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Yihang Zhang - One of the best experts on this subject based on the ideXlab platform.

  • multiple comparisons of the efficacy and safety for seven treatments in Tibia Shaft Fracture patients
    Frontiers in Pharmacology, 2019
    Co-Authors: Yihang Zhang
    Abstract:

    Background: A Tibia Shaft Fracture is one of the most common long bone Fractures, with two general types, open Fracture and close Fracture. However, there is no universally accepted guideline suggesting which treatment to use under certain circumstances. Therefore, a comprehensive network meta-analysis (NMA) is needed to summarize existing studies and to provide more credible data-based medical guidelines. Methods: Available literature was identified by searching medical databases with relevant key terms. Studies that met the inclusion and exclusion criteria, baseline, intervention, and the outcome of treatments, were extracted. A comparative connection of these studies was demonstrated through net plots. Continuous variables and binary variables were reported as mean difference (MD) and odds ratio (OR) with a 95% credible interval (CrI), respectively. The comparison of direct and indirect outcome and their P-value were listed in the node-splitting table. Treatments for each endpoint were ranked by their surface under the cumulative ranking curve (SUCRA) value. A heat plot was created to illustrate the contribution of raw data and the inconsistency between direct and indirect comparisons. Results: According to the search strategy, 697 publications were identified, and 25 records were included, involving 3,032 patients with Tibia Shaft Fractures. Seven common surgical or non-surgical treatments, including reamed intramedullary nailing (RIN), un-reamed intramedullary nailing (UIN), minimally reamed intramedullary nailing (MIN), ender nailing (EN), external fixation (EF), plate, and cast, were compared, in terms of time to union, reoperation, non-union, malunion, infection and implant failure. Plate performed relatively better for time to union, while cast might be the best choice in close cases to reduce the risks of reoperation, non-union, malunion, and infection. To prevent implant failure, EN seemed to be better. Conclusion: Cast might have the highest probability of the most optimal choice for Tibia Shaft Fracture in close cases, while reamed intramedullary nailing ranked second.

  • Image_2_Multiple Comparisons of the Efficacy and Safety for Seven Treatments in Tibia Shaft Fracture Patients.TIF
    2019
    Co-Authors: Yihang Zhang
    Abstract:

    Background: A Tibia Shaft Fracture is one of the most common long bone Fractures, with two general types, open Fracture and close Fracture. However, there is no universally accepted guideline suggesting which treatment to use under certain circumstances. Therefore, a comprehensive network meta-analysis (NMA) is needed to summarize existing studies and to provide more credible data-based medical guidelines.Methods: Available literature was identified by searching medical databases with relevant key terms. Studies that met the inclusion and exclusion criteria, baseline, intervention, and the outcome of treatments, were extracted. A comparative connection of these studies was demonstrated through net plots. Continuous variables and binary variables were reported as mean difference (MD) and odds ratio (OR) with a 95% credible interval (CrI), respectively. The comparison of direct and indirect outcome and their P-value were listed in the node-splitting table. Treatments for each endpoint were ranked by their surface under the cumulative ranking curve (SUCRA) value. A heat plot was created to illustrate the contribution of raw data and the inconsistency between direct and indirect comparisons.Results: According to the search strategy, 697 publications were identified, and 25 records were included, involving 3,032 patients with Tibia Shaft Fractures. Seven common surgical or non-surgical treatments, including reamed intramedullary nailing (RIN), un-reamed intramedullary nailing (UIN), minimally reamed intramedullary nailing (MIN), ender nailing (EN), external fixation (EF), plate, and cast, were compared, in terms of time to union, reoperation, non-union, malunion, infection and implant failure. Plate performed relatively better for time to union, while cast might be the best choice in close cases to reduce the risks of reoperation, non-union, malunion, and infection. To prevent implant failure, EN seemed to be better.Conclusion: Cast might have the highest probability of the most optimal choice for Tibia Shaft Fracture in close cases, while reamed intramedullary nailing ranked second.

  • Table_4_Multiple Comparisons of the Efficacy and Safety for Seven Treatments in Tibia Shaft Fracture Patients.DOCX
    2019
    Co-Authors: Yihang Zhang
    Abstract:

    Background: A Tibia Shaft Fracture is one of the most common long bone Fractures, with two general types, open Fracture and close Fracture. However, there is no universally accepted guideline suggesting which treatment to use under certain circumstances. Therefore, a comprehensive network meta-analysis (NMA) is needed to summarize existing studies and to provide more credible data-based medical guidelines.Methods: Available literature was identified by searching medical databases with relevant key terms. Studies that met the inclusion and exclusion criteria, baseline, intervention, and the outcome of treatments, were extracted. A comparative connection of these studies was demonstrated through net plots. Continuous variables and binary variables were reported as mean difference (MD) and odds ratio (OR) with a 95% credible interval (CrI), respectively. The comparison of direct and indirect outcome and their P-value were listed in the node-splitting table. Treatments for each endpoint were ranked by their surface under the cumulative ranking curve (SUCRA) value. A heat plot was created to illustrate the contribution of raw data and the inconsistency between direct and indirect comparisons.Results: According to the search strategy, 697 publications were identified, and 25 records were included, involving 3,032 patients with Tibia Shaft Fractures. Seven common surgical or non-surgical treatments, including reamed intramedullary nailing (RIN), un-reamed intramedullary nailing (UIN), minimally reamed intramedullary nailing (MIN), ender nailing (EN), external fixation (EF), plate, and cast, were compared, in terms of time to union, reoperation, non-union, malunion, infection and implant failure. Plate performed relatively better for time to union, while cast might be the best choice in close cases to reduce the risks of reoperation, non-union, malunion, and infection. To prevent implant failure, EN seemed to be better.Conclusion: Cast might have the highest probability of the most optimal choice for Tibia Shaft Fracture in close cases, while reamed intramedullary nailing ranked second.

Mohammad-reza Minator Sajjadi - One of the best experts on this subject based on the ideXlab platform.

  • comparative investigation of percutaneous plating and intramedullary nailing effects on il 6 production in patients with Tibia Shaft Fracture
    Acta Orthopaedica et Traumatologica Turcica, 2017
    Co-Authors: Adel Ebrahimpour, Mohammad-ali Okhovatpour, Mehrdad Sadighi, Amir-hossein Sarejloo, Mohammad-reza Minator Sajjadi
    Abstract:

    Abstract Objective The aim of this study was to analyze the effect of intramedullary nailing (IMN), open plating and percutaneous plating on the induction of IL-6 in patients with Tibia Fractures. Methods A total of 30 patients with Tibia Shaft Fracture underwent either intramedullary nailing (IMN, n = 15; 14 males and 1 female; mean age: 32.1 ± 15.6), ORIF plating (n = 8; 5 males and 3 females; mean age: 60.0 ± 17.8), or percutaneous plating (n = 7; 6 males and 1 female; mean age: 43.1 ± 21.4). Serum IL-6 cytokine levels were measured prior to, and 6 and 24 h after the surgery, using a special ELISA kit. Results The IL-6 concentration increased to peak levels at 6 h in both IMN and percutaneous plating groups, and at 24 h in ORIF plating group (p  Conclusion Our results suggest that percutaneous plating compared to the IMN has lower effects on IL-6 production in patients with Tibia Fracture. Level of evidence Level III, therapeutic study

  • Comparative investigation of percutaneous plating and intramedullary nailing effects on IL-6 production in patients with Tibia Shaft Fracture
    Elsevier, 2017
    Co-Authors: Adel Ebrahimpour, Mohammad-ali Okhovatpour, Mehrdad Sadighi, Amir-hossein Sarejloo, Mohammad-reza Minator Sajjadi
    Abstract:

    Objective: The aim of this study was to analyze the effect of intramedullary nailing (IMN), open plating and percutaneous plating on the induction of IL-6 in patients with Tibia Fractures. Methods: A total of 30 patients with Tibia Shaft Fracture underwent either intramedullary nailing (IMN, n = 15; 14 males and 1 female; mean age: 32.1 ± 15.6), ORIF plating (n = 8; 5 males and 3 females; mean age: 60.0 ± 17.8), or percutaneous plating (n = 7; 6 males and 1 female; mean age: 43.1 ± 21.4). Serum IL-6 cytokine levels were measured prior to, and 6 and 24 h after the surgery, using a special ELISA kit. Results: The IL-6 concentration increased to peak levels at 6 h in both IMN and percutaneous plating groups, and at 24 h in ORIF plating group (p 

O Esan - One of the best experts on this subject based on the ideXlab platform.

  • comparison of unreamed interlocking nail and external fixation in open Tibia Shaft Fracture management
    West African journal of medicine, 2014
    Co-Authors: L M Oginni, I C Ikem, O Esan
    Abstract:

    BACKGROUND: The management of open Tibia Fractures remains controversial despite increase in its incidence. Some surgeons avoid internal fixations for fear of infection while others have demonstrated its superiority. Identifying an optimal management modality is of utmost benefit to our patients. Study objectives were to compare the rate of infection and mean duration to healing in the management of open Tibia Fractures using unreamed interlocking intramedullary nail and external fixation. METHODS: The study was an interventional study comparing two known standard methods of managing open Tibia Fractures conducted in the orthopaedic and trauma department of a tertiary health institution in South west, Nigeria. Forty patients who presented with open Tibia Fractures were allocated alternately into primary interlocking nailing group and external fixation group. Follow-up was for two years. RESULTS: Incidences of deep wound infection in both groups were 35% (external fixation) and 11.1% (interlocking nailing) respectively. The relative risk of developing infection in external fixation group was 3.2. Mean duration to union was 14.8 weeks and 14.4 weeks in the external fixation and interlocking nailing groups respectively, difference in mean was not statistically significant, (t=0.133, p=0.895). CONCLUSION: The risk of wound infection was observed to be higher in this study with the use of external fixation in the management of open Tibia Fractures compared with unreamed interlocking intramedullary nail.

Mandala S. Leliveld - One of the best experts on this subject based on the ideXlab platform.

  • epidemiologic trends for isolated Tibia Shaft Fracture admissions in the netherlands between 1991 and 2012
    European Journal of Trauma and Emergency Surgery, 2020
    Co-Authors: Mandala S. Leliveld, Suzanne Polinder, Martien J. M. Panneman, Michael H. J. Verhofstad, Esther M M Van Lieshout
    Abstract:

    Introduction Population-based knowledge on the occurrence of specific injuries is essential for the allocation of health care services, optimization of preventive measures, and research purposes. Therefore, the aim of this study was to examine long-term nation-based trends in the incidence rate, trauma mechanism, hospital length of stay (HLOS), treatment, and outcome of hospital-admitted patients with an isolated Tibia Shaft Fracture between 1991 and 2012 in The Netherlands.

  • health care and productivity costs for isolated Tibia Shaft Fracture admissions in the netherlands
    Acta Orthopaedica Belgica, 2020
    Co-Authors: Mandala S. Leliveld, Suzanne Polinder, Martien J. M. Panneman, Michael H. J. Verhofstad, Esther M M Van Lieshout
    Abstract:

    The aim of this study was to provide a detailed overview of age and gender specific health care costs and costs due to lost productivity for hospital admitted patients with an isolated Tibia Shaft Fracture in The Netherlands between 2008 and 2012. Injury cases and length of hospital stay were extracted from the National Medical Registration. Information on extramural health care and work absence were retrieved from a patient follow-up survey on health care use. Medical costs included ambulance care, in- hospital care, general practitioner care, home care, physical therapy, and rehabilitation/nursing care. An incidence-based cost model was applied to calculate direct health care costs and lost productivity in 2012. Total direct health care costs for all patients admitted with a Tibia Shaft Fracture (n = 1,635) were €13.6 million. Costs for productivity loss were € 23.0 million. Total costs (direct health care and lost productivity) per patient were highest for men aged 40-49 years mainly due to lost productivity, and for women aged > 80 years, due to high direct medical costs.

  • Epidemiologic trends for isolated Tibia Shaft Fracture admissions in The Netherlands between 1991 and 2012
    European Journal of Trauma and Emergency Surgery, 2019
    Co-Authors: Mandala S. Leliveld, Suzanne Polinder, Martien J. M. Panneman, Michael H. J. Verhofstad, Esther M. M. Van Lieshout
    Abstract:

    Introduction Population-based knowledge on the occurrence of specific injuries is essential for the allocation of health care services, optimization of preventive measures, and research purposes. Therefore, the aim of this study was to examine long-term nation-based trends in the incidence rate, trauma mechanism, hospital length of stay (HLOS), treatment, and outcome of hospital-admitted patients with an isolated Tibia Shaft Fracture between 1991 and 2012 in The Netherlands. Methods All hospital-admitted patients in The Netherlands between 1991 and 2012 with an isolated Tibia Shaft Fracture were included. Age and gender-standardized incidence rates were calculated for each year. Data were extracted from the National Medical Registration. Results The incidence rate for men decreased to 13.8/100,000 person years (py). For women the incidence rate remained stable with 7.2/100,000 py. Incidence showed a peak for adolescent men (15–19 years), and increased in both genders from 65 years onwards. Since 1993 the mean HLOS for isolated Tibia Fractures reduced from 10.8 to 5.4 days. Mean HLOS increased with age. Mean years lived with disability (YLD) was 4.5 years, declined linearly with age, and showed no gender effect. Conclusions In 22 years, the incidence rate of hospital admitted patients with an isolated Tibia Shaft Fracture in The Netherlands dropped with 12%, which was mainly attributable to a 15% decline among men. Incidence rate, trauma mechanism, and HLOS were age and gender related. HLOS also reduced over time. Operation rate and YLD were only age related.

Adel Ebrahimpour - One of the best experts on this subject based on the ideXlab platform.

  • comparative investigation of percutaneous plating and intramedullary nailing effects on il 6 production in patients with Tibia Shaft Fracture
    Acta Orthopaedica et Traumatologica Turcica, 2017
    Co-Authors: Adel Ebrahimpour, Mohammad-ali Okhovatpour, Mehrdad Sadighi, Amir-hossein Sarejloo, Mohammad-reza Minator Sajjadi
    Abstract:

    Abstract Objective The aim of this study was to analyze the effect of intramedullary nailing (IMN), open plating and percutaneous plating on the induction of IL-6 in patients with Tibia Fractures. Methods A total of 30 patients with Tibia Shaft Fracture underwent either intramedullary nailing (IMN, n = 15; 14 males and 1 female; mean age: 32.1 ± 15.6), ORIF plating (n = 8; 5 males and 3 females; mean age: 60.0 ± 17.8), or percutaneous plating (n = 7; 6 males and 1 female; mean age: 43.1 ± 21.4). Serum IL-6 cytokine levels were measured prior to, and 6 and 24 h after the surgery, using a special ELISA kit. Results The IL-6 concentration increased to peak levels at 6 h in both IMN and percutaneous plating groups, and at 24 h in ORIF plating group (p  Conclusion Our results suggest that percutaneous plating compared to the IMN has lower effects on IL-6 production in patients with Tibia Fracture. Level of evidence Level III, therapeutic study

  • Comparative investigation of percutaneous plating and intramedullary nailing effects on IL-6 production in patients with Tibia Shaft Fracture
    Elsevier, 2017
    Co-Authors: Adel Ebrahimpour, Mohammad-ali Okhovatpour, Mehrdad Sadighi, Amir-hossein Sarejloo, Mohammad-reza Minator Sajjadi
    Abstract:

    Objective: The aim of this study was to analyze the effect of intramedullary nailing (IMN), open plating and percutaneous plating on the induction of IL-6 in patients with Tibia Fractures. Methods: A total of 30 patients with Tibia Shaft Fracture underwent either intramedullary nailing (IMN, n = 15; 14 males and 1 female; mean age: 32.1 ± 15.6), ORIF plating (n = 8; 5 males and 3 females; mean age: 60.0 ± 17.8), or percutaneous plating (n = 7; 6 males and 1 female; mean age: 43.1 ± 21.4). Serum IL-6 cytokine levels were measured prior to, and 6 and 24 h after the surgery, using a special ELISA kit. Results: The IL-6 concentration increased to peak levels at 6 h in both IMN and percutaneous plating groups, and at 24 h in ORIF plating group (p