The Experts below are selected from a list of 10887 Experts worldwide ranked by ideXlab platform
John H. Brumell - One of the best experts on this subject based on the ideXlab platform.
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An autophagy-independent role for ATG16L1: promoting lysosome-mediated plasma membrane repair
Autophagy, 2019Co-Authors: Joel M J Tan, Nora Mellouk, John H. BrumellAbstract:There is growing evidence in the literature for unconventional roles of autophagy-related (ATG) proteins, outside of their function in canonical autophagy. Here we discuss our recent study that revealed a novel ATG16L1-dependent pathway that promotes plasma membrane repair upon bacterial pore-forming Toxin Damage. Disruption of the ATG16L1-dependent pathway leads to an accumulation of cholesterol in lysosomes, which affects lysosomal exocytosis required for efficient membrane repair. Our study provides insights into the role of ATG16L1 in cholesterol homeostasis and plasma membrane integrity.
Joel M J Tan - One of the best experts on this subject based on the ideXlab platform.
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An autophagy-independent role for ATG16L1: promoting lysosome-mediated plasma membrane repair
Autophagy, 2019Co-Authors: Joel M J Tan, Nora Mellouk, John H. BrumellAbstract:There is growing evidence in the literature for unconventional roles of autophagy-related (ATG) proteins, outside of their function in canonical autophagy. Here we discuss our recent study that revealed a novel ATG16L1-dependent pathway that promotes plasma membrane repair upon bacterial pore-forming Toxin Damage. Disruption of the ATG16L1-dependent pathway leads to an accumulation of cholesterol in lysosomes, which affects lysosomal exocytosis required for efficient membrane repair. Our study provides insights into the role of ATG16L1 in cholesterol homeostasis and plasma membrane integrity.
Nora Mellouk - One of the best experts on this subject based on the ideXlab platform.
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An autophagy-independent role for ATG16L1: promoting lysosome-mediated plasma membrane repair
Autophagy, 2019Co-Authors: Joel M J Tan, Nora Mellouk, John H. BrumellAbstract:There is growing evidence in the literature for unconventional roles of autophagy-related (ATG) proteins, outside of their function in canonical autophagy. Here we discuss our recent study that revealed a novel ATG16L1-dependent pathway that promotes plasma membrane repair upon bacterial pore-forming Toxin Damage. Disruption of the ATG16L1-dependent pathway leads to an accumulation of cholesterol in lysosomes, which affects lysosomal exocytosis required for efficient membrane repair. Our study provides insights into the role of ATG16L1 in cholesterol homeostasis and plasma membrane integrity.
Kroll, Ashley Victoria - One of the best experts on this subject based on the ideXlab platform.
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Cell Membrane-Coated Nanoparticles for Immune Modulation
eScholarship University of California, 2019Co-Authors: Kroll, Ashley VictoriaAbstract:Nanotechnology is a cutting edge scientific area that is fundamentally changing the way we design and administer medicines and therapies to patients. One area in which nanomedicine can have a large impact is through immune modulation and “nano-immunoengineering”. The size and unique cell-particle interaction patterns enable nanoparticles to interact with the immune system in ways that can impact the immune system in radically new and efficacious ways. This dissertation focuses on demonstrating how cell membrane coating can be merged with nanoparticle design to facilitate immune modulation to improve a variety of pathological conditions. The rationale for cell membrane coating and the use of nanoparticles in immune modulation is discussed in the first chapter of the dissertation.The second portion of the dissertation concentrates on developing cancer cell membrane-coated nanoparticles for anticancer vaccination. Using the membrane of cancer cells serves as an ideal and multivalent antigen source, while coating around the adjuvant-loaded nanoparticle core provide immune stimulation and a codelivery of both components to the lymphatic system. The third portion of the dissertation dives into the use of erythrocyte membrane-coated nanoparticles for antibacterial vaccination. Pore-forming Toxins naturally embed into red blood cell membrane, and can be delivered in the nanoparticulate form to provide intact Toxin antigens to the immune system. Formation of anti-Toxin antibodies then protect from Toxin Damage and also provide antivirulence immunity against bacterial infections. Finally, the fourth section of this dissertation will focus on a novel “nanosponge” for immune thrombocytopenia purpura. Platelet membrane coated nanoparticles can specifically absorb anti-platelet antibodies, sparing immune destruction of real platelets and reducing disease symptoms.This dissertation will serve as an example of applying rational design and engineering of cell membrane coating and nanoparticle synthesis and loading to enhance immune system intervention in a variety of internal and external pathological challenges. By harnessing these tools, cell membrane-coated nanoparticles can have a great impact in the field of immunotherapy, and have much potential to be expanded upon for new therapeutic and prophylactic modalities
Antoine Lanot - One of the best experts on this subject based on the ideXlab platform.
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mushroom poisoning presenting with acute kidney injury and elevated transaminases
Kidney International Reports, 2019Co-Authors: Mathilde Beaumier, Jean-philippe Rioult, Marie Georges, Isabelle Brocheriou, Thierry Lobbedez, Antoine LanotAbstract:It is estimated that out of the 100,000 or more species of mushrooms worldwide, more than 100 are toxic. In the United States, the National Poison Data System reported 133,700 cases of mushroom exposure from 1999 to 2016, and 6136 cases in 2017.1, 2 Identifying the specific mushroom species involved is mandatory because specific treatment exists for some mushroom poisoning. A recent algorithm to group the multiple species and syndromes of mushroom poisoning into 6 presenting syndromes has been proposed by White et al., depending on the clinical presentation.3 Among severe mushroom intoxications, amaToxin syndrome accounts for 68% to 89% of fatalities.1 Mushroom poisoning usually causes gastroenteritis prodrome. Hepatotoxicity is rare but is associated with a limited group of mushrooms. Renal failure can be due to severe dehydration or to specific Toxin Damage. Early syndromes (onset of nausea and vomiting in <6 hours) are usually associated with a good prognosis, whereas delayed syndromes carry risk of organ failure, with the liver and kidney as the key organs of concern. Herein, we present 2 cases of hepato-nephritis after mushroom ingestion in a married couple, with a review of mushroom poisoning, toxidromes, diagnosis, and treatment.