The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Frank M Sacks - One of the best experts on this subject based on the ideXlab platform.
-
Thyroid Hormones and changes in body weight and metabolic parameters in response to weight loss diets the pounds lost trial
International Journal of Obesity, 2017Co-Authors: Liming Liang, George A Bray, Lu Qi, Frank B Hu, Frank M Sacks, Jennifer C RoodAbstract:The role of Thyroid Hormones in diet-induced weight loss and subsequent weight regain is largely unknown. To examine the associations between Thyroid Hormones and changes in body weight and resting metabolic rate (RMR) in a diet-induced weight loss setting. Data analysis was conducted among 569 overweight and obese participants aged 30–70 years with normal Thyroid function participating in the 2-year Prevention of Obesity Using Novel Dietary Strategies (POUNDS) LOST randomized clinical trial. Changes in body weight and RMR were assessed during the 2-year intervention. Thyroid Hormones (free triiodothyronine (T3), free thyroxine (T4), total T3, total T4 and Thyroid-stimulating hormone (TSH)), anthropometric measurements and biochemical parameters were assessed at baseline, 6 months and 24 months. Participants lost an average of 6.6 kg of body weight during the first 6 months and subsequently regained an average of 2.7 kg of body weight over the remaining period from 6 to 24 months. Baseline free T3 and total T3 were positively associated, whereas free T4 was inversely associated, with baseline body weight, body mass index and RMR. Total T4 and TSH were not associated with these parameters. Higher baseline free T3 and free T4 levels were significantly associated with a greater weight loss during the first 6 months (P<0.05) after multivariate adjustments including dietary intervention groups and baseline body weight. Comparing extreme tertiles, the multivariate-adjusted weight loss±s.e. was −3.87±0.9 vs −5.39±0.9 kg for free T3 (Ptrend=0.02) and −4.09±0.9 vs −5.88±0.9 kg for free T4 (Ptrend=0.004). The Thyroid Hormones did not predict weight regain in 6–24 months. A similar pattern of associations was also observed between baseline Thyroid Hormones and changes in RMR. In addition, changes in free T3 and total T3 levels were positively associated with changes in body weight, RMR, body fat mass, blood pressure, glucose, insulin, triglycerides and leptin at 6 months and 24 months (all P<0.05). In this diet-induced weight loss setting, higher baseline free T3 and free T4 predicted more weight loss, but not weight regain among overweight and obese adults with normal Thyroid function. These findings reveal a novel role of Thyroid Hormones in body weight regulation and may help identify individuals more responsive to weight loss diets.
-
abstract 11438 Thyroid Hormones and changes in body weight and metabolic parameters in response to weight loss diets the pounds lost trial
Circulation, 2016Co-Authors: Liming Liang, George A Bray, Lu Qi, Frank B Hu, Frank M SacksAbstract:Context: The role of Thyroid Hormones in diet-induced weight loss and subsequent weight regain is largely unknown. Objective: To examine the relationship between baseline Thyroid Hormones and subse...
Pochin Huang - One of the best experts on this subject based on the ideXlab platform.
-
early phthalates exposure in pregnant women is associated with alteration of Thyroid Hormones
PLOS ONE, 2016Co-Authors: Pochin Huang, Chih Hsin Tsai, Wei Yen Liang, Sih Syuan Li, Han Bin HuangAbstract:Introduction Previous studies revealed that phthalate exposure could alter Thyroid Hormones during the last trimester of pregnancy. However, Thyroid Hormones are crucial for fetal development during the first trimester. We aimed to clarify the effect of phthalate exposure on Thyroid Hormones during early pregnancy. Method We recruited 97 pregnant women who were offered an amniocentesis during the early trimester from an obstetrics clinic in southern Taiwan from 2013 to 2014. After signing an informed consent form, we collected amniotic fluid and urine samples from pregnant women to analyze 11 metabolites, including mono-ethyl phthalate (MEP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono-(2-ethylhexyl) phthalate (MEHP), mono-butyl phthalate (MnBP), of 9 phthalates using liquid chromatography/ tandem mass spectrometry. We collected blood samples from each subject to analyze serum Thyroid Hormones including thyroxine (T4), free T4, and Thyroid-binding globulin (TBG). Results Three phthalate metabolites were discovered to be >80% in the urine samples of the pregnant women: MEP (88%), MnBP (81%) and MECPP (86%). Median MnBP and MECPP levels in pregnant Taiwanese women were 21.5 and 17.6 μg/g-creatinine, respectively, that decreased after the 2011 Taiwan DEHP scandal. Results of principal component analysis suggested two major sources (DEHP and other phthalates) of phthalates exposure in pregnant women. After adjusting for age, gestational age, TBG, urinary creatinine, and other phthalate metabolites, we found a significantly negative association between urinary MnBP levels and serum T4 (β = –5.41; p-value = 0.012; n = 97) in pregnant women using Bonferroni correction. Conclusion We observed a potential change in the Thyroid Hormones of pregnant women during early pregnancy after DnBP exposure. Additional study is necessitated to clarify these associations.
-
associations between urinary phthalate monoesters and Thyroid Hormones in pregnant women
Human Reproduction, 2007Co-Authors: Pochin Huang, Paochi LiaoAbstract:BACKGROUND: Maternal hypoThyroidism during pregnancy can cause adverse effects in the fetus. Scientific evidence has shown that probable Thyroid-like function of some phthalates in vitro and in vivo, and phthalates exposure, can begin in utero. This study investigated the association between phthalate exposure and Thyroid Hormones in pregnant women. METHODS: Serum and spot urine samples were collected from 76 Taiwanese pregnant women at second trimester. Thyroid Hormones, including Thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4) and free T4 (FT4) were analysed in serum samples, and five urinary phthalate monoesters, including mono butyl phthalate (MBP), monoethyl phthalate (MEP) and mono ethylhexyl phthalate (MEHP), were measured. RESULTS: Urinary MBP, MEP and MEHP, the median levels of which were 81.8, 27.7 and 20.6 ng/ml, respectively, were the predominant substances in the urinary phthalate monoesters. Significant mild negative correlations were found between T4 and urinary MBP (R 52 0.248, P< 0.05), and between FT4 and urinary MBP (R 52 0.368, P< 0.05). After adjusting for age, BMI and gestation, urinary MBP levels showed negative associations with FT4 and T4 (FT4: b 52 0.110, P< 0.001; T4: b520.112, P 5 0.003). CONCLUSIONS: Exposure to di-n-butyl phthalate (DBP) may affect Thyroid activity in pregnant women, but how DBP affects Thyroid function is unclear. Further studies are needed to elucidate the mechanism of action and to investigate whether any other factors related to DBP exposure alter the Thyroid function.
Lu Qi - One of the best experts on this subject based on the ideXlab platform.
-
Thyroid Hormones and changes in body weight and metabolic parameters in response to weight loss diets the pounds lost trial
International Journal of Obesity, 2017Co-Authors: Liming Liang, George A Bray, Lu Qi, Frank B Hu, Frank M Sacks, Jennifer C RoodAbstract:The role of Thyroid Hormones in diet-induced weight loss and subsequent weight regain is largely unknown. To examine the associations between Thyroid Hormones and changes in body weight and resting metabolic rate (RMR) in a diet-induced weight loss setting. Data analysis was conducted among 569 overweight and obese participants aged 30–70 years with normal Thyroid function participating in the 2-year Prevention of Obesity Using Novel Dietary Strategies (POUNDS) LOST randomized clinical trial. Changes in body weight and RMR were assessed during the 2-year intervention. Thyroid Hormones (free triiodothyronine (T3), free thyroxine (T4), total T3, total T4 and Thyroid-stimulating hormone (TSH)), anthropometric measurements and biochemical parameters were assessed at baseline, 6 months and 24 months. Participants lost an average of 6.6 kg of body weight during the first 6 months and subsequently regained an average of 2.7 kg of body weight over the remaining period from 6 to 24 months. Baseline free T3 and total T3 were positively associated, whereas free T4 was inversely associated, with baseline body weight, body mass index and RMR. Total T4 and TSH were not associated with these parameters. Higher baseline free T3 and free T4 levels were significantly associated with a greater weight loss during the first 6 months (P<0.05) after multivariate adjustments including dietary intervention groups and baseline body weight. Comparing extreme tertiles, the multivariate-adjusted weight loss±s.e. was −3.87±0.9 vs −5.39±0.9 kg for free T3 (Ptrend=0.02) and −4.09±0.9 vs −5.88±0.9 kg for free T4 (Ptrend=0.004). The Thyroid Hormones did not predict weight regain in 6–24 months. A similar pattern of associations was also observed between baseline Thyroid Hormones and changes in RMR. In addition, changes in free T3 and total T3 levels were positively associated with changes in body weight, RMR, body fat mass, blood pressure, glucose, insulin, triglycerides and leptin at 6 months and 24 months (all P<0.05). In this diet-induced weight loss setting, higher baseline free T3 and free T4 predicted more weight loss, but not weight regain among overweight and obese adults with normal Thyroid function. These findings reveal a novel role of Thyroid Hormones in body weight regulation and may help identify individuals more responsive to weight loss diets.
-
abstract 11438 Thyroid Hormones and changes in body weight and metabolic parameters in response to weight loss diets the pounds lost trial
Circulation, 2016Co-Authors: Liming Liang, George A Bray, Lu Qi, Frank B Hu, Frank M SacksAbstract:Context: The role of Thyroid Hormones in diet-induced weight loss and subsequent weight regain is largely unknown. Objective: To examine the relationship between baseline Thyroid Hormones and subse...
Cilius Esmann Fonvig - One of the best experts on this subject based on the ideXlab platform.
-
reference values for fasting serum concentrations of Thyroid stimulating hormone and Thyroid Hormones in healthy danish north european white children and adolescents
Scandinavian Journal of Clinical & Laboratory Investigation, 2019Co-Authors: Gowthami Gunapalasingham, Christine Frithioffbojsoe, Morten Asp Vonsild Lund, Paula L Hedley, Cilius Esmann Fonvig, Maria DahlAbstract:AbstractThyroid-stimulating hormone (TSH) and Thyroid Hormones influence the functions of many organ systems, as well as child development and growth. Several studies have reported an association b...
Frank B Hu - One of the best experts on this subject based on the ideXlab platform.
-
Thyroid Hormones and changes in body weight and metabolic parameters in response to weight loss diets the pounds lost trial
International Journal of Obesity, 2017Co-Authors: Liming Liang, George A Bray, Lu Qi, Frank B Hu, Frank M Sacks, Jennifer C RoodAbstract:The role of Thyroid Hormones in diet-induced weight loss and subsequent weight regain is largely unknown. To examine the associations between Thyroid Hormones and changes in body weight and resting metabolic rate (RMR) in a diet-induced weight loss setting. Data analysis was conducted among 569 overweight and obese participants aged 30–70 years with normal Thyroid function participating in the 2-year Prevention of Obesity Using Novel Dietary Strategies (POUNDS) LOST randomized clinical trial. Changes in body weight and RMR were assessed during the 2-year intervention. Thyroid Hormones (free triiodothyronine (T3), free thyroxine (T4), total T3, total T4 and Thyroid-stimulating hormone (TSH)), anthropometric measurements and biochemical parameters were assessed at baseline, 6 months and 24 months. Participants lost an average of 6.6 kg of body weight during the first 6 months and subsequently regained an average of 2.7 kg of body weight over the remaining period from 6 to 24 months. Baseline free T3 and total T3 were positively associated, whereas free T4 was inversely associated, with baseline body weight, body mass index and RMR. Total T4 and TSH were not associated with these parameters. Higher baseline free T3 and free T4 levels were significantly associated with a greater weight loss during the first 6 months (P<0.05) after multivariate adjustments including dietary intervention groups and baseline body weight. Comparing extreme tertiles, the multivariate-adjusted weight loss±s.e. was −3.87±0.9 vs −5.39±0.9 kg for free T3 (Ptrend=0.02) and −4.09±0.9 vs −5.88±0.9 kg for free T4 (Ptrend=0.004). The Thyroid Hormones did not predict weight regain in 6–24 months. A similar pattern of associations was also observed between baseline Thyroid Hormones and changes in RMR. In addition, changes in free T3 and total T3 levels were positively associated with changes in body weight, RMR, body fat mass, blood pressure, glucose, insulin, triglycerides and leptin at 6 months and 24 months (all P<0.05). In this diet-induced weight loss setting, higher baseline free T3 and free T4 predicted more weight loss, but not weight regain among overweight and obese adults with normal Thyroid function. These findings reveal a novel role of Thyroid Hormones in body weight regulation and may help identify individuals more responsive to weight loss diets.
-
abstract 11438 Thyroid Hormones and changes in body weight and metabolic parameters in response to weight loss diets the pounds lost trial
Circulation, 2016Co-Authors: Liming Liang, George A Bray, Lu Qi, Frank B Hu, Frank M SacksAbstract:Context: The role of Thyroid Hormones in diet-induced weight loss and subsequent weight regain is largely unknown. Objective: To examine the relationship between baseline Thyroid Hormones and subse...