there are no firm data to define the clinical course and to estimate the risks of major bleeding and death. Because the incidence of idiopathic Thrombocytopenic Purpura is greatest in young women, its occurrence during pregnancy is a frequent problem, with specific issues related to the anticipated route of delivery and the risks for neonatal thrombocytopenia. To address these unresolved issues, the American Society of Hematology established a panel to develop a practice guideline for idiopathic Thrombocytopenic Purpura. The data from this recently published document and its recommendations are summarized in this review.
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Chronic Idiopathic Thrombocytopenic Purpura
The New England journal of medicine, 1994Co-Authors: James N. George, Mayez A. El-harake, Gary E. RaskobAbstract:Idiopathic Thrombocytopenic Purpura (ITP), also referred to as primary immune Thrombocytopenic Purpura, is defined by a low platelet count, normal bone marrow, and the absence of other causes of th...
Daniel Blickstein - One of the best experts on this subject based on the ideXlab platform.
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Erythromelalgia in a patient with thrombotic Thrombocytopenic Purpura.
Journal of the American Academy of Dermatology, 1992Co-Authors: Gil Yosipovitch, I Krause, Daniel BlicksteinAbstract:Erythromelalgia is characterized by paroxysmal burning pain and redness of the distal extremities; primary and secondary forms exist. Secondary erythromelalgia is most commonly associated with essential thrombocythemia and polycythemia vera, and the pathogenic mechanism is thought to be platelet aggregation. Thrombotic Thrombocytopenic Purpura is characterized by thrombocytopenia, microangiopathic anemia, renal failure, and fluctuating neurologic signs and symptoms. The pathogenic mechanism suggested for thrombotic Thrombocytopenic Purpura is diffuse platelet aggregation. We describe a female patient in whom thrombotic Thrombocytopenic Purpura was associated with erythromelalgia. This has not been previously reported.
V Fonollosa-pla - One of the best experts on this subject based on the ideXlab platform.
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Thrombotic Thrombocytopenic Purpura preceding systemic lupus erythematosus.
Annals of the rheumatic diseases, 1992Co-Authors: Carmen Pilar Simeón-aznar, R. Cuenca-luque, V Fonollosa-plaAbstract:The case of a patient admitted with thrombotic Thrombocytopenic Purpura nine years after developing systemic lupus erythematosus (SLE) is reported. Thrombotic Thrombocytopenic Purpura associated with SLE has been described on other occasions, but in most patients the diagnosis of SLE precedes that of thrombotic Thrombocytopenic Purpura. The unusual sequence and the chronological separation of the two diseases is emphasised.
Rohit Kumar - One of the best experts on this subject based on the ideXlab platform.
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Thrombotic Thrombocytopenic Purpura
The New England journal of medicine, 2019Co-Authors: Shruti Bhandari, Rohit KumarAbstract:Thrombotic Thrombocytopenic Purpura A 35-year-old man presented with a 2-day history of abdominal pain and headache. A peripheral-blood smear showed numerous schistocytes, and a diagnosis of thrombotic Thrombocytopenic Purpura was made.
Changgeng Ruan - One of the best experts on this subject based on the ideXlab platform.
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Alteration of ADAMTS13 antigen levels in patients with idiopathic thrombotic Thrombocytopenic Purpura, idiopathic Thrombocytopenic Purpura and systemic lupus erythematosus.
Thrombosis and haemostasis, 2006Co-Authors: Fang Liu, Hendrik B. Feys, Ning Zheng Dong, Yiming Zhao, Changgeng RuanAbstract:Letters to the Editor: Alteration of ADAMTS13 antigen levels in patients with idiopathic thrombotic Thrombocytopenic Purpura, idiopathic Thrombocytopenic Purpura and systemic lupus erythematosus -
