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Andy Sun - One of the best experts on this subject based on the ideXlab platform.

  • Anemia and hematinic deficiencies in anti-gastric parietal cell Antibody-positive and -negative recurrent aphthous stomatitis patients with anti-Thyroid Antibody positivity
    Elsevier, 2017
    Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Yiping Wang, Andy Sun
    Abstract:

    Serum anti-gastric parietal cell (GPCA), anti-thyroglobulin (TGA), and anti-Thyroid microsomal antibodies (TMA) can be found in some recurrent aphthous stomatitis (RAS) patients. This study mainly assessed whether serum GPCA, TGA, TMA and RAS itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive RAS patients with GPCA positivity (GPCA+/TGA/TMA/RAS patients) or negativity (GPCA−/TGA/TMA/RAS patients). Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 15 GPCA+/TGA/TMA/RAS patients, 69 GPCA−/TGA/TMA/RAS patients, 240 all autoantibodies-negative RAS patients (Abs−/RAS patients), and 342 healthy control subjects. Results: GPCA+/TGA/TMA/RAS patients had significantly lower mean Hb (for men only) and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects. GPCA+/TGA/TMA/RAS patients had lower serum vitamin B12 level and higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than GPCA−/TGA/TMA/RAS patients. Furthermore, both GPCA−/TGA/TMA/RAS and Abs−/RAS patients did have significantly lower mean Hb, MCV, and iron levels as well as significantly greater frequencies of Hb, iron and vitamin B12 deficiencies than healthy control subjects. There were no significant differences in blood data between GPCA−/TGA/TMA/RAS and Abs−/RAS patients Conclusion: Both serum GPCA positivity and RAS itself are the contributing factors causing anemia and hematinic deficiencies in GPCA+/TGA/TMA/RAS patients. RAS itself but not TGA/TMA positivity plays a significant role in causing anemia and hematinic deficiencies in GPCA−/TGA/TMA/RAS patients

  • Anemia and hematinic deficiencies in anti-gastric parietal cell Antibody-positive and -negative recurrent aphthous stomatitis patients with anti-Thyroid Antibody positivity.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2016
    Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Yiping Wang, Andy Sun
    Abstract:

    Background/purpose Serum anti-gastric parietal cell (GPCA), anti-thyroglobulin (TGA), and anti-Thyroid microsomal antibodies (TMA) can be found in some recurrent aphthous stomatitis (RAS) patients. This study mainly assessed whether serum GPCA, TGA, TMA and RAS itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive RAS patients with GPCA positivity (GPCA+/TGA/TMA/RAS patients) or negativity (GPCA−/TGA/TMA/RAS patients). Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 15 GPCA+/TGA/TMA/RAS patients, 69 GPCA−/TGA/TMA/RAS patients, 240 all autoantibodies-negative RAS patients (Abs−/RAS patients), and 342 healthy control subjects. Results GPCA+/TGA/TMA/RAS patients had significantly lower mean Hb (for men only) and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects. GPCA+/TGA/TMA/RAS patients had lower serum vitamin B12 level and higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than GPCA−/TGA/TMA/RAS patients. Furthermore, both GPCA−/TGA/TMA/RAS and Abs−/RAS patients did have significantly lower mean Hb, MCV, and iron levels as well as significantly greater frequencies of Hb, iron and vitamin B12 deficiencies than healthy control subjects. There were no significant differences in blood data between GPCA−/TGA/TMA/RAS and Abs−/RAS patients Conclusion Both serum GPCA positivity and RAS itself are the contributing factors causing anemia and hematinic deficiencies in GPCA+/TGA/TMA/RAS patients. RAS itself but not TGA/TMA positivity plays a significant role in causing anemia and hematinic deficiencies in GPCA−/TGA/TMA/RAS patients.

  • anemia and hematinic deficiencies in gastric parietal cell Antibody positive and Antibody negative erosive oral lichen planus patients with Thyroid Antibody positivity
    Journal of the Formosan Medical Association, 2016
    Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Yiping Wang, I-chang Chen, Andy Sun
    Abstract:

    Background/purpose Serum gastric parietal cell Antibody (GPCA), thyroglobulin Antibody (TGA), and Thyroid microsomal Antibody (TMA) are found in some erosive oral lichen planus (EOLP) patients. This study assessed whether serum GPCA, TGA and TMA and EOLP itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive EOLP patients with GPCA positivity (GPCA + /TGA/TMA/EOLP patients) or negativity (GPCA − /TGA/TMA/EOLP patients). Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 29 GPCA + /TGA/TMA/EOLP patients, 80 GPCA − /TGA/TMA/EOLP patients, 198 all antibodies-negative EOLP patients (Abs − /EOLP patients), and 218 healthy control individuals. Results GPCA + /TGA/TMA/EOLP patients had significantly lower mean Hb and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy controls. GPCA + /TGA/TMA/EOLP patients had significantly lower serum vitamin B12 level and higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than GPCA − /TGA/TMA/EOLP patients. Furthermore, both GPCA − /TGA/TMA/EOLP and Abs − /EOLP patients did have significantly lower mean Hb, MCV, and iron (for women only) levels, as well as significantly greater frequencies of Hb and iron deficiencies than healthy controls. However, there were no significant differences in measured blood data between GPCA − /TGA/TMA/EOLP and Abs − /EOLP patients. Conclusion We conclude that serum GPCA is the major factor causing vitamin B12 deficiency, macrocytosis and pernicious anemia in GPCA + /TGA/TMA/EOLP patients. ELOP itself but not TGA/TMA positivity plays a significant role in causing anemia and hematinic deficiencies in GPCA − /TGA/TMA/EOLP patients.

  • Anemia and hematinic deficiencies in gastric parietal cell Antibody-positive and Antibody-negative erosive oral lichen planus patients with Thyroid Antibody positivity
    Elsevier, 2016
    Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Yiping Wang, I-chang Chen, Andy Sun
    Abstract:

    Serum gastric parietal cell Antibody (GPCA), thyroglobulin Antibody (TGA), and Thyroid microsomal Antibody (TMA) are found in some erosive oral lichen planus (EOLP) patients. This study assessed whether serum GPCA, TGA and TMA and EOLP itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive EOLP patients with GPCA positivity (GPCA+/TGA/TMA/EOLP patients) or negativity (GPCA−/TGA/TMA/EOLP patients). Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 29 GPCA+/TGA/TMA/EOLP patients, 80 GPCA−/TGA/TMA/EOLP patients, 198 all antibodies-negative EOLP patients (Abs−/EOLP patients), and 218 healthy control individuals. Results: GPCA+/TGA/TMA/EOLP patients had significantly lower mean Hb and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy controls. GPCA+/TGA/TMA/EOLP patients had significantly lower serum vitamin B12 level and higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than GPCA−/TGA/TMA/EOLP patients. Furthermore, both GPCA−/TGA/TMA/EOLP and Abs−/EOLP patients did have significantly lower mean Hb, MCV, and iron (for women only) levels, as well as significantly greater frequencies of Hb and iron deficiencies than healthy controls. However, there were no significant differences in measured blood data between GPCA−/TGA/TMA/EOLP and Abs−/EOLP patients. Conclusion: We conclude that serum GPCA is the major factor causing vitamin B12 deficiency, macrocytosis and pernicious anemia in GPCA+/TGA/TMA/EOLP patients. ELOP itself but not TGA/TMA positivity plays a significant role in causing anemia and hematinic deficiencies in GPCA−/TGA/TMA/EOLP patients

Alex Stagnarogreen - One of the best experts on this subject based on the ideXlab platform.

  • subclinical hypoThyroidism and Thyroid autoimmunity in recurrent pregnancy loss a systematic review and meta analysis
    Fertility and Sterility, 2020
    Co-Authors: Allan C Dong, Alex Stagnarogreen, Jessica Morgan, Monica Kane, Mary D Stephenson
    Abstract:

    Objective To determine whether overt/subclinical hypoThyroidism and/or Thyroid autoimmunity is associated with recurrent pregnancy loss (RPL) and whether treatment improves outcomes. Design Systematic review and meta-analysis. Setting University obstetrics and gynecology departments. Patient(s) Women with RPL and overt/subclinical hypoThyroidism, and/or Thyroid autoimmunity. Intervention(s) None. Main Outcome Measure(s) Associations between RPL and overt/subclinical hypoThyroidism and/or Thyroid autoimmunity and any effects of treatment. Result(s) After our review of articles from PubMed, EMBASE, Web of Science, and CENTRAL, we found two interventional studies in which levothyroxine did not improve the subsequent live-birth rate in women with subclinical hypoThyroidism with or without Thyroid antibodies. A meta-analysis of five studies revealed the prevalence of subclinical hypoThyroidism in RPL to be 12.9% (95% confidence interval [CI], 0%–35.2%). A meta-analysis of 17 studies revealed a statistically significant association between RPL and Thyroid autoimmunity (odds ratio 1.94; 95% CI, 1.43–2.64). However, a randomized study suggested that levothyroxine does not benefit euThyroid women with Thyroid autoimmunity. Conclusion(s) Based on the limited observational studies available, no association exists between RPL and subclinical hypoThyroidism, nor does levothyroxine improve subsequent pregnancy outcomes. An association exists between RPL and Thyroid autoimmunity, but levothyroxine does not improve subsequent pregnancy outcomes. Women with RPL should be screened/treated for overt Thyroid disease but not Thyroid autoimmunity. Thyroid Antibody screening is not supported by the published studies, and further randomized studies are needed. No recommendation regarding the treatment of subclinical hypoThyroidism can be made at this time; prospective and randomized studies are urgently needed.

  • impact of levothyroxine in miscarriage and preterm delivery rates in first trimester Thyroid Antibody positive women with tsh less than 2 5 miu l
    The Journal of Clinical Endocrinology and Metabolism, 2016
    Co-Authors: Roberto Negro, Alan Schwartz, Alex Stagnarogreen
    Abstract:

    Background: Thyroid disease during pregnancy is associated with multiple adverse maternal and fetal outcomes. In particular, multiple observational studies have demonstrated an association between the presence of Thyroid antibodies in euThyroid women in the first trimester of miscarriage and an increased rate of spontaneous miscarriage and preterm delivery. The present study is a prospective intervention trial of the effect of levothyroxine on the rate of miscarriage and preterm delivery in euThyroid Thyroid-Antibody positive women in the first trimester of pregnancy. Methods: A total of 8530 women in the first trimester of pregnancy in Southern Italy were screened for TSH and Thyroid antibodies. Group A consisted of 198 euThyroid Thyroid Antibody positive women treated with levothyroxine, group B consisted of 195 untreated euThyroid Thyroid Antibody positive women, and group C consisted of 197 untreated Thyroid Antibody negative women. Results: The rate of miscarriage did not differ between the 3 groups ...

  • marginal iodine status and high rate of subclinical hypoThyroidism in washington dc women planning conception
    Thyroid, 2015
    Co-Authors: Alex Stagnarogreen, Carole A Spencer, Emmerita Dogoisonaige, Elizabeth N Pearce, Nancy D Gaba
    Abstract:

    Introduction: Subclinical hypoThyroidism during pregnancy has been associated with adverse maternal and fetal outcomes. A subset of pregnant women in the United States have been shown to have mild iodine deficiency. No study has evaluated the Thyroid and iodine status of women who are planning to become pregnant in the near future. Methods: Thyroid function tests, Thyroid antibodies, and urine iodine levels were evaluated in women presenting for preconception screening and counseling. A thyrotropin (TSH) level above 3.0 mIU/L was considered abnormal. Results: One hundred and forty one women enrolled in the study. The median TSH level was 1.70 mIU/L (range 0.43–5.3 mIU/L). Sixteen women (11%) had a TSH above the upper limit of normal (>3.0 mIU/L). Eleven women (8%) were positive for TPO-Ab and 21 women (15%) for TgAb. Twenty-three women (16%) were positive for at least one Thyroid Antibody (TPOAb and/or TgAb). Median serum TSH concentrations were higher in women with detectable antiThyroid antibodies than ...

  • approach to the patient with postpartum Thyroiditis
    The Journal of Clinical Endocrinology and Metabolism, 2012
    Co-Authors: Alex Stagnarogreen
    Abstract:

    Postpartum Thyroiditis (PPT) is the occurrence of de novo autoimmune Thyroid disease, excluding Graves' disease, in the first year postpartum. The incidence of PPT is 5.4% in the general population, and it is increased in individuals with other autoimmune diseases such as type 1 diabetes mellitus. The classic presentation of PPT of hyperThyroidism followed by hypoThyroidism is seen in 22% of cases. The majority of women with PPT experience an isolated hypoThyroid phase (48%), with the remainder experiencing isolated thyrotoxicosis (30%). Up to 50% of women who are Thyroid Antibody positive (Thyroid peroxidase Antibody and/or thyroglobulin Antibody) in the first trimester will develop PPT. Symptoms are more common in the hypoThyroid phase of PPT and include fatigue, dry skin, and impaired memory. Despite multiple studies exploring the relationship between PPT and postpartum depression, or postpartum depression in Thyroid Antibody-positive euThyroid women, the data are conflicting, and no firm conclusions c...

  • Thyroid Antibody positivity in the first trimester of pregnancy is associated with negative pregnancy outcomes
    The Journal of Clinical Endocrinology and Metabolism, 2011
    Co-Authors: Roberto Negro, Alan Schwartz, Riccardo Gismondi, Andrea Tinelli, Tiziana Mangieri, Alex Stagnarogreen
    Abstract:

    Thyroid antibodies in pregnancy are associated with preterm delivery and respiratory distress.

Julia Yu Fong Chang - One of the best experts on this subject based on the ideXlab platform.

  • Anemia and hematinic deficiencies in anti-gastric parietal cell Antibody-positive and -negative recurrent aphthous stomatitis patients with anti-Thyroid Antibody positivity
    Elsevier, 2017
    Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Yiping Wang, Andy Sun
    Abstract:

    Serum anti-gastric parietal cell (GPCA), anti-thyroglobulin (TGA), and anti-Thyroid microsomal antibodies (TMA) can be found in some recurrent aphthous stomatitis (RAS) patients. This study mainly assessed whether serum GPCA, TGA, TMA and RAS itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive RAS patients with GPCA positivity (GPCA+/TGA/TMA/RAS patients) or negativity (GPCA−/TGA/TMA/RAS patients). Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 15 GPCA+/TGA/TMA/RAS patients, 69 GPCA−/TGA/TMA/RAS patients, 240 all autoantibodies-negative RAS patients (Abs−/RAS patients), and 342 healthy control subjects. Results: GPCA+/TGA/TMA/RAS patients had significantly lower mean Hb (for men only) and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects. GPCA+/TGA/TMA/RAS patients had lower serum vitamin B12 level and higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than GPCA−/TGA/TMA/RAS patients. Furthermore, both GPCA−/TGA/TMA/RAS and Abs−/RAS patients did have significantly lower mean Hb, MCV, and iron levels as well as significantly greater frequencies of Hb, iron and vitamin B12 deficiencies than healthy control subjects. There were no significant differences in blood data between GPCA−/TGA/TMA/RAS and Abs−/RAS patients Conclusion: Both serum GPCA positivity and RAS itself are the contributing factors causing anemia and hematinic deficiencies in GPCA+/TGA/TMA/RAS patients. RAS itself but not TGA/TMA positivity plays a significant role in causing anemia and hematinic deficiencies in GPCA−/TGA/TMA/RAS patients

  • Anemia and hematinic deficiencies in anti-gastric parietal cell Antibody-positive and -negative recurrent aphthous stomatitis patients with anti-Thyroid Antibody positivity.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2016
    Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Yiping Wang, Andy Sun
    Abstract:

    Background/purpose Serum anti-gastric parietal cell (GPCA), anti-thyroglobulin (TGA), and anti-Thyroid microsomal antibodies (TMA) can be found in some recurrent aphthous stomatitis (RAS) patients. This study mainly assessed whether serum GPCA, TGA, TMA and RAS itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive RAS patients with GPCA positivity (GPCA+/TGA/TMA/RAS patients) or negativity (GPCA−/TGA/TMA/RAS patients). Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 15 GPCA+/TGA/TMA/RAS patients, 69 GPCA−/TGA/TMA/RAS patients, 240 all autoantibodies-negative RAS patients (Abs−/RAS patients), and 342 healthy control subjects. Results GPCA+/TGA/TMA/RAS patients had significantly lower mean Hb (for men only) and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects. GPCA+/TGA/TMA/RAS patients had lower serum vitamin B12 level and higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than GPCA−/TGA/TMA/RAS patients. Furthermore, both GPCA−/TGA/TMA/RAS and Abs−/RAS patients did have significantly lower mean Hb, MCV, and iron levels as well as significantly greater frequencies of Hb, iron and vitamin B12 deficiencies than healthy control subjects. There were no significant differences in blood data between GPCA−/TGA/TMA/RAS and Abs−/RAS patients Conclusion Both serum GPCA positivity and RAS itself are the contributing factors causing anemia and hematinic deficiencies in GPCA+/TGA/TMA/RAS patients. RAS itself but not TGA/TMA positivity plays a significant role in causing anemia and hematinic deficiencies in GPCA−/TGA/TMA/RAS patients.

  • anemia and hematinic deficiencies in gastric parietal cell Antibody positive and Antibody negative erosive oral lichen planus patients with Thyroid Antibody positivity
    Journal of the Formosan Medical Association, 2016
    Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Yiping Wang, I-chang Chen, Andy Sun
    Abstract:

    Background/purpose Serum gastric parietal cell Antibody (GPCA), thyroglobulin Antibody (TGA), and Thyroid microsomal Antibody (TMA) are found in some erosive oral lichen planus (EOLP) patients. This study assessed whether serum GPCA, TGA and TMA and EOLP itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive EOLP patients with GPCA positivity (GPCA + /TGA/TMA/EOLP patients) or negativity (GPCA − /TGA/TMA/EOLP patients). Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 29 GPCA + /TGA/TMA/EOLP patients, 80 GPCA − /TGA/TMA/EOLP patients, 198 all antibodies-negative EOLP patients (Abs − /EOLP patients), and 218 healthy control individuals. Results GPCA + /TGA/TMA/EOLP patients had significantly lower mean Hb and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy controls. GPCA + /TGA/TMA/EOLP patients had significantly lower serum vitamin B12 level and higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than GPCA − /TGA/TMA/EOLP patients. Furthermore, both GPCA − /TGA/TMA/EOLP and Abs − /EOLP patients did have significantly lower mean Hb, MCV, and iron (for women only) levels, as well as significantly greater frequencies of Hb and iron deficiencies than healthy controls. However, there were no significant differences in measured blood data between GPCA − /TGA/TMA/EOLP and Abs − /EOLP patients. Conclusion We conclude that serum GPCA is the major factor causing vitamin B12 deficiency, macrocytosis and pernicious anemia in GPCA + /TGA/TMA/EOLP patients. ELOP itself but not TGA/TMA positivity plays a significant role in causing anemia and hematinic deficiencies in GPCA − /TGA/TMA/EOLP patients.

  • Anemia and hematinic deficiencies in gastric parietal cell Antibody-positive and Antibody-negative erosive oral lichen planus patients with Thyroid Antibody positivity
    Elsevier, 2016
    Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Yiping Wang, I-chang Chen, Andy Sun
    Abstract:

    Serum gastric parietal cell Antibody (GPCA), thyroglobulin Antibody (TGA), and Thyroid microsomal Antibody (TMA) are found in some erosive oral lichen planus (EOLP) patients. This study assessed whether serum GPCA, TGA and TMA and EOLP itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive EOLP patients with GPCA positivity (GPCA+/TGA/TMA/EOLP patients) or negativity (GPCA−/TGA/TMA/EOLP patients). Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 29 GPCA+/TGA/TMA/EOLP patients, 80 GPCA−/TGA/TMA/EOLP patients, 198 all antibodies-negative EOLP patients (Abs−/EOLP patients), and 218 healthy control individuals. Results: GPCA+/TGA/TMA/EOLP patients had significantly lower mean Hb and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy controls. GPCA+/TGA/TMA/EOLP patients had significantly lower serum vitamin B12 level and higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than GPCA−/TGA/TMA/EOLP patients. Furthermore, both GPCA−/TGA/TMA/EOLP and Abs−/EOLP patients did have significantly lower mean Hb, MCV, and iron (for women only) levels, as well as significantly greater frequencies of Hb and iron deficiencies than healthy controls. However, there were no significant differences in measured blood data between GPCA−/TGA/TMA/EOLP and Abs−/EOLP patients. Conclusion: We conclude that serum GPCA is the major factor causing vitamin B12 deficiency, macrocytosis and pernicious anemia in GPCA+/TGA/TMA/EOLP patients. ELOP itself but not TGA/TMA positivity plays a significant role in causing anemia and hematinic deficiencies in GPCA−/TGA/TMA/EOLP patients

Yiping Wang - One of the best experts on this subject based on the ideXlab platform.

  • Anemia and hematinic deficiencies in anti-gastric parietal cell Antibody-positive and -negative recurrent aphthous stomatitis patients with anti-Thyroid Antibody positivity
    Elsevier, 2017
    Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Yiping Wang, Andy Sun
    Abstract:

    Serum anti-gastric parietal cell (GPCA), anti-thyroglobulin (TGA), and anti-Thyroid microsomal antibodies (TMA) can be found in some recurrent aphthous stomatitis (RAS) patients. This study mainly assessed whether serum GPCA, TGA, TMA and RAS itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive RAS patients with GPCA positivity (GPCA+/TGA/TMA/RAS patients) or negativity (GPCA−/TGA/TMA/RAS patients). Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 15 GPCA+/TGA/TMA/RAS patients, 69 GPCA−/TGA/TMA/RAS patients, 240 all autoantibodies-negative RAS patients (Abs−/RAS patients), and 342 healthy control subjects. Results: GPCA+/TGA/TMA/RAS patients had significantly lower mean Hb (for men only) and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects. GPCA+/TGA/TMA/RAS patients had lower serum vitamin B12 level and higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than GPCA−/TGA/TMA/RAS patients. Furthermore, both GPCA−/TGA/TMA/RAS and Abs−/RAS patients did have significantly lower mean Hb, MCV, and iron levels as well as significantly greater frequencies of Hb, iron and vitamin B12 deficiencies than healthy control subjects. There were no significant differences in blood data between GPCA−/TGA/TMA/RAS and Abs−/RAS patients Conclusion: Both serum GPCA positivity and RAS itself are the contributing factors causing anemia and hematinic deficiencies in GPCA+/TGA/TMA/RAS patients. RAS itself but not TGA/TMA positivity plays a significant role in causing anemia and hematinic deficiencies in GPCA−/TGA/TMA/RAS patients

  • Anemia and hematinic deficiencies in anti-gastric parietal cell Antibody-positive and -negative recurrent aphthous stomatitis patients with anti-Thyroid Antibody positivity.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2016
    Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Yiping Wang, Andy Sun
    Abstract:

    Background/purpose Serum anti-gastric parietal cell (GPCA), anti-thyroglobulin (TGA), and anti-Thyroid microsomal antibodies (TMA) can be found in some recurrent aphthous stomatitis (RAS) patients. This study mainly assessed whether serum GPCA, TGA, TMA and RAS itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive RAS patients with GPCA positivity (GPCA+/TGA/TMA/RAS patients) or negativity (GPCA−/TGA/TMA/RAS patients). Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 15 GPCA+/TGA/TMA/RAS patients, 69 GPCA−/TGA/TMA/RAS patients, 240 all autoantibodies-negative RAS patients (Abs−/RAS patients), and 342 healthy control subjects. Results GPCA+/TGA/TMA/RAS patients had significantly lower mean Hb (for men only) and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects. GPCA+/TGA/TMA/RAS patients had lower serum vitamin B12 level and higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than GPCA−/TGA/TMA/RAS patients. Furthermore, both GPCA−/TGA/TMA/RAS and Abs−/RAS patients did have significantly lower mean Hb, MCV, and iron levels as well as significantly greater frequencies of Hb, iron and vitamin B12 deficiencies than healthy control subjects. There were no significant differences in blood data between GPCA−/TGA/TMA/RAS and Abs−/RAS patients Conclusion Both serum GPCA positivity and RAS itself are the contributing factors causing anemia and hematinic deficiencies in GPCA+/TGA/TMA/RAS patients. RAS itself but not TGA/TMA positivity plays a significant role in causing anemia and hematinic deficiencies in GPCA−/TGA/TMA/RAS patients.

  • anemia and hematinic deficiencies in gastric parietal cell Antibody positive and Antibody negative erosive oral lichen planus patients with Thyroid Antibody positivity
    Journal of the Formosan Medical Association, 2016
    Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Yiping Wang, I-chang Chen, Andy Sun
    Abstract:

    Background/purpose Serum gastric parietal cell Antibody (GPCA), thyroglobulin Antibody (TGA), and Thyroid microsomal Antibody (TMA) are found in some erosive oral lichen planus (EOLP) patients. This study assessed whether serum GPCA, TGA and TMA and EOLP itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive EOLP patients with GPCA positivity (GPCA + /TGA/TMA/EOLP patients) or negativity (GPCA − /TGA/TMA/EOLP patients). Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 29 GPCA + /TGA/TMA/EOLP patients, 80 GPCA − /TGA/TMA/EOLP patients, 198 all antibodies-negative EOLP patients (Abs − /EOLP patients), and 218 healthy control individuals. Results GPCA + /TGA/TMA/EOLP patients had significantly lower mean Hb and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy controls. GPCA + /TGA/TMA/EOLP patients had significantly lower serum vitamin B12 level and higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than GPCA − /TGA/TMA/EOLP patients. Furthermore, both GPCA − /TGA/TMA/EOLP and Abs − /EOLP patients did have significantly lower mean Hb, MCV, and iron (for women only) levels, as well as significantly greater frequencies of Hb and iron deficiencies than healthy controls. However, there were no significant differences in measured blood data between GPCA − /TGA/TMA/EOLP and Abs − /EOLP patients. Conclusion We conclude that serum GPCA is the major factor causing vitamin B12 deficiency, macrocytosis and pernicious anemia in GPCA + /TGA/TMA/EOLP patients. ELOP itself but not TGA/TMA positivity plays a significant role in causing anemia and hematinic deficiencies in GPCA − /TGA/TMA/EOLP patients.

  • Anemia and hematinic deficiencies in gastric parietal cell Antibody-positive and Antibody-negative erosive oral lichen planus patients with Thyroid Antibody positivity
    Elsevier, 2016
    Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Yiping Wang, I-chang Chen, Andy Sun
    Abstract:

    Serum gastric parietal cell Antibody (GPCA), thyroglobulin Antibody (TGA), and Thyroid microsomal Antibody (TMA) are found in some erosive oral lichen planus (EOLP) patients. This study assessed whether serum GPCA, TGA and TMA and EOLP itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive EOLP patients with GPCA positivity (GPCA+/TGA/TMA/EOLP patients) or negativity (GPCA−/TGA/TMA/EOLP patients). Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 29 GPCA+/TGA/TMA/EOLP patients, 80 GPCA−/TGA/TMA/EOLP patients, 198 all antibodies-negative EOLP patients (Abs−/EOLP patients), and 218 healthy control individuals. Results: GPCA+/TGA/TMA/EOLP patients had significantly lower mean Hb and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy controls. GPCA+/TGA/TMA/EOLP patients had significantly lower serum vitamin B12 level and higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than GPCA−/TGA/TMA/EOLP patients. Furthermore, both GPCA−/TGA/TMA/EOLP and Abs−/EOLP patients did have significantly lower mean Hb, MCV, and iron (for women only) levels, as well as significantly greater frequencies of Hb and iron deficiencies than healthy controls. However, there were no significant differences in measured blood data between GPCA−/TGA/TMA/EOLP and Abs−/EOLP patients. Conclusion: We conclude that serum GPCA is the major factor causing vitamin B12 deficiency, macrocytosis and pernicious anemia in GPCA+/TGA/TMA/EOLP patients. ELOP itself but not TGA/TMA positivity plays a significant role in causing anemia and hematinic deficiencies in GPCA−/TGA/TMA/EOLP patients

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  • Anemia and hematinic deficiencies in anti-gastric parietal cell Antibody-positive and -negative recurrent aphthous stomatitis patients with anti-Thyroid Antibody positivity
    Elsevier, 2017
    Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Yiping Wang, Andy Sun
    Abstract:

    Serum anti-gastric parietal cell (GPCA), anti-thyroglobulin (TGA), and anti-Thyroid microsomal antibodies (TMA) can be found in some recurrent aphthous stomatitis (RAS) patients. This study mainly assessed whether serum GPCA, TGA, TMA and RAS itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive RAS patients with GPCA positivity (GPCA+/TGA/TMA/RAS patients) or negativity (GPCA−/TGA/TMA/RAS patients). Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 15 GPCA+/TGA/TMA/RAS patients, 69 GPCA−/TGA/TMA/RAS patients, 240 all autoantibodies-negative RAS patients (Abs−/RAS patients), and 342 healthy control subjects. Results: GPCA+/TGA/TMA/RAS patients had significantly lower mean Hb (for men only) and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects. GPCA+/TGA/TMA/RAS patients had lower serum vitamin B12 level and higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than GPCA−/TGA/TMA/RAS patients. Furthermore, both GPCA−/TGA/TMA/RAS and Abs−/RAS patients did have significantly lower mean Hb, MCV, and iron levels as well as significantly greater frequencies of Hb, iron and vitamin B12 deficiencies than healthy control subjects. There were no significant differences in blood data between GPCA−/TGA/TMA/RAS and Abs−/RAS patients Conclusion: Both serum GPCA positivity and RAS itself are the contributing factors causing anemia and hematinic deficiencies in GPCA+/TGA/TMA/RAS patients. RAS itself but not TGA/TMA positivity plays a significant role in causing anemia and hematinic deficiencies in GPCA−/TGA/TMA/RAS patients

  • Anemia and hematinic deficiencies in anti-gastric parietal cell Antibody-positive and -negative recurrent aphthous stomatitis patients with anti-Thyroid Antibody positivity.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2016
    Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Yiping Wang, Andy Sun
    Abstract:

    Background/purpose Serum anti-gastric parietal cell (GPCA), anti-thyroglobulin (TGA), and anti-Thyroid microsomal antibodies (TMA) can be found in some recurrent aphthous stomatitis (RAS) patients. This study mainly assessed whether serum GPCA, TGA, TMA and RAS itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive RAS patients with GPCA positivity (GPCA+/TGA/TMA/RAS patients) or negativity (GPCA−/TGA/TMA/RAS patients). Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 15 GPCA+/TGA/TMA/RAS patients, 69 GPCA−/TGA/TMA/RAS patients, 240 all autoantibodies-negative RAS patients (Abs−/RAS patients), and 342 healthy control subjects. Results GPCA+/TGA/TMA/RAS patients had significantly lower mean Hb (for men only) and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects. GPCA+/TGA/TMA/RAS patients had lower serum vitamin B12 level and higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than GPCA−/TGA/TMA/RAS patients. Furthermore, both GPCA−/TGA/TMA/RAS and Abs−/RAS patients did have significantly lower mean Hb, MCV, and iron levels as well as significantly greater frequencies of Hb, iron and vitamin B12 deficiencies than healthy control subjects. There were no significant differences in blood data between GPCA−/TGA/TMA/RAS and Abs−/RAS patients Conclusion Both serum GPCA positivity and RAS itself are the contributing factors causing anemia and hematinic deficiencies in GPCA+/TGA/TMA/RAS patients. RAS itself but not TGA/TMA positivity plays a significant role in causing anemia and hematinic deficiencies in GPCA−/TGA/TMA/RAS patients.

  • anemia and hematinic deficiencies in gastric parietal cell Antibody positive and Antibody negative erosive oral lichen planus patients with Thyroid Antibody positivity
    Journal of the Formosan Medical Association, 2016
    Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Yiping Wang, I-chang Chen, Andy Sun
    Abstract:

    Background/purpose Serum gastric parietal cell Antibody (GPCA), thyroglobulin Antibody (TGA), and Thyroid microsomal Antibody (TMA) are found in some erosive oral lichen planus (EOLP) patients. This study assessed whether serum GPCA, TGA and TMA and EOLP itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive EOLP patients with GPCA positivity (GPCA + /TGA/TMA/EOLP patients) or negativity (GPCA − /TGA/TMA/EOLP patients). Methods The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 29 GPCA + /TGA/TMA/EOLP patients, 80 GPCA − /TGA/TMA/EOLP patients, 198 all antibodies-negative EOLP patients (Abs − /EOLP patients), and 218 healthy control individuals. Results GPCA + /TGA/TMA/EOLP patients had significantly lower mean Hb and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy controls. GPCA + /TGA/TMA/EOLP patients had significantly lower serum vitamin B12 level and higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than GPCA − /TGA/TMA/EOLP patients. Furthermore, both GPCA − /TGA/TMA/EOLP and Abs − /EOLP patients did have significantly lower mean Hb, MCV, and iron (for women only) levels, as well as significantly greater frequencies of Hb and iron deficiencies than healthy controls. However, there were no significant differences in measured blood data between GPCA − /TGA/TMA/EOLP and Abs − /EOLP patients. Conclusion We conclude that serum GPCA is the major factor causing vitamin B12 deficiency, macrocytosis and pernicious anemia in GPCA + /TGA/TMA/EOLP patients. ELOP itself but not TGA/TMA positivity plays a significant role in causing anemia and hematinic deficiencies in GPCA − /TGA/TMA/EOLP patients.

  • Anemia and hematinic deficiencies in gastric parietal cell Antibody-positive and Antibody-negative erosive oral lichen planus patients with Thyroid Antibody positivity
    Elsevier, 2016
    Co-Authors: Julia Yu Fong Chang, Hsinming Chen, Yiping Wang, I-chang Chen, Andy Sun
    Abstract:

    Serum gastric parietal cell Antibody (GPCA), thyroglobulin Antibody (TGA), and Thyroid microsomal Antibody (TMA) are found in some erosive oral lichen planus (EOLP) patients. This study assessed whether serum GPCA, TGA and TMA and EOLP itself played significant roles in causing anemia and hematinic deficiencies in TGA/TMA-positive EOLP patients with GPCA positivity (GPCA+/TGA/TMA/EOLP patients) or negativity (GPCA−/TGA/TMA/EOLP patients). Methods: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of the four groups of 29 GPCA+/TGA/TMA/EOLP patients, 80 GPCA−/TGA/TMA/EOLP patients, 198 all antibodies-negative EOLP patients (Abs−/EOLP patients), and 218 healthy control individuals. Results: GPCA+/TGA/TMA/EOLP patients had significantly lower mean Hb and vitamin B12 levels as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy controls. GPCA+/TGA/TMA/EOLP patients had significantly lower serum vitamin B12 level and higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than GPCA−/TGA/TMA/EOLP patients. Furthermore, both GPCA−/TGA/TMA/EOLP and Abs−/EOLP patients did have significantly lower mean Hb, MCV, and iron (for women only) levels, as well as significantly greater frequencies of Hb and iron deficiencies than healthy controls. However, there were no significant differences in measured blood data between GPCA−/TGA/TMA/EOLP and Abs−/EOLP patients. Conclusion: We conclude that serum GPCA is the major factor causing vitamin B12 deficiency, macrocytosis and pernicious anemia in GPCA+/TGA/TMA/EOLP patients. ELOP itself but not TGA/TMA positivity plays a significant role in causing anemia and hematinic deficiencies in GPCA−/TGA/TMA/EOLP patients