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Daniel Brasnu - One of the best experts on this subject based on the ideXlab platform.

  • Thyroid Cartilage invasion in early stage squamous cell carcinoma involving the anterior commissure
    Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2012
    Co-Authors: Dana M Hartl, Guillaume Landry, Stephane Hans, P Marandas, François Janot, Odile Casiraghi, Daniel Brasnu
    Abstract:

    Background Anterior commissure (AC) carcinoma is in close proximity to the Thyroid Cartilage. Our objective was to evaluate risk factors for Thyroid Cartilage invasion. Methods This was a retrospective study of tumors involving the AC treated by open surgery. Tumor stage, extensions, vocal fold (VF) mobility, CT scan, and pathologic Cartilage status were recorded. Results Ninety-four patients with clinical T (cT) classifications cT1b (44%), cT2 (50%), and cT3 (6%) were included. The incidence of Thyroid Cartilage invasion was 8.5%, significantly related to VF mobility, with invasion in 31% versus 5% with normal mobility (p = .002). Sensitivity, specificity, and positive and negative predictive values for decreased VF mobility were 50%, 90%, 31%, and 95%, respectively. After a median follow-up of 49 months, there was no difference in local control between tumors with or without Cartilage invasion. Conclusions For these tumors involving the AC, VF mobility was the only significant factor related to Thyroid Cartilage invasion and should be taken into consideration when planning surgery. © 2011 Wiley Periodicals, Inc. Head Neck, 2011

  • organ preservation surgery for laryngeal squamous cell carcinoma low incidence of Thyroid Cartilage invasion
    Laryngoscope, 2010
    Co-Authors: Dana M Hartl, Guillaume Landry, Stephane Hans, P Marandas, Daniel Brasnu
    Abstract:

    Objectives/Hypothesis: Determine the incidence and risk factors for Thyroid Cartilage invasion in early and midstage laryngeal cancer. Study Design: Retrospective review. Methods: A retrospective review was carried out of tumors treated by open surgery with at least partial resection of Thyroid Cartilage from 1992 to 2008. Preoperative laser, radiation therapy, or chemotherapy were excluded. Tumor stage, anterior commissure involvement, vocal fold (VF) mobility, computed tomography (CT) scan, and pathological Cartilage status were recorded. Results: Three hundred fifty-eight patients were treated for tumors staged cT1 (32%), cT2 (53%), and cT3 (15%) by vertical (26%), supracricoid (62%), or supraglottic partial laryngectomy (12%). The Thyroid Cartilage was invaded in 8.9% of cases. Abnormal VF mobility was significantly related to Thyroid Cartilage invasion (Fisher exact test, P = .0002). Neither anterior commissure involvement nor CT scan were related to Cartilage invasion. Conclusions: Thyroid Cartilage invasion was rare but increased if VF mobility was impaired. This has implications for transoral resection, which unlike open surgery avoids unnecessary Cartilage resection.

Dana M Hartl - One of the best experts on this subject based on the ideXlab platform.

  • Thyroid Cartilage invasion in early stage squamous cell carcinoma involving the anterior commissure
    Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2012
    Co-Authors: Dana M Hartl, Guillaume Landry, Stephane Hans, P Marandas, François Janot, Odile Casiraghi, Daniel Brasnu
    Abstract:

    Background Anterior commissure (AC) carcinoma is in close proximity to the Thyroid Cartilage. Our objective was to evaluate risk factors for Thyroid Cartilage invasion. Methods This was a retrospective study of tumors involving the AC treated by open surgery. Tumor stage, extensions, vocal fold (VF) mobility, CT scan, and pathologic Cartilage status were recorded. Results Ninety-four patients with clinical T (cT) classifications cT1b (44%), cT2 (50%), and cT3 (6%) were included. The incidence of Thyroid Cartilage invasion was 8.5%, significantly related to VF mobility, with invasion in 31% versus 5% with normal mobility (p = .002). Sensitivity, specificity, and positive and negative predictive values for decreased VF mobility were 50%, 90%, 31%, and 95%, respectively. After a median follow-up of 49 months, there was no difference in local control between tumors with or without Cartilage invasion. Conclusions For these tumors involving the AC, VF mobility was the only significant factor related to Thyroid Cartilage invasion and should be taken into consideration when planning surgery. © 2011 Wiley Periodicals, Inc. Head Neck, 2011

  • CT-scan prediction of Thyroid Cartilage invasion for early laryngeal squamous cell carcinoma
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated wi, 2012
    Co-Authors: Dana M Hartl, Guillaume Landry, Stephane Hans, François Bidault, Morbize Julieron, Gérard Mamelle, François Janot, Brasnu D
    Abstract:

    Treatment choice for laryngeal cancer may be influenced by the diagnosis of Thyroid Cartilage invasion on preoperative computed tomography (CT). Our objective was to determine the predictive value of CT for Thyroid Cartilage invasion in early- to mid-stage laryngeal cancer. Retrospective study (1992–2008) of laryngeal squamous cell carcinoma treated with open partial laryngectomy and resection of at least part of the Thyroid Cartilage. Previous laser surgery, radiation therapy, chemotherapy and second primaries were excluded. CT prediction of Thyroid Cartilage invasion was determined by specialized radiologists. Tumor characteristics and pathologic Thyroid Cartilage invasion were compared to the radiologic assessment. 236 patients were treated by vertical (20 %), supracricoid (67 %) or supraglottic partial laryngectomy (13 %) for tumors staged cT1 (26 %), cT2 (55 %), and cT3 (19 %). The Thyroid Cartilage was invaded on pathology in 19 cases (8 %). CT’s sensitivity was 10.5 %, specificity 94 %, positive predictive value 13 %, and negative predictive value 92 %. CT correctly predicted Thyroid Cartilage invasion in only two cases for an overall accuracy of 87 %. Among the false-positive CT’s, tumors involving the anterior commissure were significantly over-represented (61.5 % vs. 27 %, p = .004). Tumors with decreased vocal fold (VF) mobility were significantly over-represented in the group of false-negatives (41 vs. 13 %, p = .0035). Preoperative CT was not effective in predicting Thyroid Cartilage invasion in these early- to mid-stage lesions, overestimating Cartilage invasion for AC lesions and underestimating invasion for lesions with decreased VF mobility.

  • organ preservation surgery for laryngeal squamous cell carcinoma low incidence of Thyroid Cartilage invasion
    Laryngoscope, 2010
    Co-Authors: Dana M Hartl, Guillaume Landry, Stephane Hans, P Marandas, Daniel Brasnu
    Abstract:

    Objectives/Hypothesis: Determine the incidence and risk factors for Thyroid Cartilage invasion in early and midstage laryngeal cancer. Study Design: Retrospective review. Methods: A retrospective review was carried out of tumors treated by open surgery with at least partial resection of Thyroid Cartilage from 1992 to 2008. Preoperative laser, radiation therapy, or chemotherapy were excluded. Tumor stage, anterior commissure involvement, vocal fold (VF) mobility, computed tomography (CT) scan, and pathological Cartilage status were recorded. Results: Three hundred fifty-eight patients were treated for tumors staged cT1 (32%), cT2 (53%), and cT3 (15%) by vertical (26%), supracricoid (62%), or supraglottic partial laryngectomy (12%). The Thyroid Cartilage was invaded in 8.9% of cases. Abnormal VF mobility was significantly related to Thyroid Cartilage invasion (Fisher exact test, P = .0002). Neither anterior commissure involvement nor CT scan were related to Cartilage invasion. Conclusions: Thyroid Cartilage invasion was rare but increased if VF mobility was impaired. This has implications for transoral resection, which unlike open surgery avoids unnecessary Cartilage resection.

Stephane Hans - One of the best experts on this subject based on the ideXlab platform.

  • Thyroid Cartilage invasion in early stage squamous cell carcinoma involving the anterior commissure
    Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2012
    Co-Authors: Dana M Hartl, Guillaume Landry, Stephane Hans, P Marandas, François Janot, Odile Casiraghi, Daniel Brasnu
    Abstract:

    Background Anterior commissure (AC) carcinoma is in close proximity to the Thyroid Cartilage. Our objective was to evaluate risk factors for Thyroid Cartilage invasion. Methods This was a retrospective study of tumors involving the AC treated by open surgery. Tumor stage, extensions, vocal fold (VF) mobility, CT scan, and pathologic Cartilage status were recorded. Results Ninety-four patients with clinical T (cT) classifications cT1b (44%), cT2 (50%), and cT3 (6%) were included. The incidence of Thyroid Cartilage invasion was 8.5%, significantly related to VF mobility, with invasion in 31% versus 5% with normal mobility (p = .002). Sensitivity, specificity, and positive and negative predictive values for decreased VF mobility were 50%, 90%, 31%, and 95%, respectively. After a median follow-up of 49 months, there was no difference in local control between tumors with or without Cartilage invasion. Conclusions For these tumors involving the AC, VF mobility was the only significant factor related to Thyroid Cartilage invasion and should be taken into consideration when planning surgery. © 2011 Wiley Periodicals, Inc. Head Neck, 2011

  • CT-scan prediction of Thyroid Cartilage invasion for early laryngeal squamous cell carcinoma
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated wi, 2012
    Co-Authors: Dana M Hartl, Guillaume Landry, Stephane Hans, François Bidault, Morbize Julieron, Gérard Mamelle, François Janot, Brasnu D
    Abstract:

    Treatment choice for laryngeal cancer may be influenced by the diagnosis of Thyroid Cartilage invasion on preoperative computed tomography (CT). Our objective was to determine the predictive value of CT for Thyroid Cartilage invasion in early- to mid-stage laryngeal cancer. Retrospective study (1992–2008) of laryngeal squamous cell carcinoma treated with open partial laryngectomy and resection of at least part of the Thyroid Cartilage. Previous laser surgery, radiation therapy, chemotherapy and second primaries were excluded. CT prediction of Thyroid Cartilage invasion was determined by specialized radiologists. Tumor characteristics and pathologic Thyroid Cartilage invasion were compared to the radiologic assessment. 236 patients were treated by vertical (20 %), supracricoid (67 %) or supraglottic partial laryngectomy (13 %) for tumors staged cT1 (26 %), cT2 (55 %), and cT3 (19 %). The Thyroid Cartilage was invaded on pathology in 19 cases (8 %). CT’s sensitivity was 10.5 %, specificity 94 %, positive predictive value 13 %, and negative predictive value 92 %. CT correctly predicted Thyroid Cartilage invasion in only two cases for an overall accuracy of 87 %. Among the false-positive CT’s, tumors involving the anterior commissure were significantly over-represented (61.5 % vs. 27 %, p = .004). Tumors with decreased vocal fold (VF) mobility were significantly over-represented in the group of false-negatives (41 vs. 13 %, p = .0035). Preoperative CT was not effective in predicting Thyroid Cartilage invasion in these early- to mid-stage lesions, overestimating Cartilage invasion for AC lesions and underestimating invasion for lesions with decreased VF mobility.

  • organ preservation surgery for laryngeal squamous cell carcinoma low incidence of Thyroid Cartilage invasion
    Laryngoscope, 2010
    Co-Authors: Dana M Hartl, Guillaume Landry, Stephane Hans, P Marandas, Daniel Brasnu
    Abstract:

    Objectives/Hypothesis: Determine the incidence and risk factors for Thyroid Cartilage invasion in early and midstage laryngeal cancer. Study Design: Retrospective review. Methods: A retrospective review was carried out of tumors treated by open surgery with at least partial resection of Thyroid Cartilage from 1992 to 2008. Preoperative laser, radiation therapy, or chemotherapy were excluded. Tumor stage, anterior commissure involvement, vocal fold (VF) mobility, computed tomography (CT) scan, and pathological Cartilage status were recorded. Results: Three hundred fifty-eight patients were treated for tumors staged cT1 (32%), cT2 (53%), and cT3 (15%) by vertical (26%), supracricoid (62%), or supraglottic partial laryngectomy (12%). The Thyroid Cartilage was invaded in 8.9% of cases. Abnormal VF mobility was significantly related to Thyroid Cartilage invasion (Fisher exact test, P = .0002). Neither anterior commissure involvement nor CT scan were related to Cartilage invasion. Conclusions: Thyroid Cartilage invasion was rare but increased if VF mobility was impaired. This has implications for transoral resection, which unlike open surgery avoids unnecessary Cartilage resection.

Guillaume Landry - One of the best experts on this subject based on the ideXlab platform.

  • Thyroid Cartilage invasion in early stage squamous cell carcinoma involving the anterior commissure
    Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2012
    Co-Authors: Dana M Hartl, Guillaume Landry, Stephane Hans, P Marandas, François Janot, Odile Casiraghi, Daniel Brasnu
    Abstract:

    Background Anterior commissure (AC) carcinoma is in close proximity to the Thyroid Cartilage. Our objective was to evaluate risk factors for Thyroid Cartilage invasion. Methods This was a retrospective study of tumors involving the AC treated by open surgery. Tumor stage, extensions, vocal fold (VF) mobility, CT scan, and pathologic Cartilage status were recorded. Results Ninety-four patients with clinical T (cT) classifications cT1b (44%), cT2 (50%), and cT3 (6%) were included. The incidence of Thyroid Cartilage invasion was 8.5%, significantly related to VF mobility, with invasion in 31% versus 5% with normal mobility (p = .002). Sensitivity, specificity, and positive and negative predictive values for decreased VF mobility were 50%, 90%, 31%, and 95%, respectively. After a median follow-up of 49 months, there was no difference in local control between tumors with or without Cartilage invasion. Conclusions For these tumors involving the AC, VF mobility was the only significant factor related to Thyroid Cartilage invasion and should be taken into consideration when planning surgery. © 2011 Wiley Periodicals, Inc. Head Neck, 2011

  • CT-scan prediction of Thyroid Cartilage invasion for early laryngeal squamous cell carcinoma
    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated wi, 2012
    Co-Authors: Dana M Hartl, Guillaume Landry, Stephane Hans, François Bidault, Morbize Julieron, Gérard Mamelle, François Janot, Brasnu D
    Abstract:

    Treatment choice for laryngeal cancer may be influenced by the diagnosis of Thyroid Cartilage invasion on preoperative computed tomography (CT). Our objective was to determine the predictive value of CT for Thyroid Cartilage invasion in early- to mid-stage laryngeal cancer. Retrospective study (1992–2008) of laryngeal squamous cell carcinoma treated with open partial laryngectomy and resection of at least part of the Thyroid Cartilage. Previous laser surgery, radiation therapy, chemotherapy and second primaries were excluded. CT prediction of Thyroid Cartilage invasion was determined by specialized radiologists. Tumor characteristics and pathologic Thyroid Cartilage invasion were compared to the radiologic assessment. 236 patients were treated by vertical (20 %), supracricoid (67 %) or supraglottic partial laryngectomy (13 %) for tumors staged cT1 (26 %), cT2 (55 %), and cT3 (19 %). The Thyroid Cartilage was invaded on pathology in 19 cases (8 %). CT’s sensitivity was 10.5 %, specificity 94 %, positive predictive value 13 %, and negative predictive value 92 %. CT correctly predicted Thyroid Cartilage invasion in only two cases for an overall accuracy of 87 %. Among the false-positive CT’s, tumors involving the anterior commissure were significantly over-represented (61.5 % vs. 27 %, p = .004). Tumors with decreased vocal fold (VF) mobility were significantly over-represented in the group of false-negatives (41 vs. 13 %, p = .0035). Preoperative CT was not effective in predicting Thyroid Cartilage invasion in these early- to mid-stage lesions, overestimating Cartilage invasion for AC lesions and underestimating invasion for lesions with decreased VF mobility.

  • organ preservation surgery for laryngeal squamous cell carcinoma low incidence of Thyroid Cartilage invasion
    Laryngoscope, 2010
    Co-Authors: Dana M Hartl, Guillaume Landry, Stephane Hans, P Marandas, Daniel Brasnu
    Abstract:

    Objectives/Hypothesis: Determine the incidence and risk factors for Thyroid Cartilage invasion in early and midstage laryngeal cancer. Study Design: Retrospective review. Methods: A retrospective review was carried out of tumors treated by open surgery with at least partial resection of Thyroid Cartilage from 1992 to 2008. Preoperative laser, radiation therapy, or chemotherapy were excluded. Tumor stage, anterior commissure involvement, vocal fold (VF) mobility, computed tomography (CT) scan, and pathological Cartilage status were recorded. Results: Three hundred fifty-eight patients were treated for tumors staged cT1 (32%), cT2 (53%), and cT3 (15%) by vertical (26%), supracricoid (62%), or supraglottic partial laryngectomy (12%). The Thyroid Cartilage was invaded in 8.9% of cases. Abnormal VF mobility was significantly related to Thyroid Cartilage invasion (Fisher exact test, P = .0002). Neither anterior commissure involvement nor CT scan were related to Cartilage invasion. Conclusions: Thyroid Cartilage invasion was rare but increased if VF mobility was impaired. This has implications for transoral resection, which unlike open surgery avoids unnecessary Cartilage resection.

P Marandas - One of the best experts on this subject based on the ideXlab platform.

  • Thyroid Cartilage invasion in early stage squamous cell carcinoma involving the anterior commissure
    Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2012
    Co-Authors: Dana M Hartl, Guillaume Landry, Stephane Hans, P Marandas, François Janot, Odile Casiraghi, Daniel Brasnu
    Abstract:

    Background Anterior commissure (AC) carcinoma is in close proximity to the Thyroid Cartilage. Our objective was to evaluate risk factors for Thyroid Cartilage invasion. Methods This was a retrospective study of tumors involving the AC treated by open surgery. Tumor stage, extensions, vocal fold (VF) mobility, CT scan, and pathologic Cartilage status were recorded. Results Ninety-four patients with clinical T (cT) classifications cT1b (44%), cT2 (50%), and cT3 (6%) were included. The incidence of Thyroid Cartilage invasion was 8.5%, significantly related to VF mobility, with invasion in 31% versus 5% with normal mobility (p = .002). Sensitivity, specificity, and positive and negative predictive values for decreased VF mobility were 50%, 90%, 31%, and 95%, respectively. After a median follow-up of 49 months, there was no difference in local control between tumors with or without Cartilage invasion. Conclusions For these tumors involving the AC, VF mobility was the only significant factor related to Thyroid Cartilage invasion and should be taken into consideration when planning surgery. © 2011 Wiley Periodicals, Inc. Head Neck, 2011

  • organ preservation surgery for laryngeal squamous cell carcinoma low incidence of Thyroid Cartilage invasion
    Laryngoscope, 2010
    Co-Authors: Dana M Hartl, Guillaume Landry, Stephane Hans, P Marandas, Daniel Brasnu
    Abstract:

    Objectives/Hypothesis: Determine the incidence and risk factors for Thyroid Cartilage invasion in early and midstage laryngeal cancer. Study Design: Retrospective review. Methods: A retrospective review was carried out of tumors treated by open surgery with at least partial resection of Thyroid Cartilage from 1992 to 2008. Preoperative laser, radiation therapy, or chemotherapy were excluded. Tumor stage, anterior commissure involvement, vocal fold (VF) mobility, computed tomography (CT) scan, and pathological Cartilage status were recorded. Results: Three hundred fifty-eight patients were treated for tumors staged cT1 (32%), cT2 (53%), and cT3 (15%) by vertical (26%), supracricoid (62%), or supraglottic partial laryngectomy (12%). The Thyroid Cartilage was invaded in 8.9% of cases. Abnormal VF mobility was significantly related to Thyroid Cartilage invasion (Fisher exact test, P = .0002). Neither anterior commissure involvement nor CT scan were related to Cartilage invasion. Conclusions: Thyroid Cartilage invasion was rare but increased if VF mobility was impaired. This has implications for transoral resection, which unlike open surgery avoids unnecessary Cartilage resection.