The Experts below are selected from a list of 225 Experts worldwide ranked by ideXlab platform
Mark P. Schoenberg - One of the best experts on this subject based on the ideXlab platform.
-
TESTICULAR METASTASIS OF Transitional Cell Carcinoma OF THE PROSTATE
The Journal of urology, 2000Co-Authors: Misop Han, Joseph D. Kronz, Mark P. SchoenbergAbstract:Testicular metastasis of Transitional Cell Carcinoma of the prostate and bladder is rare. We report on a patient who underwent surgery and radiation for infilterating Transitional Cell Carcinoma of the prostate and distal bladder, and 9 years later returned with a solitary testicular metastasis. CASE REPORT A 70-year-old white man presented elsewhere with symptoms of obstructive uropathy and underwent transurethral resection of the prostate for presumed benign disease in 1990. Medical history was significant for diabetes mellitus. The patient had undergone prior appendectomy, right hemicolectomy for cecal adenoCarcinoma, percutaneous drainage of infected right renal cyst and cholecystectomy. Pathological examination of the surgical specimen revealed Transitional Cell Carcinoma of the prostatic urethra with involvement of prostatic stroma, ducts and acini. Metastatic evaluation, including bone scan and computerized tomography of the chest, abdomen and pelvis, was negative. Excretory urography was negative for concurrent upper urinary tract disease. The patient underwent radical cystoprostatectomy and ileal conduit urinary diversion, and subsequent total urethrectomy and radiation therapy for infiltrating Transitional Cell Carcinoma of the prostate and distal bladder. All surgical margins and pelvic lymph nodes were negative for tumor. Nine years later a new, painless right testicular mass was noted during an annual followup for Transitional Cell Carcinoma. Scrotal ultrasonography revealed a large, heterogeneous mass of the right testis. Computerized tomography of the chest, abdomen and pelvis was negative for metastasis. Serum markers for primary germ Cell neoplasms were negative as well. The patient underwent right radical orchiectomy and pathological examination revealed poorly differentiated metastatic Transitional Cell Carcinoma involving the testis and spermatic cord (see figure). Extensive vascular invasion was identified, although the spermatic cord margin was negative for tumor. The tumor stained intensely for cytokeratin 7, which supports urothelial origin. DISCUSSION
-
Familial Transitional Cell Carcinoma Among the Population of Iceland
The Journal of urology, 1997Co-Authors: Lambertus A. Kiemeney, Mark P. Schoenberg, N. Charlotte Moret, J. Alfred Witjes, Hrafn TuliniusAbstract:AbstractPurpose: Several case reports have described familial aggregation of Transitional Cell Carcinoma of the urinary tract but to our knowledge only 1 epidemiological study specifically addressed the issue of familial bladder cancer. We evaluated the extent of familial aggregation of Transitional Cell Carcinoma among the population of Iceland.Materials and Methods: The first to third degree relatives of 190 patients with bladder, ureter or renal pelvis Transitional Cell Carcinoma diagnosed between 1983 and 1992 in Iceland were identified through the Icelandic Cancer Family Resource. The records of these 12,328 relatives were subsequently linked to the 1965 to 1994 cancer registry. The observed occurrence of Transitional Cell Carcinoma of the urinary tract was compared to the expected occurrence based on age, gender and calendar specific incidence rates. Observed-to-expected ratios and 95% confidence intervals were calculated.Results: In 41 of the 190 pedigrees at least 1 relative had Transitional Cell ...
-
Familial Transitional Cell Carcinoma
The Journal of urology, 1996Co-Authors: Lambertus A. Kiemeney, Mark P. SchoenbergAbstract:AbstractPurpose: Bladder cancer is a common malignancy, and a frequent cause of urological consultation and surgical intervention. Except for smoking and certain occupational exposures, the etiology of bladder cancer is largely unknown. Although the majority of patients with bladder cancer do not have a family history of Transitional Cell Carcinoma of the urinary tract, the study of familial Transitional Cell Carcinoma may lead to knowledge of the pathogenesis of this disease.Materials and Methods: To evaluate the current understanding of familial Transitional Cell Carcinoma, we reviewed the contemporary literature for case reports and epidemiological studies about this disease.Results: Numerous case reports document the clustering of Transitional Cell Carcinoma in families, several of which demonstrate an extremely early age at onset of disease, which argues in favor of a genetic component to familial Transitional Cell Carcinoma. The results of large epidemiological studies also suggest the existence of ...
Muhammad A. Siddiky - One of the best experts on this subject based on the ideXlab platform.
-
Transitional Cell Carcinoma of the renal pelvis with ovarian metastasis.
Gynecologic oncology, 1991Co-Authors: Jeng-gwang Hsiu, George M. Kemp, Gerard A. Singer, William H. Rawls, Muhammad A. SiddikyAbstract:This article describes the first reported case of a primary Transitional Cell Carcinoma of the renal pelvis metastatic to the ovary. The clinical presentation in our patient was similar to that of a primary ovarian Carcinoma. The differential diagnosis of a primary or metastatic Transitional Cell Carcinoma in the ovary is important and has therapeutic as well as prognostic implications.
Mark P. Seraly - One of the best experts on this subject based on the ideXlab platform.
-
A painful cutaneous nodule as the presentation of metastatic Transitional Cell Carcinoma of the renal pelvis.
Journal of the American Academy of Dermatology, 2000Co-Authors: Matthew J. Zirwas, Susan Hunt, T. Logan, John L. Abernethy, Mark P. SeralyAbstract:We report a 43-year-old man with HIV who presented with a painful, vascular-appearing nodule as the initial manifestation of metastasis of a prior Transitional Cell Carcinoma of the renal pelvis. The Transitional Cell Carcinoma had been treated by nephroureterectomy 4 years before the appearance of the nodule. Histopathologic comparison of the nodule with the prior Transitional Cell Carcinoma and immunoperoxidase staining with monoclonal antibodies confirmed that the nodule was a metastasis of the original Transitional Cell Carcinoma. In general, metastasis of Transitional Cell Carcinoma to the skin is quite uncommon. This case is the first reported episode of Transitional Cell Carcinoma of the renal pelvis metastasizing to the skin in the form of a vascular-appearing nodule. The significance of this unusual metastasis occurring in a person with HIV is unknown.
Jeng-gwang Hsiu - One of the best experts on this subject based on the ideXlab platform.
-
Transitional Cell Carcinoma of the renal pelvis with ovarian metastasis.
Gynecologic oncology, 1991Co-Authors: Jeng-gwang Hsiu, George M. Kemp, Gerard A. Singer, William H. Rawls, Muhammad A. SiddikyAbstract:This article describes the first reported case of a primary Transitional Cell Carcinoma of the renal pelvis metastatic to the ovary. The clinical presentation in our patient was similar to that of a primary ovarian Carcinoma. The differential diagnosis of a primary or metastatic Transitional Cell Carcinoma in the ovary is important and has therapeutic as well as prognostic implications.
Misop Han - One of the best experts on this subject based on the ideXlab platform.
-
TESTICULAR METASTASIS OF Transitional Cell Carcinoma OF THE PROSTATE
The Journal of urology, 2000Co-Authors: Misop Han, Joseph D. Kronz, Mark P. SchoenbergAbstract:Testicular metastasis of Transitional Cell Carcinoma of the prostate and bladder is rare. We report on a patient who underwent surgery and radiation for infilterating Transitional Cell Carcinoma of the prostate and distal bladder, and 9 years later returned with a solitary testicular metastasis. CASE REPORT A 70-year-old white man presented elsewhere with symptoms of obstructive uropathy and underwent transurethral resection of the prostate for presumed benign disease in 1990. Medical history was significant for diabetes mellitus. The patient had undergone prior appendectomy, right hemicolectomy for cecal adenoCarcinoma, percutaneous drainage of infected right renal cyst and cholecystectomy. Pathological examination of the surgical specimen revealed Transitional Cell Carcinoma of the prostatic urethra with involvement of prostatic stroma, ducts and acini. Metastatic evaluation, including bone scan and computerized tomography of the chest, abdomen and pelvis, was negative. Excretory urography was negative for concurrent upper urinary tract disease. The patient underwent radical cystoprostatectomy and ileal conduit urinary diversion, and subsequent total urethrectomy and radiation therapy for infiltrating Transitional Cell Carcinoma of the prostate and distal bladder. All surgical margins and pelvic lymph nodes were negative for tumor. Nine years later a new, painless right testicular mass was noted during an annual followup for Transitional Cell Carcinoma. Scrotal ultrasonography revealed a large, heterogeneous mass of the right testis. Computerized tomography of the chest, abdomen and pelvis was negative for metastasis. Serum markers for primary germ Cell neoplasms were negative as well. The patient underwent right radical orchiectomy and pathological examination revealed poorly differentiated metastatic Transitional Cell Carcinoma involving the testis and spermatic cord (see figure). Extensive vascular invasion was identified, although the spermatic cord margin was negative for tumor. The tumor stained intensely for cytokeratin 7, which supports urothelial origin. DISCUSSION
