The Experts below are selected from a list of 1194 Experts worldwide ranked by ideXlab platform

Ji Hwa Ryu - One of the best experts on this subject based on the ideXlab platform.

Zubair W. Baloch - One of the best experts on this subject based on the ideXlab platform.

  • the molecular landscape of noninvasive follicular Thyroid neoplasm with papillary like nuclear features niftp a literature review
    Advances in Anatomic Pathology, 2017
    Co-Authors: Fulvio Basolo, Elisabetta Macerola, Clara Ugolini, David N Poller, Zubair W. Baloch
    Abstract:

    The encapsulated and noninvasive follicular variant of papillary Thyroid carcinoma has been recently reclassified as noninvasive follicular Thyroid neoplasm with papillary-like nuclear features (NIFTP). These tumors demonstrate indolent behavior. This change in nomenclature will have great clinical impact by avoiding overtreatment of patients with NIFTP lesions who in the past were diagnosed with Thyroid carcinoma and typically received completion Thyroidectomy followed by radioactive iodine ablation. The pathologic diagnosis of NIFTP requires surgical removal of the Thyroid lesion or the lobe harboring it, and thorough sampling of the complete interface between the tumor capsule and the Thyroid Parenchyma, to exclude foci of invasion. From a cytologic point of view, the unequivocal differential diagnosis between NIFTP and infiltrative follicular variant of papillary Thyroid carcinoma in fine-needle aspiration is close to impossible based on cellular and architectural features. Therefore, use of adjunct molecular testing on fine-needle aspiration specimens may be essential for the preoperative diagnosis of low-risk tumors such as NIFTP for appropriate patient management. This review discusses and summarizes the existing known literature on molecular characteristics of NIFTP tumors, so far reported, including cases retrospectively classified or prospectively diagnosed as NIFTP. Brief reference is also made to new and promising approaches applicable to the diagnosis of this tumor.

  • Granular cell tumor of the Thyroid: a case report.
    International Journal of Surgical Pathology, 2005
    Co-Authors: Zubair W. Baloch, Susan Martin, Virginia A. Livolsi
    Abstract:

    We report a rare case of granular cell tumor (GCT) arising within the Thyroid Parenchyma. The differential diagnosis of GCT in Thyroid includes all oncocytic/Hurthle cell lesions of the Thyroid, medullary carcinoma and metastasis. The classic histomorphologic features and immunohistochemistry are helpful in arriving at the correct diagnosis.

  • differential expression of cytokeratins in follicular variant of papillary carcinoma an immunohistochemical study and its diagnostic utility
    Human Pathology, 1999
    Co-Authors: Zubair W. Baloch, Susan C Abraham, Shelly Roberts, Virginia A. Livolsi
    Abstract:

    The follicular variant of papillary carcinoma (FVPTC) is characterized by follicular growth pattern and tumor cells with appropriate nuclear features of papillary carcinoma. However, occasionally these lesions may show focal or multifocal instead of diffuse distribution of nuclear features of papillary carcinoma. Such lesions can be underdiagnosed as benign follicular nodule. Previous studies have shown that cytokeratins, especially 19, are helpful in differentiating papillary carcinoma from other benign and malignant follicular patterned lesions. In this study, we applied monoclonal antibodies to CK5/6/18, CK18, CK10/13, CK20, CK17, and CK19 to paraffin sections of formaldehyde-fixed tissue from 26 cases of FVPTC with multifocal distribution of papillary cancer nuclei, 10 cases of usual variant of papillary carcinoma, 1 case of Warthin's tumor-like papillary carcinoma, and 2 cases of the columnar cell carcinoma. CK19 stained strongly and diffusely all cases of papillary carcinoma. FVPTC cases showed strong staining of the areas with papillary cancer nuclei in all cases and moderate to strong staining in areas of tumor without obvious nuclear features of papillary cancer. Normal Thyroid Parenchyma adjacent to the tumor nodule showed focal staining in most cases; however, tissue away from the tumor nodule failed to show any staining. All cases of usual type of papillary carcinoma, 2 of columnar cell carcinoma, and 1 Warthin's tumor-like papillary carcinoma showed strong and diffuse staining with CK19 and failed to show any staining of adjacent normal Thyroid Parenchyma. Similar but less intense staining patterns were seen with CK17 and CK20. The control group, consisting of cases of follicular adenoma, follicular carcinoma, and hyperplastic nodule, showed no staining with CK19. We suggest that if one is using immunohistochemistry to aid in the diagnosis of cases of FVPTC with multifocal distribution of nuclear features of papillary cancer, an antibody panel comprising CKs 17, 19, and 20 may prove helpful. In addition, we hypothesize that the staining of adjacent nontumorous Thyroid Parenchyma with CK19, seen only in cases of FVPTC, suggests that some factors secreted/produced by this particular tumor may lead to modification in keratin expression of surrounding follicular epithelium.

Dong Wook Kim - One of the best experts on this subject based on the ideXlab platform.

Hye Jin Baek - One of the best experts on this subject based on the ideXlab platform.

Hye Shin Ahn - One of the best experts on this subject based on the ideXlab platform.