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Rodolfo G Goya - One of the best experts on this subject based on the ideXlab platform.

  • dna nanoparticle mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma
    Journal of Controlled Release, 2014
    Co-Authors: Adriana L Silva, Sabrina V Martini, Cynthia S Samary, Sandra Fernezlian, Nicholas J Boylan, Soraia C. Abreu, Vera Luiza Capelozzi, Bruno L. Diaz, Rodolfo G Goya
    Abstract:

    Abstract Thymulin has been shown to present anti-inflammatory and anti-fibrotic properties in experimental lung diseases. We hypothesized that a biologically active thymulin analog gene, methionine serum Thymus Factor, delivered by highly compacted DNA nanoparticles may prevent lung inflammation and remodeling in a mouse model of allergic asthma. The DNA nanoparticles are composed of a single molecule of plasmid DNA compacted with block copolymers of poly-L-lysine and polyethylene glycol (CK 30 PEG), which have been found safe in a human phase I/II clinical trial. Thymulin plasmids were detected in the lungs of ovalbumin-challenged asthmatic mice up to 27 days after administration of DNA nanoparticles carrying thymulin plasmids. A single dose of DNA nanoparticles carrying thymulin plasmids prevented lung inflammation, collagen deposition and smooth muscle hypertrophy in the lungs of a murine model of ovalbumin-challenged allergic asthma, leading to improved lung mechanics. In the present model of chronic allergic asthma, highly compacted DNA nanoparticles using thymulin analog gene modulated the inflammatory and remodeling processes improving lung mechanics.

  • dna nanoparticle mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma
    Journal of Controlled Release, 2014
    Co-Authors: Adriana L Silva, Sabrina V Martini, Cynthia S Samary, Sandra Fernezlian, Nicholas J Boylan, Soraia C. Abreu, Vera Luiza Capelozzi, Bruno L. Diaz, Rodolfo G Goya
    Abstract:

    Abstract Thymulin has been shown to present anti-inflammatory and anti-fibrotic properties in experimental lung diseases. We hypothesized that a biologically active thymulin analog gene, methionine serum Thymus Factor, delivered by highly compacted DNA nanoparticles may prevent lung inflammation and remodeling in a mouse model of allergic asthma. The DNA nanoparticles are composed of a single molecule of plasmid DNA compacted with block copolymers of poly-L-lysine and polyethylene glycol (CK 30 PEG), which have been found safe in a human phase I/II clinical trial. Thymulin plasmids were detected in the lungs of ovalbumin-challenged asthmatic mice up to 27 days after administration of DNA nanoparticles carrying thymulin plasmids. A single dose of DNA nanoparticles carrying thymulin plasmids prevented lung inflammation, collagen deposition and smooth muscle hypertrophy in the lungs of a murine model of ovalbumin-challenged allergic asthma, leading to improved lung mechanics. In the present model of chronic allergic asthma, highly compacted DNA nanoparticles using thymulin analog gene modulated the inflammatory and remodeling processes improving lung mechanics.

  • The Thymus-pituitary axis and its changes during aging.
    Neuroimmunomodulation, 1999
    Co-Authors: Rodolfo G Goya, Oscar A Brown, Federico Bolognani
    Abstract:

    The pituitary-thymic axis constitutes a bidirectional circuit where the ascending feedback loop is effected by thymic Factors of epithelial origin. The aim of the present article is to review the evidence demonstrating that aging brings about a progressive disruption in the integration of this network. In doing so, we briefly review the experimental evidence supporting the view that immune and neuroendocrine aging are interdependent processes. The advantages and limits of the nude mouse as a model of Thymus-dependent accelerated aging is also discussed. Next, we review a number of studies which show that the endocrine Thymus produces several bioactive molecules, generally called thymic hormones, which in addition to possessing immunoregulatory properties are also active on nervous and endocrine circuits. In particular, the reported activities of thymosin fraction 5 (TF5), thymosin alpha-1 and thymosin beta-4 on beta-endorphin, ACTH, glucocorticoids, LHRH and LH secretion in different animal and cell models are reviewed. The known hypophysiotropic actions of other thymic hormones like thymulin, homeostatic Thymus hormone (HTH) and Thymus Factor are summarized. Aging has a significant impact on pituitary responsiveness to thymic hormones. Thus, it has been reported that TF5 and HTH have thyrotropin-inhibiting activity in young but not in old rats. Furthermore, intravenous administration of HTH was also able to reduce plasma GH and increase corticosterone levels in both young and old rats, although these responses were much weaker in the old animals. Further evidence on this topic is discussed. It is proposed that in addition to its central role in the regulation of the immune function, the Thymus gland may extend its influence to nonimmunologic components of the body, including the neuroendocrine system. The early onset of Thymus involution might therefore act as a triggering event which would initiate the gradual decline in homeostatic potential that characterizes the aging process.

  • Homeostasis, thymic hormones and aging.
    Gerontology, 1999
    Co-Authors: Rodolfo G Goya, Federico Bolognani
    Abstract:

    The thymic-pituitary axis constitutes a bidirectional circuit where the ascending feedback loop is effected by thymic Factors of epithelial origin. The aim of the present article is, first, to introduce the idea of an immune-neuroendocrine homeostatic network in higher animals. Next, the relevance of the Thymus in this network and the possible role of this gland in the neuroendocrine imbalances associated with aging are discussed. A number of studies are next reviewed which show that the endocrine Thymus produces several bioactive molecules, generally called thymic hormones, which in addition to possessing immunoregulatory properties are also active on nervous and endocrine circuits. In particular, the reported activities of thymosin fraction five, thymosin alpha 1 and thymosin beta 4 on β-endorphin, adrenocorticotropic hormone, glucocorticoids, luteinizing hormone-releasing hormone and luteinizing hormone secretion in different animal and cell models are reviewed. The known hypophysiotropic actions of other thymic hormones like thymulin, homeostatic Thymus hormone and Thymus Factor are also summarized, and the impact of aging on pituitary responsiveness to thymic hormones is discussed. As a conclusion, it is proposed that in addition to its central role in the regulation of the immune function, the Thymus gland may extend its influence to nonimmunologic components of the body, including the neuroendocrine system. The early onset of Thymus involution might, therefore, act as a triggering event which would initiate the gradual decline in homeostatic potential that characterizes the aging process.

Nicholas J Boylan - One of the best experts on this subject based on the ideXlab platform.

  • dna nanoparticle mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma
    Journal of Controlled Release, 2014
    Co-Authors: Adriana L Silva, Sabrina V Martini, Cynthia S Samary, Sandra Fernezlian, Nicholas J Boylan, Soraia C. Abreu, Vera Luiza Capelozzi, Bruno L. Diaz, Rodolfo G Goya
    Abstract:

    Abstract Thymulin has been shown to present anti-inflammatory and anti-fibrotic properties in experimental lung diseases. We hypothesized that a biologically active thymulin analog gene, methionine serum Thymus Factor, delivered by highly compacted DNA nanoparticles may prevent lung inflammation and remodeling in a mouse model of allergic asthma. The DNA nanoparticles are composed of a single molecule of plasmid DNA compacted with block copolymers of poly-L-lysine and polyethylene glycol (CK 30 PEG), which have been found safe in a human phase I/II clinical trial. Thymulin plasmids were detected in the lungs of ovalbumin-challenged asthmatic mice up to 27 days after administration of DNA nanoparticles carrying thymulin plasmids. A single dose of DNA nanoparticles carrying thymulin plasmids prevented lung inflammation, collagen deposition and smooth muscle hypertrophy in the lungs of a murine model of ovalbumin-challenged allergic asthma, leading to improved lung mechanics. In the present model of chronic allergic asthma, highly compacted DNA nanoparticles using thymulin analog gene modulated the inflammatory and remodeling processes improving lung mechanics.

  • dna nanoparticle mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma
    Journal of Controlled Release, 2014
    Co-Authors: Adriana L Silva, Sabrina V Martini, Cynthia S Samary, Sandra Fernezlian, Nicholas J Boylan, Soraia C. Abreu, Vera Luiza Capelozzi, Bruno L. Diaz, Rodolfo G Goya
    Abstract:

    Abstract Thymulin has been shown to present anti-inflammatory and anti-fibrotic properties in experimental lung diseases. We hypothesized that a biologically active thymulin analog gene, methionine serum Thymus Factor, delivered by highly compacted DNA nanoparticles may prevent lung inflammation and remodeling in a mouse model of allergic asthma. The DNA nanoparticles are composed of a single molecule of plasmid DNA compacted with block copolymers of poly-L-lysine and polyethylene glycol (CK 30 PEG), which have been found safe in a human phase I/II clinical trial. Thymulin plasmids were detected in the lungs of ovalbumin-challenged asthmatic mice up to 27 days after administration of DNA nanoparticles carrying thymulin plasmids. A single dose of DNA nanoparticles carrying thymulin plasmids prevented lung inflammation, collagen deposition and smooth muscle hypertrophy in the lungs of a murine model of ovalbumin-challenged allergic asthma, leading to improved lung mechanics. In the present model of chronic allergic asthma, highly compacted DNA nanoparticles using thymulin analog gene modulated the inflammatory and remodeling processes improving lung mechanics.

Adriana L Silva - One of the best experts on this subject based on the ideXlab platform.

  • dna nanoparticle mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma
    Journal of Controlled Release, 2014
    Co-Authors: Adriana L Silva, Sabrina V Martini, Cynthia S Samary, Sandra Fernezlian, Nicholas J Boylan, Soraia C. Abreu, Vera Luiza Capelozzi, Bruno L. Diaz, Rodolfo G Goya
    Abstract:

    Abstract Thymulin has been shown to present anti-inflammatory and anti-fibrotic properties in experimental lung diseases. We hypothesized that a biologically active thymulin analog gene, methionine serum Thymus Factor, delivered by highly compacted DNA nanoparticles may prevent lung inflammation and remodeling in a mouse model of allergic asthma. The DNA nanoparticles are composed of a single molecule of plasmid DNA compacted with block copolymers of poly-L-lysine and polyethylene glycol (CK 30 PEG), which have been found safe in a human phase I/II clinical trial. Thymulin plasmids were detected in the lungs of ovalbumin-challenged asthmatic mice up to 27 days after administration of DNA nanoparticles carrying thymulin plasmids. A single dose of DNA nanoparticles carrying thymulin plasmids prevented lung inflammation, collagen deposition and smooth muscle hypertrophy in the lungs of a murine model of ovalbumin-challenged allergic asthma, leading to improved lung mechanics. In the present model of chronic allergic asthma, highly compacted DNA nanoparticles using thymulin analog gene modulated the inflammatory and remodeling processes improving lung mechanics.

  • dna nanoparticle mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma
    Journal of Controlled Release, 2014
    Co-Authors: Adriana L Silva, Sabrina V Martini, Cynthia S Samary, Sandra Fernezlian, Nicholas J Boylan, Soraia C. Abreu, Vera Luiza Capelozzi, Bruno L. Diaz, Rodolfo G Goya
    Abstract:

    Abstract Thymulin has been shown to present anti-inflammatory and anti-fibrotic properties in experimental lung diseases. We hypothesized that a biologically active thymulin analog gene, methionine serum Thymus Factor, delivered by highly compacted DNA nanoparticles may prevent lung inflammation and remodeling in a mouse model of allergic asthma. The DNA nanoparticles are composed of a single molecule of plasmid DNA compacted with block copolymers of poly-L-lysine and polyethylene glycol (CK 30 PEG), which have been found safe in a human phase I/II clinical trial. Thymulin plasmids were detected in the lungs of ovalbumin-challenged asthmatic mice up to 27 days after administration of DNA nanoparticles carrying thymulin plasmids. A single dose of DNA nanoparticles carrying thymulin plasmids prevented lung inflammation, collagen deposition and smooth muscle hypertrophy in the lungs of a murine model of ovalbumin-challenged allergic asthma, leading to improved lung mechanics. In the present model of chronic allergic asthma, highly compacted DNA nanoparticles using thymulin analog gene modulated the inflammatory and remodeling processes improving lung mechanics.

Federico Bolognani - One of the best experts on this subject based on the ideXlab platform.

  • The Thymus-pituitary axis and its changes during aging.
    Neuroimmunomodulation, 1999
    Co-Authors: Rodolfo G Goya, Oscar A Brown, Federico Bolognani
    Abstract:

    The pituitary-thymic axis constitutes a bidirectional circuit where the ascending feedback loop is effected by thymic Factors of epithelial origin. The aim of the present article is to review the evidence demonstrating that aging brings about a progressive disruption in the integration of this network. In doing so, we briefly review the experimental evidence supporting the view that immune and neuroendocrine aging are interdependent processes. The advantages and limits of the nude mouse as a model of Thymus-dependent accelerated aging is also discussed. Next, we review a number of studies which show that the endocrine Thymus produces several bioactive molecules, generally called thymic hormones, which in addition to possessing immunoregulatory properties are also active on nervous and endocrine circuits. In particular, the reported activities of thymosin fraction 5 (TF5), thymosin alpha-1 and thymosin beta-4 on beta-endorphin, ACTH, glucocorticoids, LHRH and LH secretion in different animal and cell models are reviewed. The known hypophysiotropic actions of other thymic hormones like thymulin, homeostatic Thymus hormone (HTH) and Thymus Factor are summarized. Aging has a significant impact on pituitary responsiveness to thymic hormones. Thus, it has been reported that TF5 and HTH have thyrotropin-inhibiting activity in young but not in old rats. Furthermore, intravenous administration of HTH was also able to reduce plasma GH and increase corticosterone levels in both young and old rats, although these responses were much weaker in the old animals. Further evidence on this topic is discussed. It is proposed that in addition to its central role in the regulation of the immune function, the Thymus gland may extend its influence to nonimmunologic components of the body, including the neuroendocrine system. The early onset of Thymus involution might therefore act as a triggering event which would initiate the gradual decline in homeostatic potential that characterizes the aging process.

  • Homeostasis, thymic hormones and aging.
    Gerontology, 1999
    Co-Authors: Rodolfo G Goya, Federico Bolognani
    Abstract:

    The thymic-pituitary axis constitutes a bidirectional circuit where the ascending feedback loop is effected by thymic Factors of epithelial origin. The aim of the present article is, first, to introduce the idea of an immune-neuroendocrine homeostatic network in higher animals. Next, the relevance of the Thymus in this network and the possible role of this gland in the neuroendocrine imbalances associated with aging are discussed. A number of studies are next reviewed which show that the endocrine Thymus produces several bioactive molecules, generally called thymic hormones, which in addition to possessing immunoregulatory properties are also active on nervous and endocrine circuits. In particular, the reported activities of thymosin fraction five, thymosin alpha 1 and thymosin beta 4 on β-endorphin, adrenocorticotropic hormone, glucocorticoids, luteinizing hormone-releasing hormone and luteinizing hormone secretion in different animal and cell models are reviewed. The known hypophysiotropic actions of other thymic hormones like thymulin, homeostatic Thymus hormone and Thymus Factor are also summarized, and the impact of aging on pituitary responsiveness to thymic hormones is discussed. As a conclusion, it is proposed that in addition to its central role in the regulation of the immune function, the Thymus gland may extend its influence to nonimmunologic components of the body, including the neuroendocrine system. The early onset of Thymus involution might, therefore, act as a triggering event which would initiate the gradual decline in homeostatic potential that characterizes the aging process.

Cynthia S Samary - One of the best experts on this subject based on the ideXlab platform.

  • dna nanoparticle mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma
    Journal of Controlled Release, 2014
    Co-Authors: Adriana L Silva, Sabrina V Martini, Cynthia S Samary, Sandra Fernezlian, Nicholas J Boylan, Soraia C. Abreu, Vera Luiza Capelozzi, Bruno L. Diaz, Rodolfo G Goya
    Abstract:

    Abstract Thymulin has been shown to present anti-inflammatory and anti-fibrotic properties in experimental lung diseases. We hypothesized that a biologically active thymulin analog gene, methionine serum Thymus Factor, delivered by highly compacted DNA nanoparticles may prevent lung inflammation and remodeling in a mouse model of allergic asthma. The DNA nanoparticles are composed of a single molecule of plasmid DNA compacted with block copolymers of poly-L-lysine and polyethylene glycol (CK 30 PEG), which have been found safe in a human phase I/II clinical trial. Thymulin plasmids were detected in the lungs of ovalbumin-challenged asthmatic mice up to 27 days after administration of DNA nanoparticles carrying thymulin plasmids. A single dose of DNA nanoparticles carrying thymulin plasmids prevented lung inflammation, collagen deposition and smooth muscle hypertrophy in the lungs of a murine model of ovalbumin-challenged allergic asthma, leading to improved lung mechanics. In the present model of chronic allergic asthma, highly compacted DNA nanoparticles using thymulin analog gene modulated the inflammatory and remodeling processes improving lung mechanics.

  • dna nanoparticle mediated thymulin gene therapy prevents airway remodeling in experimental allergic asthma
    Journal of Controlled Release, 2014
    Co-Authors: Adriana L Silva, Sabrina V Martini, Cynthia S Samary, Sandra Fernezlian, Nicholas J Boylan, Soraia C. Abreu, Vera Luiza Capelozzi, Bruno L. Diaz, Rodolfo G Goya
    Abstract:

    Abstract Thymulin has been shown to present anti-inflammatory and anti-fibrotic properties in experimental lung diseases. We hypothesized that a biologically active thymulin analog gene, methionine serum Thymus Factor, delivered by highly compacted DNA nanoparticles may prevent lung inflammation and remodeling in a mouse model of allergic asthma. The DNA nanoparticles are composed of a single molecule of plasmid DNA compacted with block copolymers of poly-L-lysine and polyethylene glycol (CK 30 PEG), which have been found safe in a human phase I/II clinical trial. Thymulin plasmids were detected in the lungs of ovalbumin-challenged asthmatic mice up to 27 days after administration of DNA nanoparticles carrying thymulin plasmids. A single dose of DNA nanoparticles carrying thymulin plasmids prevented lung inflammation, collagen deposition and smooth muscle hypertrophy in the lungs of a murine model of ovalbumin-challenged allergic asthma, leading to improved lung mechanics. In the present model of chronic allergic asthma, highly compacted DNA nanoparticles using thymulin analog gene modulated the inflammatory and remodeling processes improving lung mechanics.