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Fumio Itoh - One of the best experts on this subject based on the ideXlab platform.
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correlation between hepatic Blood Flow and liver function in alcoholic liver cirrhosis
World Journal of Gastroenterology, 2014Co-Authors: Hideaki Takahashi, Hiroki Ikeda, Shigeru Sase, Fumio Itoh, Ryuta Shigefuku, Yoshihito Yoshida, Kotaro Matsunaga, Nobuyuki Matsumoto, Chiaki Okuse, Michihiro SuzukiAbstract:AIM: To elucidate the correlation between hepatic Blood Flow and liver function in alcoholic liver cirrhosis (AL-LC). METHODS: The subjects included 35 patients with AL-LC (34 men, 1 woman; mean age, 58.9 ± 10.7 years; median age, 61 years; range: 37-76 years). All patients were enrolled in this study after obtaining written informed consent. Liver function was measured with tests measuring albumin (Alb), prothrombin time (PT), brain natriuretic peptide (BNP), branched amino acid and tyrosine ratio (BTR), branched chain amino acid (BCAA), tyrosine, ammonia (NH3), cholinesterase (ChE), immunoreactive insulin (IRI), total bile acid (TBA), and the retention rate of indocyanine green 15 min after administration (ICG R15). Hepatic Blood Flow, hepatic arterial Tissue Blood Flow (HATBF), portal venous Tissue Blood Flow (PVTBF), and total hepatic Tissue Blood Flow (THTBF) were simultaneously calculated using xenon computed tomography. RESULTS: PVTBF, HATBF and THTBF were 30.2 ± 10.4, 20.0 ± 10.7, and 50.3 ± 14.9 mL/100 mL/min, respectively. Alb, PT, BNP, BTR, BCAA, tyrosine, NH3, ChE, IRI, TBA, and ICG R15 were 3.50 ± 0.50 g/dL, 72.0% ± 11.5%, 63.2 ± 56.7 pg/mL, 4.06 ± 1.24, 437.5 ± 89.4 μmol/L, 117.7 ± 32.8 μmol/L, 59.4 ± 22.7 μg/dL, 161.0 ± 70.8 IU/L, 12.8 ± 5.0 μg/dL, 68.0 ± 51.8 μmol/L, and 28.6% ± 13.5%, respectively. PVTBF showed a significant negative correlation with ICG R15 (r = -0.468, P <0.01). No significant correlation was seen between ICG 15R, HATBF and THTBF. There was a significant correlation between PVTBF and Alb (r = 0.2499, P < 0.05), and NH3 tended to have an inverse correlation with PVTBF (r = -0.2428, P = 0.0894). There were also many significant correlations between ICG R15 and liver function parameters, including Alb, NH3, PT, BNP, TBA, BCAA, and tyrosine (r = -0.2156, P < 0.05; r = 0.4318, P < 0.01; r = 0.4140, P < 0.01; r = 0.3610, P < 0.05; r = 0.5085, P < 0.001; r = 0.4496, P < 0.01; and r = 0.4740, P < 0.05, respectively). CONCLUSION: Our investigation showed that there is a close correlation between liver function and hepatic Blood Flow.
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evaluation of quantitative portal venous hepatic arterial and total hepatic Tissue Blood Flow using xenon ct in alcoholic liver cirrhosis comparison with liver cirrhosis related to hepatitis c virus and nonalcoholic steatohepatitis
Alcoholism: Clinical and Experimental Research, 2010Co-Authors: Hideaki Takahashi, Michihiro Suzuki, Hiroki Ikeda, Minoru Kobayashi, Shigeru Sase, Hiroshi Yotsuyanagi, Shiro Maeyama, Shiro Iino, Fumio ItohAbstract:Background/Aims: Xenon computed tomography (Xe-CT) is a noninvasive method of quantifying and visualizing Tissue Blood Flow (TBF). For the liver, Xe-CT allows separate measurement of hepatic arterial and portal venous TBF. The present study evaluated the usefulness of Xe-CT as a noninvasive diagnostic procedure for measuring hepatic TBF in alcoholic liver cirrhosis (AL-LC), compared with liver cirrhosis related to nonalcoholic steatohepatitis (NASH), (NASH-LC), and hepatitis C virus (HCV), (C-LC). Methods: Xe-CT was performed on 22 patients with AL-LC, 7 patients with NASH-LC, and 24 patients with C-LC. Severity of LC was classified according to Child-Pugh classification. Correlations between hepatic TBF, Child-Pugh classification, and indocyanin green retention (ICG) rate after 15 minutes (ICG15R) were examined. Correlations of hepatic TBF in Child-Pugh class A to AL-LC, NASH-LC, and C-LC were also examined. Results: Portal venous TBF (PVTBF) displayed a significant negative correlation with Child-Pugh score and ICG15R (r = ―0.432, p < 0.01, r = ―0.442, p < 0.01, respectively). Moreover, ICG15R displayed a significant positive correlation with Child-Pugh score (r = 0.661, p < 0.001). Meanwhile, mean PVTBF and total hepatic TBF (THTBF) was significantly lower in AL-LC than in C-LC (p < 0.05). Mean PVTBF was significantly lower in Child-Pugh class A to AL-LC and NASH-LC than in that to C-LC (p < 0.05). Similarly, mean THTBF was significantly lower in Child-Pugh class A to NASH-LC than in that to C-LC (p < 0.05). Conclusions: Measurement of hepatic TBF using Xe-CT is useful as a noninvasive, objective method of assessing the state of the liver in chronic liver disease.
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evaluation of quantitative portal venous hepatic arterial and total hepatic Tissue Blood Flow using xenon ct in alcoholic liver cirrhosis comparison with liver cirrhosis c
Alcoholism: Clinical and Experimental Research, 2007Co-Authors: Hideaki Takahashi, Michihiro Suzuki, Hiroki Ikeda, Minoru Kobayashi, Shigeru Sase, Hiroshi Yotsuyanagi, Shiro Maeyama, Shiro Iino, Fumio ItohAbstract:Background/Aims: Xenon computed tomography (Xe-CT) is a noninvasive method of quantifying and visualizing Tissue Blood Flow (TBF). For the liver, Xe-CT allows separate measurement of hepatic arterial and portal venous TBF. The present study evaluated the usefulness of Xe-CT as a noninvasive diagnostic procedure for measuring hepatic TBF in alcoholic liver cirrhosis (AL-LC), compared with liver cirrhosis C (C-LC). Methods: Xenon computed tomography was performed on 12 patients with AL-LC and 17 patients with C-LC. The severity of LC was classified according to Child–Pugh classification. Correlations between hepatic TBF and Child–Pugh classification were examined. Correlations of hepatic TBF in Child–Pugh class A to C-LC and AL-LC were also examined. Results: The mean portal venous TBF (PVTBF) was significantly lower in AL-LC than in C-LC (p=0.0316). Similarly, the mean total hepatic TBF (THTBF) was significantly lower in AL-LC than in C-LC (p=0.0390). PVTBF displayed a significant negative correlation with Child–Pugh score (r=−0.396, p=0.0368). Conclusions: Measurement of hepatic TBF using Xe-CT is useful as a noninvasive, objective method of assessing the state of the liver in chronic liver disease.
Turgut Durduran - One of the best experts on this subject based on the ideXlab platform.
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compact multi exposure speckle contrast optical spectroscopy scos device for measuring deep Tissue Blood Flow
Biomedical Optics Express, 2018Co-Authors: Tanja Dragojevic, Joseph L Hollmann, Davide Tamborini, Davide Portaluppi, Mauro Buttafava, Joseph P Culver, Federica Villa, Turgut DurduranAbstract:Speckle contrast optical spectroscopy (SCOS) measures absolute Blood Flow in deep Tissue, by taking advantage of multi-distance (previously reported in the literature) or multi-exposure (reported here) approach. This method promises to use inexpensive detectors to obtain good signal-to-noise ratio, but it has not yet been implemented in a suitable manner for a mass production. Here we present a new, compact, low power consumption, 32 by 2 single photon avalanche diode (SPAD) array that has no readout noise, low dead time and has high sensitivity in low light conditions, such as in vivo measurements. To demonstrate the capability to measure Blood Flow in deep Tissue, healthy volunteers were measured, showing no significant differences from the diffuse correlation spectroscopy. In the future, this array can be miniaturized to a low-cost, robust, battery operated wireless device paving the way for measuring Blood Flow in a wide-range of applications from sport injury recovery and training to, on-field concussion detection to wearables.
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speckle contrast optical spectroscopy a non invasive diffuse optical method for measuring microvascular Blood Flow in Tissue
Biomedical Optics Express, 2014Co-Authors: Claudia P Valdes, Hari M Varma, Anna K Kristoffersen, Tanja Dragojevic, Joseph P Culver, Turgut DurduranAbstract:We introduce a new, non-invasive, diffuse optical technique, speckle contrast optical spectroscopy (SCOS), for probing deep Tissue Blood Flow using the statistical properties of laser speckle contrast and the photon diffusion model for a point source. The feasibility of the method is tested using liquid phantoms which demonstrate that SCOS is capable of measuring the dynamic properties of turbid media non-invasively. We further present an in vivo measurement in a human forearm muscle using SCOS in two modalities: one with the dependence of the speckle contrast on the source-detector separation and another on the exposure time. In doing so, we also introduce crucial corrections to the speckle contrast that account for the variance of the shot and sensor dark noises.
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speckle contrast optical tomography a new method for deep Tissue three dimensional tomography of Blood Flow
Biomedical Optics Express, 2014Co-Authors: Hari M Varma, Claudia P Valdes, Anna K Kristoffersen, Turgut DurduranAbstract:A novel tomographic method based on the laser speckle contrast, speckle contrast optical tomography (SCOT) is introduced that allows us to reconstruct three dimensional distribution of Blood Flow in deep Tissues. This method is analogous to the diffuse optical tomography (DOT) but for deep Tissue Blood Flow. We develop a reconstruction algorithm based on first Born approximation to generate three dimensional distribution of Flow using the experimental data obtained from Tissue simulating phantoms.
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Blood Flow reduction in breast Tissue due to mammographic compression
Academic Radiology, 2014Co-Authors: David R Busch, Turgut Durduran, Regine Choe, Wesley B Baker, Daniel H Friedman, Andrew D A Maidment, Mark A Rosen, Mitchell D Schnall, Arjun G YodhAbstract:Rationale and objectives This study measures hemodynamic properties such as Blood Flow and hemoglobin concentration and oxygenation in the healthy human breast under a wide range of compressive loads. Because many breast-imaging technologies derive contrast from the deformed breast, these load-dependent vascular responses affect contrast agent–enhanced and hemoglobin-based breast imaging. Methods Diffuse optical and diffuse correlation spectroscopies were used to measure the concentrations of oxygenated and deoxygenated hemoglobin, lipid, water, and microvascular Blood Flow during axial breast compression in the parallel-plate transmission geometry. Results Significant reductions ( P Conclusions Imaging protocols based on injected contrast agents should account for variation in Tissue Blood Flow due to mammographic compression. Similarly, imaging techniques that depend on endogenous Blood contrasts will be affected by breast compression during imaging.
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direct measurement of Tissue Blood Flow and metabolism with diffuse optics
Philosophical Transactions of the Royal Society A, 2011Co-Authors: Rickson C Mesquita, Turgut Durduran, Erin M Buckley, Meeri N Kim, Chao Zhou, Regine Choe, Ulas Sunar, Arjun G YodhAbstract:Diffuse optics has proven useful for quantitative assessment of Tissue oxy- and deoxyhaemoglobin concentrations and, more recently, for measurement of microvascular Blood Flow. In this paper, we focus on the Flow monitoring technique: diffuse correlation spectroscopy (DCS). Representative clinical and pre-clinical studies from our laboratory illustrate the potential of DCS. Validation of DCS Blood Flow indices in human brain and muscle is presented. Comparison of DCS with arterial spin-labelled MRI, xenon-CT and Doppler ultrasound shows good agreement (0.50 r in vivo at the microvasculature level. All-optical measurements of cerebral oxygen metabolism in both rat brain, following middle cerebral artery occlusion, and human brain, during functional activation, are also described. In both situations, the use of combined DCS and diffuse optical spectroscopy/near-infrared spectroscopy to monitor changes in oxygen consumption by the Tissue is demonstrated. Finally, recent results spanning from gene expression-induced angiogenic response to stroke care and cancer treatment monitoring are discussed. Collectively, the research illustrates the capability of DCS to quantitatively monitor perfusion from bench to bedside, providing results that match up both with literature findings and with similar experiments performed with other techniques.
Hideaki Takahashi - One of the best experts on this subject based on the ideXlab platform.
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correlation between hepatic Blood Flow and liver function in alcoholic liver cirrhosis
World Journal of Gastroenterology, 2014Co-Authors: Hideaki Takahashi, Hiroki Ikeda, Shigeru Sase, Fumio Itoh, Ryuta Shigefuku, Yoshihito Yoshida, Kotaro Matsunaga, Nobuyuki Matsumoto, Chiaki Okuse, Michihiro SuzukiAbstract:AIM: To elucidate the correlation between hepatic Blood Flow and liver function in alcoholic liver cirrhosis (AL-LC). METHODS: The subjects included 35 patients with AL-LC (34 men, 1 woman; mean age, 58.9 ± 10.7 years; median age, 61 years; range: 37-76 years). All patients were enrolled in this study after obtaining written informed consent. Liver function was measured with tests measuring albumin (Alb), prothrombin time (PT), brain natriuretic peptide (BNP), branched amino acid and tyrosine ratio (BTR), branched chain amino acid (BCAA), tyrosine, ammonia (NH3), cholinesterase (ChE), immunoreactive insulin (IRI), total bile acid (TBA), and the retention rate of indocyanine green 15 min after administration (ICG R15). Hepatic Blood Flow, hepatic arterial Tissue Blood Flow (HATBF), portal venous Tissue Blood Flow (PVTBF), and total hepatic Tissue Blood Flow (THTBF) were simultaneously calculated using xenon computed tomography. RESULTS: PVTBF, HATBF and THTBF were 30.2 ± 10.4, 20.0 ± 10.7, and 50.3 ± 14.9 mL/100 mL/min, respectively. Alb, PT, BNP, BTR, BCAA, tyrosine, NH3, ChE, IRI, TBA, and ICG R15 were 3.50 ± 0.50 g/dL, 72.0% ± 11.5%, 63.2 ± 56.7 pg/mL, 4.06 ± 1.24, 437.5 ± 89.4 μmol/L, 117.7 ± 32.8 μmol/L, 59.4 ± 22.7 μg/dL, 161.0 ± 70.8 IU/L, 12.8 ± 5.0 μg/dL, 68.0 ± 51.8 μmol/L, and 28.6% ± 13.5%, respectively. PVTBF showed a significant negative correlation with ICG R15 (r = -0.468, P <0.01). No significant correlation was seen between ICG 15R, HATBF and THTBF. There was a significant correlation between PVTBF and Alb (r = 0.2499, P < 0.05), and NH3 tended to have an inverse correlation with PVTBF (r = -0.2428, P = 0.0894). There were also many significant correlations between ICG R15 and liver function parameters, including Alb, NH3, PT, BNP, TBA, BCAA, and tyrosine (r = -0.2156, P < 0.05; r = 0.4318, P < 0.01; r = 0.4140, P < 0.01; r = 0.3610, P < 0.05; r = 0.5085, P < 0.001; r = 0.4496, P < 0.01; and r = 0.4740, P < 0.05, respectively). CONCLUSION: Our investigation showed that there is a close correlation between liver function and hepatic Blood Flow.
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evaluation of quantitative portal venous hepatic arterial and total hepatic Tissue Blood Flow using xenon ct in alcoholic liver cirrhosis comparison with liver cirrhosis related to hepatitis c virus and nonalcoholic steatohepatitis
Alcoholism: Clinical and Experimental Research, 2010Co-Authors: Hideaki Takahashi, Michihiro Suzuki, Hiroki Ikeda, Minoru Kobayashi, Shigeru Sase, Hiroshi Yotsuyanagi, Shiro Maeyama, Shiro Iino, Fumio ItohAbstract:Background/Aims: Xenon computed tomography (Xe-CT) is a noninvasive method of quantifying and visualizing Tissue Blood Flow (TBF). For the liver, Xe-CT allows separate measurement of hepatic arterial and portal venous TBF. The present study evaluated the usefulness of Xe-CT as a noninvasive diagnostic procedure for measuring hepatic TBF in alcoholic liver cirrhosis (AL-LC), compared with liver cirrhosis related to nonalcoholic steatohepatitis (NASH), (NASH-LC), and hepatitis C virus (HCV), (C-LC). Methods: Xe-CT was performed on 22 patients with AL-LC, 7 patients with NASH-LC, and 24 patients with C-LC. Severity of LC was classified according to Child-Pugh classification. Correlations between hepatic TBF, Child-Pugh classification, and indocyanin green retention (ICG) rate after 15 minutes (ICG15R) were examined. Correlations of hepatic TBF in Child-Pugh class A to AL-LC, NASH-LC, and C-LC were also examined. Results: Portal venous TBF (PVTBF) displayed a significant negative correlation with Child-Pugh score and ICG15R (r = ―0.432, p < 0.01, r = ―0.442, p < 0.01, respectively). Moreover, ICG15R displayed a significant positive correlation with Child-Pugh score (r = 0.661, p < 0.001). Meanwhile, mean PVTBF and total hepatic TBF (THTBF) was significantly lower in AL-LC than in C-LC (p < 0.05). Mean PVTBF was significantly lower in Child-Pugh class A to AL-LC and NASH-LC than in that to C-LC (p < 0.05). Similarly, mean THTBF was significantly lower in Child-Pugh class A to NASH-LC than in that to C-LC (p < 0.05). Conclusions: Measurement of hepatic TBF using Xe-CT is useful as a noninvasive, objective method of assessing the state of the liver in chronic liver disease.
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evaluation of quantitative portal venous hepatic arterial and total hepatic Tissue Blood Flow using xenon ct in alcoholic liver cirrhosis comparison with liver cirrhosis c
Alcoholism: Clinical and Experimental Research, 2007Co-Authors: Hideaki Takahashi, Michihiro Suzuki, Hiroki Ikeda, Minoru Kobayashi, Shigeru Sase, Hiroshi Yotsuyanagi, Shiro Maeyama, Shiro Iino, Fumio ItohAbstract:Background/Aims: Xenon computed tomography (Xe-CT) is a noninvasive method of quantifying and visualizing Tissue Blood Flow (TBF). For the liver, Xe-CT allows separate measurement of hepatic arterial and portal venous TBF. The present study evaluated the usefulness of Xe-CT as a noninvasive diagnostic procedure for measuring hepatic TBF in alcoholic liver cirrhosis (AL-LC), compared with liver cirrhosis C (C-LC). Methods: Xenon computed tomography was performed on 12 patients with AL-LC and 17 patients with C-LC. The severity of LC was classified according to Child–Pugh classification. Correlations between hepatic TBF and Child–Pugh classification were examined. Correlations of hepatic TBF in Child–Pugh class A to C-LC and AL-LC were also examined. Results: The mean portal venous TBF (PVTBF) was significantly lower in AL-LC than in C-LC (p=0.0316). Similarly, the mean total hepatic TBF (THTBF) was significantly lower in AL-LC than in C-LC (p=0.0390). PVTBF displayed a significant negative correlation with Child–Pugh score (r=−0.396, p=0.0368). Conclusions: Measurement of hepatic TBF using Xe-CT is useful as a noninvasive, objective method of assessing the state of the liver in chronic liver disease.
Michihiro Suzuki - One of the best experts on this subject based on the ideXlab platform.
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correlation between hepatic Blood Flow and liver function in alcoholic liver cirrhosis
World Journal of Gastroenterology, 2014Co-Authors: Hideaki Takahashi, Hiroki Ikeda, Shigeru Sase, Fumio Itoh, Ryuta Shigefuku, Yoshihito Yoshida, Kotaro Matsunaga, Nobuyuki Matsumoto, Chiaki Okuse, Michihiro SuzukiAbstract:AIM: To elucidate the correlation between hepatic Blood Flow and liver function in alcoholic liver cirrhosis (AL-LC). METHODS: The subjects included 35 patients with AL-LC (34 men, 1 woman; mean age, 58.9 ± 10.7 years; median age, 61 years; range: 37-76 years). All patients were enrolled in this study after obtaining written informed consent. Liver function was measured with tests measuring albumin (Alb), prothrombin time (PT), brain natriuretic peptide (BNP), branched amino acid and tyrosine ratio (BTR), branched chain amino acid (BCAA), tyrosine, ammonia (NH3), cholinesterase (ChE), immunoreactive insulin (IRI), total bile acid (TBA), and the retention rate of indocyanine green 15 min after administration (ICG R15). Hepatic Blood Flow, hepatic arterial Tissue Blood Flow (HATBF), portal venous Tissue Blood Flow (PVTBF), and total hepatic Tissue Blood Flow (THTBF) were simultaneously calculated using xenon computed tomography. RESULTS: PVTBF, HATBF and THTBF were 30.2 ± 10.4, 20.0 ± 10.7, and 50.3 ± 14.9 mL/100 mL/min, respectively. Alb, PT, BNP, BTR, BCAA, tyrosine, NH3, ChE, IRI, TBA, and ICG R15 were 3.50 ± 0.50 g/dL, 72.0% ± 11.5%, 63.2 ± 56.7 pg/mL, 4.06 ± 1.24, 437.5 ± 89.4 μmol/L, 117.7 ± 32.8 μmol/L, 59.4 ± 22.7 μg/dL, 161.0 ± 70.8 IU/L, 12.8 ± 5.0 μg/dL, 68.0 ± 51.8 μmol/L, and 28.6% ± 13.5%, respectively. PVTBF showed a significant negative correlation with ICG R15 (r = -0.468, P <0.01). No significant correlation was seen between ICG 15R, HATBF and THTBF. There was a significant correlation between PVTBF and Alb (r = 0.2499, P < 0.05), and NH3 tended to have an inverse correlation with PVTBF (r = -0.2428, P = 0.0894). There were also many significant correlations between ICG R15 and liver function parameters, including Alb, NH3, PT, BNP, TBA, BCAA, and tyrosine (r = -0.2156, P < 0.05; r = 0.4318, P < 0.01; r = 0.4140, P < 0.01; r = 0.3610, P < 0.05; r = 0.5085, P < 0.001; r = 0.4496, P < 0.01; and r = 0.4740, P < 0.05, respectively). CONCLUSION: Our investigation showed that there is a close correlation between liver function and hepatic Blood Flow.
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evaluation of quantitative portal venous hepatic arterial and total hepatic Tissue Blood Flow using xenon ct in alcoholic liver cirrhosis comparison with liver cirrhosis related to hepatitis c virus and nonalcoholic steatohepatitis
Alcoholism: Clinical and Experimental Research, 2010Co-Authors: Hideaki Takahashi, Michihiro Suzuki, Hiroki Ikeda, Minoru Kobayashi, Shigeru Sase, Hiroshi Yotsuyanagi, Shiro Maeyama, Shiro Iino, Fumio ItohAbstract:Background/Aims: Xenon computed tomography (Xe-CT) is a noninvasive method of quantifying and visualizing Tissue Blood Flow (TBF). For the liver, Xe-CT allows separate measurement of hepatic arterial and portal venous TBF. The present study evaluated the usefulness of Xe-CT as a noninvasive diagnostic procedure for measuring hepatic TBF in alcoholic liver cirrhosis (AL-LC), compared with liver cirrhosis related to nonalcoholic steatohepatitis (NASH), (NASH-LC), and hepatitis C virus (HCV), (C-LC). Methods: Xe-CT was performed on 22 patients with AL-LC, 7 patients with NASH-LC, and 24 patients with C-LC. Severity of LC was classified according to Child-Pugh classification. Correlations between hepatic TBF, Child-Pugh classification, and indocyanin green retention (ICG) rate after 15 minutes (ICG15R) were examined. Correlations of hepatic TBF in Child-Pugh class A to AL-LC, NASH-LC, and C-LC were also examined. Results: Portal venous TBF (PVTBF) displayed a significant negative correlation with Child-Pugh score and ICG15R (r = ―0.432, p < 0.01, r = ―0.442, p < 0.01, respectively). Moreover, ICG15R displayed a significant positive correlation with Child-Pugh score (r = 0.661, p < 0.001). Meanwhile, mean PVTBF and total hepatic TBF (THTBF) was significantly lower in AL-LC than in C-LC (p < 0.05). Mean PVTBF was significantly lower in Child-Pugh class A to AL-LC and NASH-LC than in that to C-LC (p < 0.05). Similarly, mean THTBF was significantly lower in Child-Pugh class A to NASH-LC than in that to C-LC (p < 0.05). Conclusions: Measurement of hepatic TBF using Xe-CT is useful as a noninvasive, objective method of assessing the state of the liver in chronic liver disease.
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evaluation of quantitative portal venous hepatic arterial and total hepatic Tissue Blood Flow using xenon ct in alcoholic liver cirrhosis comparison with liver cirrhosis c
Alcoholism: Clinical and Experimental Research, 2007Co-Authors: Hideaki Takahashi, Michihiro Suzuki, Hiroki Ikeda, Minoru Kobayashi, Shigeru Sase, Hiroshi Yotsuyanagi, Shiro Maeyama, Shiro Iino, Fumio ItohAbstract:Background/Aims: Xenon computed tomography (Xe-CT) is a noninvasive method of quantifying and visualizing Tissue Blood Flow (TBF). For the liver, Xe-CT allows separate measurement of hepatic arterial and portal venous TBF. The present study evaluated the usefulness of Xe-CT as a noninvasive diagnostic procedure for measuring hepatic TBF in alcoholic liver cirrhosis (AL-LC), compared with liver cirrhosis C (C-LC). Methods: Xenon computed tomography was performed on 12 patients with AL-LC and 17 patients with C-LC. The severity of LC was classified according to Child–Pugh classification. Correlations between hepatic TBF and Child–Pugh classification were examined. Correlations of hepatic TBF in Child–Pugh class A to C-LC and AL-LC were also examined. Results: The mean portal venous TBF (PVTBF) was significantly lower in AL-LC than in C-LC (p=0.0316). Similarly, the mean total hepatic TBF (THTBF) was significantly lower in AL-LC than in C-LC (p=0.0390). PVTBF displayed a significant negative correlation with Child–Pugh score (r=−0.396, p=0.0368). Conclusions: Measurement of hepatic TBF using Xe-CT is useful as a noninvasive, objective method of assessing the state of the liver in chronic liver disease.
Hiroki Ikeda - One of the best experts on this subject based on the ideXlab platform.
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correlation between hepatic Blood Flow and liver function in alcoholic liver cirrhosis
World Journal of Gastroenterology, 2014Co-Authors: Hideaki Takahashi, Hiroki Ikeda, Shigeru Sase, Fumio Itoh, Ryuta Shigefuku, Yoshihito Yoshida, Kotaro Matsunaga, Nobuyuki Matsumoto, Chiaki Okuse, Michihiro SuzukiAbstract:AIM: To elucidate the correlation between hepatic Blood Flow and liver function in alcoholic liver cirrhosis (AL-LC). METHODS: The subjects included 35 patients with AL-LC (34 men, 1 woman; mean age, 58.9 ± 10.7 years; median age, 61 years; range: 37-76 years). All patients were enrolled in this study after obtaining written informed consent. Liver function was measured with tests measuring albumin (Alb), prothrombin time (PT), brain natriuretic peptide (BNP), branched amino acid and tyrosine ratio (BTR), branched chain amino acid (BCAA), tyrosine, ammonia (NH3), cholinesterase (ChE), immunoreactive insulin (IRI), total bile acid (TBA), and the retention rate of indocyanine green 15 min after administration (ICG R15). Hepatic Blood Flow, hepatic arterial Tissue Blood Flow (HATBF), portal venous Tissue Blood Flow (PVTBF), and total hepatic Tissue Blood Flow (THTBF) were simultaneously calculated using xenon computed tomography. RESULTS: PVTBF, HATBF and THTBF were 30.2 ± 10.4, 20.0 ± 10.7, and 50.3 ± 14.9 mL/100 mL/min, respectively. Alb, PT, BNP, BTR, BCAA, tyrosine, NH3, ChE, IRI, TBA, and ICG R15 were 3.50 ± 0.50 g/dL, 72.0% ± 11.5%, 63.2 ± 56.7 pg/mL, 4.06 ± 1.24, 437.5 ± 89.4 μmol/L, 117.7 ± 32.8 μmol/L, 59.4 ± 22.7 μg/dL, 161.0 ± 70.8 IU/L, 12.8 ± 5.0 μg/dL, 68.0 ± 51.8 μmol/L, and 28.6% ± 13.5%, respectively. PVTBF showed a significant negative correlation with ICG R15 (r = -0.468, P <0.01). No significant correlation was seen between ICG 15R, HATBF and THTBF. There was a significant correlation between PVTBF and Alb (r = 0.2499, P < 0.05), and NH3 tended to have an inverse correlation with PVTBF (r = -0.2428, P = 0.0894). There were also many significant correlations between ICG R15 and liver function parameters, including Alb, NH3, PT, BNP, TBA, BCAA, and tyrosine (r = -0.2156, P < 0.05; r = 0.4318, P < 0.01; r = 0.4140, P < 0.01; r = 0.3610, P < 0.05; r = 0.5085, P < 0.001; r = 0.4496, P < 0.01; and r = 0.4740, P < 0.05, respectively). CONCLUSION: Our investigation showed that there is a close correlation between liver function and hepatic Blood Flow.
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evaluation of quantitative portal venous hepatic arterial and total hepatic Tissue Blood Flow using xenon ct in alcoholic liver cirrhosis comparison with liver cirrhosis related to hepatitis c virus and nonalcoholic steatohepatitis
Alcoholism: Clinical and Experimental Research, 2010Co-Authors: Hideaki Takahashi, Michihiro Suzuki, Hiroki Ikeda, Minoru Kobayashi, Shigeru Sase, Hiroshi Yotsuyanagi, Shiro Maeyama, Shiro Iino, Fumio ItohAbstract:Background/Aims: Xenon computed tomography (Xe-CT) is a noninvasive method of quantifying and visualizing Tissue Blood Flow (TBF). For the liver, Xe-CT allows separate measurement of hepatic arterial and portal venous TBF. The present study evaluated the usefulness of Xe-CT as a noninvasive diagnostic procedure for measuring hepatic TBF in alcoholic liver cirrhosis (AL-LC), compared with liver cirrhosis related to nonalcoholic steatohepatitis (NASH), (NASH-LC), and hepatitis C virus (HCV), (C-LC). Methods: Xe-CT was performed on 22 patients with AL-LC, 7 patients with NASH-LC, and 24 patients with C-LC. Severity of LC was classified according to Child-Pugh classification. Correlations between hepatic TBF, Child-Pugh classification, and indocyanin green retention (ICG) rate after 15 minutes (ICG15R) were examined. Correlations of hepatic TBF in Child-Pugh class A to AL-LC, NASH-LC, and C-LC were also examined. Results: Portal venous TBF (PVTBF) displayed a significant negative correlation with Child-Pugh score and ICG15R (r = ―0.432, p < 0.01, r = ―0.442, p < 0.01, respectively). Moreover, ICG15R displayed a significant positive correlation with Child-Pugh score (r = 0.661, p < 0.001). Meanwhile, mean PVTBF and total hepatic TBF (THTBF) was significantly lower in AL-LC than in C-LC (p < 0.05). Mean PVTBF was significantly lower in Child-Pugh class A to AL-LC and NASH-LC than in that to C-LC (p < 0.05). Similarly, mean THTBF was significantly lower in Child-Pugh class A to NASH-LC than in that to C-LC (p < 0.05). Conclusions: Measurement of hepatic TBF using Xe-CT is useful as a noninvasive, objective method of assessing the state of the liver in chronic liver disease.
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evaluation of quantitative portal venous hepatic arterial and total hepatic Tissue Blood Flow using xenon ct in alcoholic liver cirrhosis comparison with liver cirrhosis c
Alcoholism: Clinical and Experimental Research, 2007Co-Authors: Hideaki Takahashi, Michihiro Suzuki, Hiroki Ikeda, Minoru Kobayashi, Shigeru Sase, Hiroshi Yotsuyanagi, Shiro Maeyama, Shiro Iino, Fumio ItohAbstract:Background/Aims: Xenon computed tomography (Xe-CT) is a noninvasive method of quantifying and visualizing Tissue Blood Flow (TBF). For the liver, Xe-CT allows separate measurement of hepatic arterial and portal venous TBF. The present study evaluated the usefulness of Xe-CT as a noninvasive diagnostic procedure for measuring hepatic TBF in alcoholic liver cirrhosis (AL-LC), compared with liver cirrhosis C (C-LC). Methods: Xenon computed tomography was performed on 12 patients with AL-LC and 17 patients with C-LC. The severity of LC was classified according to Child–Pugh classification. Correlations between hepatic TBF and Child–Pugh classification were examined. Correlations of hepatic TBF in Child–Pugh class A to C-LC and AL-LC were also examined. Results: The mean portal venous TBF (PVTBF) was significantly lower in AL-LC than in C-LC (p=0.0316). Similarly, the mean total hepatic TBF (THTBF) was significantly lower in AL-LC than in C-LC (p=0.0390). PVTBF displayed a significant negative correlation with Child–Pugh score (r=−0.396, p=0.0368). Conclusions: Measurement of hepatic TBF using Xe-CT is useful as a noninvasive, objective method of assessing the state of the liver in chronic liver disease.
