The Experts below are selected from a list of 3066 Experts worldwide ranked by ideXlab platform
Aydogmus U - One of the best experts on this subject based on the ideXlab platform.
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LID - 10.1055/s-0040-1715435 [doi]
2020Co-Authors: Aydogmus U, Kis A, Ugurlu E, Ozturk GAbstract:INTRODUCTION:  Due to the variations in (laryngeal) Tracheal stenosis (TS) patient groups, there is still no consensus on which patient should be treated with endoscopy or Surgery. The aim of the present study was to generate an algorithm in the light of the related literature and the data obtained from a clinic where both endoscopic and surgical treatments are conducted. METHOD:  A retrospective analysis was performed on the data of a total of 56 patients during 2013 to 2019. A total of 38 patients were subject to Surgery with 31 as a first treatment option and 7 due to the unsatisfactory results of endoscopic treatments. Endoscopic approaches were tried on a total of 29 patients with 25 as initial treatment and 4 due to postsurgical recurrence. RESULTS:  Symptomatic full control ratio was determined as 69% with endoscopic treatments, 89.5% in subglottic stenosis (SGS) Surgery (n = 19), and 89.5% in Trachea Surgery (n = 19). However, success rates with no recurrence were determined, respectively, as 40.0, 36.4, and 36.4% for patients subject to dilatation, stent, or T tube treatment. Dilatation was observed to be successful in patients with stenotic segment lengths of less than 1.5 cm (p = 0.02). Failure rates increased in SGS (p = 0.03) and TS (p = 0.12) in the surgical group with increasing stenotic segment length. The presence of comorbidities was not effective on treatment success. CONCLUSION:  Endoscopic methods are preferred in cases of web-like stenosis. Surgical methods should first be considered for other patients and endoscopic methods should be used on patients who are not suited for Surgery or in cases of postsurgical recurrence
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Effectiveness of palatal mucosa graft in surgical treatment of sub-glottic stenosis
'Korean Society of Otorhinolaryngology-Head and Neck Surgery', 2016Co-Authors: Aydogmus U, Topkara A., Akbulut M., Ozkan A., Turk F., Sahin B., Yuncu G.Abstract:Objectives. Mucosal free grafts may be successfully applied in many surgical interventions. This study aims at investigating the feasibility of palatal mucosa graft in sub-glottic field in an animal model. Methods. This randomized prospective controlled study was conducted with an animal model. Sub-glottic inflammation was created in 15 adult rabbits in each group and sub-glottic stenosis Surgery was applied thereafter. The rabbits in group 1 (control group) underwent segmental resection, partial cricoidectomy, and Trachea-thyroid cartilage anasto¬mosis; the rabbits in group 2 underwent segmental resection, cricoplasty, and crico-Tracheal anastomosis using free buccal mucosa graft; and the rabbits in group 3 underwent segmental resection, cricoplasty, and crico-Tracheal anastomosis using free palatal mucosa graft. Restenosis was evaluated after 42 days. Results. The percentages of stenosis were 27%±20%, 40%±20%, and 34%±23% for group 1, 2, and 3, respectively and the difference was not statistically significant (P=0.29). Intensive and tight fibrosis was observed in 2 rabbits (13%) in group 1, in 5 rabbits (33%) in group 2, and in 3 rabbits (20%) in group 3. There was not a statistically significant difference between groups (P=0.41). Excessive inflammation was observed in 3 rabbits (20%) in group 1, in 7 rabbits (47%) in group 2, and 3 rabbits (20%) in group 3. There was no a statistically significant difference between groups although inflammation rate was higher in the rabbits which underwent buccal mucosa graft (P=0.18). Conclusion. The surgical treatments applied with free mucosa graft reduced anastomosis tension through enabling anasto¬mosis to the distal of cricoid instead of thyroid cartilage. Free palatal mucosa grafts may be used in sub-glottic field, one of the most challenging fields of Trachea Surgery, due to ease of application and rapid vascularization. © 2016 by Korean Society of Otorhinolaryngology-Head and Neck Surgery
Gokhan Yuncu - One of the best experts on this subject based on the ideXlab platform.
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Effectiveness of Palatal Mucosa Graft in Surgical Treatment of Sub-Glottic Stenosis
Korean Society of Otorhinolaryngology-Head and Neck Surgery, 2016Co-Authors: Umit Aydogmus, Adem Topkara, Metin Akbulut, Adem Ozkan, Figen Turk, Barbaros Sahin, Gokhan YuncuAbstract:Objectives Mucosal free grafts may be successfully applied in many surgical interventions. This study aims at investigating the feasibility of palatal mucosa graft in sub-glottic field in an animal model. Methods This randomized prospective controlled study was conducted with an animal model. Sub-glottic inflammation was created in 15 adult rabbits in each group and sub-glottic stenosis Surgery was applied thereafter. The rabbits in group 1 (control group) underwent segmental resection, partial cricoidectomy, and Trachea-thyroid cartilage anastomosis; the rabbits in group 2 underwent segmental resection, cricoplasty, and crico-Tracheal anastomosis using free buccal mucosa graft; and the rabbits in group 3 underwent segmental resection, cricoplasty, and crico-Tracheal anastomosis using free palatal mucosa graft. Re-stenosis was evaluated after 42 days. Results The percentages of stenosis were 27%±20%, 40%±20%, and 34%±23% for group 1, 2, and 3, respectively and the difference was not statistically significant (P=0.29). Intensive and tight fibrosis was observed in 2 rabbits (13%) in group 1, in 5 rabbits (33%) in group 2, and in 3 rabbits (20%) in group 3. There was not a statistically significant difference between groups (P=0.41). Excessive inflammation was observed in 3 rabbits (20%) in group 1, in 7 rabbits (47%) in group 2, and 3 rabbits (20%) in group 3. There was no a statistically significant difference between groups although inflammation rate was higher in the rabbits which underwent buccal mucosa graft (P=0.18). Conclusion The surgical treatments applied with free mucosa graft reduced anastomosis tension through enabling anastomosis to the distal of cricoid instead of thyroid cartilage. Free palatal mucosa grafts may be used in sub-glottic field, one of the most challenging fields of Trachea Surgery, due to ease of application and rapid vascularization
Yuncu G. - One of the best experts on this subject based on the ideXlab platform.
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Effectiveness of palatal mucosa graft in surgical treatment of sub-glottic stenosis
'Korean Society of Otorhinolaryngology-Head and Neck Surgery', 2016Co-Authors: Aydogmus U, Topkara A., Akbulut M., Ozkan A., Turk F., Sahin B., Yuncu G.Abstract:Objectives. Mucosal free grafts may be successfully applied in many surgical interventions. This study aims at investigating the feasibility of palatal mucosa graft in sub-glottic field in an animal model. Methods. This randomized prospective controlled study was conducted with an animal model. Sub-glottic inflammation was created in 15 adult rabbits in each group and sub-glottic stenosis Surgery was applied thereafter. The rabbits in group 1 (control group) underwent segmental resection, partial cricoidectomy, and Trachea-thyroid cartilage anasto¬mosis; the rabbits in group 2 underwent segmental resection, cricoplasty, and crico-Tracheal anastomosis using free buccal mucosa graft; and the rabbits in group 3 underwent segmental resection, cricoplasty, and crico-Tracheal anastomosis using free palatal mucosa graft. Restenosis was evaluated after 42 days. Results. The percentages of stenosis were 27%±20%, 40%±20%, and 34%±23% for group 1, 2, and 3, respectively and the difference was not statistically significant (P=0.29). Intensive and tight fibrosis was observed in 2 rabbits (13%) in group 1, in 5 rabbits (33%) in group 2, and in 3 rabbits (20%) in group 3. There was not a statistically significant difference between groups (P=0.41). Excessive inflammation was observed in 3 rabbits (20%) in group 1, in 7 rabbits (47%) in group 2, and 3 rabbits (20%) in group 3. There was no a statistically significant difference between groups although inflammation rate was higher in the rabbits which underwent buccal mucosa graft (P=0.18). Conclusion. The surgical treatments applied with free mucosa graft reduced anastomosis tension through enabling anasto¬mosis to the distal of cricoid instead of thyroid cartilage. Free palatal mucosa grafts may be used in sub-glottic field, one of the most challenging fields of Trachea Surgery, due to ease of application and rapid vascularization. © 2016 by Korean Society of Otorhinolaryngology-Head and Neck Surgery
Guangdong Zhou - One of the best experts on this subject based on the ideXlab platform.
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long term functional reconstruction of segmental Tracheal defect by pedicled tissue engineered Trachea in rabbits
Biomaterials, 2013Co-Authors: Zhiyong Zhang, Aijuan He, Dan Li, Wenjie Zhang, Guangdong ZhouAbstract:Due to lack of satisfactory Tracheal substitutes, reconstruction of long segmental Tracheal defects (>6 cm) is always a major challenge in Trachea Surgery. Tissue-engineered Trachea (TET) provides a promising approach to address this challenge, but no breakthrough has been achieved yet in repairing segmental Tracheal defect. The longest survival time only reached 60 days. The leading reasons for the failure of segmental Tracheal defect reconstruction were mainly related to airway stenosis (caused by the overgrowth of granulation tissue), airway collapse (caused by cartilage softening) and mucous impaction (mainly caused by lack of epithelium). To address these problems, the current study proposed an improved strategy, which involved in vitro pre-culture, in vivo maturation, and pre-vascularization of TET grafts as well as the use of silicone stent. The results demonstrated that the two-step strategy of in vitro pre-culture plus in vivo implantation could successfully regenerate tubular cartilage with a mechanical strength similar to native Trachea in immunocompetent animals. The use of silicone stents effectively depressed granulation overgrowth, prevented airway stenosis, and thus dramatically enhanced the survival rate at the early stage post-operation. Most importantly, through intramuscular implantation and transplantation with pedicled muscular flap, the TET grafts established stable blood supply, which guaranteed maintenance of tubular cartilage structure and function, accelerated epithelialization of TET grafts, and thus realized long-term functional reconstruction of segmental Tracheal defects. The integration of all these improved strategies finally realized long-term survival of animals: 60% of rabbits survived over 6 months. The current improved strategy provided a promising approach for long-term functional reconstruction of long segmental Tracheal defect.
Umit Aydogmus - One of the best experts on this subject based on the ideXlab platform.
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Effectiveness of Palatal Mucosa Graft in Surgical Treatment of Sub-Glottic Stenosis
Korean Society of Otorhinolaryngology-Head and Neck Surgery, 2016Co-Authors: Umit Aydogmus, Adem Topkara, Metin Akbulut, Adem Ozkan, Figen Turk, Barbaros Sahin, Gokhan YuncuAbstract:Objectives Mucosal free grafts may be successfully applied in many surgical interventions. This study aims at investigating the feasibility of palatal mucosa graft in sub-glottic field in an animal model. Methods This randomized prospective controlled study was conducted with an animal model. Sub-glottic inflammation was created in 15 adult rabbits in each group and sub-glottic stenosis Surgery was applied thereafter. The rabbits in group 1 (control group) underwent segmental resection, partial cricoidectomy, and Trachea-thyroid cartilage anastomosis; the rabbits in group 2 underwent segmental resection, cricoplasty, and crico-Tracheal anastomosis using free buccal mucosa graft; and the rabbits in group 3 underwent segmental resection, cricoplasty, and crico-Tracheal anastomosis using free palatal mucosa graft. Re-stenosis was evaluated after 42 days. Results The percentages of stenosis were 27%±20%, 40%±20%, and 34%±23% for group 1, 2, and 3, respectively and the difference was not statistically significant (P=0.29). Intensive and tight fibrosis was observed in 2 rabbits (13%) in group 1, in 5 rabbits (33%) in group 2, and in 3 rabbits (20%) in group 3. There was not a statistically significant difference between groups (P=0.41). Excessive inflammation was observed in 3 rabbits (20%) in group 1, in 7 rabbits (47%) in group 2, and 3 rabbits (20%) in group 3. There was no a statistically significant difference between groups although inflammation rate was higher in the rabbits which underwent buccal mucosa graft (P=0.18). Conclusion The surgical treatments applied with free mucosa graft reduced anastomosis tension through enabling anastomosis to the distal of cricoid instead of thyroid cartilage. Free palatal mucosa grafts may be used in sub-glottic field, one of the most challenging fields of Trachea Surgery, due to ease of application and rapid vascularization