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Eva Munck-wikland - One of the best experts on this subject based on the ideXlab platform.
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Differential survival trends for patients with tonsillar, base of Tongue and Tongue Cancer in Sweden.
Oral oncology, 2011Co-Authors: Lalle Hammarstedt, Tina Dalianis, Linda Marklund, Eva Munck-wiklandAbstract:Tonsillar, base of Tongue and Tongue Cancer have similar anatomical and histopathological appearances but present differences in prognosis. Human papillomavirus (HPV) is a known risk factor for tonsillar and base of Tongue Cancer, and a survival benefit has been shown for these tumors; however, HPV prevalence in Tongue Cancer is low. Tonsillar, base of Tongue and Tongue Cancer patients registered in the Swedish Cancer Registry between 1960 and 2004 were followed from the date of Cancer diagnosis until death, emigration out of Sweden, or the end of a follow-up (5 years since Cancer diagnosis), whichever occurred first. The relative survival rate was computed as the ratio of the observed to the expected survival rate, in which the latter was inferred from the survival of the entire Swedish population in the same age, sex and calendar year stratum. The relative survival rate has improved significantly over time for patients with tonsillar and base of Tongue Cancer although delineated by different patterns. However, the relative survival rate in Tongue Cancer patients exhibited only a very modest improvement during the same time period. Contrary to the overall improved survival for patients with tonsillar and base of Tongue Cancer, the patients with Tongue Cancer show a very modest improvement in Sweden since 1960. Further studies are warranted to elucidate more effective treatment options for Tongue Cancer patients.
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Human papillomavirus and survival in patients with base of Tongue Cancer.
International journal of cancer, 2010Co-Authors: Per Attner, Johan Lindholm, Tina Dalianis, Lalle Hammarstedt, Linda Marklund, Anders Näsman, Torbjörn Ramqvist, Eva Munck-wiklandAbstract:The incidence of base of Tongue Cancer is increasing in Sweden and the proportion of human papillomavirus (HPV) positive Cancer has increased in Stockholm, Sweden. Between 2006 and 2007, 84% of base of Tongue Cancer cases in Stockholm were HPV-positive. The objective of this study was to assess the impact of HPV status on prognosis for base of Tongue Cancer patients. One-hundred and nine patients were diagnosed with base of Tongue Cancer between 1998 and 2007 in Stockholm County and 95 paraffin-embedded diagnostic tumor biopsies were obtained and tested for HPV by PCR. Eighty-seven patients had available biopsies, were treated with intention to cure and could be included in the survival analysis. Age, sex, TNM-stage, stage, treatment and survival were recorded from patient charts. Kaplan–Meier curves were used to present survival data. In multivariable analyses, a Cox proportional hazards model was used to adjust for covariates. In total 68 (78%) tumor biopsies from the 87 included patients were HPV DNA positive. Kaplan–Meier estimates showed that the overall survival for patients with HPV-positive Cancer was significantly better (p = 0.0004), (log-rank test) than that of patients with HPV-negative Cancer. Patients with HPV-positive tumors also had significantly better disease-free survival (p = 0.0008), (log-rank test) than those with HPV-negative tumors. These results further strengthen the option to consider HPV-status when planning prospective studies on treatment for base of Tongue Cancer.
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The role of human papillomavirus in the increased incidence of base of Tongue Cancer
International journal of cancer, 2010Co-Authors: Per Attner, Johan Lindholm, Tina Dalianis, Lalle Hammarstedt, Linda Marklund, Anders Näsman, Torbjörn Ramqvist, Eva Munck-wiklandAbstract:Numerous reports have shown that the incidence for oropharyngeal Cancer is increasing and that human papillomavirus (HPV) is a risk factor. However, few studies have investigated the specific subsites of the oropharynx. Following our previous research on tonsillar Cancer, we assessed the increase in the incidence of base of Tongue Cancer and the prevalence of HPV in this disease. Between 1998 and 2007, 109 patients were diagnosed for base of Tongue Cancer in Stockholm county. Ninety-five paraffin-embedded diagnostic tumor biopsies from patients were obtained and tested for HPV, both by general HPV PCR and HPV-16/HPV-33 type-specific PCR. Expression of HPV-16 RNA was analyzed to confirm E6 and/or E7 expression. Incidence data were obtained from the Swedish Cancer Registry. An overall increase in the incidence of base of Tongue Cancer from 0.15/100,000 person-years during 1970-1974 to 0.47/100,000 person-years during 2005-2007 was found in Sweden. The prevalence of HPV in base of Tongue Cancer in Stockholm county increased from 58% during 1998-2001 to 84% during 2004-2007 (p < 0.05). In the HPV-positive tumors, HPV-16 dominated (86%) but interestingly, HPV33 was detected in as many as 10%. E6 and/or E7 RNA were found in 85% of the samples tested. The incidence of base of Tongue Cancer, as well as the proportion of HPV-positive tumors, has increased in Sweden during the study period, suggesting that HPV may contribute to this increase.
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Human papillomavirus is more common in base of Tongue than in mobile Tongue Cancer and is a favorable prognostic factor in base of Tongue Cancer patients.
International journal of cancer, 2004Co-Authors: Liselotte Dahlgren, Hanna Dahlstrand, David Lindquist, Anders Högmo, Linda Björnestål, Johan Lindholm, Bertil Lundberg, Tina Dalianis, Eva Munck-wiklandAbstract:The frequency of human papilloma virus (HPV) and its influence on clinical outcome was analyzed retrospectively in pre-treatment paraffin embedded biopsies from 110 patients with Tongue Cancer. The presence of HPV DNA was examined in 85 mobile Tongue tumors and 25 base of Tongue tumors by a polymerase chain reaction (PCR) with 2 general primer pairs, GP5+/6+ and CPI/IIG. When HPV-DNA was found, HPV-type specific primers and direct sequencing were used for HPV sub-type verification. Twelve of 110 (10.9%) samples were HPV-positive; 9 for HPV-16, 1 for HPV-33, 1 for HPV-35 and 1 could not be analyzed because of shortage of DNA. HPV was significantly more common in base of Tongue tumors (10/25, 40.0%) compared to tumors of the mobile Tongue (2/85, 2.3%). The influence of HPV on clinical outcome in mobile Tongue Cancer could not be studied, due to that HPV was present in too few cases. Of the 19 patients with base of Tongue Cancer that were included in the survival analysis, however, 7 patients with HPV-positive base of Tongue Cancer had a significantly favorable 5-year survival rate compared to the 12 HPV-negative patients. In conclusion, HPV is significantly more common in base of Tongue Cancer than in mobile Tongue Cancer, and has a positive impact on disease-specific survival in patients with base of Tongue Cancer.
Chun Shi - One of the best experts on this subject based on the ideXlab platform.
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E3 ubiquitin ligase, RNF139, inhibits the progression of Tongue Cancer
BMC cancer, 2017Co-Authors: Lina Wang, Wei Yin, Chun ShiAbstract:Tongue Cancer is still one of the leading causes of mortality around the world. Recently, the ubiquitin system has been established as a critical modulator of tumors. In order to find the oral Cancer related E3 ubiquitin ligases, we screened the human E3 ubiquitin ligase library and found that RING finger protein 139 (RNF139) regulated the biological behavior of Tongue Cancer cells. MTT assay was used to analyze the cell viability changes of Tongue Cancer SCC9 and SCC25 cells caused by RNF139. The invasion ability of SCC9 and SCC25 cells with or without the knockdown of RNF139 was evaluated through transwell assay. The immunoblotting was recruited to determine the expression level of RNF139 in human Tongue Cancer tissues and para-carcinoma tissues. The effect of RNF139 on tumorigenicity of Tongue Cancer cells was analyzed by xenograft model on immunodeficient Balb/c nude mice. Overexpression of RNF139 inhibits the viability of Tongue Cancer cells since day 2. The colony formation ability of SCC9 and SCC25 cells was also decreased with the overexpression of RNF139. Knockdown of RNF139 significantly promoted the invasion ability of SCC9 and SCC25 cells. Furthermore, knockdown of RNF139 also induced the activation of AKT signaling pathway. While human Tongue Cancer tissues had low expression of RNF139. In nude mice, knockdown of RNF139 promoted the tumorigenicity of the SCC25 cells. Our data establish a role for RNF139 in regulating the progression of Tongue Cancer.
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E3 Ubiquitin ligase RNF126 regulates the progression of Tongue Cancer.
Cancer medicine, 2016Co-Authors: Lina Wang, Wei Yin, Xin Wang, Yuehan Zhao, Weidong Niu, Chun ShiAbstract:This study aims to analyze the role of RNF126 in the oncogenesis of Tongue Cancer. The cell proliferation and viability of human Tongue Cancer cells, SCC25 and SCC9 cells, were determined by cell counting and MTT assay, respectively. The effect of RNF126 on regulating AKT signaling pathway was analyzed through western blotting. The transplantation tumor model of nude mice was used to evaluate the tumorigenecity of RNF126. Knockdown of RNF126 inhibited the proliferation and viability of SCC9 and SCC25 cells. Inhibition of RNF126 also decreased the activity of AKT1 as well as its downstream molecules. Furthermore, RNF126 regulated the tumor volume on mice model. These data suggested that RNF126 might be related to the progression of Tongue Cancer through regulating AKT signaling pathway.
Tonghan Zhang - One of the best experts on this subject based on the ideXlab platform.
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lncrna uca1 mir 124 axis modulates tgfβ1 induced epithelial mesenchymal transition and invasion of Tongue Cancer cells through jag1 notch signaling
Journal of Cellular Biochemistry, 2019Co-Authors: Tonghan Zhang, Li Zhong Liang, Ji Nan Wu, Kui Su, Jue Yao Chen, Qiao Yi ZhengAbstract:Tongue Cancer remains a massive threat to public health due to the high rate of metastasis. Tumor cell epithelial-mesenchymal transition (EMT), which can be induced by transforming growth factor β1 (TGFβ1), has been regarded as a significant contributor to Cancer invasion and migration. In our previous study, long noncoding RNA (lncRNA) MALAT1/miR-124/JAG1 axis modulates the growth of Tongue Cancer. In addition to metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), another lncRNA, urothelial Cancer associated 1 (UCA1), can promote EMT and Cancer metastasis. In the present study, UCA1 was overexpressed in Tongue Cancer tissues and cell lines. UCA1 overexpression was correlated to the poorer prognosis of patients with Tongue Cancer. UCA1 knockdown significantly suppressed TGFβ1-induced Tongue Cancer cell invasion and EMT by decreasing vimentin and increasing E-cadherin. Regarding the molecular mechanism, UCA1 could directly bind to microRNA-124 (miR-124) and negatively regulate each other. UCA1 knockdown ameliorated, whereas miR-124 inhibition exacerbated TGFβ1-induced EMT and invasion in Tongue Cancer cells through miR-124 downstream jagged 1 (JAG1) and Notch signaling. Moreover, miR-124 inhibition partially impaired the effect of UCA1 knockdown. In Tongue Cancer tissues, miR-124 expression was remarkably decreased, whereas JAG1 mRNA expression was increased. miR-124 was negatively correlated with UCA1 and JAG1. UCA1 and JAG1 were positively correlated. In summary, we provided a novel mechanism by which the EMT process and Cancer cell invasion in Tongue Cancer could be modulated from the perspective of lncRNA-miRNA-mRNA regulation.
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retracted long non coding rna malat1 interacts with mir 124 and modulates Tongue Cancer growth by targeting jag1
Oncology Reports, 2017Co-Authors: Tonghan Zhang, Hong-zhang Huang, Li Zhong Liang, Ji Nan Wu, Kui Su, Jue Yao Chen, Qiao Yi Zheng, Gui-qing LiaoAbstract:Abstract Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non-coding RNA (lncRNA), was the earliest discovered to be correlated with Cancer and contributes to the initiation and development of several types of tumors. Dysregulation of MALAT1 expression is frequently observed in many types of Cancer such as gastric Cancer, esophageal squamous cell carcinoma and glioma. To date, the role of MALAT1 and the underlying mechanisms in Tongue Cancer development remain unclear. In the present study, we studied the influence of MALAT1 on Tongue Cancer cell lines and clinical Tongue Cancer samples so as to detect its function and the underlying mechanism. In the present study, lncRNA-MALAT1 was specifically upregulated in Tongue Cancer cell lines and overexpression promoted Tongue Cancer cell growth by targeting miR-124. Knockdown of MALAT1 suppressed the growth and invasion of human Tongue Cancer cells and inhibited metastasis in vitro and in vivo. In addition, miR-124-dependent jagged1 (JAG1) regulation was required for MALAT1-induced Tongue Cancer cell growth. Our data revealed that MALAT1 inhibited Tongue Cancer cell growth and metastasis through miR-124-dependent JAG1 regulation. In conclusion, we revealed that MALAT1 may play an oncogenic role by increasing proliferation and metastasis of Tongue Cancer and is a potential therapeutic target in human Tongue Cancer.
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Disruption of mediator complex subunit 19 (Med19) inhibits cell growth and migration in Tongue Cancer
World journal of surgical oncology, 2013Co-Authors: Li-jun Zhu, Wangxiang Yan, Zhong-wei Chen, Yu Chen, Dan Chen, Tonghan Zhang, Gui-qing LiaoAbstract:Mediator complex subunit 19 (Med19) is a critical subunit of the mediator complex that forms a bridge between the transcription factors and RNA polymerase II. Although it has been reported that Med19 plays an important role in stabilizing the whole mediator complex, its biological importance in Tongue Cancer cell proliferation and migration has not been addressed. By using MTT, BrdU incorporation, colony formation, flow cytometric, tumorigenesis and transwell assays, We tested the Med19 role on Tongue Cancer cell growth and migration. We demonstrated that lentivirus-mediated Med19 knockdown could arrest Tongue Cancer cells at G1 phase, inhibit Tongue Cancer cell proliferation and migration in vitro. The tumorigenicity of Med19 short hairpin RNA (shRNA)-expressing lentivirus infected Tongue Cancer cells were decreased after inoculating into nude mice. These results indicate that Med19 plays an important role in Tongue Cancer proliferation and migration, and suggest possible applications for Tongue Cancer therapy.
Damodar B. Balar - One of the best experts on this subject based on the ideXlab platform.
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CIRCULATING HORMONES IN PATIENTS WITH Tongue Cancer
Oncology reports, 1994Co-Authors: Jyotsna M. Bhatavdekar, Dd Patel, Hh Vora, Damodar B. BalarAbstract:Serum FSH, LH, prolactin and plasma estradiol, progesterone, testosterone, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) were estimated by RIA method in male patients with Tongue Cancer (N=110) and in healthy age-matched male controls (N=25). In this retrospective study, there was a trend towards higher levels of FSH (P
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Prolactin: Its role in advanced Tongue Cancer
Journal of surgical oncology, 1994Co-Authors: Jyotsna M. Bhatavdekar, Devendra D. Patel, Hemangini H. Vora, Neelam G. Shah, Nilkamal H. Karelia, Nandita Ghosh, Damodar B. BalarAbstract:Serum prolactin was measured pretherapeutically and sequentially thereafter using immunoradiometric assay method in 37 male patients with advanced Tongue Cancer and compared with 23 healthy, age-matched controls. Prolactin levels were correlated with age, various clinicopathologic parameters, overall survival, and patients with response and those with progressive disease. Patients with advanced Tongue Cancer had higher prolactin levels than controls (P 15.0 ng/ml). To assess the prognostic significance of pretherapeutic prolactin level, the patients were divided according to the cutoff level of prolactin (15.0 ng/ml). Hyperprolactinemic patients had more unfavourable prognosis than patients with prolactin
Lalle Hammarstedt - One of the best experts on this subject based on the ideXlab platform.
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Differential survival trends for patients with tonsillar, base of Tongue and Tongue Cancer in Sweden.
Oral oncology, 2011Co-Authors: Lalle Hammarstedt, Tina Dalianis, Linda Marklund, Eva Munck-wiklandAbstract:Tonsillar, base of Tongue and Tongue Cancer have similar anatomical and histopathological appearances but present differences in prognosis. Human papillomavirus (HPV) is a known risk factor for tonsillar and base of Tongue Cancer, and a survival benefit has been shown for these tumors; however, HPV prevalence in Tongue Cancer is low. Tonsillar, base of Tongue and Tongue Cancer patients registered in the Swedish Cancer Registry between 1960 and 2004 were followed from the date of Cancer diagnosis until death, emigration out of Sweden, or the end of a follow-up (5 years since Cancer diagnosis), whichever occurred first. The relative survival rate was computed as the ratio of the observed to the expected survival rate, in which the latter was inferred from the survival of the entire Swedish population in the same age, sex and calendar year stratum. The relative survival rate has improved significantly over time for patients with tonsillar and base of Tongue Cancer although delineated by different patterns. However, the relative survival rate in Tongue Cancer patients exhibited only a very modest improvement during the same time period. Contrary to the overall improved survival for patients with tonsillar and base of Tongue Cancer, the patients with Tongue Cancer show a very modest improvement in Sweden since 1960. Further studies are warranted to elucidate more effective treatment options for Tongue Cancer patients.
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Human papillomavirus and survival in patients with base of Tongue Cancer.
International journal of cancer, 2010Co-Authors: Per Attner, Johan Lindholm, Tina Dalianis, Lalle Hammarstedt, Linda Marklund, Anders Näsman, Torbjörn Ramqvist, Eva Munck-wiklandAbstract:The incidence of base of Tongue Cancer is increasing in Sweden and the proportion of human papillomavirus (HPV) positive Cancer has increased in Stockholm, Sweden. Between 2006 and 2007, 84% of base of Tongue Cancer cases in Stockholm were HPV-positive. The objective of this study was to assess the impact of HPV status on prognosis for base of Tongue Cancer patients. One-hundred and nine patients were diagnosed with base of Tongue Cancer between 1998 and 2007 in Stockholm County and 95 paraffin-embedded diagnostic tumor biopsies were obtained and tested for HPV by PCR. Eighty-seven patients had available biopsies, were treated with intention to cure and could be included in the survival analysis. Age, sex, TNM-stage, stage, treatment and survival were recorded from patient charts. Kaplan–Meier curves were used to present survival data. In multivariable analyses, a Cox proportional hazards model was used to adjust for covariates. In total 68 (78%) tumor biopsies from the 87 included patients were HPV DNA positive. Kaplan–Meier estimates showed that the overall survival for patients with HPV-positive Cancer was significantly better (p = 0.0004), (log-rank test) than that of patients with HPV-negative Cancer. Patients with HPV-positive tumors also had significantly better disease-free survival (p = 0.0008), (log-rank test) than those with HPV-negative tumors. These results further strengthen the option to consider HPV-status when planning prospective studies on treatment for base of Tongue Cancer.
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The role of human papillomavirus in the increased incidence of base of Tongue Cancer
International journal of cancer, 2010Co-Authors: Per Attner, Johan Lindholm, Tina Dalianis, Lalle Hammarstedt, Linda Marklund, Anders Näsman, Torbjörn Ramqvist, Eva Munck-wiklandAbstract:Numerous reports have shown that the incidence for oropharyngeal Cancer is increasing and that human papillomavirus (HPV) is a risk factor. However, few studies have investigated the specific subsites of the oropharynx. Following our previous research on tonsillar Cancer, we assessed the increase in the incidence of base of Tongue Cancer and the prevalence of HPV in this disease. Between 1998 and 2007, 109 patients were diagnosed for base of Tongue Cancer in Stockholm county. Ninety-five paraffin-embedded diagnostic tumor biopsies from patients were obtained and tested for HPV, both by general HPV PCR and HPV-16/HPV-33 type-specific PCR. Expression of HPV-16 RNA was analyzed to confirm E6 and/or E7 expression. Incidence data were obtained from the Swedish Cancer Registry. An overall increase in the incidence of base of Tongue Cancer from 0.15/100,000 person-years during 1970-1974 to 0.47/100,000 person-years during 2005-2007 was found in Sweden. The prevalence of HPV in base of Tongue Cancer in Stockholm county increased from 58% during 1998-2001 to 84% during 2004-2007 (p < 0.05). In the HPV-positive tumors, HPV-16 dominated (86%) but interestingly, HPV33 was detected in as many as 10%. E6 and/or E7 RNA were found in 85% of the samples tested. The incidence of base of Tongue Cancer, as well as the proportion of HPV-positive tumors, has increased in Sweden during the study period, suggesting that HPV may contribute to this increase.
