The Experts below are selected from a list of 39 Experts worldwide ranked by ideXlab platform
Marie-cécile Nollevaux - One of the best experts on this subject based on the ideXlab platform.
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Combining a new CO_2 laser wave guide with transoral robotic surgery: a feasibility study on four patients with malignant Tumors
European Archives of Oto-Rhino-Laryngology, 2012Co-Authors: Marc Remacle, Nayla Matar, Georges Lawson, Vincent Bachy, Monique Delos, Marie-cécile NollevauxAbstract:We present a series of patients treated by transoral robotic surgery (TORS) using a new CO_2 laser wave guide (CO_2 LWG) (Lumenis, Santa Clara, CA). Patients older than 18 years, with malignant pharyngo-laryngeal Tumors were enrolled in this prospective study after signing an informed consent. Four patients were enrolled in the study. The mean age was 56 years. One patient had a T1 base of tongue Tumor, two patients had supraglottic Tumors (T1, T2), and one had a T1 palatine Tonsil Tumor. All the procedures could be performed using a Maryland forceps, a 0° endoscope and a CO_2 LWG introduced via the robotic arm introducer. The laser parameters were: superpulse or continuous mode, 7–15 W, continuous delivery. The average set-up time was 30 min. The average surgical time was 94 min. No complications were noted due to the intraoperative use of the robot or the CO_2 LWG. One laser fiber was used for each of the surgeries. The mean coagulation depth was 200 μm (range 100–300). The mean hospital stay was 6 days. The CO_2 LWG is a reliable tool for TORS. It allowed more than 1 h of work without any trouble.
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Combining a new CO2 laser wave guide with transoral robotic surgery: a feasibility study on four patients with malignant Tumors.
European Archives of Oto-rhino-laryngology, 2011Co-Authors: Marc Remacle, Nayla Matar, Georges Lawson, Vincent Bachy, Monique Delos, Marie-cécile NollevauxAbstract:We present a series of patients treated by transoral robotic surgery (TORS) using a new CO2 laser wave guide (CO2 LWG) (Lumenis, Santa Clara, CA). Patients older than 18 years, with malignant pharyngo-laryngeal Tumors were enrolled in this prospective study after signing an informed consent. Four patients were enrolled in the study. The mean age was 56 years. One patient had a T1 base of tongue Tumor, two patients had supraglottic Tumors (T1, T2), and one had a T1 palatine Tonsil Tumor. All the procedures could be performed using a Maryland forceps, a 0° endoscope and a CO2 LWG introduced via the robotic arm introducer. The laser parameters were: superpulse or continuous mode, 7–15 W, continuous delivery. The average set-up time was 30 min. The average surgical time was 94 min. No complications were noted due to the intraoperative use of the robot or the CO2 LWG. One laser fiber was used for each of the surgeries. The mean coagulation depth was 200 μm (range 100–300). The mean hospital stay was 6 days. The CO2 LWG is a reliable tool for TORS. It allowed more than 1 h of work without any trouble.
K G Wiman - One of the best experts on this subject based on the ideXlab platform.
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in frame deletion of intron 7 in the p53 gene in a human Tonsil Tumor
International Journal of Oncology, 1995Co-Authors: Kp Magnusson, Zsofia Berke, Eva Munckwikland, Ilona Lewensohnfuchs, G Klein, T Dallianis, K G WimanAbstract:: We here report a unique intron deletion in the p53 gene. Analysis of a human Tonsil Tumor that expressed elevated levels of p53 showed a deletion of the entire intron 7 in one of the p53 alleles, leaving the coding sequence intact. The significance of the intron 7 deletion for the development of the Tonsil Tumor is discussed.
Verena Schildgen - One of the best experts on this subject based on the ideXlab platform.
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association of the human bocavirus with Tonsil squamous cell carcinomas
Frontiers in Microbiology, 2018Co-Authors: M Hopken, Isabel Forster, S Maune, Michael Brockmann, Oliver Schildgen, Verena SchildgenAbstract:Background The human bocavirus (HBoV) is known to persist latently in the infected host cells and seems to replicate its DNA via the DNA damage response system, which is frequently defect in tumours and correlates with microsatellite instability (MSI). Because HBoV is able to persist in the infected tissues, induces pro-fibrotic and pro- cancerogenic cytokines in vivo and in vitro, and is detected in colorectal and lung Tumors, the virus may be involved in cancerogenesis at least as a cofactor. Recently it was shown that the adenoTonsillar tissue is an important site of HBoV1 persistence and replication. Considering the background that approximately 60% of oropharyngeal cancers were thought to be attributable to a HPV infection, a co-participation of HBoV in terms of a chronic virus infection might play a role in the cancerogenesis of Tonsil Tumors. Methods Formalin-fixed, paraffin-embedded Tonsil Tumor samples were screened for HBoV and HPV DNA. Positive tissue sections were afterwards subjected to fluorescence in situ hybridization (FISH) analysis to identify HBoV and HPV infected cells. By use of an in vitro cell culture model with primary Tonsil fibroblasts, keratinocytes, and lymphocytes infected by HBoV we tried to find the target cells of virus replication. MSI testing was based on a previously published protocol using a de-multiplexed PCR followed by fluorescent detection of PCR products in a capillary sequencing device. Results In total 62 of 103 (60,19%) Tonsil squamous cell carcinomas tested positive for HBoV-DNA, 66 of 103 (66%) samples were identified as HPV-positive. The FISH analysis revealed both double infection of HPV and HBoV in the same cells as well as single infections of both viruses within the Tumor tissue. Twenty-two of 62 HBoV-positive Tumors tested HPV-negative, 40 of 62 tissue sections were HBoV and HPV positive. We analyzed 21 out of the 62 HBoV--positive Tumors for MSI. Of those four Tonsils displayed MSI in at least one of ten microsatellite markers. Conclusions Our findings support the hypothesis that human bocavirus infections as a cofactor may have an impact on Tumor development in Tonsils, although it still remains possible that HBoV solely displays a Tumor tropism.
Marc Remacle - One of the best experts on this subject based on the ideXlab platform.
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Combining a new CO_2 laser wave guide with transoral robotic surgery: a feasibility study on four patients with malignant Tumors
European Archives of Oto-Rhino-Laryngology, 2012Co-Authors: Marc Remacle, Nayla Matar, Georges Lawson, Vincent Bachy, Monique Delos, Marie-cécile NollevauxAbstract:We present a series of patients treated by transoral robotic surgery (TORS) using a new CO_2 laser wave guide (CO_2 LWG) (Lumenis, Santa Clara, CA). Patients older than 18 years, with malignant pharyngo-laryngeal Tumors were enrolled in this prospective study after signing an informed consent. Four patients were enrolled in the study. The mean age was 56 years. One patient had a T1 base of tongue Tumor, two patients had supraglottic Tumors (T1, T2), and one had a T1 palatine Tonsil Tumor. All the procedures could be performed using a Maryland forceps, a 0° endoscope and a CO_2 LWG introduced via the robotic arm introducer. The laser parameters were: superpulse or continuous mode, 7–15 W, continuous delivery. The average set-up time was 30 min. The average surgical time was 94 min. No complications were noted due to the intraoperative use of the robot or the CO_2 LWG. One laser fiber was used for each of the surgeries. The mean coagulation depth was 200 μm (range 100–300). The mean hospital stay was 6 days. The CO_2 LWG is a reliable tool for TORS. It allowed more than 1 h of work without any trouble.
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Combining a new CO2 laser wave guide with transoral robotic surgery: a feasibility study on four patients with malignant Tumors.
European Archives of Oto-rhino-laryngology, 2011Co-Authors: Marc Remacle, Nayla Matar, Georges Lawson, Vincent Bachy, Monique Delos, Marie-cécile NollevauxAbstract:We present a series of patients treated by transoral robotic surgery (TORS) using a new CO2 laser wave guide (CO2 LWG) (Lumenis, Santa Clara, CA). Patients older than 18 years, with malignant pharyngo-laryngeal Tumors were enrolled in this prospective study after signing an informed consent. Four patients were enrolled in the study. The mean age was 56 years. One patient had a T1 base of tongue Tumor, two patients had supraglottic Tumors (T1, T2), and one had a T1 palatine Tonsil Tumor. All the procedures could be performed using a Maryland forceps, a 0° endoscope and a CO2 LWG introduced via the robotic arm introducer. The laser parameters were: superpulse or continuous mode, 7–15 W, continuous delivery. The average set-up time was 30 min. The average surgical time was 94 min. No complications were noted due to the intraoperative use of the robot or the CO2 LWG. One laser fiber was used for each of the surgeries. The mean coagulation depth was 200 μm (range 100–300). The mean hospital stay was 6 days. The CO2 LWG is a reliable tool for TORS. It allowed more than 1 h of work without any trouble.
Kp Magnusson - One of the best experts on this subject based on the ideXlab platform.
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in frame deletion of intron 7 in the p53 gene in a human Tonsil Tumor
International Journal of Oncology, 1995Co-Authors: Kp Magnusson, Zsofia Berke, Eva Munckwikland, Ilona Lewensohnfuchs, G Klein, T Dallianis, K G WimanAbstract:: We here report a unique intron deletion in the p53 gene. Analysis of a human Tonsil Tumor that expressed elevated levels of p53 showed a deletion of the entire intron 7 in one of the p53 alleles, leaving the coding sequence intact. The significance of the intron 7 deletion for the development of the Tonsil Tumor is discussed.