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Gian Luigi Gianfranceschi - One of the best experts on this subject based on the ideXlab platform.

  • Aging Reversibility: from Thymus Graft to Vegetable Extract Treatment – Application to Cure an Age-associated Pathology
    Biogerontology, 2005
    Co-Authors: Andrea Basso, Giuliana Rossolini, Anna Piantanelli, Domenico Amici, Isabella Calzuola, Loretta Mancinelli, Valeria Marsili, Gian Luigi Gianfranceschi
    Abstract:

    Neonatal Thymus Graft and Thymus calf extract (TME) in vivo treatment exert similar corrective actions on different mouse age-related alterations. The aim of the present paper is to investigate whether a vegetal extract, wheat sprout extract (WESPRE), could mimic the Thymus action on recovering age-related alterations and if this extract can cure an age-associated pathology, the cataract in dogs. Present experiments were carried out by using WESPRE and TME in vivo in old mice to check their ability to recover the altered DNA synthesis in hepatocyte primary cultures. Old mice treated with WESPRE and TME showed a recovery of hepatocyte DNA synthesis levels when compared with the old untreated ones. The increase of DNA and protein contents observed in aged animals is reduced by WESPRE treatments to levels observed in young mice hepatocytes. We measured also WESPRE phosphorylation activity by endogenous kinase: it was from 10 to 40 times higher with respect to wheat seeds. Old dogs were orally treated for a month and the lens opacity analysed before and after the treatment. Results showed a reduction from 25 to 40% of lens opacity. The efficacy of wheat sprouts in the recovery of age-related alterations and in treating age-associated pathologies could be due to the contemporary presence of small regulatory acid peptides, a remarkable level of highly energetic phosphoric radicals and antioxidant molecules, peculiarities that may be, to some extent, related to the aging process regulation.

  • Aging reversibility: from Thymus Graft to vegetable extract treatment-- application to cure an age-associated pathology.
    Biogerontology, 2005
    Co-Authors: Andrea Basso, Giuliana Rossolini, Anna Piantanelli, Domenico Amici, Isabella Calzuola, Loretta Mancinelli, Valeria Marsili, Gian Luigi Gianfranceschi
    Abstract:

    Neonatal Thymus Graft and Thymus calf extract (TME) in vivo treatment exert similar corrective actions on different mouse age-related alterations. The aim of the present paper is to investigate whether a vegetal extract, wheat sprout extract (WESPRE), could mimic the Thymus action on recovering age-related alterations and if this extract can cure an age-associated pathology, the cataract in dogs. Present experiments were carried out by using WESPRE and TME in vivo in old mice to check their ability to recover the altered DNA synthesis in hepatocyte primary cultures. Old mice treated with WESPRE and TME showed a recovery of hepatocyte DNA synthesis levels when compared with the old untreated ones. The increase of DNA and protein contents observed in aged animals is reduced by WESPRE treatments to levels observed in young mice hepatocytes. We measured also WESPRE phosphorylation activity by endogenous kinase: it was from 10 to 40 times higher with respect to wheat seeds. Old dogs were orally treated for a month and the lens opacity analysed before and after the treatment. Results showed a reduction from 25 to 40% of lens opacity. The efficacy of wheat sprouts in the recovery of age-related alterations and in treating age-associated pathologies could be due to the contemporary presence of small regulatory acid peptides, a remarkable level of highly energetic phosphoric radicals and antioxidant molecules, peculiarities that may be, to some extent, related to the aging process regulation.

  • differential influence of a thymic extract on α and β adrenoceptors of mouse brain cortex
    Annals of the New York Academy of Sciences, 1994
    Co-Authors: A Basso, Domenico Amici, L Piantanelli, G Rossolini, Gian Luigi Gianfranceschi
    Abstract:

    Experimental findings support the hypothesis that the Thymus plays an important role in maintaining the efficient network of interactions among immune, endocrine, and nervous functions.14 One of the numerous targets of thymic action is the adrenergic system. We previously found a restoring influence of a Thymus Graft on the alterations of some P-adrenergic responsiveness in young athymic nude and old normal mice.5 Both the alterations and the Thymus-induced restoring actions involve modifications of P-adrenergic receptors PARS).^.' Thymus control was also demonstrated as effective in the brain cortex of old mice where it exerts selective action on PIARs altered during aging, whereas it does not alter P2AR density which does not show age-related

Muneo Inaba - One of the best experts on this subject based on the ideXlab platform.

Andrea Basso - One of the best experts on this subject based on the ideXlab platform.

  • Noninvasive neonatal Thymus Graft into the axillary cavity extends the lifespan of old mice.
    Rejuvenation research, 2010
    Co-Authors: Andrea Basso, Marco Malavolta, Francesco Piacenza, Lory Santarelli, Fiorella Marcellini, Roberta Papa, Eugenio Mocchegiani
    Abstract:

    Abstract Neonatal Thymus Grafts exert a rejuvenating action on various immunological and nonimmunological functions found altered in old mice. Commonly, half of a Thymus is Grafted under the kidney...

  • Aging Reversibility: from Thymus Graft to Vegetable Extract Treatment – Application to Cure an Age-associated Pathology
    Biogerontology, 2005
    Co-Authors: Andrea Basso, Giuliana Rossolini, Anna Piantanelli, Domenico Amici, Isabella Calzuola, Loretta Mancinelli, Valeria Marsili, Gian Luigi Gianfranceschi
    Abstract:

    Neonatal Thymus Graft and Thymus calf extract (TME) in vivo treatment exert similar corrective actions on different mouse age-related alterations. The aim of the present paper is to investigate whether a vegetal extract, wheat sprout extract (WESPRE), could mimic the Thymus action on recovering age-related alterations and if this extract can cure an age-associated pathology, the cataract in dogs. Present experiments were carried out by using WESPRE and TME in vivo in old mice to check their ability to recover the altered DNA synthesis in hepatocyte primary cultures. Old mice treated with WESPRE and TME showed a recovery of hepatocyte DNA synthesis levels when compared with the old untreated ones. The increase of DNA and protein contents observed in aged animals is reduced by WESPRE treatments to levels observed in young mice hepatocytes. We measured also WESPRE phosphorylation activity by endogenous kinase: it was from 10 to 40 times higher with respect to wheat seeds. Old dogs were orally treated for a month and the lens opacity analysed before and after the treatment. Results showed a reduction from 25 to 40% of lens opacity. The efficacy of wheat sprouts in the recovery of age-related alterations and in treating age-associated pathologies could be due to the contemporary presence of small regulatory acid peptides, a remarkable level of highly energetic phosphoric radicals and antioxidant molecules, peculiarities that may be, to some extent, related to the aging process regulation.

  • Aging reversibility: from Thymus Graft to vegetable extract treatment-- application to cure an age-associated pathology.
    Biogerontology, 2005
    Co-Authors: Andrea Basso, Giuliana Rossolini, Anna Piantanelli, Domenico Amici, Isabella Calzuola, Loretta Mancinelli, Valeria Marsili, Gian Luigi Gianfranceschi
    Abstract:

    Neonatal Thymus Graft and Thymus calf extract (TME) in vivo treatment exert similar corrective actions on different mouse age-related alterations. The aim of the present paper is to investigate whether a vegetal extract, wheat sprout extract (WESPRE), could mimic the Thymus action on recovering age-related alterations and if this extract can cure an age-associated pathology, the cataract in dogs. Present experiments were carried out by using WESPRE and TME in vivo in old mice to check their ability to recover the altered DNA synthesis in hepatocyte primary cultures. Old mice treated with WESPRE and TME showed a recovery of hepatocyte DNA synthesis levels when compared with the old untreated ones. The increase of DNA and protein contents observed in aged animals is reduced by WESPRE treatments to levels observed in young mice hepatocytes. We measured also WESPRE phosphorylation activity by endogenous kinase: it was from 10 to 40 times higher with respect to wheat seeds. Old dogs were orally treated for a month and the lens opacity analysed before and after the treatment. Results showed a reduction from 25 to 40% of lens opacity. The efficacy of wheat sprouts in the recovery of age-related alterations and in treating age-associated pathologies could be due to the contemporary presence of small regulatory acid peptides, a remarkable level of highly energetic phosphoric radicals and antioxidant molecules, peculiarities that may be, to some extent, related to the aging process regulation.

Domenico Amici - One of the best experts on this subject based on the ideXlab platform.

  • Aging Reversibility: from Thymus Graft to Vegetable Extract Treatment – Application to Cure an Age-associated Pathology
    Biogerontology, 2005
    Co-Authors: Andrea Basso, Giuliana Rossolini, Anna Piantanelli, Domenico Amici, Isabella Calzuola, Loretta Mancinelli, Valeria Marsili, Gian Luigi Gianfranceschi
    Abstract:

    Neonatal Thymus Graft and Thymus calf extract (TME) in vivo treatment exert similar corrective actions on different mouse age-related alterations. The aim of the present paper is to investigate whether a vegetal extract, wheat sprout extract (WESPRE), could mimic the Thymus action on recovering age-related alterations and if this extract can cure an age-associated pathology, the cataract in dogs. Present experiments were carried out by using WESPRE and TME in vivo in old mice to check their ability to recover the altered DNA synthesis in hepatocyte primary cultures. Old mice treated with WESPRE and TME showed a recovery of hepatocyte DNA synthesis levels when compared with the old untreated ones. The increase of DNA and protein contents observed in aged animals is reduced by WESPRE treatments to levels observed in young mice hepatocytes. We measured also WESPRE phosphorylation activity by endogenous kinase: it was from 10 to 40 times higher with respect to wheat seeds. Old dogs were orally treated for a month and the lens opacity analysed before and after the treatment. Results showed a reduction from 25 to 40% of lens opacity. The efficacy of wheat sprouts in the recovery of age-related alterations and in treating age-associated pathologies could be due to the contemporary presence of small regulatory acid peptides, a remarkable level of highly energetic phosphoric radicals and antioxidant molecules, peculiarities that may be, to some extent, related to the aging process regulation.

  • Aging reversibility: from Thymus Graft to vegetable extract treatment-- application to cure an age-associated pathology.
    Biogerontology, 2005
    Co-Authors: Andrea Basso, Giuliana Rossolini, Anna Piantanelli, Domenico Amici, Isabella Calzuola, Loretta Mancinelli, Valeria Marsili, Gian Luigi Gianfranceschi
    Abstract:

    Neonatal Thymus Graft and Thymus calf extract (TME) in vivo treatment exert similar corrective actions on different mouse age-related alterations. The aim of the present paper is to investigate whether a vegetal extract, wheat sprout extract (WESPRE), could mimic the Thymus action on recovering age-related alterations and if this extract can cure an age-associated pathology, the cataract in dogs. Present experiments were carried out by using WESPRE and TME in vivo in old mice to check their ability to recover the altered DNA synthesis in hepatocyte primary cultures. Old mice treated with WESPRE and TME showed a recovery of hepatocyte DNA synthesis levels when compared with the old untreated ones. The increase of DNA and protein contents observed in aged animals is reduced by WESPRE treatments to levels observed in young mice hepatocytes. We measured also WESPRE phosphorylation activity by endogenous kinase: it was from 10 to 40 times higher with respect to wheat seeds. Old dogs were orally treated for a month and the lens opacity analysed before and after the treatment. Results showed a reduction from 25 to 40% of lens opacity. The efficacy of wheat sprouts in the recovery of age-related alterations and in treating age-associated pathologies could be due to the contemporary presence of small regulatory acid peptides, a remarkable level of highly energetic phosphoric radicals and antioxidant molecules, peculiarities that may be, to some extent, related to the aging process regulation.

  • differential influence of a thymic extract on α and β adrenoceptors of mouse brain cortex
    Annals of the New York Academy of Sciences, 1994
    Co-Authors: A Basso, Domenico Amici, L Piantanelli, G Rossolini, Gian Luigi Gianfranceschi
    Abstract:

    Experimental findings support the hypothesis that the Thymus plays an important role in maintaining the efficient network of interactions among immune, endocrine, and nervous functions.14 One of the numerous targets of thymic action is the adrenergic system. We previously found a restoring influence of a Thymus Graft on the alterations of some P-adrenergic responsiveness in young athymic nude and old normal mice.5 Both the alterations and the Thymus-induced restoring actions involve modifications of P-adrenergic receptors PARS).^.' Thymus control was also demonstrated as effective in the brain cortex of old mice where it exerts selective action on PIARs altered during aging, whereas it does not alter P2AR density which does not show age-related

Hiroshi Iwai - One of the best experts on this subject based on the ideXlab platform.