The Experts below are selected from a list of 5163 Experts worldwide ranked by ideXlab platform
C. T. Lim - One of the best experts on this subject based on the ideXlab platform.
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Tissue Scaffolds for skin wound healing and dermal reconstruction
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2010Co-Authors: S. P. Zhong, Y Z Zhang, C. T. LimAbstract:One of the major applications of Tissue-engineered skin substitutes for wound healing is to promote the healing of cutaneous wounds. In this respect, many important clinical milestones have been reached in the past decades. However, currently available skin substitutes for wound healing often suffer from a range of problems including wound contraction, scar formation, and poor integration with host Tissue. Engineering skin substitutes by Tissue engineering approach has relied upon the creation of three-dimensional Scaffolds as extracellular matrix (ECM) analog to guide cell adhesion, growth, and differentiation to form skin-functional and structural Tissue. The three-dimensional Scaffolds can not only cover wound and give a physical barrier against external infection as wound dressing, but also can provide support both for dermal fibroblasts and the overlying keratinocytes for skin Tissue engineering. A successful Tissue scaffold should exhibit appropriate physical and mechanical characteristics and provide an appropriate surface chemistry and nano and microstructures to facilitate cellular attachment, proliferation, and differentiation. A variety of Scaffolds have been fabricated based on materials ranging from naturally occurring ones to those manufactured synthetically. This review discusses a variety of commercial or laboratory-engineered skin substitutes for wound healing. Central to the discussion are the Scaffolds/materials, fabrication techniques, and their characteristics associated with wound healing. One specifically highlighted emerging fabrication technique is electrospinning that allows the design and fabrication of biomimetic Scaffolds that offer tremendous potential applications in wound healing of skin.
Yanzhong Zhang - One of the best experts on this subject based on the ideXlab platform.
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Tissue Scaffolds for skin wound healing and dermal reconstruction
Wiley Interdisciplinary Reviews-nanomedicine and Nanobiotechnology, 2010Co-Authors: Shaoping Zhong, Yanzhong ZhangAbstract:One of the major applications of Tissue-engineered skin substitutes for wound healing is to promote the healing of cutaneous wounds. In this respect, many important clinical milestones have been reached in the past decades. However, currently available skin substitutes for wound healing often suffer from a range of problems including wound contraction, scar formation, and poor integration with host Tissue. Engineering skin substitutes by Tissue engineering approach has relied upon the creation of three-dimensional Scaffolds as extracellular matrix (ECM) analog to guide cell adhesion, growth, and differentiation to form skin-functional and structural Tissue. The three-dimensional Scaffolds can not only cover wound and give a physical barrier against external infection as wound dressing, but also can provide support both for dermal fibroblasts and the overlying keratinocytes for skin Tissue engineering. A successful Tissue scaffold should exhibit appropriate physical and mechanical characteristics and provide an appropriate surface chemistry and nano and microstructures to facilitate cellular attachment, proliferation, and differentiation. A variety of Scaffolds have been fabricated based on materials ranging from naturally occurring ones to those manufactured synthetically. This review discusses a variety of commercial or laboratory-engineered skin substitutes for wound healing. Central to the discussion are the Scaffolds/materials, fabrication techniques, and their characteristics associated with wound healing. One specifically highlighted emerging fabrication technique is electrospinning that allows the design and fabrication of biomimetic Scaffolds that offer tremendous potential applications in wound healing of skin. WIREs Nanomed Nanobiotechnol 2010 2 510–525 For further resources related to this article, please visit the WIREs website
S. P. Zhong - One of the best experts on this subject based on the ideXlab platform.
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Tissue Scaffolds for skin wound healing and dermal reconstruction
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2010Co-Authors: S. P. Zhong, Y Z Zhang, C. T. LimAbstract:One of the major applications of Tissue-engineered skin substitutes for wound healing is to promote the healing of cutaneous wounds. In this respect, many important clinical milestones have been reached in the past decades. However, currently available skin substitutes for wound healing often suffer from a range of problems including wound contraction, scar formation, and poor integration with host Tissue. Engineering skin substitutes by Tissue engineering approach has relied upon the creation of three-dimensional Scaffolds as extracellular matrix (ECM) analog to guide cell adhesion, growth, and differentiation to form skin-functional and structural Tissue. The three-dimensional Scaffolds can not only cover wound and give a physical barrier against external infection as wound dressing, but also can provide support both for dermal fibroblasts and the overlying keratinocytes for skin Tissue engineering. A successful Tissue scaffold should exhibit appropriate physical and mechanical characteristics and provide an appropriate surface chemistry and nano and microstructures to facilitate cellular attachment, proliferation, and differentiation. A variety of Scaffolds have been fabricated based on materials ranging from naturally occurring ones to those manufactured synthetically. This review discusses a variety of commercial or laboratory-engineered skin substitutes for wound healing. Central to the discussion are the Scaffolds/materials, fabrication techniques, and their characteristics associated with wound healing. One specifically highlighted emerging fabrication technique is electrospinning that allows the design and fabrication of biomimetic Scaffolds that offer tremendous potential applications in wound healing of skin.
Shaoping Zhong - One of the best experts on this subject based on the ideXlab platform.
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Tissue Scaffolds for skin wound healing and dermal reconstruction
Wiley Interdisciplinary Reviews-nanomedicine and Nanobiotechnology, 2010Co-Authors: Shaoping Zhong, Yanzhong ZhangAbstract:One of the major applications of Tissue-engineered skin substitutes for wound healing is to promote the healing of cutaneous wounds. In this respect, many important clinical milestones have been reached in the past decades. However, currently available skin substitutes for wound healing often suffer from a range of problems including wound contraction, scar formation, and poor integration with host Tissue. Engineering skin substitutes by Tissue engineering approach has relied upon the creation of three-dimensional Scaffolds as extracellular matrix (ECM) analog to guide cell adhesion, growth, and differentiation to form skin-functional and structural Tissue. The three-dimensional Scaffolds can not only cover wound and give a physical barrier against external infection as wound dressing, but also can provide support both for dermal fibroblasts and the overlying keratinocytes for skin Tissue engineering. A successful Tissue scaffold should exhibit appropriate physical and mechanical characteristics and provide an appropriate surface chemistry and nano and microstructures to facilitate cellular attachment, proliferation, and differentiation. A variety of Scaffolds have been fabricated based on materials ranging from naturally occurring ones to those manufactured synthetically. This review discusses a variety of commercial or laboratory-engineered skin substitutes for wound healing. Central to the discussion are the Scaffolds/materials, fabrication techniques, and their characteristics associated with wound healing. One specifically highlighted emerging fabrication technique is electrospinning that allows the design and fabrication of biomimetic Scaffolds that offer tremendous potential applications in wound healing of skin. WIREs Nanomed Nanobiotechnol 2010 2 510–525 For further resources related to this article, please visit the WIREs website
A. Shokoufandeh - One of the best experts on this subject based on the ideXlab platform.
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Homogenization of Heterogeneous Tissue Scaffold: A Comparison of Mechanics, Asymptotic Homogenization, and Finite Element Approach
Applied Bionics and Biomechanics, 2020Co-Authors: Z. Fang, A. Shokoufandeh, W. RegliAbstract:Actual prediction of the effective mechanical properties of Tissue Scaffolds is very important for Tissue engineering applications. Currently common homogenization methods are based on three available approaches: standard mechanics modeling, homogenization theory, and finite element methods. Each of these methods has advantages and limitations. This paper presents comparisons and applications of these approaches for the prediction of the effective properties of a Tissue scaffold. Derivations and formulations of mechanics, homogenization, and finite element approach as they relate to Tissue engineering are described. The process for the development of a computational algorithm, finite element implementation, and numerical solution for calculating the effective mechanical properties of porous Tissue Scaffolds are also given. A comparison of the results based upon these different approaches is presented. Parametric analyses using the homogenization approach to study the effects of different scaffold materials and pore shapes on the properties of the scaffold are conducted, and the results of the analyses are also presented.
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Multi - Parameter Optimization for Two-Phase Unit-Cell based Tissue Scaffolds
Proceedings of the IEEE 32nd Annual Northeast Bioengineering Conference, 2006Co-Authors: C. Gomez, T. Denton, A. ShokoufandehAbstract:Porous three-dimensional (3D) Tissue Scaffolds directly influence cell attachment, proliferation, and guidance of new Tissue formation. Cells respond to a scaffold's architecture, mechanical properties, and transport properties. Given the number of design constraints, scaffold design must include multiple design parameters. Using a unit-cell based assembly approach, we introduce a method to account for multiple design parameters during scaffold assembly. This paper presents our method for integrating multiple parameters for unit-cell selection.
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Unit cell analysis and characterization of three-dimensional two-phase Tissue Scaffolds
Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference 2005., 2005Co-Authors: C. Gomez, M.f. Demirci, A. ShokoufandehAbstract:Three-dimensional (3D) porous Tissue Scaffolds are being engineered to promote cell attachment, cell proliferation and functioning heterogeneous Tissue formation. A scaffold's structure and transport capabilities need to mimic cells' natural geometrical and architectural environment and will need to consistently provide a flux throughout the scaffold to deliver materials for growth and waste removal. This paper presents our work on establishing a connectivity characterization of designed unit cell Tissue structures for surface alignment between units to insure both geometric connectivity and mass and fluid transport within a heterogeneous Tissue scaffold to meet both structural and biological requirements for cell growth and Tissue growth. To capture this information, skeletal representations of the unit cell structures have been utilized for subsequent assembly processes.
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Connectivity for mass and fluid transport in three dimensional two-phase structures
Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference 2005., 2005Co-Authors: M.f. Demirci, C. Gomez, A. ShokoufandehAbstract:Porous three-dimensional (3D) Tissue Scaffolds provide vital function for cell attachment, proliferation, and guidance of new Tissue formation. In the cellular Tissue engineering process, heterogeneous Tissue Scaffolds play an important role in heterogeneous Tissue formation. The goal of this research is to develop an approach that will assemble characterized unit cell structures into a larger heterogeneous scaffold that is suitable for Tissue regrowth. To construct the assembly, 3D skeletons are first generated for unit cell structures, and for every skeleton point, the physical properties and quantities under given flow conditions are assigned. A unit cell alignment approach then quantifies the matching potential between two 3D skeletons. Based on the priority of the physical properties that were ranked prior to the assembly process, unit cells are assembled into a larger scaffold in a bottom-up fashion.
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Tissue engineered constructs: connectivity study for three dimensional two-phase structures
IEEE 30th Annual Northeast Bioengineering Conference 2004. Proceedings of the, 2004Co-Authors: C. Gomez, A. Shokoufandeh, M.f. Demirci, W. RegliAbstract:Porous three-dimensional (3D) Tissue Scaffolds play an important role in cell attachment, proliferation, and guidance of new Tissue formation. Performance of engineered heterogeneous Tissues depends on porous scaffold microstructures with specific porosity characteristics. This paper presents our recent study on establishing topological connectivity criteria for surface matching between designed Tissue Scaffolds for freeform fabrication and for the insurance of suitable connections creation for scaffold flow and mass transport. To provide a structural and/or contour connectivity between surfaces, the concept of many-to-many matching of skeletal representations is adopted. The matching algorithm is based on the metric-tree encoding of surface skeletal representations, their low-distortion embeddings into normed vector spaces, and the Earth Mover's Distance under transformation.
