The Experts below are selected from a list of 8625 Experts worldwide ranked by ideXlab platform
Anthony Po Wing Yuen - One of the best experts on this subject based on the ideXlab platform.
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prospective randomized study of selective neck dissection versus observation for n0 neck of early Tongue Carcinoma
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2009Co-Authors: Anthony Po Wing Yuen, William I. Wei, Tam Lin Chow, Lap Chiu Tang, W Y Cheung, Chi Kwan Kong, Kwok Shing Book, Wai Cheung Yuen, Alfred Kingyin Lam, Nancy Wahfun YuenAbstract:Background. There are controversies on the benefits of elective neck dissection (END) for oral Tongue Carcinoma. Method. This is a prospective randomized study of elective selective I, II, III neck dissection versus observation for N0 neck of stage I to II oral Tongue Carcinoma. There were 35 patients on the observation arm and 36 patients on the END arm. The main outcome assessment parameters are node-related mortality and disease-specific survival rate. Results. There were 11 patients in the observed arm and 2 patients in the END arm who developed nodal recurrence alone without associated local or distant recurrence. All 13 patients were salvaged, and no patient died of nodal recurrence. The 5-year disease-specific survival rate was 87% for the observation arm and was 89% for the END arm; the 2% difference was not significant. Conclusion. Observation may be an acceptable alternative to END if strict adherence to a cancer surveillance protocol is followed. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
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preoperative measurement of tumor thickness of oral Tongue Carcinoma with intraoral ultrasonography
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2008Co-Authors: Anthony Po Wing Yuen, Paul K Y LamAbstract:Background. Tumor thickness of oral Tongue Carcinoma is an important independent prognostic factor for local recurrence, subclinical nodal metastasis, and survival. An accurate preoperative assessment of tumor thickness is therefore essential in optimizing treatment algorithm. The present study aims at evaluating the accuracy of intraoral ultrasonography in preoperative measurement of tumor thickness. Methods. Forty-five patients with oral Tongue Carcinoma had intraoral ultrasonography to document tumor thickness using a 7.5 MHz right angle probe. The ultrasonic tumor thickness was correlated with the fresh unpreserved surgical specimen pathologic tumor thickness. Results. Ultrasonic tumor thickness had significant correlation with pathologic tumor thickness. The accuracies of ultrasonic measurement of tumor thickness in staging of tumor thickness at cutoff values between 3 and 15 mm were above 91%. Conclusion. Intraoral ultrasonography had satisfactory accuracy in the measurement of tumor thickness and is a useful adjunct in assisting pretreatment staging and prognosis evaluation of oral Tongue Carcinoma. © 2007 Wiley Periodicals, Inc. Head Neck, 2008
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Clinicopathologic significance of bcl-2 expression in the surgical treatment of oral Tongue Carcinoma
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2002Co-Authors: Anthony Po Wing Yuen, Y. Lam, J.t.h. Choy, Lai-yung Wong, William I. WeiAbstract:Abstract Aim: There is still controversy on the incidence of positive expression of bcl-2 and its prognostic significance for oral Tongue Carcinoma patients who are treated by surgery. The present study aims at resolving the controversy on the clinicopathologic significance of bcl-2 in a well selected group of patients who satisfy the recruitment criteria: (1) oral Tongue Carcinoma, (2) squamous cell Carcinoma, (3) primary surgical treatment. Method: Bcl-2 expression was studied by immunohistochemistry on glossectomy specimens of 73 patients. The expression of bcl-2 was correlated with clinicopathologic data. Results: Of the 73 tumours, 11% had positive expression of bcl-2. Bcl-2 expression was not significantly correlated with tumour grade, stage, nodal metastasis and survival. Conclusion: Bcl-2 expression played a minor role in oral Tongue Carcinoma. It had no significant correlation with tumour grade, stage and nodal metastasis. It also had no prognostic value on survival for patients who were treated by primary surgery.
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a comparison of the prognostic significance of tumor diameter length width thickness area volume and clinicopathological features of oral Tongue Carcinoma
American Journal of Surgery, 2000Co-Authors: Anthony Po Wing Yuen, William I. Wei, Tam Lin Chow, K Y Lam, Kin Lam, Wah Fun YuenAbstract:Abstract Background: The present study aims at evaluation of the prognostic value of tumor size including diameter, length, thickness, width, area, and volume in the prediction of nodal metastasis, local recurrence, and survival of oral Tongue Carcinoma. The results will have important implications for the management of patients. Methods: Eighty-five glossectomy specimens of oral Tongue Carcinoma were serially sectioned in 3 mm thickness for the tumor size evaluation with computer image analyzer. Results: Among all the tumor size parameters being evaluated, tumor thickness was the only significant factor for the prediction of local recurrence, nodal metastasis, and survival. With the use of 3 mm and 9 mm division, tumor of up to 3 mm thickness has 10% nodal metastasis, 0% local recurrence, and 100% 5-year actuarial disease-free survival; tumor thickness of more than 3 mm and up to 9 mm has 50% nodal metastasis, 11% local recurrence, and 77% 5-year actuarial disease free survival; tumor of more than 9 mm has 65% nodal metastasis, 26% local recurrence, and 60% 5-year actuarial disease-free survival. Conclusions: Tumor thickness should be considered in the management of patients with oral Tongue Carcinoma.
Paul K Y Lam - One of the best experts on this subject based on the ideXlab platform.
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preoperative measurement of tumor thickness of oral Tongue Carcinoma with intraoral ultrasonography
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2008Co-Authors: Anthony Po Wing Yuen, Paul K Y LamAbstract:Background. Tumor thickness of oral Tongue Carcinoma is an important independent prognostic factor for local recurrence, subclinical nodal metastasis, and survival. An accurate preoperative assessment of tumor thickness is therefore essential in optimizing treatment algorithm. The present study aims at evaluating the accuracy of intraoral ultrasonography in preoperative measurement of tumor thickness. Methods. Forty-five patients with oral Tongue Carcinoma had intraoral ultrasonography to document tumor thickness using a 7.5 MHz right angle probe. The ultrasonic tumor thickness was correlated with the fresh unpreserved surgical specimen pathologic tumor thickness. Results. Ultrasonic tumor thickness had significant correlation with pathologic tumor thickness. The accuracies of ultrasonic measurement of tumor thickness in staging of tumor thickness at cutoff values between 3 and 15 mm were above 91%. Conclusion. Intraoral ultrasonography had satisfactory accuracy in the measurement of tumor thickness and is a useful adjunct in assisting pretreatment staging and prognosis evaluation of oral Tongue Carcinoma. © 2007 Wiley Periodicals, Inc. Head Neck, 2008
William I. Wei - One of the best experts on this subject based on the ideXlab platform.
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Curcumin inhibits Tongue Carcinoma cells migration and invasion through downregulation of matrix metallopeptidase 10.
Cancer investigation, 2012Co-Authors: Raymond K. Y. Tsang, Whitney Wing-yan Tang, Wei Gao, Jimmy Yu Wai Chan, William I. Wei, Thian-sze WongAbstract:Squamous cell Carcinoma (SCC) of Tongue is an aggressive head and neck cancer with high propensity of regional spreading and invasion. Tongue Carcinoma cells treated with curcumin, the major curcuminoid of the turmeric, demonstrated reduction in adhesion, migration, and invasion ability. High-throughput microarray analysis indicated that curcumin treatment suppressed matrix metallopeptidase 10 (MMP10) expression. MMP10 is overexpressed in Tongue Carcinoma tissues in comparison with the normal epithelia. Curcumin treatment on Tongue Carcinoma cell lines suppressed MMP10 expression at both mRNA and protein levels. Our results suggested that curcumin is a promising inhibitor to Tongue cancer cells migration and invasion.
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prospective randomized study of selective neck dissection versus observation for n0 neck of early Tongue Carcinoma
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 2009Co-Authors: Anthony Po Wing Yuen, William I. Wei, Tam Lin Chow, Lap Chiu Tang, W Y Cheung, Chi Kwan Kong, Kwok Shing Book, Wai Cheung Yuen, Alfred Kingyin Lam, Nancy Wahfun YuenAbstract:Background. There are controversies on the benefits of elective neck dissection (END) for oral Tongue Carcinoma. Method. This is a prospective randomized study of elective selective I, II, III neck dissection versus observation for N0 neck of stage I to II oral Tongue Carcinoma. There were 35 patients on the observation arm and 36 patients on the END arm. The main outcome assessment parameters are node-related mortality and disease-specific survival rate. Results. There were 11 patients in the observed arm and 2 patients in the END arm who developed nodal recurrence alone without associated local or distant recurrence. All 13 patients were salvaged, and no patient died of nodal recurrence. The 5-year disease-specific survival rate was 87% for the observation arm and was 89% for the END arm; the 2% difference was not significant. Conclusion. Observation may be an acceptable alternative to END if strict adherence to a cancer surveillance protocol is followed. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
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Clinicopathologic significance of bcl-2 expression in the surgical treatment of oral Tongue Carcinoma
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2002Co-Authors: Anthony Po Wing Yuen, Y. Lam, J.t.h. Choy, Lai-yung Wong, William I. WeiAbstract:Abstract Aim: There is still controversy on the incidence of positive expression of bcl-2 and its prognostic significance for oral Tongue Carcinoma patients who are treated by surgery. The present study aims at resolving the controversy on the clinicopathologic significance of bcl-2 in a well selected group of patients who satisfy the recruitment criteria: (1) oral Tongue Carcinoma, (2) squamous cell Carcinoma, (3) primary surgical treatment. Method: Bcl-2 expression was studied by immunohistochemistry on glossectomy specimens of 73 patients. The expression of bcl-2 was correlated with clinicopathologic data. Results: Of the 73 tumours, 11% had positive expression of bcl-2. Bcl-2 expression was not significantly correlated with tumour grade, stage, nodal metastasis and survival. Conclusion: Bcl-2 expression played a minor role in oral Tongue Carcinoma. It had no significant correlation with tumour grade, stage and nodal metastasis. It also had no prognostic value on survival for patients who were treated by primary surgery.
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a comparison of the prognostic significance of tumor diameter length width thickness area volume and clinicopathological features of oral Tongue Carcinoma
American Journal of Surgery, 2000Co-Authors: Anthony Po Wing Yuen, William I. Wei, Tam Lin Chow, K Y Lam, Kin Lam, Wah Fun YuenAbstract:Abstract Background: The present study aims at evaluation of the prognostic value of tumor size including diameter, length, thickness, width, area, and volume in the prediction of nodal metastasis, local recurrence, and survival of oral Tongue Carcinoma. The results will have important implications for the management of patients. Methods: Eighty-five glossectomy specimens of oral Tongue Carcinoma were serially sectioned in 3 mm thickness for the tumor size evaluation with computer image analyzer. Results: Among all the tumor size parameters being evaluated, tumor thickness was the only significant factor for the prediction of local recurrence, nodal metastasis, and survival. With the use of 3 mm and 9 mm division, tumor of up to 3 mm thickness has 10% nodal metastasis, 0% local recurrence, and 100% 5-year actuarial disease-free survival; tumor thickness of more than 3 mm and up to 9 mm has 50% nodal metastasis, 11% local recurrence, and 77% 5-year actuarial disease free survival; tumor of more than 9 mm has 65% nodal metastasis, 26% local recurrence, and 60% 5-year actuarial disease-free survival. Conclusions: Tumor thickness should be considered in the management of patients with oral Tongue Carcinoma.
Tuankay Lim - One of the best experts on this subject based on the ideXlab platform.
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Tongue Carcinoma tumor volume measurement
International Journal of Radiation Oncology Biology Physics, 2004Co-Authors: Vincent F. H. Chong, Jiayin Zhou, James B. K. Khoo, Jing Huang, Tuankay LimAbstract:Abstract Purpose To validate the semiautomated methods of Tongue Carcinoma tumor volume measurement by comparing the conventional manual trace method with 2 semiautomated computer methods: seed growing and region deformation. Materials and methods The study population consisted of 16 patients with histology-proven Tongue Carcinoma. Two head-and-neck radiologists independently measured the tumor volume demonstrated on pretreatment T2-weighted magnetic resonance data sets. The tumor volumes were measured using manual tracing and semiautomated seed growing and region deformation algorithm. Data were recorded for analysis of interoperator variance and interobserver reliability at volume and pixel levels. Results There was no significant difference between the manually traced volume and semiautomated segmentation volumes for both operators. No significant difference was found in interobserver variance among the 3 methods at volume level. However, there was significant difference between manual tracing and semiautomated segmentation methods in interobserver reliability at pixel level. Conclusion The semiautomated methods could achieve satisfactory segmentation results. They could also reduce interoperator variance and obtain a higher interobserver reliability. This study validates the use of semiautomated volume measurement methods for Tongue Carcinoma.
Yuko Nakayama - One of the best experts on this subject based on the ideXlab platform.
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Predictive Significance of Tumor Depth and Budding for Late Lymph Node Metastases in Patients with Clinical N0 Early Oral Tongue Carcinoma
Head and Neck Pathology, 2017Co-Authors: Yukiko Hori, Nobutaka Mizoguchi, Takahiro Nonaka, Sachiyo Mitsunaga, Madoka Furukawa, Morihito Takita, Tomoyuki Yokose, Akira Kubota, Takeshi Matsushita, Yuko NakayamaAbstract:In clinical N0 early oral Tongue Carcinoma, treatment of occult lymph node metastasis is controversial. The purpose of this study was to assess the histopathological risk factors for predicting late lymph node metastasis in early oral Tongue Carcinoma. We retrospectively reviewed 48 patients with early oral Tongue squamous cell Carcinoma. Associations between the histopathological factors (depth of tumor, differentiation, blood vessel invasion, lymphatic invasion, and tumor budding) and late lymph metastasis were analyzed. Although the univariate analysis identified blood vessel invasion, lymphatic invasion, and high-grade tumor budding as predictive factors for neck recurrence (p
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predictive significance of tumor depth and budding for late lymph node metastases in patients with clinical n0 early oral Tongue Carcinoma
Head and Neck Pathology, 2017Co-Authors: Yukiko Hori, Nobutaka Mizoguchi, Sachiyo Mitsunaga, Madoka Furukawa, Morihito Takita, Tomoyuki Yokose, Akira Kubota, Takeshi Matsushita, Tetsuo Nonaka, Yuko NakayamaAbstract:In clinical N0 early oral Tongue Carcinoma, treatment of occult lymph node metastasis is controversial. The purpose of this study was to assess the histopathological risk factors for predicting late lymph node metastasis in early oral Tongue Carcinoma. We retrospectively reviewed 48 patients with early oral Tongue squamous cell Carcinoma. Associations between the histopathological factors (depth of tumor, differentiation, blood vessel invasion, lymphatic invasion, and tumor budding) and late lymph metastasis were analyzed. Although the univariate analysis identified blood vessel invasion, lymphatic invasion, and high-grade tumor budding as predictive factors for neck recurrence (p < 0.001), the Cox proportional hazards model identified high-grade tumor budding as an independent predictive factor (p < 0.01). The combination of a tumor depth ≥ 3 mm and high-grade tumor budding yielded high diagnostic accuracy. Tumor depth and budding grade were identified as histopathological risk factors for late neck recurrence in clinical N0 early oral Tongue Carcinoma.
